roles of cio
Tài liệu Roles of CIO for Innovative Government ppt
... changing roles of CIOsThe changing roles of CIOs The changing roles of CIOsThe changing roles of CIOs In the 1980s In the 1980s - CIOs are chief information officers who manage - CIOs ... Government Agencies will strengthen roles of CIO as full time officer roles of CIO as full time officer•Function of CIO will be extend to CRO, CKO, Function of CIO will be extend to CRO, CKO, ... ）Progress of Core Competencies of CIOs in USProgress of Core Competencies of CIOs in US 1999-2004-20061999-2004-2006 40Future Prospect of CIO in JapanFuture Prospect of CIO in Japan•All...
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Tài liệu THE ROLES OF AMINO ACID CHELATES IN ANIMAL NUTRITION pdf
... intoenzymesystemsandfunctionaspart of a metalloenzyme are other examples of metabolicallyessentialchelates.(16)Thethirdgroup of chelatesconsist of thosewhichinterferewithutilization of essentialcations.Manymetalchelatesare ... ionsisdependentuponnumerousfactors,including the levels of the elements ingested,theage of the animal,Ph of theintestinalcontentsandenvironment, thestate of theanimalwith respect todeficiency oradequacy of the element,andthe ... Cagliero6.ANASSESSMENT OF LONGTERMFEEDING OF AMINO ACID CHELATES 106RobertB.JeppsenSECTION 2CATTLE7. THEUSE OF AMINO ACID CHELATESTOENHANCETHE IMMUNE SYSTEM 117RobertT.Coffey8.THEUSE OF AMINO...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... FEBSREVIEW ARTICLE Roles of AP-2 transcription factors in the regulation of cartilage and skeletal developmentAnn-Kathrin Wenke and Anja K. BosserhoffInstitute of Pathology, University of Regensburg, ... treatment of the chick face with RA, and this is accompanied byan increase in apoptosis [73]. The authors of this studyascribe the regulation of outgrowth of limb buds andpatterning of the digits ... role of AP-2a and AP-2ein chondrogenesis. Overview of the differen-tiation stages during chondrogenesis andthe involvement of transcription factors(henatoxylin and eosin-stained section of...
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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... molecular basis of incorrect pairing of sister chromatids and of the lack of integrity of thesynaptonemal complex in Hsf2) ⁄ )spermatocytes is apending question [62].Role of HSF1 in the quality ... possible roles of HSF2 in the organization of chromatin and of thegenome structure. First, HSF2 binding to its targetgenes correlates with the acetylation of histones H3and H4, a frequent mark of ... of their bindingsites. HSF4 binding was shown to be closely associatedwith reduced methylation of the histone H3K9, irre-spective of the relative location of the HSF4-bindingregions and of...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... (WH2-1)or even deletion of the entire N-terminal module of Vrp1p did not significantly perturb the activity of Vrp1p in polarization of cortical actin patches [23].One role of the LBD is to target ... andprotein interactions of the various truncated forms of C-Vrp1p364)817(Fig. S3A,B). Consistent with theresults observed for alanine substitution of K485R486,none of the five deletions abolished ... mutation of the CABSVH2-C domain charged cluster nor deletion of theLBD significantly affected the steady-state expressionlevel of GFP-tagged C-Vrp1p364)817(Figs 2E and 5E).Moreover, mutation of...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... Theamount of inorganic phosphate released was determined bya colorimetric assay [51,52]. Briefly, 500 lL of a malachitegreen solution [0.034% (w ⁄ v) malachite green oxalate, Roles of the HsRad51 ... the DNA-bindingmode of HsRad51 should be somewhat different fromthat of HsDmc1. The octameric ring form [38,39] andthe helical filament form [40] of HsDmc1 are capable of binding DNA, but Rad51 ... loop of E. coli RecA. This fact suggests that the L1loop of Rad51 interacts with DNA in a different man-ner from that of RecA. His163 is the only residue witha ring structure similar to that of...
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Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... the FG loop regionand movement of t wo subunits. These structural changesmay play critical roles in c atalytic regulation of the PD Edomain [4].Structures of the haem-bound PAS domain have ... channel.However, the catalytic activities of Met95 mutants werecomparable to those of wild-type [14], implying no directinvolvement in the catalytic control of Ec DOS. A number of site-directed mutagenesis ... akamura, H., Iizuka, T. & Shiro, Y.(2000) Roles of Ile209 and Ile210 on the heme pocket structure andregulation of histidine kinase activity of o xygen sensor FixL fromRhizo bi um m el ilo...
