... england journal of medicine original article Intensive Lipid Lowering with Atorvastatin in PatientswithStableCoronaryDisease John C LaRosa, M.D., Scott M Grundy, M.D., Ph.D., David D Waters, ... in patientswith acute coronary syndromes We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patientswithstable ... therapy with 80 mg of atorvastatin per day in patientswithstable CHD provides significant clinical benefit beyond that afforded by treatment with 10 mg of atorvastatin per day This occurred with...
... patientswith vascular disease who not have overt heart failure reduces the risk of major atherosclerotic events In HOPE, high-risk patientswith vascular disease (including coronaryartery disease) ... population of patientswithcoronaryarterydisease who had a better prognosis than those in HOPE In the third trial (the PEACE Trial, the subject of the current report), 8290 patientswithstablecoronary ... Reduction of Cardiac Events with Perindopril in StableCoronaryArteryDisease (EUROPA),16 patientswithcoronary or other vascular disease or with diabetes and another cardiovascular risk factor...
... Abbreviations: Cx, left circumflex coronary artery; LAD, left anterior descending coronary artery; LVEF, left ventricular ejection fraction; RCA, right coronaryartery a Indicates patients who received zotarolimus-eluting ... outcomes of unselected patientswith CAD treated with either ZES or PES in southern Turkey METHODS Patient Population The study population consisted of 217 patients who had undergone coronary Zotarolimus- ... an selected patientswith symptomatic coronaryarterydisease of simple to moderate complexity (4) Since the population used in our study was an unselected, high-risk group, four patients in...
... 204 consecutive series of all patients who had undergone coronary stent implantation for coronaryarterydisease between February 2005 and March 2007; 103 of the patients received the SES (CYPHER; ... Abbreviations: Cx, left circumflex coronary artery; LAD, left anterior descending coronary artery; LVEF, left ventricular ejection fraction; RCA, right coronaryartery a Indicates patients who received sirolimus-eluting ... and the other 101 patients received the PES (TAXUS, Boston Scientific, Natick, Massachusetts) Patients were eligible for enrollment if there was symptomatic coronaryarterydisease or positive...
... [3,4] Patientswithcoronaryarterydisease (CAD) and refractory or recurrent retrosternal symptoms have a reduction in life expectancy and HRQL compared to patientswithstablecoronaryarterydisease ... Investigators: Clopidogrel with or without omeprazole in coronaryarterydisease N Engl J Med 2010, 363:1909-17 43 Juurlink DN: Clopidogrel with or without omeprazole in coronarydisease N Engl J Med ... AA, Heintzen MP, Schoebel FC: Percutaneous coronaryrevascularization in patientswith formerly “refractory angina pectoris in end-stage coronaryartery disease" -not “end-stage” after all BMC Cardiovasc...
... prevention in patientswithcoronary disease, they can be easily modified and applied in other communities and for other target conditions Background and rationale Coronaryarterydisease (CAD) ... among patientswithstablecoronaryartery disease: randomized, doubleblind, placebo-controlled, multicentre trial (the EUROPA study) Lancet 2003, 362:782-788 The Simvastatin/Enalapril Coronary ... risk factors in outpatients with atherothrombosis JAMA 2006, 295:180-189 Jackevicius CA, Mamdani M, Tu JV: Adherence with statin therapy in elderly patientswith and without acute coronary syndromes...
... [3,4] Patientswithcoronaryarterydisease (CAD) and refractory or recurrent retrosternal symptoms have a reduction in life expectancy and HRQL compared to patientswithstablecoronaryarterydisease ... Investigators: Clopidogrel with or without omeprazole in coronaryarterydisease N Engl J Med 2010, 363:1909-17 43 Juurlink DN: Clopidogrel with or without omeprazole in coronarydisease N Engl J Med ... AA, Heintzen MP, Schoebel FC: Percutaneous coronaryrevascularization in patientswith formerly “refractory angina pectoris in end-stage coronaryartery disease" -not “end-stage” after all BMC Cardiovasc...
... aspirin and clopidogrel were studied in patientswithcoronaryartery disease, concentrating on patients undergoing PCI Initially, a pilot study of 40 patients investigated the use of thromboxane ... Antiplatelet Response to Aspirin and Clopidogrel in PatientswithCoronaryArteryDisease Undergoing Percutaneous Coronary Intervention by Dr Richard I.S Good B.A., M.B.B.S., M.R.C.P ... Assessing response to clopidogrel in patientswithcoronaryarterydisease 138 Study 5.1 VerifyNow P2Y12, fibrinogen activation and VASP-phosphorylation before and after the introduction...
... alone for preventing vascular events in patientswith unstable angina [3] and myocardial infarction [4,5] as well as in patients undergoing percutaneous coronary intervention (PCI) [6,7] Despite ... significant Comparisons between patientswithcoronaryarterydisease and controls The factors were further analysed by One-sample t-test for differences between patients and controls Thus, platelet ... however complicated since it has also been reported that patientswith unstable angina had a decreased platelet count compared withstable angina patients and controls [43] From this discussion it...
... limited for patientswith high-grade atherosclerosis Methods One-hundred and four patientswith diffuse coronaryarterydisease underwent coronaryartery bypass grafting (CABG) with adjunctive coronary ... adjunctive treatment to coronaryartery bypass grafting (CABG) for patientswith highly calcified, end-staged coronaryarterydisease Conclusion This study demonstrates that results of coronary endarterectomy ... Extensive endarterectomy of the left anterior descending coronaryartery combined withcoronaryartery bypass grafting CoronaryArteryDisease 1995, 6:731-737 Gill IS, Beanlands DS, Boyd WD: Left...
