... treat-ment and lung functionin further prospective studies.ConclusionsOur findings are in line with previous observations show-ing an inverse association between blood pressure andlung function. Furthermore, ... effects onlung function or respiratory symptoms [13,14]. However,these studies investigated the potential effect of BBLintake on lung function mainly in patients with alreadyexisting pulmonary ... lung function has been discussed.However, side effects of beta-blockers have been investigated mainly in patients with already reduced lung function. Thus, aim of this analysis is to determine...
... reaching markets. Ac-cess can therefore not explain the variance in efficiency of Chinesewheat production. Market in uence (market), as a proxy for landrent indicating the investments in machinery, ... these interact with local constraints. The results of our analysis have confirmed that the factors explaining inefficiencies in production widely vary by region. Furthermore, factors explain-ing ... 2010Available online 26 March 2010Keywords:Grain productionYield gapLand managementIntensificationInefficiencyFrontier analysis abstractGlobal grain production has increased dramatically during the...
... correlated. Spatial regressionThe descriptive analysisin Figure 3 is univariate. The aimof the spatial regression analysis is to combine multiplefactors in a model which explains these spatial ... beneficiaries in 2000 CMS Geographic Service Area File, countyCINCREASE Binary indicator of an increase in competition among the MMC plans available, between 1998–2000, from inverse Herfindahl indexCMS ... reside in rural areas. We interact the pro-portion of elderly in poverty with the proportion in ruralareas to include in the model.We also expect that elderly living among elderly in ruralareas...
... determine the regional dorsal PFCWMH volume for each individual.fMRI Data Preprocessing and Spatial NormalizationFunctional imaging data were realigned in SPM99and spatially normalized using in- house, ... Prefrontal cortex andepisodic memory: Integrating findings fromneuropscyhology and functional brain imaging. In T. B.Amanda Parker & E. Wilding (Eds.), Memory encodingand retrieval: A cognitive ... having controlpoints as vertices. These result in a matching of fineanatomical details. Each data voxel in the target andsubject image is contained within a 4 Â 4 Â 4 cubeof such control points,...
... sion of SREBP-1 in the brain does increase in miceduring aging [39], a phenomenon also observed in theperipheral nerve [3]. The meaning of this aging-relatedincrease in SREBP-1 in both the PNS ... myelin protein-22, myelin asso-ciated glycoprotein (MAG) and myelin basic protein,but no myelin-specific lipids. Nevertheless, whereas allmajor lipid classes are present in myelin, as in othermembranes, ... depletionof Lpin1 functionin Schwann cells only is sufficient toinduce a demyelinating phenotype [23]. Whether lipidsfrom the epineurial compartment are implicated in functioning of axons and...
... VH2-N)which we previously showed does contain an actin-binding domain (this actin-binding domain has not yetbeen mapped) [23]. We name the actin-binding domainthat we have identified VH2-C and VH2-N ... submodules in C-Vrp1p are required foractin-cytoskeleton polarization: a novel C-terminal actin-binding submod-ule (CABS) that contains a novel G-actin-binding domain, which we call averprolin homology ... domains are directlyimplicated in polarization of the yeast actin cytoskele-ton. The presence of the novel actin-binding VH2-Cdomain in C-Vrp1p364)817may explain why mutations in the N-terminal...
... additional insights into thisinteresting question.Conclusions In summary, we have identified a novel metabolicgene switch (decrease in fatty acid utilization,increase in glucose utilization) in the ... 2007)doi:10.1111/j.1742-4658.2007.06051.xThe mechanisms underlying increased cardioprotection in younger femalemice are unclear. We hypothesized that serine-threonine protein kinase(protein kinase B; Akt) triggers a metabolic ... prosurvival serine-threonineprotein kinase, Akt (also known as protein kinase B)[2]. In agreement with this, elevated levels of activatedAkt in female hearts are linked to improved cardiaccell...
... 2nd line Risk management function, compliance function and other monitoring functions 3rd line Internal audit function 56. Control failings by one line of defence should, in principle, ... 4 The internal audit functionin banks 1. The internal audit function 8. The internal audit function plays a crucial role in the ongoing maintenance and assessment of a bank’s internal ... not interfere in its business decisions, it can be in a position to influence them by challenging management. Both the internal audit function and banking supervisors have an interest in the...
... responsibility for maintaining the function s independence and objectivity. 14. The internal audit function should not be involved in designing, selecting, implementing or operating specific internal control ... directors remains ultimately responsible for these activities and for maintaining an internal audit function within the bank. Outsourcing of internal audit activities is further addressed in principle ... authority of the internal audit function within the bank in a manner that promotes an effective internal audit function as described in Principle 1. Principle 6: Every activity (including outsourced...
... dynamicspace, complex feedbacks, or nonlinearities in responses. These componentsrequire a more dynamic consideration of interacting elements.Interacting ElementsAn interacting element approach is required ... new understanding about ecosystem functionin time andspace.Looking AheadUnderstanding spatial heterogeneity has been referred to as “the final fron-tier” in other areas within ecology (e.g., ... Consequences of Spatial Heterogeneity in Ecosystem Function MONICAG. TURNER and F. STUART CHAPIN IIIAbstractUnderstanding the causes and consequences of spatial heterogeneity in ecosystem function...
... cystein, methionine and serine (Fig. 2).Mutants containing asparagine, aspartic acid, glycine,lysine or valine were nonfunctional (Fig. 2). Clonesexpressing eEF2 in which the adjacent threonine ... recombi-nation using LR clonase. The destination vector was trans-formed into strain YOR133w for confirming geneexpression, and into strain GB1 for functional analysis byplasmid shuffling. A copy ... were unable to functionally complementwild-type eEF2) were able to bind to ribosomes in cellsalso expressing wild-type eEF2 from one of theremaining eEF2 coding genes. Because binding ofeEF2...
... SH3 domain(N-terminal) of CrkII binds to guanine nucleotide exchangefactors such as C3G, which in turn activate transductioncascades involving small GTP-binding proteins [10,12].Recent investigations ... migrating band (lane 2),showing that it contains the more tyrosine phosphorylatedband of Crk. Pretreatment with tyrosine kinase inhibitoralone increased the intensity of the lower migrating ... CrkII mediating CCK actions in the exocrine pancreas in vivo.Keywords: Crk; protein complex; CCK; transduction path-ways; pancreatic acini.Cholecystokinin (CCK) is a peptide acting as a hormone/neurotransmitter...