... purifying them and determining the substrates from which they arose by the action of P450scc, as well as the products that they gave rise to This revealed both the major and minor pathways forthemetabolism ... prerequisite for cleavage ofthe bond between C20 and C22 [1,14] Another difference between themetabolismof vitamin D3 and cholesterol by P450scc is that the dissociation of intermediates occurs forthe ... vitamin D from the bloodstream for further metabolism [4] In conclusion, the identification of new metabolites of vitamin D3 made by the action of P450scc will enable us to proceed with further biological...
... of mouse weight) [13] Clone 3F was matured by three cycles of directed evolutionThe use of a set of stringent conditions in the third cycle allowed the selection of several improved clones The ... C noxius venom To the best of our knowledge, this is the first report ofthe generation of a human recombinant antibody fragment capable of neutralizing the toxic effects ofthe whole venom from ... corresponding germ lines For clone 3F, VH3-VK3 were the closest families for VH and VL domains, respectively In the case of C1, VH3Vk1 were the families with highest scores The specificity of these two scFvs...
... knowledge related to the mechanics of human movement The work at the University of California formed the basis for many ofthe fundamental techniques currently used forthe study of human locomotion ... there was a need for an improved understanding of locomotion forthe treatment of World War II veterans The classic work at the University of California [5,6] provided a tremendous resource of ... limiting the advancement ofthe study of human movement is the measurement of skeletal movement from markers or sensors placed on the skin The movement ofthe markers is typically used to infer the...
... on the prevalence in the population, and more reflective ofthe test itself, lessening the impact of any unique features ofthe VA population Moreover, we might expect that the PPV and NPV ofthe ... NC) Results The characteristics ofthe VARA participants measured at the start of each treatment episode were evaluated Because the characteristics of VARA patients at the start of non-biologic ... contrast to other RA therapies where the drugs are typically discontinued if they are not effective Because of similarities in both the descriptive characteristics ofthe study populations of biologic...
... attempted for three SPT patients in whom the mass was located in the portion of body or tail ofthe pancreas For tumors of SPT located in the neck and body ofthe pancreas, resection ofthe midportion ... midportion ofthe pancreas and the mass with preserving the rim ofthe head and tail portion can be achieved However, forthe patient in whom the mass was located within the head ofthe pancreas, ... 311 Fig The CT scan indicated the typical internal or capsular calcification in the SPT Once the diagnosis of SPT is made, surgery is the first choice of treatment, since other adjuvant therapies,...
... 100% relief of their pain in 86% ofthe patients with a median relief period of months The range of relief varied from zero days to up to 13 months forthe facet injection group None ofthe lumbar ... median period of pain relief being months The range of relief forthe radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Ofthe 14 patients ... that the direct visualization ofthe joint allows better de-innervation ofthe joint and removal ofthe entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results ofthe study All twelve patients (10 males, females) completed the surgery without...
... system, in the distal segment ofthe tubule Inhibition of glucose reabsorption in the kidney, mediated by the SGLT cotransport system, represents a promising therapeutic target forthe control of hyperglycemia ... larvae of beetles (Chrysomelidae) Their synthesis has been previously described [31-33] Forthe purpose ofthe present study the thioglycosides used were selected and grouped based on their differences ... IC50 values of 30 µM for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects of thioglycoside...
... large inventory of normalized mathematical indexes of abnormality It is the pattern of these mathematical indexes of abnormality, obtained from analysis of multiple cardiac cycles ofthe resting ... Moreover, to assess the performance ofthe prediction of stenosis independent ofthe prevalence of stenosis, the positive and negative likelihood ratios (LR) were calculated [24] A value of p
... Step 3: The director ofthe branch will responsible for approving the loan application form or not if the value ofthe loan does not exceed 500 million In case of an exceed, the director ofthe branch ... expanded the scope and form of lending to customers The orientation ofthe branch: expanding, strengthening and improving the operational efficiency ofthe office agency To attract more customers, the ... actually the major activity ofthe bank Therefore, continuing research and offering solutions would bring enormous significance for both theoretical and practical aspects forthe diversification of the...
... supported by the research project The research on the development ofthe total evaluation technique forthe hazardous impacts by the chemical substances towards human and ecology (the project ... and N2- and C8-modified deoxyguanosine as major products ofthe in vivo reaction of N-hydroxy-6-aminochrysene with DNA and the formation ofthe adducts in isolated rat hepatocytes treated with 6-nitrochrysene, ... postlabeling method, etc.) Therefore, it is important to develop a simple rapid in vitro method for evaluating the generation of reactive oxygen species from a variety of genotoxic chemicals We...
... study, the ozone and UV combination (ozone/UV) process is applied forthe reuse of sewage effluent Therefore, the aim of this study is to evaluate the effectiveness of ozone/UV process forthe treatment ... reduction of A410 after 10 of run time On the other hand, the UV alone process did not show much color change Therefore, for color reduction, the ozone alone process was considered as the best ... the mechanism ofthe reaction of ozone with substances in the water can be divided into two distinct pathways (7) The first route is the direct attack of molecular ozone The second route is the...
... of 95 ml) The A280 to A260 ratio ofthe UV-absorbing peak indicated it was composed mainly of nucleic acid In the profile ofthe NaOH-extracted polymer (B), the elution volume (80 ml) of saccharide ... control test was calculated every minute using the following formula: The relative A660 = A660 of flocculating test A660 of control test Forthe control, the polymer solution was replaced by distilled ... compared to the other methods The SDS-extracted polymer included a small amount of material other than protein Furthermore, the steaming- and washing-extracted polymers contained large amounts of phosphorus...
... know the benefit of having the connection of their latrines to biogas plants At the installation, the community agreed to share the 20% ofthe installation cost and the 100% of cleaning cost of ... latrine/others Table shows the claimed performance ofthe Figure Change ofthe use of sanitation options sanitation options according to the household interview Before 1999, more than 40% ofthe people ... purpose of this study is to document how the local people came to use the biogas plant for sanitation purpose, and to clarify the performance ofthe biogas plant forthe reduction ofthe pollution...
... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each ofthe samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost ofthe chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...
... with the increased HRT ofthe adsorption tank From an engineering application point of view, the appropriate operational parameters ofthe recycle ratio, HRT ofthe regeneration tank, HRT ofthe ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT ofthe regeneration tank, HRT ofthe adsorption tank and SRT ofthe system were evaluated The removal efficiency ... in the PO43 P removal These results revealed that the selection ofthe operational parameters ofthe CARS process had a great influence on the overall system performance Adsorptive capability of...
... govern the washout of sludge from the reactor, and therefore, we investigated the effect of surface loading rate and aeration rate on the selection of well-settling sludge and the formation of aerobic ... ofthe AUFB reactor Reactor Setup and Operation forthe Formation of Aerobic Granular Sludge Two AUFB reactors were used forthe formation of aerobic granular sludge Air was introduced from the ... been formed in our previous studies Based on the preliminary experimental results, we decided the control strategy forthe selection of well-settling sludge Then, we applied the strategy to the formation...
... investors of 25% ofthe purchase price ofthe installation, with maximum subsidy of 233€ and 50% ofthe purchase price with maximum subsidy of 3k€, respectively In the Netherlands, the investment ... programs The National Program forthe promotion of energy saving measures and the use of RES, provides subsidies of up to 40% ofthe eligible costs of small hydro power systems with the maximum ... forthe promotion of energy from RES It sets mandatory national targets for each Member State forthe overall share of energy from RES in gross final consumption of energy and forthe share of...