short term modulation of gabaa receptor function in the adult female rat
Báo cáo y học: "Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation" pot
... half the specific binding was defined as EC50, which is same as IC50 The affinity of the receptor for the competing drug is designated as Ki and is defined as the concentration of the competing ... affinity) EC50 is the concentration of competitor that competes for half the specific binding The equation built -in to the program is defined in terms of the log (EC50) If the concentrations of unlabelled ... hypoxia in preterm human infants In the present study, we investigated the functional regulation of GABAB receptors and GAD in hypoxic neonatal rats and the role of glucose, oxygen and epinephrine in...
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Báo cáo y học: " Short-term outcomes of cadaveric lung transplantation in ventilator-dependent patient" pptx
... was continued during the move from the operating theater to the ICU In the event of extension of the duration of ECMO support from temporary (in operating theater) to prolonged use (in the ICU), ... routinely instituted from the groin area under general anesthesia in the operating theater before pneumonectomy of the native lung The 800 mL ECMO priming solution contains 1600 U heparin, the ... heparin-bound Carmeda Bioactive surface Except for one patient receiving ECMO support preoperatively due to pulmonary crisis in the ICU and its continued use in the operating theater for intraoperative...
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Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica ppt
... four of its nine windows lit The participant was instructed to memorize the position of the illuminated windows In 36 subsequent presentations of the house, one of the windows was illuminated ... occur via the modulation of dopamine and norepinephrine in prefrontal cortex together with the modulation of acetylcholine and serotonin in hippocampus However, the possible underlying mechanisms ... constantly displayed to the right of the monitor screen A series of digits was presented in the centre of the screen at the rate of 80 min−1 and the participant was required to press the ‘yes’ button...
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Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
... forced expiratory volume in second LTRA administration Another group reproduced these findings by showing similar protection against EIB during the first days of treatment with either montelukast ... EIB.” Minute ventilation (exercise intensity), temperature and humidity of the inspired air (climatic conditions), and underlying baseline airway responsiveness are the primary determinants of the ... action of a single mediator (An in- depth discussion of the mediators involved in EIB and their cellular sources are beyond the scope of this review.) 61 activity in individuals with underlying airway...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... Shh insert Therefore, presence of GFP in prostates indicated successful introduction of pCX-shh-IG vector and expression of Hh protein Intraprostatic injection and electroporation ICR strain male ... whether P63+ basal/stem cells were activated under the influence of Hedgehog overexpression, we examined the pCX-shh-IG-injected prostates during the progression of PIN toward CaP to gain further ... bars: 50 μm in upper (d) of panel A; 10 μm in lower (d) of panel A and in (d) of panel C CaP: prostate cancer; HE: hematoxylin-eosin stain; PIN: prostatic intraepithelial neoplasia; HGPIN: high...
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Báo cáo y học: "Identification of motifs that function in the splicing of non-canonical introns" doc
... motifs Strengthening the PY tract eliminates the role of the C-rich motifs We next investigated the role of the PY tract in LCAT intron splicing We mutated the PY tract to determine whether the C-rich ... levels of U2AF65 binding at the protein concentrations tested (Figure 2) Meanwhile, all three of the cytidine-rich sequences with moderate S65 scores demonstrated moderate affinities in the binding ... lower affinities Binding of U2AF65 to low-scoring PY tracts In order to asses the relationship between the S65 score and observed U2AF65 binding affinities, we evaluated the binding of recombinant...
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Báo cáo y học modulation of pulmonary vasomotor tone in the fetus and neonate
... until the increase in shear stress due to increased flow is offset by the decrease in shear stress due to increased vessel diameter Distinguishing the role of shear stress, or indeed the effects of ... the potent endothelium-derived contracting factor endothelin-1 plays a key role in maintaining high fetal pulmonary vasomotor tone Endothelin-1 causes vasoconstriction by activating endothelin ... Prostacyclin synthesis increases during the last trimester [22], and several endothelium-dependent vasodilators, including acetylcholine and bradykinin, act at least in part by enhancing Changes in pulmonary...
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Báo cáo khoa học: The multifarious short-term regulation of ammonium assimilation of Escherichia coli: dissection using an in silico replica pdf
... concentration at time zero, the rate of GS (and GDH) initially increased rapidly, as expected from the increase in the concentration of one of their substrates After a few seconds the rates began ... on proline, i.e to the virtual absence of ammonium They stopped short of determining the actual composite rates of ammonium assimilation and of confirming that the system shifted between rates ... assimilation fluxes of the original and the mutated model at 0.05 mM ammonium, the fluxes in the insets were calculated with the following values for the maximal rates of GS (in mM min)1), 555 (1, inset A),...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... ligand binding, therefore reducing apoptotic signaling Procedures All treatments including milrinone dosing was at the discretion of the patient's attending physician, with initial dosing between ... troponin may reveal sub-clinical cardiac injury due to inotrope initiation We sought to determine the effect of initiating milrinone on biomarkers of myocardial function (N-terminal pro-B-type Natriuretic ... practical Another related concern is whether standard therapy, particularly increased loop diuretic dosing, could explain the findings and confound the milrinone effects In terms of TnI levels, there...
