... drotrecogin alfa would be used more widely [11] in patients, including those with severeacutepancreatitis A recent report describes the use of this drug in two patients with severeacutepancreatitis ... specific treatment for severeacute pancreatitis, yet although drotrecogin alfa holds promise in sepsis, is it safe for use insevereacute pancreatitis? In the absence of specific clinical trial evidence, ... of severeacutepancreatitis Br J Intensive Care 2000, 10:51-59 Ammori BJ, Fitzgerald P, Hawkey P, McMahon MJ: The early increase in intestinal permeability and systemic endotoxin exposure in...
... tomography associated with typical clinical findings, including acute abdominal pain The patients had severe AP according to the Atlanta classification [18], in which severe AP is associated with organ ... protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, doubleblinded, placebo-controlled, dose-finding study Crit ... evidence of specific anti-inflammatory action of APC [12] The remaining human studies finding associations between APC and inflammatory phenomena have involved only hyperacute proinflammatory/procoagulant...
... during the surgical management of severe necrotizing pancreatitis Pancreas 2004, 29:152-156 Ping C, Youngping Z, Minmin Q, Weiyan Y, Yaozong Y: Activated protein C improves severity of acutepancreatitis ... moderate protein C deficiency Abbreviations APACHE, Acute Physiology and Chronic Health Evaluation; APC, activated protein C; SAP, severeacutepancreatitis Page of Competing interests In the last ... Wang D, Sundin DP, Macias WL; Xigris and prophylactic heparin Evaluation inSevere Sepsis (XPRESS) Study Group: Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated)...
... and so infection status was not included in the analysis Current trends in treatment for severeacutepancreatitis Although the studies cited above yielded contradictory findings regarding the ... importance of gram-negative intestinal colonization preceding pancreatic infection insevereacute pancreatitis; results of a controlled clinical trial of selective decontamination Intensive Care Med ... Fungal infections in patients with severeacutepancreatitis and the use of prophylactic therapy Clin Infect Dis 2003, 37:208-213 Halonen KI, Leppäniemi AK, Lundin JE, Puolakkainen PA, Kemppainen...
... when there was the clinical suspicion of IAH These clinical indications included oliguria, hypoxia, abdominal distension, and severe abdominal pain The incidence of IAH (defined as IAP ≥ 15 mmHg) ... etiology of acutepancreatitis was biliary tract stones in 19 patients, alcohol intake in 12, hyperlipemia in 4, and trauma inIn patients, the cause of pancreatitis could not be determined Mean ... Austrums E, Snippe K, Berzins M: Clinical significance of increased intraabdominal pressure insevereacutepancreatitis Acta Chir Belg 2002, 102:71-74 Tao HQ, Zhang JX, Zou SC: Clinical characteristics...
... insevereacute pancreatitis: an indication for a decompressing laparotomy? Dig Surg 2002, 19:402-405 De Waele JJ, Hoste E, Decruyenaere J, Colardyn F: Adrenal insufficiency insevereacutepancreatitis ... 2003, 1:CD002837 Pupelis G, Austrums E, Snippe K, Berzins M: Clinical significance of increased intraabdominal pressure insevereacutepancreatitis Acta Chir Belg 2002, 102:71-74 Mier J, Leon ... necrosis were confounding factors and were a bias in finding increased mortality rates for early surgery In this paper we report our study on the impact of the timing of surgical intervention and...
... Siriwardena AK: Drotrecogin alfa (recombinant human activated protein C) insevereacutepancreatitis Crit Care 2005, 9:321-322 Gerlach H: Risk management in patients with severeacutepancreatitis Crit ... early increase in intestinal permeability and systemic endotoxin exposure in patients with severeacutepancreatitis is not associated with systemic bacterial translocation: molecular investigation ... underlying principle that patients with infected necrosis require debridement/drainage of their intraabdominal focus of sepsis Competing interests The author(s) declare that they have no competing interests...
... of acutepancreatitis [15,18,32,33] In fact, Abe and colleagues have demonstrated in experimental models of acutepancreatitis that inflammation is more severe and mortality is increased in adrenalectomized ... insufficiency in patients with severeacutepancreatitis Intensive Care Med 2007, 33:1754-1760 Frakes JT: Biliary pancreatitis: a review Emphasizing appropriate endoscopic intervention J Clin Gastroenterol ... occurring in the early stage of SAP share many similarities with severe sepsis and septic shock The profiles of inflammatory mediators in SAP are similar to those insevere sepsis, suggesting that...
... showed an increasing steepness toward higher doses and an increase in steepness from V10 to V40 was more pronounced for the total lung; A 10% increase in V10 resulted in a 10% increase in pneumonitis ... versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer J Clin Oncol 1999, 17:2692-2699 Komaki R, Seiferheld ... radiochemotherapy with vinorelbine plus cisplatin or carboplatin in patients with locally advanced non-small-cell lung cancer (NSCLC) and an increased risk of treatment complications: Preliminary results...
... continued to complain of severe abdominal pain radiating through his back and lower chest An abdominal ultrasound demonstrated an increased echogenicity consistent with inspissated secretions in ... acutepancreatitis occurring in an older adult with pancreatic insufficiency and cystic fibrosis but in the setting of normal amylase and lipase The few reports available concerning acutepancreatitis ... dilated intrahepatic and extrahepatic biliary ducts These findings were thought to be consistent with either acutepancreatitis or a pancreatic malignancy Results of his liver function tests remained...
