stage 4 small cell lung cancer with metastases to the liver and brain
Báo cáo khoa học: " Absence of toxicity with hypofractionated 3-dimensional radiation therapy for inoperable, early stage non-small cell lung cancer" pot
... considered to have N1 diseaseclose to the primary lung tumor. In 19 cases (59%) the tumor was in the right lung. In 22 cases (69%) the tumorwas located in the upper lobes.Radiotherapy was delivered ... normal lung and to facilitate monitoring the respi-ratory motion. The median area of the fields was 72 cm2 (typically 8 cmì 9 cm) and the median PTV volume was 150 cm3 (range:28–1110). The ... as lung cancer. It is more convenient for the patients and reduces health care costs.This study reports our results on patients with medically inoperable, early stage, non -small cell lung cancer...
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Báo cáo hóa học: " Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer" pdf
... [10,11].MethodsSources of cell lines and culture The PC-9 lung tumor cell line was kindly provided byRoche (Basel, Switzerland); the A 549 and H460 cell lineswere purchased from the American Type Culture ... the H1975 cell line and five of the H1650 cell line with 4- μ m sections for IHC analysisfrom the Cell Signaling Technology laboratory.Study population and tumor pathologyTwenty-six stage IV ... compared with IHC results in five non -small- cell lung cancer (NSCLC) cell lines and tumor samples from 78 stage IV NSCLC patients.Results: IHC correctly identified del 19 in the H1650 and PC9 cell...
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Báo cáo khoa học: "The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer" pdf
... radiotherapy (TRT) com-bined with chemotherapy represents the standard ofcar e in the management of limited -stage small- cell lung cancer (LS-SCLC), the optimal radiation schedule and total ... radiotherapy is feasible concurrent with chemotherapy for limited -stage small- cell lung cancer: analysis of Cancer and Leukemia Group B study 39808. Int J Radiat Oncol Biol Phys20 04, 59 :46 0 -46 8.7. ... interruptions to palliate the toxicity from concurrent chemoradiation for limited small cell lung cancer decreases survival and disease control. Lung Cancer 2001,33: 249 -258.26. Cisplatin, etoposide, and...
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Báo cáo khoa học: " Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer" docx
... Rad iotherapy, Oligometastases, Non -Small Cell Lung Cancer BackgroundNon -small cell lung cancer (NSCLC) is the leadingcause of cancer mortality in the United States [1].Patients with stage ... Standard therapy for metastatic non small cell lung cancer (NSCLC) includes palliative systemicchemotherapy and/ or radiotherapy. Recent studies of patients with limited metastases treated with ... categorizedas stage III NSCLC, 38 patients (26.0%) with initial lim-ited stage IV NSCLC and 14 patients (9.6%) with stage I/II NSCLC who progressed to limited metastatic stage IV. Fifty-five of the 94 patients...
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Báo cáo khoa học: " Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases" docx
... primary tumors of the liver and of the lungs and metastases in the liver and lungs [1,2]. At the same time,laser-induced thermotherapy (LITT) or high frequency-induced thermotherapy (HITT) became ... (range: 1.6 to 16 .4 %) and 5.3% (range: 1.2 to 14. 3%), respectively.Yet, these volumes and the planning target volumes werestill small in comparison to the total volume of the lungs and, up to this ... with peripheral stage Inon -small cell lung cancer. Lung Cancer 1999, 26:137- 142 .23. Slotman BJ, Antonisse IE, Njo KH: Limited field irradiation inearly stage (T1-2N0) non -small cell lung cancer. ...
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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
... 16 (46 ) 16 (47 )Time to progression (TTP) (A) and overall survival (OS) (B)Figure 1Time to progression (TTP) (A) and overall survival (OS) (B).0 4 8 121620 242 8323 640 444 852Weeks00.20 .4 0.60.81TTPPatients ... G,Gozzelino F, Tonato M: Gemcitabine and cisplatin versus mito-mycin, ifosfamide, and cisplatin in advanced non -small- cell lung cancer: a randomized phase III study of the Italian Lung Cancer Project. ... ( 14. 6)Site of disease Lung ± lymph nodes 14 (35) 14 ( 34. 1) Lung and 1 metastatic site 12 (30) 15 (36.6) Lung and ≥ 2 metastatic sites 9 (22.5) 10 ( 24. 4)Extra-pulmonary disease 5 (12.5) 2 (4. 9)Previous...
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Báo cáo khoa học: "Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer" pptx
... tumorshrinkage, with no additional toxicity, and gave the patient the possibility to undergo a lobectomy ratherthan a pneumectomy, with the obvious advantages of aless invasive and more limited surgical ... appeared to measure 65 ì 41 mm. The safety profile was good, with patient reportinggrade 1 ane mia, grade 3 neutropenia without fever,weight loss inferior to 10% and asthenia. Therefore, the treatment ... chemotherapy with single agentdocetaxel in a patient with advanced non small cell lung cancer Ferdinando Riccardi1*, Giuseppe Di Lorenzo1, Carlo Buonerba1, Guglielmo Monaco2, Roberto Monaco3,Mimma...
