... binding ofthe C-terminal domain of hirudin and amidase activity in human alpha-thrombin Biochem J 289, 475480 Baglia FA & Walsh PN (1996) A binding site for thrombin inthe apple domain of factor ... concentration of wild-type and mutant FXIa and using the program grafit (Erithacus Software Ltd., Staines, UK) Structural analysis The structural analysis was conducted using the crystal structure of ... times, an aliquot ofthe activation solution was taken to measure the Michaelis parameters of S-2366 hydrolysis by FXIa The Michaelis parameters, kcat and Km, were calculated on the basis of known...
... experimental work including the extraction of RNA, validation of microarray data by real-time PCR andthe analysis of serum samples The microarray experiment andthe analysis of array data were carried ... out by Almac Diagnostics, Craigavon, N Ireland PMW was responsible for the annotation ofthe microarray data andthe preparation ofthe manuscript All authors read and approved the final manuscript ... stress including oxidative stress, andthe regulation of cell death was also observed (Table 4) Validation of microarray analysis using real-time PCR Figure Analysis of microarray data (A) Venn diagram...
... Weakened ISP binding, as a result ofthe introduction ofa bulky and potentially charged glutamate residue at position 167, may also explain the variations inthe ISP content observed in different ... would, in turn, alter the catalytic activity ofthe complex The mutation could also affect the binding ofthe ISP to the bc1 complex and distort the Qo site Our data showed that, inthe mutant, the ... because the addition of an equal amount of decylubiquinone to decylubiquinol at the beginning ofthe assay had no effect on the kinetics (data not shown) It is more probable that the mutant was...
... unit of fibroin, having the same molar ratio of H- and L-chains, and fhx/P25 as ofthe elementary unit present inthe PSG extract, could be isolated from the ER extract of PSG cells ofa normal-level ... [1] The L-chains inthe majority of elementary units may interact noncovalently with the oligosaccharide chains of fhx/P25 or act as structural barriers and cause protection ofthe terminal mannose ... composition of H6fhx1 [1] The disulfide linkage between H- and L-chains is not formed in Nd-s and Nd-sD mutants because ofthe lack of Cys-172 inthe mutant L-chain [8] It isof interest to note that the...
... mean time between egg laying and hatching in C fornicata, Richard et al in press), all the 18 females had released larvae These females anda sample of 239 larvae (77, 72 and 90 larvae from the ... larger males than small males inthe Rozegat population Analysis of variance showed that fathers are, on average, significantly taller than nonfathers within a stack (d.f = 1, Fig Percentage of ... 0.024) Inthe same way, ‘male fathers’ (i.e fathers that were males at time of sampling) are, on average, significantly taller than ‘male nonfathers’ (i.e males ofthe maternal stack that were...
... b-Rha B A B A a-Rha B A B A a-Rha B AA a-Rha B AAA a-Rha B AAA a-Rha AA B a- Rha AA B a- Rha B AAA a-Rha B A B a- Rha Fuc3NAc B AA a-Rha Fuc3NAc B AA a-Rha Fuc3NAc AA B a- Rha Fuc3NAc ... B AA B AA A, B AA A, B AA A, B AA A, B AA A, B AA A, B AA A, B AAA Several of these combinations were found by means of an in- depth NMR analysis The a- Fuc3NAc in uenced the chemical ... bold): B A B A, B A B A, B AA A, B AA A, B AA A/ B, AA A, AA B, AA B, B A B, B A A, B A A, AA B (Table 1) In summary, eight ofthe 14 possible combinations could be assigned by NMR, as illustrated...
... Laskar S, Bahl G, Muckaden M, Pai SK, Gupta T, Banavali S, Arora B, Sharma D, Kurkure PA, Ramadwar M, Viswanathan S, Rangarajan V, Qureshi S, Deshpande DD, Shrivastava SK, Dinshaw KA: Nasopharyngeal ... statistical analysis and writing ofthe manuscript SN is responsible for the physical aspects of IMRT planning and treatment ofthe children HB is responsible for the anaesthesia management of ... or inner ears represent an extraordinary challenge inthe radiotherapeutic management Starting with the biggest of all central nervous treatments the irradiation ofthe entire craniospinal axis...
... Diagnosis (years) % 136 Statistical analysis was performed using the Chi-square test or analysis of variance (ANOVA) analysis for categorical variables and continuous variables, respectively The ... that had previously disappeared or the appearance ofa new lesion that was histopathologically confirmed by a biopsy Information about the date of last contact and status of patients at the last ... supported the study L-EW participated inthe study design, oversaw the entirety ofthe project and assisted inthe analysis andthe manuscript preparation All authors read and approved the manuscript...
... other abdominal or omental diseases was challenging andthe radiological findings were misinterpreted as a small incarcerated umbilical hernia Diagnosis of an omental infarction has traditionally ... Predisposing factors for torsion are anomalies ofthe omentum, such as a small root, irregular vascular anatomy, abdominal trauma, cough and physical strain [2] The etiology of omental infarction ... publication of this case report and any accompanying images A copy ofthe written consent is available for review by the Editor -in- Chief of this journal Page of 10 Naffaa LN, Shabb NS, Haddad MC:...
