special topics in heart failure
Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... lack of increase in LV dyssynchrony during dobutamine stress in patients with wide QRS duration (20) In contrast, Kurita et al reported on an increased mechanical dyssynchrony during pacing–induced ... pacing–induced tachycardia in patients with normal QRS duration (21) A remarkable increase in intra-LV dyssynchrony was also demonstrated during pharmacological stress in systolic heart failure patients ... rest or during exercise or the exercise-related increase in EDVI and the corresponding LDT values were found in both IDCM subgroups Results Systolic and diastolic time intervals The clinical characteristics...
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Special Topics in Cardiac Surgery Edited by Cuneyt Narin potx
... be maintained by several factors including the production of cytokines such as TNF-alpha (α), interleukin (IL-1), IL-1 (beta), interleukin (IL-2), interleukin ( IL-6), interleukin (IL-8), interleukin ... appropriate 20 Special Topics in Cardiac Surgery Commonly used catecholamines such as dopamine, dobutamine, isoproterenol, epinephrine, norepinephrine and inotropic catecholamines not milrinone and ... the FDA for this indication, their mechanisms of action are the first to inhibit the binding of plasmin to fibrin occupying the binding sites of lysine of the proenzyme plasminogen and the second...
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THE ROLE OF SURGERY IN HEART FAILURE - part 2 pps
... who have heart failure worldwide Heart failure is primarily a disease of the elderly, and the prevalence of chronic heart failure increases with advancing age Currently, chronic heart failure ... chronic shortage of donor hearts Currently, the mainstay of heart failure treatment is pharmacologic and includes angiotensin converting enzyme inhibitors, angiotensin receptor blockers, b-adrenergic ... diastolic heart failure ranges from 5% to 15%, and admission rate for recurrent heart failure is 50% within the first months [1–4] The remaining 50% to 70% of patients present with systolic heart failure...
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THE ROLE OF SURGERY IN HEART FAILURE - part 3 pptx
... Heart Failure Clin (2007) 139–157 Surgery for Heart Failure: Now Something for Everyone? Stephen Westaby, MS, PhD, FRCS* Oxford Heart Centre, John Radcliffe Hospital, Headington Oxford, ... better understanding of the anatomy and pathophysiology of heart failure The failing heart beats at more than 120,000 beats per day, pumping more than 6,000 L of blood against an increased systemic ... This procedure was the landmark beginning of cardiac pacing (Fig 1) For the past 50 years cardiac surgery has been in a continuous state of flux In congenital heart disease palliative techniques...
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THE ROLE OF SURGERY IN HEART FAILURE - part 4 ppsx
... transvalvular gradient [4] Intraoperative myocardial injury remains prevalent in the increasingly elderly surgical population because tolerance to ischemia is reduced in aged myocardium [5] Patients ... coronary bypass and unstable angina to a glycoprotein IIb/IIIa inhibitor or placebo, the 7-day mortality or myocardial infarction rate was 22.3% in almost 700 patients in the control arm [2] A collective ... unit with borderline cardiac index and a blood pressure of 110/70 mm Hg Over the next hours the blood pressure remains acceptable on inotropic support but the urine output dwindles and the ankles...
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THE ROLE OF SURGERY IN HEART FAILURE - part 6 doc
... their rationale in the setting of life-threatening AMI and acute on chronic * Corresponding author New York Presbyterian Hospital, Milstein Hospital Building, Room 7-435, 177 Fort Washington Avenue, ... In the first minute, contractile dysfunction within the ischemic zone results from sarcomere deterioration Active systolic shortening progresses to passive lengthening Within 20 minutes of IRA ... to innovations in pharmacologic treatment, interventional cardiology, as well as techniques in bypass surgery and circulatory support [4] Surgery has played a key role in addressing emergent catastrophes...
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THE ROLE OF SURGERY IN HEART FAILURE - part 8 pdf
... Heart Failure Clin (2007) 211–228 Revascularization in Heart Failure: Coronary Bypass or Percutaneous Coronary Intervention? Sorin V Pusca, MD, John D Puskas, MD* ... Puskas, MD* Emory University School of Medicine, Atlanta, GA, USA Coronary artery disease (CAD) is currently the single most common cause of heart failure in adults [1] The prognosis of patients ... scarring after previous myocardial infarction There is increasing evidence that chronic LV dysfunction resulting from hibernating myocardium in patients who have severe multivessel disease is not...
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THE ROLE OF SURGERY IN HEART FAILURE - part 9 potx
... b Ischemic heart disease is the leading cause of heart failure in North America, accounting for approximately two thirds of heart failure cases [1] Patients who have ischemic heart failure suffer ... The increase in tension plays a key role in activating complex neurohormonal mechanisms, including an increase in angiotensin II, collagen deposition, and degradation through metalloproteinase-1 ... doi:10.1016/j.hfc.2007.05.003 heartfailure.theclinics.com Heart Failure Clin (2007) 237–243 Left Ventricular Restoration: How Important is the Surgical Treatment of Ischemic Heart Failure Trial? Lorenzo...
