rodent models of adaptive decision making
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... not considered in the category of animal models of disease, one can view the field of human genetics as probing a vast natural mutagenesis screen involving billions of individual organisms As in ... developing animal models of CCM disease Classically, a CCM consists of a cluster of dilated blood vessels [12,13] Each vessel in the cluster is grossly dilated, earning the name of a cavern; each ... orthologue of CCM2) Zebrafish with loss -of- function mutations in san or vtn share a common phenotype with fish lacking heart of glass (heg) Although mutations in the human orthologue of heart of glass...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... end of both inflammatory models, a panel of cytokines was analyzed in blood At sacrifice whole blood was collected from the heart of the animals and plasma was obtained by centrifugation 25 μl of ... detected the withdrawal of the paw Latency of each paw withdrawal was recorded and mean values of left and right paws were used as reaction index for the individual animal A cut-off of 25 seconds was ... [25,26] CARR injection in the hind paw of the mouse is one of the most commonly used models of inflammation and inflammatory pain and it has a biphasic profile [27] Recent studies pointed out...
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Báo cáo khoa học: "Tree-ring characteristics of subalpine fir (Abies lasiocarpa (Hook.) Nutt.) in relation to elevation and climatic fluctuations" docx
... growth relationships of different species in the same area Considering the importance of density as an index of wood quality, the role of climate as the major determinant of tree growth, and the ... 32] The presence of a strong positive response of RW to July temperature of the current year (corresponding to the spring season) and of LW, LW%, and MXD to August temperature of the current year ... Columbia The number of study stands in each location is indicated adjusted by adding a 100 m to the measured elevation for every degree of latitude north of the reference latitude of 49° N This adjustment...
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Báo cáo y học: " Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample" pot
... Bahrain model [36]; (vi) the higher order models of each of these lower - order factor models (Fig 4); (vii) the bifactor model of each of the lower-order factor models (Fig 5); and (viii) the one-factor ... by comparing the “goodness - of - fit” (GOF) indices of the various models We used the maximum likelihood method of estimation (MLE) There are three broad types of GOF measures Hooper et al [54] ... objectives of the study were: (i) using the responses of a sample of Arab college students to the Beck Depression Inventory (BDI-II) in CFA, to compare the “goodness of fit” indices of the original...
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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc
... use of animal models in the study of ARF Despite their limitations, animal models remain fundamental to improving our understanding of human ARF [28-30] There are three basic types of animal models ... choice, validity and relevance of animal models of ARF [4]; and the choice regarding appropriate physiological and clinical end-points for trials of new treatments of ARF [5] They also include ... randomization of animals Models should be chosen on the basis of their relevance to the clinical situation, and not merely by the reproducibility of the model Similar baseline characteristics of the...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease-causing APP mutations Animal models expressing wild-type (wt) human APP are of interest ... disease pathogenesis Familial forms of AD, with an autosomal dominant mode of inheritance, account for < 2% of all AD cases Onset is most often before 65 years of age, and the penetrance is nearly ... [54] A substantial amount of CAA is often found in transgenic mice with the Swedish mutation, which is likely to be because of the high rate of synthesis and accumulation of Ab1-40 In Tg2576, more...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... consequence of the presence of the same kind of spectrum for 4N complexes of GGH, where the a carbon of the His residue is the sole source of chirality [10] However, while positions of the component ... studies of the Ni(II) complex of HSA [6] Due to different protonation patterns, the stability constants of particular complexes of model peptides cannot be compared directly There are two ways of ... in the middle of the range of values for both Cu(II) and Ni(II) Note that the variation of side chain substituents can result in changes of complex stabilities by up to six orders of magnitude,...
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Báo cáo khoa học: "Corpus-Based Induction of Syntactic Structure: Models of Dependency and Constituency" pdf
... ordered (head, dependent) pairs of words, but the score of a dependency can optionally condition on other characteristics of the structure, most often the direction of the dependency (whether the ... A huge limitation of both of the above models is that they are incapable of encoding even first-order valence facts For example, the latter model learns that nouns to the left of the verb (usually ... (expected) number of trees headed by h whose rightmost edge i is strictly left of h The second is the number of trees headed by h with rightmost edge i strictly left of h The ratio is the MLE of that local...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... and inconsistency of tumor development, led to a shift towards implantation of neoplastic cells propagated in vitro [4] While the majority of these models involve the use of rodent glioma cells ... these rodents obviously limits the use of the xenograft models in some immunologic investigations, namely studies involving T-cell related immunity These models however maintain some aspects of ... function of specific genes of interest and thus exploit defined genetic lesions to produce more biologically correct models of CNS cancers that result from activation and/or inactivation of endogenous...
