role of oxidative stress in the etiology of sperm dna damage
Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
... activation of the S-phase checkpoint The Mre11-binding domain is responsible for binding to Mre11 during formation of the Mre11–Rad50–Nbs1 (MRN) complex The ATM-binding domain at the COOH-terminus binds ... its role in the DNA damage response In addition, the extreme COOH-terminal region (amino acids 734–754) of Nbs1 mediates the interaction of Nbs1 with ATM and the recruitment of ATM to sites of DNA ... DNA damage, thereby promoting ATM-dependent signaling [23] Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... Oxidative stress after status epilepticus in rats inefficiency of the electron-carrying components of the mitochondrial transport chain, monoamine degradation, xanthine oxidase reaction, ... determined by analysis of variance markedly increased in this model compared with corresponding values for the control group After pilocarpine-induced SE, there was a significant (77%) increase in ... findings show that pilocarpine induces SE, which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby protecting the brain from neuronal damage induced...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... utility of anti-inflammatory drug therapies in the treatment of AD Microglia are the principle immune effector cells in the brain and represent approximately 5–10% of all glia found in the brain The ... use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110] Finally, ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... for the present biological evaluation The second evaluation was carried out in the morning, hour after the last intake of nifedipine The study was approved by the local Ethics Committee (Cochin ... endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1 Endothelium injury is critical in SSc and is suspected to occur early in the ... transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative stress and angiogenesis is emphasised in SSc...
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Báo cáo khoa học: " The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise" doc
... The exercise-induced increase in LPO content was reverted by supplementation with MSM, pointing to an improvement in the oxidative status of the cells, according to the MSM-induced increase of ... mechanism for the exercise-related increase in oxidative stress Our finding of increased horse's plasma LPO content after jumping exercise supports the hypothesis of augmented oxidative stress with ... Discussion The role of ROS in the exercise-induced damage is supported by many studies ROS production has been found to increase with exercise, thus augmenting the amount of oxidative damage induced...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22]; ... continuous load of calcium to the neuron The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in ... Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence of PTP in situ has not gained wide acceptance among investigators and results published in the literature...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... apoptosis In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in the ... generation of ROS Blocking the formation of ROS could sufficiently inhibit the effects of NSC741909, including JNK activation, cell growth suppression, and apoptosis These results indicate that the oxidative ... evaluated the effects on NSC-741909's antitumor cell activity of several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein),...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... oxidative stress and inflammation are indeed functionally relevant in the development of the phenotype of these animals However, we also provide new information on the critical issue of the in ... receiving indomethacin plus vitamin E Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E underlie the effect of this compound in vivo, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16] This finding suggests that...
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ADVANCES IN THE ETIOLOGY, PATHOGENESIS AND PATHOLOGY OF VASCULITIS potx
... with the strong involvement of the endothelial cell-induced inflammatory reaction in the development of the encephalitis, as described in the introduction To refine the significance of these ... which could be involved in the control of the vascular inflammation and disruption of endothelium, allowing the passage of the virus in the organs The early NiV infection of endothelial cells ... perspective, the activation of interleukin-8 by M pneumoniae is one of the key steps in inducing the vasculitic disorders which are the main subject of this chapter As regards the presence of pneumonia in...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... Western Blotting The lower shows the ratio of Nrf2/actin using calculatging by densitometor In the cell treated with PM2.5, the level of Nrf2 was much highly increased than in the cell treated ... suggesting that PM2.5 induced more oxidative stress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form Comparative study of PM2.5 ... level of medium PM Fig Reactions by using strand breaks in plasmid pBR322 DNA is shown as reduction of form II (open circular DNA) The graph shows the ratio of open circular DNA/ total DNA See the...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... increased in response to O3 in both groups of seedlings (Figs 5E5H) during the growing season The level of activity decreased in the neoformed ush of the episodic seedlings when the O3 concentration ... grown in the absence of O3 decreased more than two-fold during the growing season In the truncated seedlings there was no change in the NR activity under O3 (Figs 6A6C) On day 85, the rst ush of the ... produced during the day [4] and may use the NADPH produced by G6PDH In the neoformed ush of the episodic seedlings, stimulation of G6PDH activity was not maintained until the end of the season (day...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... clarify the role of oxidative damage in the pathogenesis of OA, we looked for the presence of oxidative damage in degenerated cartilage from OA patients and examined whether chemical oxidative stress ... and the Japan Rheumatism Foundation References Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced ... 72 hours of incubation, the percentage of proteoglycan remaining in the cartilage tissue was significantly lower in the H2O2 treated group than in the control group In contrast, the antioxidative...