... acquisition and analysis of data and drafted the manuscript AC and AB helped in drafting of manuscript and given their valuable suggestions, MG provided the images All the authors read and approved the ... mucin infiltrating and dissecting the native tissue The tumor cells were found to be floating within the mucin and many of them had a signet ring appearance Case Clinical findings A 62-year-old ... Mohali, India Department of Pathology, Maharshi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala Haryana, India Authors’ contributions YK designed, carried out acquisition...
... for a 60% response rate The final study had greater statistical power than envisaged as the final response rate was 76% Analysis All statistical analyses were undertaken using the statistical software ... psychological distress and psychiatric injury [4,5] Recent US reports indicate that the prevalence of mental disorders after deployment to Iraq and Afghanistan is particularly high and rising [4,6] Since ... study, and contributed to the article submitted NF assisted inthe design ofthe study, led on the planning and execution ofthe analysis and co-wrote the article submitted All authors read and approved...
... or in combination with other modalities such as phototherapy in psoriasis HBO2 therapy may have a place inthe management of psoriasis Further studies including large numbers of patients and involving ... affects the liberation of TNF -a and endothelins Vascular endothelial growth factor levels are significantly increased with HBO2 therapy, whereas levels of prostaglandin E2 and cyclo-oxygenase-2 mRNA ... topical mineral oil, Eucerin Calming Creme, and diphenhydramine 50 three times a day He had erythema, and his skin was scaling and itching He underwent daily HBO2 at atmospheres for 90 minutes,...
... uptake of satu- rated and unsaturated FFAs into the cells After their internalization, FFAs are converted to fatty acyl-CoA, a reaction catalyzed by ACS Fatty acyl-CoAs are activated forms of fatty ... Mantzaris et al Ctrl A SA OA SA/OA B 6h 3h SA/OA OA Counts Ctrl SA/OA Ctrl SA SA 24 h 12 h 36 h SA/OA OA OA SA/OA Ctrl OA Ctrl SA/OA Ctrl OA SA SA SA FL1-Log Fig Stearate (SA) supplementation interrupts ... of eukaryotic translation initiation factor 2a (eIF 2a) was Saturated fatty acid-induced lipotoxicity apparent after 16 h of stearate treatment, reached a peak at 22 h, and declined thereafter...
... of X are in uenced by the algebraic subvarieties of X; a subvariety of X has a cycle class inthe dual ofa rational homology space of X andthe duals of these cycle classes span a subspace of ... dimensional abelian varieties inthe work of several people (precise references are given below), including Anderson and Colmez They show that the abelian integrals arising as periods of abelian varieties ... periods ina very general setting Recall that a period of an algebraic variety defined by polynomial equations with algebraic coefficients isthe integral of an algebraic differential against a rational...
... salt, sea salt, and any foods containing iodized salt and sea salt • Seafood and sea products (fish, shellfish, seaweed, seaweed tablets, carrageenan, agar-agar, alginate, nori and other sea-based ... from heat and add vinegar, sugar, salt and pepper to the pan Stir until dissolved Begin slowly adding spinach and continue stirring Continue until all of your spinach isinthe pan and has started ... rhubarb and potato skins The inside ofthe potato is fine • Iodine-Containing Vitamins, and Food Supplements Also products containing iodate or iodide Check the label and ingredients and discontinue...
... captains—“They’re all great guys, and this way they can all put ‘Captain’ on their resumé,” he says Their calisthenics, a parody ofa typical team’s cals, include such exercises as Mary Catharine Gallagher-Superstar ... weary of serial gridiron thrashings at the hands of Concordia, St Olaf’s, and Gustavus Adolphus Gagliardi was hired, and college football hasn’t been the same since All his seniors are captains—“They’re ... I am narcoleptic and cranky when I get there Laura calls my crankiness and raises it It’s not as if she is baking bread in my absence It’s not as if she is hosting napkin-folding parties for the...
... A, Santoro A, Mantovani A, Roncalli M, Malesci A: CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study Lancet ... liver metastasis in colorectal adenocarcinoma based on the combination of risk factors including CD10 expression: multivariate analysis of clinicopathological and immunohistochemical factors Oncol ... XQ, and HJH carried out the immunohistochemical staining; and PRQ and ZX analyzed the results ZXS and ZYX conceived the study, participated inthe design, and coordinated and helped draft the manuscript...
... Mean (±51 standard deviation) HR (left axis) and VR (right axis) for each participant Mean (± standard deviation) HR (left axis) and VR (right axis) for each participant Statistical analysis was ... limits The lower limit ofthe cardiovascular training zone for each individual is noted in Table We determined the total accumulated time that the individual's HR was within the target training ... 0.0207) and VR (black circle; p < 0.0001) generally increased as AC increased HR and VR increased For participant S2, the standard deviations for both HR and VR in AC0 are small and therefore the...
... may facilitate the discovery of therapeutic agents that can ameliorate the prognosis for AD patients Indeed, clinical studies have addresses the use of antioxidant and statins as potential therapies ... interaction ofA with microglia andthe assembly ofthe active microglial NADPH oxidase maybe largely responsible for the oxidative damage observed inthe AD brain Astrocytes andthe NADPH oxidase ... analyzed the relationship between antioxidant supplements and AD risk, and concluded that use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population;...