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báo cáo hóa học:" General anxiety, depression, and physical health in relation to symptoms of heart-focused anxietya cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death" doc
... the last year Of the total sample of patients, 25% (n = 32) had a clinical diagnosis of either LQTS or HCM as opposed to 75% (n = 94) at genetic risk because of family history of LQTS or HCM ... terms of general anxiety, the variables (gender, age, having children, clinical diagnosis of either LQTS or HCM, recent SCD of a relative) entered at step of the model accounted for 10% of the ... comparison of general anxiety and depression scores with expected scores of the general population was a clear strength of study, since assessing symptoms based only on cut-off points may be of little...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... of formation of the immunological synapse, a specific supramolecular pattern of receptors involved in immune cell communication, in vivo [42,43] Two-photon microscopy One of the limitations of ... experimental animal models through the expression of herpes simplex virus thymidine kinase (HSV-Tk) in cells of animals and then injecting the animals with 2′-fluoro-2′-deoxy-1-beta-Darabinofuranosyl-5-iodo-uracil ... combination of molecular genetics and noninvasive imaging: the presence of the HSV-Tk gene can mark a specific cell population in a spe- cific state of activation based on the activity of the promoter...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... investigation in animal models of arthritis This review focuses on the gene therapeutic strategies of restoring the cytokine balance and genetic synovectomy in animal models of RA, as summarized ... independently in animal models of arthritis Recent human trials of IL-1Ra revealed moderate efficacy, probably because of poor pharmacokinetics and the 100- to 1000-fold excess of this molecule that ... presentation of the various gene transfer methods that are used in experimental models of rheumatoid arthritis Central to gene therapy is the transfer of therapeutic genes to the site of inflammation...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... varying patterns of expression [14] Extracellular domains of FGFRs consist of three immunoglobulin-like loops (loop I, loop II, and loop III) Alternative mRNA splicing of loop III of FGFR1 to FGFR3 ... and progression of OA The purpose of the present study was to examine whether FGF8 is involved in the destruction of cartilage in OA models Initially, a rabbit meniscectomy model of OA, in which ... FGF8f specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to...
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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease by the usual immunisation ... strengthens the validity of previous studies of the PGIA model in different laboratories, and throws down the gauntlet as a challenge to research groups that use inbred strains of mice as models for other ... R: Dissection of the genetic complexity of arthritis using animal models Immunol Lett 2005, 103:86-91 Rosenthal N, Brown S: The mouse ascending: perspectives for human-disease models Nat Cell...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
... likely that IC models mimic part of the RA pathology There is growing interest in the use of passive IC models, together with a range of transgenic knockouts, to identify Page of 10 (page number ... 14 The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to ... identification of its role in subgroups of RA with a distinct T cell signature Increasing support for a pathogenic role of autoantibodies in RA has shifted the interest of researchers to passive IC models...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... are computationally expensive requiring the solution and inversion of equations of the order of number of animals x numher of traits, but there are simplifications when all the traits are measured ... increase ; ’;2) the dimension of the search by We now develop a method that does not increase the dimension of search It is useful to think of a composite matrix of y and y i , of the form Y! _ [yi Y2] ... matrix of effects for the traits yi, y* and (Y c a x matrix of sums of squares and cross-products of residuals for these traits By using these relationships, and the formulae for log-likelihood of...
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Báo cáo y học: " General and Specific Components of Depression and Anxiety in an Adolescent Population" pdf
... Revised measure of children’s manifest anxiety J Abnorm Child Psychol 1978, 6:271-280 14 Chen FF, West SG, Sousa KH: A comparison of bifactor and second-order models of quality of life Multivariate ... hierarchical structure of comorbidity between depression and anxiety [8, 10] These models acknowledge the role of an underlying general distress component which accounts for the communality of depression ... errors of measurement were computed from the inverse of the square root of the information function and were plotted using graphics commands These graphs are important to provide an indication of...
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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt
... Q25 Knowledge of different kinds of treatments Q18 Knowledge of the magnitude of therapeutic efficacy of treatments Q20 Knowledge of common side-effects Q19 Q24 Predicting success of treatment ... following are recognized symptoms of depression EXCEPT: 73 Which of the following is true about the age of onset of depression? 69 All of the following are typical of patients suffering from clinical ... consists of items, has an internal consistency of 0.51, and explains 5.2% of the observed variance It refers to the awareness of the common side-effects of antidepressants and the efficacy of electro-convulsive...
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báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia" pot
... perceived likelihood of future overdose and witnessing multiple overdoses recently is that the act of witnessing may heighten one's awareness of the pervasiveness of overdose and sense of fatalism about ... level of psychological distress (i.e., global severity index) The Russian version of the SCL-90-R has not been normed, and clinical cutoff scores not exist However, higher scores are indicative of ... in the Community Reports of overdoses, both fatal and nonfatal, were common Participants reported having heard of a median of five (range = – 60) non-fatal overdoses and of two (range = – 30) fatal...
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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx
... to the experimentalist Animal models that may be of great benefit to the study of the mechanisms involved in the development of COPD were described The importance of animal and strain selection ... antielastase and lack of sensitivity to oxidants) Conclusion It was evident from this meeting that a great deal of effort is going on worldwide to produce animal models of COPD Page of (page number ... accounts for 85–90% of cases of COPD in humans and, although a cigarette-smoke-driven model would be desirable, Dr Tralau-Stewart (GSK) also discussed a variety of other animal models and outlined...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008