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THE ROLE OF SURGERY IN HEART FAILURE - PART 2 pdf
... individual patient basis [13] Indeed, it may not be 1551-7136/07/$ - see front matter Ó 2007 Elsevier Inc All rights reserved doi:10.1016/j.hfc.2007.05.005 heartfailure.theclinics.com Heart Failure ... obtain the first results of trials in 2007 Revascularization is not discussed further in this manuscript The initial enthusiasm for skeletal myoblast and stem cell transplantation into the failing ... erythropoietin-stimulating peptides when not due to specific haematinic deficiency may also improve symptoms, although the data are not robust [5] Withdrawal of nonsteroidal anti -in ammatory drugs, including...
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THE ROLE OF SURGERY IN HEART FAILURE - PART 4 ppt
... allows the heart a period of relative rest in which functional improvement may be achieved by interrupting the vicious circle of increasing wall tension and functional impairment The hearts of ... Heart Failure Clin (2007) 299–315 Patients who Have Dilated Cardiomyopathy Must Have a Trial of Bridge to Recovery (Pro) Johannes Mueller, MDa,*, Gerd Wallukat, PhDb b a Berlin Heart, Berlin, ... devices with biventricular pacing * Corresponding author Berlin Heart, Wiesenweg 10, 12247 Berlin, Germany E-mail address: johannes.mueller@berlinheart.de (J Mueller) capability postpones the...
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THE ROLE OF SURGERY IN HEART FAILURE - PART 6 pdf
... efficacy remains somewhat uncertain [2,3] 1551-7136/07/$ - see front matter Ó 2007 Elsevier Inc All rights reserved doi:10.1016/j.hfc.2007.05.007 heartfailure.theclinics.com Heart Failure Clin (2007) ... multidisciplinary teams; new pharmacologic compounds, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers, spironolactone and beta-blockers; novel devices, including ... understanding and refinement of the therapeutic orchestra available for patients in the advanced phase of heart failure have occurred, specifically with the introduction of highly specialized heart failure...
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THE ROLE OF SURGERY IN HEART FAILURE - PART 9 docx
... to heart failure [7] Transplant outcomes are improved because terminally ill patients are in better condition to survive major surgery [8] In turn comes the observation that mechanical unloading ... and infrequent intervention In the study by Sharples and colleagues [11] evaluating the ventricular assist device program in the United 1551-7136/07/$ - see front matter Ó 2007 Elsevier Inc All ... significant comorbidity, fewer than 2,200 donor hearts per year are made available in the United States and around 150 in the United Kingdom [3] In a population constantly bombarded with media...
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THE ROLE OF SURGERY IN HEART FAILURE - PART 10 potx
... surgery, in advanced heart failure, 328 Coronary interventions, percutaneous, in advanced heart failure, 327–328 D Defibrillator, cardiac, automatic implantable, in advanced heart failure, 326–327 in atable, ... disease in, 295 Aortic valve replacement, in aortic stenosis, 294–295 return of congestive heart failure following, 295 Aortic valve surgery, decision for, in aortic regurgitation, 293 in advanced heart ... 369–375 mechanical, in advanced heart failure, 331, 332 Coagulopathies, destination mechanical circulatory support devices and, 331, 353 Congestive heart failure See Heart failure, congestive...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... of the attending physician, including inotrope administration and dosing It is well recognized that heart failure leads to increased circulating levels of pro-inflammatory cytokines, such as ... much insight regarding inotrope use in the setting of more routine decompensated heart failure, and the effect milrinone in ischemic subset of patients deserves further investigation Conclusion Initiation ... studies examining natriuretic peptide levels and/or inflammatory markers during inotrope administration with inconsistent results [8-11] Adding complexity to this picture is data indicating that...
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Báo cáo hóa học: "Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion" doc
... cells in ischemic heart failure Proc Natl Acad Sci USA 2005, 102:8692-8697 Fedak PW: Paracrine effects of cell transplantation: Modifying ventricular remodeling in the failing heart Semin Thorac ... into new, functioning cardiomyocytes improving cardiac performance is inferential Whether this therapy can achieve reverse remodelling and improve LVEF in the chronically ischemic heart remains ... http://www.translational-medicine.com/content/9/1/12 Figure Intraoperative view showing clinical application of stem cells into the failing heart with multiple targeted injections following device insertion Note the outflow graft (1) connected...
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Báo cáo sinh học: "Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-g in patients with chronic heart failure" potx
... interleukins and 6, TNF-a, matrix metalloproteinases, neuroepinephrine, renin, galectin-3 [16-18], some of which are also important tools in the diagnosis and pathogenesis of heart failure, in the ... disease to heart failure still need further investigation The identification of the cytokines associated with chronic heart failure is not only important to get deeper insights into the inflammatory ... modulated in CHF Grey ovals: genes found to be regulated in CHF in the present study Endothelin-1 (ET-1), Galectin (GAL3), Norepinephrine (NOR), Tumor necrosis factor (TNF) a, Interferon (IFN)- g, Interleukin...
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