... continued to complain of severe abdominal pain radiating through his back and lower chest An abdominal ultrasound demonstrated an increased echogenicity consistent with inspissated secretions in ... acutepancreatitis occurring in an older adult with pancreatic insufficiency and cystic fibrosis but in the setting of normal amylase and lipase The few reports available concerning acutepancreatitis ... dilated intrahepatic and extrahepatic biliary ducts These findings were thought to be consistent with either acutepancreatitis or a pancreatic malignancy Results of his liver function tests remained...
... chemokines inacutepancreatitisAcutepancreatitis was induced by intraperitoneal administration of caerulein ((50 μg/kg hourly, for 10 h) Column labeled CTRL' refers to chemokines level in mice injected ... on acute pancreatitisassociated lung injury Acute pancreatitis, in mice pretreated with DW, followed by 10 hourly injections of caerulein (50 μg/kg) was associated with lung injury As shown in ... effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation Clin Sci (Lond) 2008, 115:91-97 Sivarajah A, Collino M, Yasin M, Benetti E, Gallicchio...
... http://www.jmedicalcasereports.com/content/1/1/75 Competing interests The author(s) declare that they have no competing interests Authors' contributions UR was involved in collecting patient details, reviewing the literature and ... manuscript as the main author RSY was involved in reviewing the literature and proof reading of the manuscript RSY has approved the final manuscript All authors have read and approved the final manuscript ... to ranitidine in an obstetric patient Anaesthesia 1992, 47(4):360-1 Greer IA, Fellows K: Anaphylactoid reaction to ranitidine in labour Br J Clin Pract 1990, 44(2):78 Natsch S, Vinkins MH, Voogt...
... contribution in analysing and interpreting the patient’s data during the ICU admission and has been involved in drafting the manuscript for the part concerning the ICU admission He gave final approval ... encouraging In particular, rituximab is increasingly being used off-label, for difficult-to-treat auto-immune diseases and presents the advantage of inducing a selective B-cell depletion, sparing ... gave final approval of the version to be published VL made a substantial contribution in the data-analysis and interpretation, and has been involved in drafting the manuscript She gave final approval...
... of inflammation-mediated cellular or tissue injury, including severe sepsis, hemorrhagic shock, ischemia/reperfusion-induced intestinal mucosal injury, and ileus induced by bowel manipulation in ... edema in endotoxin-induced acute lung inflammation [23] Thus, delayed release of HMGB1 can participate in the downstream development of lung injury, and HMGB1 may be a distal mediator of acute inflammatory ... results in lung injury without causing systemic inflammation and multi-organ failure Moreover, the LPS-induced ALI model results in microvascular injury and diffuse alveolar damage with intrapulmonary...
... case-definition, acute renal failure severe enough, in the opinion of the treating intensivist, to warrant the initiation of RRT This definition was selected because the initiation of RRT in critically ... in 68 (28%), hyperkalemia in 59 (25%), and toxins in (2%) The modality of renal replacement in the ICU was exclusively CRRT in 147, exclusively IHD in 48, and some combination of regimens using ... media in 107 (45%), aminoglycosides in 47 (20%) and amphotericin B in 10 (4%) The indications for institution of RRT were diuretic-resistant fluid overload in 178 (74%), metabolic acidosis in 87...
... support during the ICU stay and during the rehabilitation period was associated with a decrease in PTSD symptoms In addition, 'high-scoring patients', indicating an increased risk of developing PTSD, ... difference; btrend rating between (never) and (always) was possible, leading to a total score ranging from 10 to 70 points A total of 70 points indicates severe PTSD symptoms Using the German version ... controlled study was performed at a single university centre specializing in the treatment of patients with severe ARDS Our clinical treatment algorithm included the inhalation of nitric oxide and...
... health services In future Valid International's emphasis will change from ongoing technical support to training health ministry trainers, which could be less costly Thus costing of longer term ... to raise community awareness of SAM and CTC Valid International, a company specialising in nutritional research in developing countries, helped initiate the programme and provided technical support ... constraints are critical for the expansion of CTC, we are aware of only one published study reporting original data on costs of ambulatory treatment of severeacute malnutrition in a developing...
... of severeacutepancreatitis Tohoku J Exp Med 2006, 208:261-266 Nakae H, Endo S, Inoue Y, Fujino Y, Wakabayashi G, Inada K, Sato S: Matrix metalloproteinase-1 and cytokines in patients with acute ... differentiating mild and severe forms of AP, or for differentiating infected from non-infected patients with AP, but an increase in TREM-1 expression is associated with the inflammatory process in these ... severity inacutepancreatitis Pancreatology 2002, 2:543-549 Swaroop VS, Chari ST, Clain JE: Severeacutepancreatitis JAMA 2004, 291:2865-2868 Karne S, Gorelick FS: Etiopathogenesis of acute pancreatitis...
... in the treatment of severe sepsis and septic shock in adults JAMA 2009, 301:2362-2375 Eklund A, Leppäniemi A, Kemppainen E, Petillä V: Vasodilatory shock insevereacutepancreatitis without ... metabolism in human acutepancreatitis Crit Care Med 2006, 34:1060-1066 Bollen TL, van Santvoort HC, Besselink MG, van Ramshorst B, van Es HW, Gooszen HG; Dutch AcutePancreatitis Study Group: Intense ... necrotizing pancreatitisin rats Pancreas 2008, 37:316320 13 Xu S, Chen C, Wang W-X, Huang S-R, Yu J, Chen X-Y: Crucial role of group IIa phospholipase A2 in pancreatitis- associated adrenal injury in acute...