signal transduction by tgf β
Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... Kardassis et al TGFb signaling and small GTPases TGF A TβRI TβRII C CCVME Activin A B ActRIIB Caveolae Ral GTP P Rab5 GTP RIN1 POB Degradation Rab11 P ARIP2 RalBP1 E ps 15 Endocytosis and signaling ... caveolae, thereby stabilizing the receptors [11] In support of the above model, hyaluronan, an extracellular matrix polysaccharide, attenuated TGFb TGFb signaling and small GTPases signaling by increasing ... execution of the TGFb signaling pathway Interconnection between TGFb signaling and receptor traffickingregulation by small GTPases Endocytosis has long been considered a way of terminating signaling...
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Structure and mechanism of hormone perception and signal transduction by abscisic acid receptors
... if the signals have been there Thus, in the process of conveying a signal, perception of the signal is as important as existence of the signal itself At the cellular level, extracellular signals ... gate-latch-lock mechanism of ligand perception and signal transduction by the PYL ABA receptors 99 Figure 39 Mutations in the PYR1 latch and gate affect ABA signalling in vitro and in vivo ... are constantly surrounded by signals, for example, traffic signals, notifications, advertisements and feelings of pain or hunger However, we are only aware of these signals if we perceive them...
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Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... cells no luciferase activity could be transduced by non-modified adenovirus, this implies that the transduction by the chemically modified virus is αvβ3 integrin specific [15] This specificity furthermore ... on activated endothelium by the homing ligand, thereby evading the endogenous CAR-based tropism of the virus [15] In the present study, we constructed an RGD-modified, αvβ3 integrin specific adenovirus ... NF-κB-dependent signal transduction in endothelial cells Integrin specificity of RGD-modified adenovirus with respect to its gene transfer and transgene expression was evaluated by western blot...
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Báo cáo y học: "Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain" docx
... IL-4-induced signal transduction J Immunol 1999, 162:4385-4389 Servidei T, Aoki Y, Lewis SE, Symes A, Fink JS, Reeves SA: Coordinate regulation of STAT signaling and c-fos expression by the tyrosine ... would influence STAT3 signaling through an impaired SHP binding and activation capacity (in accordance with the work of Hershey et al.[12]) SHP-1/2 STAT3 signaling is controlled by the phosphatase ... activated differentially by IL-4 and IL-13 In wildtype individuals SHP-1 phosphorylation is predominately induced by IL-4, while SHP-2 phosphorylation is predominately induced by IL-13 As expected,...
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... demonstrated by a strong inhibition of GPCR signaling pathway in association with a slight inhibition of JNK and NFκB signaling in association with a slight activation of the cell death receptor signaling ... regulation of signal transduction initiated through the GPCR [26, 27] Furthermore, the regulatory mechanism of ethanol-induced apoptosis through the GPCR signaling pathway was also confirmed by the ... resulted in a pro-apoptotic effect that was intensified by a slight inhibition of the JNK and the NFκB signaling pathway as demonstrated by a reduced phosphorylation of MEK4, IKKα, JNK and MEK6;...
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Tài liệu Báo cáo khoa học: Effects of sequestration on signal transduction cascades docx
... transient signals However, interpretation of the signal by the signal transduction network requires circuits that respond only to prolonged activation As pointed out by Deshaies & Ferrell [22], such signal ... sequestration of the enzymes The extent of ultrasensitivity that can be generated by signal transduction cascades is thereby limited by sequestration This effect FEBS Journal 273 (2006) 895–906 ª 2006 The ... Finally, we analyse the effect of sequestration on a complex signal transduction cascade, the MAPK cascade Computational studies by Kholodenko [9] have shown that oscillation can arise in this...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
... of Rho-family signalling pathways, for example by down-regulation of ROCK or Rho activation and up-regulating Rac activation S1.6-2 Signal transduction via receptors for PDGF and TGF- beta – possible ... conformation, Syk can recruit other signalling molecules thus facilitating their phosphorylation and the propagation of the BCR signal These studies, which are conducted in a novel signalling pathway reconstitution ... genes by binding as a dimer to glucocorticoid response elements (GRE) as well as by interaction as a coactivator with DNA-bound Stat5 The receptor is able to repress expression of genes by protein–protein...
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Tài liệu Báo cáo khoa học: Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction doc
... of TCR signalling In addition to signalling machinery molecules, PAG and Csk, which are known to be negative regulators of TCR signalling [26], were also detected in BCh-bound membranes By association ... tested were retained by the avidin-magnet beads by western blot analyses (Fig 3B and data not shown) This indicates that membrane vesicles are not retained on the beads by nonspecific adsorption ... membrane groups, and that the cholesterol-enriched membrane domain isolated by BCh contains a core membrane domain for TCR signal transduction Results BCh binds to a subpopulation of membranes in lipid...
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Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs) docx
... leads to the termination of cAMP signals Interestingly, the same AKAP A B C D Fig mAKAP signaling complexes (A) mAKAP assembles a cAMP-responsive complex of signaling enzymes at the perinuclear ... cAMP by the phosphodiesterase Likewise, cAMP activation of Epac1 in the complex activates Rap1 to inhibit ERK5 signaling (C) As cAMP levels decrease, the Epac1-mediated inhibition of ERK signaling ... participates in response to oxygen tension by facilitating the proteasomal degradation or stabilization of the transcription factor HIF-1a AKAP signaling AKAP-Lbc signaling complex AKAP-Lbc is another...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... with a heterogeneous helix exhibited an identical effect on signaling as well as on internalization, i.e poor signaling was accompanied by reduced internalization We suggest therefore that helix ... segment is given the number of the helix followed by the number 50 Residues proximal to this reference residue are obtained by counting down, those distal by counting up from 50 The highest conserved ... IP accumulation was started by placing the tray in a water bath at 37 °C for 30 It was stopped by exchanging the buffer with 0.75 mL of ice-cold 20 mm formic acid and by transferring the tray onto...