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Báo cáo khoa hoc:" Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan" ppsx
... in many types of tumors [13] The number of cytosines in the first stretch of the D310 region can vary from to in normal individuals The homopolymeric C-stretch is part of CSBII, located within ... the result of just type of mtDNA damage but rather the sum total of a large number of mtDNA mutations that accumulate concurrently over time This assumption may explain our findings on the association ... difference in levels of oxidative stress biomarkers and the mtDNA copy number in dialysis patients Discussion An increased oxidative burden is observed in chronic renal failure patients [1] The onset of...
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Báo cáo y học: "The role of unintegrated DNA in HIV infection" docx
... primary function of unintegrated DNA in the HIV replication cycle is to provide the link between viral RNA and integrated proviral DNA, in the form of linear cDNA [2] Yet, when viral integration may ... dependent on the import of Vpr with the virion in order to promote the initiation of transcription [109] In studies using the Rev-CEM cell line, it was seen that Nef, expressed in the absence of integration, ... [117] Expression of Rev might not significantly inhibit the first infecting and Rev producing virus, but might inhibit further superinfecting viruses from integrating The authors of these studies...
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Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx
... by the presence in the histological examination of ballooning, steatosis, necrosis and the presence of neutrophils in the liver, similar to what is observed in NASH [45] In the evaluation of ... in the present study further promotes oxidative stress, contributing to aggravation of the liver tissue injury This kind of pathological synergy is evidenced in experimental models of liver damage ... group in comparison to the SIH group No evidence of damage was observed in blood tissue The rate of DNA damage detected by the comet assay depends on the tissue or organ analyzed [55] Here, the DNA...
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Báo cáo y học: "A model analysis of static stress in the vestibular membranes" ppsx
... bear the brunt of the stress load in the vestibular membranes However in the absence of this collagen layer the very thin basement membrane acting as a support for epithelial cells facing the ... select ideal shapes for the model membranes (c) describe the general mechanics of membranes (d) define the determinants of membrane stress The shape of the membranes in the three vestibular structures ... cylindrical shapes for the model chambers Therefore in the current model, the narrow toroidal shape of the semicircular canal will be construed to be a long thin straight cylinder, the dome of the...
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Báo cáo y học: "Genomic neighborhoods for Arabidopsis retrotransposons: a role for targeted integration in the distribution of the Metaviridae" docx
... those of the Metaviridae The position of the median is shown as a gray bar in the box that delimits the boundaries of the lower and upper quartiles Data points more than 1.5 times the inter-quartile ... heterochromatin The major source of differences was the distribution of solo LTRs in the Metaviridae Age of insertions LTR retroelements have a built -in clock that can be used to estimate the age of given ... accurate of the two deposited research Our data on the genomic distribution of retroelements can be considered in the light of theoretical work predicting the distribution of TE populations within...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... of the resulting effect of the thermal stress, all mechanisms point to the involvement of oxidative stress in the early stages of symbiosis breakdown In fact, several authors have suggested the ... D (2004) The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer Semin Cancer Biol 14, 231–243 48 Beere HM (2004) The stress of dying’: the role of heat shock ... gastrodermal tissue harboring the zooxanthellae (Fig 6B) Effect of heat stress on antioxidant defenses and bleaching in animal tissue of A viridis The occurrence of oxidative stress in the animal tissue...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... Ca2+ influx (41) The increased activity of NOS and the increased formation of NO in brain in anoxia as observed by increase in NOx concentration in this study support the earlier findings of NO involvement ... brain regions significantly in anoxia suggesting an increased utilization of citrulline for the production of arginine in anoxia In reperfusion group the activities of these enzymes were increased ... continuous supply of arginine at the site of synthesis Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circulating arginine and (b) recycling...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... domain, containing an iron-binding domain, which is involved in ADH activity The integrity of both domains and that of the iron-binding domain are required for ALDH activity [16] Moreover, the enzyme ... probably involved An explanation for the protective effect of the coenzymes against oxidative stress in EhPFOR is that they bind close to the FeS clusters, blocking the access of ROS In this regard, ... complete, with minimal nonmatching regions in the surfaces of the proteins (Fig 3) The extra C-terminal portion in the DaPFOR structure responsible for protection against O2 [25] was absent in the amebal...
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