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Báo cáo lâm nghiệp: "Short-term effects of fire on plant cover and soil conditions in two Austrocedrus chilensis (cypress) forests in Patagonia, Argentina" potx
... sites in the east [22] In the past, fire frequency increased in the majority of cypress stands after 1850, coincidentally with an increase in number of indigenous people that inhabited the region ... effects of fire [5] The classification of the severity of a fire based only on function of the remaining surviving trees could be then insufficient to classify that event with certain degree of accuracy ... example in CB treatment, SM-0 reached values higher than 50% during spring of the first growing season and up to the following winter, descending to 11% during the next season (very dry) In the UN,...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... low levels of Bcl-2 in the PC3 cells may explain why the radiation-induced down -modulation of Bcl-2 was of minor importance for the response of PC3-cells to radiotherapy and the combined treatment ... potency In contrast, the anti-neoplastic effects of ionizing radiation in LNCaP cells did not involve apoptosis induction implicating a role of proliferation inhibition or the induction of non-apoptotic ... cells the down-regulation of the two anti-apoptotic Bcl-2 proteins may contribute to the antineoplastic effects of ErPC3 and radiotherapy In contrast, the radiation-induced down -modulation of the...
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Báo cáo y học: "Short term outcomes of total arterial coronary revascularization in patients above 65 years: a propensity score analys" pot
... aortic clamping was performed in the other 49 patients The mean operative time was 197.6 ± 42.4 minutes in group I vs 191 ± 44.3 minutes in group II (P = 0.033) The incidence of postoperative stroke ... T-graft configuration is minimizing the risk of stroke by avoiding performing the proximal anastomosis to the ascending aorta In our 415 patients there was no single patient with postoperative stroke ... results in a minimal incidence of perioperative stroke [18] An apparent disadvantage of bilateral mammary revascularization is the increase in amount of postoperative blood loss In our study, the...
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Báo cáo khoa hoc:" Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment" doc
... Journal of Negative Results in BioMedicine 2006, 5:14 Median (interquartile range) are shown A decrease in HOMA-S and ISI is indicative of a reduction in insulin sensitivity * Changes in insulin sensitivity ... change circulating concentrations of metabolically active hormones, despite increasing insulin resistance Competing interests The author(s) declare that they have no competing interests Authors' ... Cavallo-Perin P, Cassader M, et al.: An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects J Clin Invest 1983, 72:1814-1820 Asensio C, Muzzin P,...
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Báo cáo y học: " Short-term prediction of threatening and violent behaviour in an Acute Psychiatric Intensive Care Unit based on patient and environment characteristics" pps
... document a decline in aggressive incidents after extending space in a ward [33] In the present study the number of beds and the space were identical in the two inclusions [15] This finding indicates ... factor in reducing aggressive incidents is the separation of single patients or patient groups in the ward, not the physical space in terms of square meters per patient Our data predicting short- term ... ordinary area of the ward In the end of the corridor a locked door separates the PICU area from the ordinary area The PICU area consists of two wings with two single patient rooms in each The patients...
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báo cáo khoa học:" Short-term effects of amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar pulp" pptx
... in each of the three facets Altogether, they are prominently involved in the formation, structure and mineralization of dentin and bone In addition, some of them may promote pulp healing We have ... amelogenin isoforms are the principal products directing the formation of the mineralized enamel The M194 mRNA includes both the full exon and exon sequences, while M180, the major mature amelogenin ... implantation of A +/- in the exposed pulp of rat maxillary molars [33] In parallel, to get a better understanding of the mechanisms involved, the in vitro effects of A+4 and A-4 on clones of odontoblast...
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Báo cáo y học: " Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency" pdf
... patients in the present study were carefully controlled during the conduct of the study, including two overnight stays in the clinic and three visits in the out The assays were performed in three ... desmosines The calculated analytical interassay coefficient of variation (CVa) was 4.2 % Desmosines concentration in urine is normalized to urine creatinine (µg/g creatinine), whereas desmosines ... losses in the system and to decrease the degree of variability of data, the determination of urinary desmosines was performed on urine Page of (page number not for citation purposes) Respiratory...
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Báo cáo khoa học: "Short-term effects of positive end-expiratory pressure on breathing pattern: an interventional study in adult intensive care patients" pot
... than the effect found in anaesthetized animals [24] Our findings are in accordance with the results of other studies in adult humans at normal tidal breathing [12-14], in which the findings were ... examination of the expiratory flow pattern during the investigation did not suggest expiratory flow limitation as an indirect sign of the occurrence of intrinsic PEEP Conclusion In tracheally intubated, ... intensive care patients, indicate that the level of PEEP significantly influences resting short- term breathing patterns by selectively affecting the duration of expiration Thus, a reduction in...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... studies examining the role of GIF in AD, linked to its initial discovery as a factor deficient in the AD brain There remains no clear consensus on the role of GIF in the pathogenesis of AD, and therefore ... explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory ... 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly within the injured or diseased brain In the case of GIF, the protein has many neuroprotective...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... on NaCl concentration were determined as part of the investigation into the shielding from solvent of the electrostatic interaction between Asp113 and His210 With increasing NaCl, the maximum activity ... Amino–aromatic interactions in proteins FEBS Lett 203, 139–143 19 Chakrabarti, P & Samanta, U (1995) CH/, p interaction in the packing of the adenine ring in protein structures Advan Protein ... was determined using VLK-MCA as the substrate and the increase in fluorescence of the released MCA was monitored The maximum peptidase activity at each respective pH (v0) was determined as a function...
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Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx
... Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid receptor- interacting protein), and their importance for the function of GRIP1 ... [23,26,28] The exposure of any GRIP1 C-terminal interacting protein, including the GRIP1 C terminus in this model, might alter GRIP1 conformation I through intramolecular interaction into conformation ... conserved AF-2 domain of NRs [22] The C-terminal region of the p160 co-activator can interact with the AF-1 domain of some NRs and enhance their AF-1 activities in the absence of ligands [23–25]...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008