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Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
... is called a signal transduction pathway Typically, the end result of signal transduction pathways is to regulate transcription factors, which in turn regulate gene expression Signal transduction ... is then degraded by the 26S proteasome 13 Gene Expression and Signal Transduction Sensor protein Response regulator + P – Input signal Input Transmitter Receiver Figure 14.10 Signaling via bacterial ... activation of PKC by DAG plays a role in plant signal transduction Phospholipase A2 Generates Other MembraneDerived Signaling Agents In animals, the endocrine system is involved in signaling between...
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Báo cáo khoa học: Signal Transduction pot
... cH2AX by DNA damage to partly cytosol Here, we first suggest that cH2AX could be implicated in cell death signaling cascade by TrkA in the absence or presence of DNA damage 135 Abstracts Signal Transduction ... Specific signals/genes induced by VEGF-A, but not by other growth factors and cytokines, have so far not been fully established We have analyzed here the induction of signals and genes by VEGF-A/VEGFR2 ... familial Mutated presenilins may cause familial AD by altering neuronal signal transduction pathways, by increasing beta-amyloid production or by triggering a number of proapoptotic mechanisms...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
... multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in several different ... is ubiquitous in MAPK and other signal transduction pathways, this article also reports a new putative mechanism that per se explains multistability in signal transduction networks in which feedback ... that some of its individual signaling elements could satisfy these requirements In particular, for the double phosphorylation of MAPKK1 by p74raf-1, it has been reported by Alessi et al [17] that...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
... in control With respect to duration and integral signal strength, this is different By taking away signal, the phosphatases accelerate the signal transduction dynamics Also, the total control corresponds ... affects signaling amplitude much more than signaling duration Phosphatases control duration of signaling In the model simulation, phosphatases controlled maximum signaling amplitude, signaling ... amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under-the-curve) For MAPK and other signaling pathways,...
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Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx
... insulin signal transduction Structure of several phosphatases implicated in insulin signal transduction rPTP-a, LAR, PTP-1B and SHP-2 are the major phosphatases acting on the insulin signaling ... modulates signaling by multiple receptor tyrosine kinases J Biol Chem 271, 748–754 38 Zhang, W.R., Li, P.M., Oswald, M.A & Goldstein, B.J (1996) Modulation of insulin signal transduction by eutopic ... phosphatases in insulin signaling (Eur J Biochem 269) 1059 89 Dadke, S., Kusari, J & Chernoff, J (2000) Down-regulation of insulin signaling by protein-tyrosine phosphatase 1B is mediated by an N-terminal...
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Báo cáo khoa học: Growth hormone/JAK-STAT axis signal-transduction defect A novel treatable cause of growth failure pdf
... compilation ª 2006 FEBS GH ⁄ JAK-STAT axis signal- transduction defect A P Rojas-Gil et al A 100 U/ml INF -β C2 C1 S1 S2 S3 S4 pTyr STAT3 TUBULIN B U/ml INF -β C1 0.1 S2 10 100 1000 0.1 10 100 1000 ... in any of the patients, by employing gene sequencing Expression of GHR The fact that no mutations were found in the GHR or GH-1 genes prompted us to investigate the signaltransduction pathway of ... STAT3 in the signal transduction pathway of GH in fibroblasts from children with ISS This defect is associated with a cell-cycle arrest at the Go ⁄ G1 phase, which is also reflected by increased...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx
... post-translational signal transduction mechanism [7,8] Many reports in the last decade have suggested that protein phosphorylation by protein kinase C (PKC) plays a key role in the regulation of the signal transduction ... involvement of PKC in the signal transduction mechanism participating in TCDD-induced cellular responses [14] We also looked for evidence of the involvement of PKC in the signal transduction mechanism ... hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology 112, 19–28 Weber TJ, Chapkin RS, Davidson LA & Ramos KS (1996) Modulation of protein kinase C-related signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... by insertion of a variant as-1 element The data are in accord with the conclusion that the tobacco PR-1a promoter is targeted by at least two distinct signal transduction pathways, elicited by ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent ... induced by a yet unknown signal molecule formed in tissues undergoing necrosis during the HR The identification of factors whose expression is regulated solely by SA or by HR released signals...
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Báo cáo khoa học: Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction pdf
... cellular proliferation signal, and farnesol inhibits generation of, or signaling by, this DAG pool However, some studies have indicated that (lyso)PA can be dephosphorylated by cell-surface lipid ... apoptosis by shifting the balance of life-and-death signals away from apoptosis Our results predict that farnesol is inhibiting a PLD ⁄ LPP3-generated DAG signaling pool If augmentation of DAG signaling ... pro-proliferative DAG pool, and signaling by this DAG pool is inhibited by farnesol The precise farnesol target remains to be determined but our evidence supports a mechanism by which farnesol inhibits...
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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx
... Ó FEBS 2003 Endogenous ouabain in normal signal- transduction? (Eur J Biochem 270) 1919 Conclusions Giving ouabain a novel physiological role in signal- transduction appears erroneous unless putative ... sublocalization critical for the observations looking at ouabain as a signal- transducer Experiments pointing to a pivotal role of ouabain in signal- transduction In the following, more details are discussed ... mimicked ouabain with respect to the cascade in cardiac myocytes [9] Other implications of signal- transduction by ouabain Fig Ouabain affinities to rat Na+/K+-ATPase isoforms and actual ouabain or OLF...
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