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Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
... (1971) The regulation of rabbitskeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin–troponin complexwith actin and the proteolytic fragments of myosin.J Biol ... forthe quantitation of microgram quantities of protein util-izing the principle of protein-dye binding. Anal Biochem72, 248–254.41 Harafuji H & Ogawa Y (1980) Re-examination of theapparent ... using known amounts of protein run on thesame gel, as a standard. The amount of nonspecificprecipitation of the TnI-fragment was also monitored bysimultaneous centrifugation of the sample containing...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... Department of Biochemistry, University of Leicester, UK2 CNAP, Department of Biology, University of York, UKPentaerythritol tetranitrate (PETN) reductase was ori-ginally purified from a strain of Enterobacter ... analysis of the titration of H181A PETN reductase with progesterone. (C) Plot of absorbance change as a function of 2,4 dinitrophenolconcentration for the data shown in (A). (D) Plot of absorbance ... is % twofoldless than that for wild-type enzyme (Table 2). Stopped-flow studies of the oxidative half-reaction of Y186FPETN reductase with TNT indicated formation andsubsequent decay of the...
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Báo cáo khoa học: Roles of conserved arginines in ATP-binding domains of AAA+ chaperone ClpB from Thermus thermophilus pptx
... used TClpB to exam-ine the roles of the conserved arginines, Arg322 (P2)and Arg323 (P1) of AAA-1, and Ar g747 (P1) of AAA- 2,and determined that the arginines of TClpB are notinvolved in ... values may only represent a lower limit, because of the intrin-sic ATPase activity of TClpB.T. Yamasaki et al. Roles of conserved arginine of ClpB chaperoneFEBS Journal 278 (2011) 2395–2403 ... middle domain of 1R ⁄ A(P2) leans towards AAA-1upon nucleotide binding to AAA-1, regardless of thestability of the hexameric form.DiscussionPreviously, the effects of mutations of the P1 argininesin...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... activity of SFKs is tightly regulated by the reversible phosphoryla-tion of Y527 in chicken c-Src in vivo. The phosphoryla-tion of Y527 may decrease the activity of SFKs, withdephosphorylation of ... phosphorylationand activity of NMDARs observed with dysfunction of the SH3 and ⁄ or SH2 domains in Src may be due toa change in interaction of Src with its substrate, bind-ing of wild-type or mutant ... (3) Fig. 4. Effects of dysfunction of the SH3 and ⁄ or SH2 domains onphosphorylation of NMDAR NR2A C-tail protein by n-Src. (A) Wes-tern blot showing phosphorylation of NR2A C-terminal fragment(amino...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... of GH3, Aux ⁄ IAA, SAUR and ARF gene family members in various tissues ⁄ organs and developmental stages of rice. A heatmap representing hierarchical clustering of average log signal values of ... controlling the activity of ARFs [9,10]. The devel-opmental specificity of auxin response is determined bythe interacting pairs of ARFs and Aux ⁄ IAAs [14]. Themembers of the GH3 gene family ... characterization of the members of the GH3, Aux ⁄ IAAand SAUR gene families in rice. In this study, whole genome microarrayanalysis of auxin-responsive genes in rice was performed, with the aim of gaining...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... SMasses of oligomers (kDa)Numbers of subunitsG6G5G4G3G2G1AB CFig. 6. Determination of the Stokes radius and mass of AChEBoligomers. (A) Oligomers were isolated from sucrose gradients of ... sup-pressed by mutation of the aromatic residues toleucines [3–6].However, the major function of the t peptides is thatthey allow the assembly of tetramers of AChET[7] and of BChET[8] and their ... assembly of amy-loid-beta-peptides into Alzheimer’s fibrils: possible role of the peripheral site of the enzyme. Neuron 16, 881–891.52 Inestrosa NC & Alarcon R (1998) Molecular interac-tions of...
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Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc
... helix andthe M loop) of these c-tubulins causes cold-sensitivity of cell growth and ⁄ or loss of basal bodies [25,26]. Inlight of this evidence, we propose that the capacity of c-tubulin to perform ... immunofluorescencemicroscopy, we found that the c-tubulins of E. focardii associate throughoutthe cell cycle with basal bodies of the non-motile dorsal cilia and of all of the cirri of the ventral surface (i.e. adoral ... validation.Transcription of the E. focardii c-T1 and c-T2nanochromosomesTo gain insight into the roles of the E. focardii c-tubu-lin isotypes, we measured the steady-state levels of macronuclear mRNAs...
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