... In the present case, the given time interval represents the time between the first presentation andthe detection ofthe intraspinal metastases as the primary site ofthe tumor; in this case, the ... conceived the idea ofthe study All authors participated in data collection KAK wrote the manuscript All authors read and contributed to the editing ofthe manuscript and gave their approval ofthe ... evidence of osseous vertebral metastases, which is a usual source ofthe epidural tumor extension The possible explanation forthe route ofthe intradural metastases is the meningeal spread of the...
... wire and also lifted above the solution To minimize the size ofthe stimulus artifact and maximize the size ofthe CAP signal, the diameter ofthe suction electrode matched the diameter ofthe ... a disease ofthe central nervoussystem (CNS) and elucidation oftheperipheralnervoussystem (PNS) in patients and animal models remains incomplete To illuminate our understanding of SD as pertaining ... peaks provide information about the relative number of myelin layers in a diffracting region ofthe sheath andthe regularity ofthe membrane packing [16] When the squares ofthe integral widths...
... alleles The allele that appears in the majority of a population is termed the major allele, the other is called the minor allele In our illustration, the genotypes ofthe SNPs forthe 1st, 2nd and ... example, the null hypothesis andthe alternative hypothesis forthe dominant model can be restated as follow: H0 : The proportion of case vs control is independent ofthe frequency distribution ofthe ... lists of sample ids in CEO model- one is sample id list from the SNP whose PT and GT are and 1, the other is the sample id list from the SNP whose PT and GT are and ; (b2) is the data format...
... impractical for systems with large numbers of tracks per group Therefore, the scope of this part ofthe thesis covers the development of reduced-complexity 2D Viterbi-like detection techniques 32 The ... 1.2 the historic development of optical storage technology andthe current state ofthe art in detection techniquesfor optical storage On the other hand, in wireless communication systems, the ... of OFDM systems and gives an overview of existing channel estimation techniques Chapter represents MIMO-OFDM systems in the angle domain, which inspires our work forthe development of MIMO-OFDM...
... the left occipital nerve as well as two divisions ofthe greater occipital artery as they pierce the substance ofthe trapezious muscle 1.0 cm to 1.2 cm from the skin Re-implantation oftheperipheral ... monthly and was distributed throughout the greater occipital nerves, beginning in theoccipital region and radiating upward to the top ofthe head When theoccipital neuralgia occurred, her occipital ... sent for pathological analysis The clinical significance of these nodules is also unknown, since they could interfere with the surrounding branches ofthe greater and lesser occipital nerves and...
... 25.10) For patients with other CNS cancer, the spine was the most common primary site (53.9% of total), followed by the brain (41.3% of total) and other (4.8% of total) Other CNS cancers in the ... Monograph Chapter 25 Cancer ofthe Brain andNervousSystemFor all analyses, brain cancer and other CNS cancer are analyzed separately because ofthe distinct differences between these two groups in ... grade and primary site The combinations of particular interest were: race and sex, histologic type and sex and histologic type and race Size of tumor information was not analyzed because of the...
... crucial forthe understanding of therapeutic modulation andthe validation of CCR1, CCR2 and CCR5 as feasible targets for therapeutic intervention in MS Page 10 of 13 (page number not for citation ... together, the results ofthe present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis of MS [39,40,42] and EAE [22,44,46], have provided evidence for an important ... crucial forthe understanding of therapeutic modulation andthe validation of CCR1, CCR2 and CCR5 as feasible targets for therapeutic intervention in MS Background Multiple sclerosis (MS) is the...
... combinations of chemotherapy and cranial radiation The excellent correlation ofthe in vitro and in vivo results of Noble and colleagues’ study [1] raises the hope that the technique used might ... Abnormal CT scans ofthe brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatmentofthe central nervoussystem with radiation and intrathecal chemotherapy N Engl ... doses of chemotherapy, necessitating either bone marrow transplantation or peripheral stem cell support to boost the immune system, and either no craniospinal radiation or focused radiation to the...
... marrow transplants and cytokine therapies can improve the outcome of many forms of cancer treatment In contrast, there has been no comparable level of analysis for most other organ systems compromised ... andthe interaction oftreatmentand time is very significant (p < 0.01); (b) in the CC, both thetreatment effect and time effect are extremely significant (p < 0.001), andthe interaction of ... prove of great value in the discovery and evaluation of therapies that either allow selective killing of cancer cells or offer selective protection to the normal cells ofthe body Materials and...