... associated with tiotropium use in patientswith chronic obstructive pulmonary disease Arch Intern Med 2009, 169(15):1403-1410 Soriano JB, Kiri VA, Pride NB, Vestbo J: Inhaled corticosteroids with/ without ... biomarkers in patientswith COPD: associations with clinical parameters Thorax 2007, 62(7):595-601 Drummond MB, Dasenbrook EC, Pitz MW, Murphy DJ, Fan E: Inhaled corticosteroids in patientswithstable ... Kesten S: Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patientswith COPD Thorax 2003, 58(5):399-404 44 Vogelmeier C, Kardos...
... Patient withcoronarydisease Under utilization of diagnostic testing Under utilization of medications - side effects - cost Lower rates of revascularization Higher complication rates with ... Clin Pract Cardiovasc Med 2008;5:738-46 Revascularization in the Ultra-Elderly Revascularization appears to improve outcomes in elderly patientswithstable angina (PCI or CABG), ACS (PCI or ... 40 35 30 25 < 75 20 75 and older 15 10 CHF VHD PVD COPD All p75 years have more extensive coronaryarterydisease • • • • Left main: ~8% (vs ~4%) Proximal / Mid LAD : 68% (vs...
... to CoronaryArteryDisease Chapter Introduction to CoronaryArteryDisease Chapter1: Introduction to CoronaryArteryDisease 1.1 Definition of coronaryartery disease( CAD) Coronaryarterydisease ... vasospasm Over 90% of the patientswith one of the ischemic 10 Chapter1: Introduction to CoronaryArteryDisease heart diseases have the advanced coronary atherosclerosis with one or more stenotic ... CoronaryArteryDisease survival risk and reduces risk of atherosclerosis related events in patientswith established CAD with elevated (29) or average (30) cholesterol levels as well as in patients...
... TaqMan PCR in serum Bacteriological assay with further PCR validation PRELIMINARY GROUP Patientswith ACS 18 MAYOR GROUPS Healthy volunteers 26 - Patientswith ACS 38 13 - Figure Recovery of PCR ... 18 patientswith acute coronary syndrome (11 males and females aged from 47 to 68) Once conditions for combined microbiologic and nucleic acid amplification protocol were established, 38 more patients ... established, 38 more patientswith acute coronary syndrome (21 males and 17 females, aged from 42 to 71) and 26 healthy volunteers with no indication of cardiovascular disease were enrolled (major...
... aspects of coronaryartery function and structure with prevalent genetic factors Gene Polymorphism and Coronary Heart Disease 11 Fig The risk factors contributing to coronaryarterydisease pathways ... of atherothrombotic disease of coronary, cerebral and other vessels in diabetes The disease has emerged as an important condition of older patients in 10 CoronaryArteryDisease – New Insights ... 7-like Table Summary of the important risk genes and disease pathways leading to the manifestation of coronaryarterydisease 14 CoronaryArteryDisease – New Insights and Novel Approaches Familial...
... Pathophysiology of CoronaryArteryDisease Chapter Epidemiology of CoronaryArteryDisease John F Beltrame, Rachel Dreyer and Rosanna Tavella Chapter Gender Differences in CoronaryArteryDisease 31 ... cardiovascular system with respect to hypertension, stroke, renal failure, heart failure and coronary heart disease are discussed Being able to identify patientswithcoronaryarterydisease early will ... Exercise ECG should not be used to diagnose or exclude angina for people without known coronaryarterydisease Historically exercise electrocardiography in the diagnosis of coronaryartery disease...
... important difference of 1.5 generalizes to patientswith other diseases Patients included in our study might, however, represent patientswith advanced chronic disease because mean HADS anxiety (7.03) ... commonly encountered in patientswith chronic disease. [26,27] A change of 1.5 points corresponds approximately to a 20% change from these baseline scores In patientswith substantially lower ... not differ from patients included in the analyses The mean age of included patients was 68.7 (SD 8.9) years, 59 (67.0%) were males, patients had moderate to very severe COPD with a mean FEV1...
... measure their symptoms, the patients filled out a questionnaire on breathlessness, anxiety, and depression • Using long-term oxygen treatment • Unstable heart diseasePatients were given verbal ... measured with the ISWT The ISWT is a standardized progressive walking test used to measure functional exercise capacity in patientswith cardiorespiratory conditions The test requires patients ... indicators of the disease and the patients' subjective experience of their health status In this respect, studies of COPD patients have found weak associations between objective measures of disease, symptoms,...
... be reconciled with the existing randomized trials of statins in patientswith es tablished coronaryartery disease? First, statins as a class may not be efficacious in patientswith ischemic ... (P=0.001) conclusions For patientswithcoronaryartery disease, the reduced rate of progression of atherosclerosis associated with intensive statin treatment, as compared with moderate statin treatment, ... on coronary events after myocardial infarction in patientswith average cholesterol levels N Engl J Med 1996; 335:1001-9 17 Randomised trial of cholesterol lowering in 4444 patientswith coronary...
... mortality from all causes in a large cohort of patientswithstablecoronaryartery disease; our emphasis was on patientswith angiographic evidence of coronarydisease and normal left ventricular systolic ... 0.01 0.10 verity of coronaryarterydisease as having no clinically significant disease, one-, two-, or three-vessel disease, or disease of the left main coronaryarteryPatientswith three-vessel ... higher in patientswith than in those without coronaryarterydisease Table shows the baseline characteristics of patients according to LVEF and the presence or absence of coronaryartery disease...