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Báo cáo khoa học: "Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy" pot
... factors associated with SARP. The incidences of SARP in the group with NTCP > 4. 2% and NTCP 4. 2% were 43 .5% and 1 .4% , respectively (p < 0.01). The incidences of SARP in the group with ... for 94 patients; the incidences ofSARP in the group with NTCP > 4. 2% and NTCP ≤ 4. 2%were 43 .5% and 1 .4% , respectively (p < 0.01); the inci-dences of SARP in the group with V10 ≤50% and ... statisti-cally; the incidences of SARP in the group with NTCP > 4. 2% and NTCP ≤ 4. 2% were 43 .5% and 1 .4% , respectively(p < 0.01). The incidences of SARP in the group with V10≤ 50% and V10 >50%...
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Báo cáo khoa học: "Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size" ppsx
... allpatients, and it was 81% for the stage IA patients treated with 48 Gy and 74% for the stage IB patients, with nosignificant diffe rence between them ( p =0.35).Two stage IA patients treated with 44 ... 70all patients stage IA patients treated with 48 Gy in 4 fractions stage IB patients treated with 52 Gy in 4 fractionsall patients stage IA patients treated with 48 Gy in 4 fractions stage IB patients ... 1 24 NSCLC patients treated with SBRT, 87 had stage IA and 37 had stage IB disease. Tw o stage IApatients with tumors of less than 1.5 cm in diameterwere treated with 44 Gy in 4 fractions, and...
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Báo cáo khoa học: "Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma" pot
... .002 .961 4. 638 .031 .895 . 344 3~5 cm .002 .961 10.977 .001 4. 541 .0335~7 cm 4. 638 .031 10.977 .001 .108 . 742 >7 cm .895 . 344 4. 541 .033 .108 . 742 Wu et al. Radiation Oncology 2011, 6: 84 http://www.ro-journal.com/content/6/1/ 84 Page ... mortality of the patients with stage II was 4. 0 64 times higher than that of the patients with stageI (p = 0.015). Systemic chemotherapy increased the risk of death of the patients with early stage NSCLCin ... (range, 142 .8~ 240 .0 Gy) in 24 patients with tumor size of 3~5 cm, 165.5 Gy (range, 142 .8~212.2 G y)in 10 patients with tumor size of 5~7 cm and 144 .0 Gy(range, 142 .8~1 84. 8 Gy) in 9 patients with...
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Báo cáo khoa học: "Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study" pps
... 18 to 22 25 > 25 to 28Oesophagus 1 24 > 24 to 27 27 > 27 to 28.5Ipsilateral Brachial Plexus 1 24 > 24 to 26 27 > 27 to 29Heart 1 24 > 24 to 26 27 > 27 to 29Trachea and ... mini-mum of 40 hours, in line with the RTOG protocol 0618.Ratio of 50% Prescription Isodose Volume to the PTV (R50%) from a total of 22 patients with stage IA tumours and 4 patients with stage 1B ... stereotacticradiotherapy. Therefore, an additional planning study wasperformed in 22 stage IA and 4 stage 1B non -small cell lung cancer patients in order to develop and evaluate the planning guidelines...
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Báo cáo khoa học: " Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer" potx
... retrospectively reviewed the records of 115 patients with non -small cell lung cancer treated at our institution with definitive radiation therapy with or without concurrentchemotherapy (CHT). All ... regional recurrence, and distant metastases (DM).Results: The median follow-up time was 18 months (3 to 44 months) among all patients and 27months (6 to 44 months) among survivors. The median overall ... coded the patient data-base, conducted the analysis and wrote the manuscriptdraft. JYC designed the project, analyzed the data and revised the manuscript. AK helped with the database and data...
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Báo cáo khoa học: " Accelerated high-dose radiotherapy alone or combined with either concomitant or sequential chemotherapy; treatments of choice in patients with Non-Small Cell Lung Cancer" pps
... chemotherapy for stage III non -small- cell lung cancer. JClin Oncol 1995, 13 :45 2 -45 8. 34. Jeremic B, Shibamoto Y, Acimovic L, Milisavljevic S: Hyperfraction-ated radiation therapy with or without ... Surg20 04, 128 :41 4 -41 9.39. The International Adjuvant Lung Cancer Collaborative Trial Group:Cisplatin-based adjuvant chemotherapy in patients with completely resected non -small cell lung cancer. ... modality trials of the Cancer and Leukemia Group Bin stage III non -small- cell lung cancer: analysis of factorsinfluencing survival and toxicity. Ann Oncol 20 04, 15:1033-1 041 .22. Zatloukal P,...
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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot
... patients with non -small cell lung cancer. J Thorac Oncol 2010, 5:825-9. 4. Ou SH, Zell JA: Validation study of the proposed IASLC staging revisions of the T4 and M non -small cell lung cancer descriptors ... radiotherapy is the currentstandard of care for pati ents with locally advan ced (stage IIIA and stage IIIB) NSCLC. However, regardless of the total dose of radiation and the optimal chemotherapy, the ... Lung Cancer Registry. Prognosis of 6 644 resected non -small cell lung cancersin Japan: a Japanese lung cancer registry study. Lung Cancer 2005,50:227- 34. 11. Andre F, Grunenwald D, Pignon JP, Dujon...
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báo cáo khoa học: "EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features" pptx
... growthfactor receptor expression or activation in operable non -small cell lung cancer. Lung Cancer 2005, 48 (1) :47 -57. 40 . Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M,Ramirez ... 2-mediatedpathways and its implications for the chemoprevention of head and neck cancer. Mol Cancer Ther 2005, 4( 9): 144 8-55, (Georgia).7. Sahin M, Sahin E, Gümüslü S: Cyclooxygenase-2 in cancer and angiogenesis. ... anepidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non -small cell lung cancer (NSCLC)....
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