... immunoreactivity of both iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years old) (Cases and 2) and two controls ... hematoxylin Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervoussystemof goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected ... of nNOS and iNOS in the nonneurological control brain Both nNOS and iNOS immunoreactivity was recognized in the brain of control goats No inflammatory cells were found in the brain sections of...
... findings The question of whether our findings are of any significance forthe understanding of CIJD is justified and needs answering TLR ligands are found in the synovia of patients with CIJD ... after stimulationof splenic and thymic T cells The R440 However, the differential effect of Lip-OspA on B6, TLR4def and TLR-2-/- T cell populations suggests the surface expression ofthe respective ... sensors ofthe innate immune responses against microbial pathogens [42] but also as costimulators of cells ofthe adaptive immune system TLR-2 engagement therefore influences the differentiation of...
... central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis ofthe central nervoussystem Neurology ... Vasculitis ofthenervoussystem Curr Opin Neurol 2004, 17:317-336 16 Calabrese LH, Furlan AJ, Gragg LA, Ropos TJ: Primary angiitis ofthe central nervous system: diagnostic criteria and clinical ... presentation of primary angiitis ofthe central nervoussystem Ann Rheum Dis 2008, 67:1732-1735 doi:10.1186/1477-7819-9-97 Cite this article as: You et al.: Isolated angiitis ofthe central nervous system...
... between the two randomised treatment arms [27], thus increasing the importance of identifying any adverse effects oftreatment Here, we report the results of intelligence tests for patients and controls ... tested) and can only rule out differences of 10 points These results were unchanged when allowing for age at the start of treatment, gender, andthe number of previous tests taken Again, analysis of ... around the ideal test date: Within the first year forthe month test, and year either side of both the 3- and 5-year test dates The study was not designed as a longitudinal study, but rather as...
... This correlation of activity andthe effect ofthe nAuNPs on the CNS ofthe insect are due to how the brain ofthe cockroach controls its muscle response and locomotion [6] There is a significant ... injected the nanoparticles, and monitored food and water forthe duration ofthe experiment SK fabricated the nanoparticles and performed the TEM imaging SBV and HL conceived research and approaches, ... and a nAuNPs treated brains were scanned for comparison Figure 5a shows the results forthe control sample and Figure 5b forthe nAuNPs treated brain The binding energy for gold is at 85 eV The...
... tool for detection of productive virus replication in situ and therefore allows further studies to improve the understanding ofthe pathogenesis ofthe IBV infection Methods Cells and viruses The ... in the detection of several RNA viruses [11] Aim of this study was first to evaluate the suitability of IHC for detection of IBV antigen in paraffinwax embedded CAM and second to analyse the ... isolation and IFA GMK and JPT initiated the project, provide continued directions and critically reviewed the manuscript JPT also performed and supervised histopathology and IHC All authors read and...
... stage, thenervoussystem is largely in place and should, therefore, express a broad array of transcripts that define the development and function of most neurons Sub-microgram quantities of mRNA ... is to the left (b) Close-up ofthe adult head, showing the serotonergic neuron NSM and two sensory neurons, AFD and ASI For simplicity, only one ofthe two pairs of neurons is diagrammed The pharynx ... indication ofthe complex signaling capacity ofthe C elegans nervous system, most ofthe known peptide neurotransmitter genes (for example, 20 of 23 FMRFamide genes or 'flps') are enriched in the larval...
... experiments and drafted the manuscript WK carried out the in situ hybridization and sectioning experiments and participated in the design ofthe study and drafting ofthe manuscript EB participated in the ... to the majority of CNS cells and from transient to constitutive expression We describe several classes of expression profile and discuss these in terms of known and predicted modes of action of ... structures ofthe zebrafish central and/ or peripheralnervoussystem Additional data file 28 includes Tables J-L, listing the miRNAs analyzed, the family/cluster they belong to andthe mismatch...
... development of technology forthe simultaneous measurement of most ofthe mRNAs encoded by the mouse and human genomes has led to efforts to establish the transcriptomes of tissues and cells under ... males and females (c) Gene cluster analysis comparison ofthe effects of CR on hippocampal transcriptomes of male and female mice of different ages Note the similarities in responses of young and ... Waltham MA, USA) The sequences ofthe primers used andthe results ofthe validation of microarray data by real-time RT-PCR are listed in SPrimers in Additional data file The results for each gene...