relevance of antibody screening and crossmatching in solid organ hematopoietic stem cell transplantation and blood transfusion
Báo cáo y học: "Marked increase of procalcitonin after the administration of anti-thymocyte globulin in patients before hematopoietic stem cell transplantation does not indicate sepsis: a prospective study" pptx
... duration of T -cell antibody administration [8] Pihusch and colleagues [9] prospectively studied PCT, CRP, and interleukin-6 (IL-6) in 350 stem cell recipients Conditioning with ATG increased ... Anti-thymocyte globulin (ATG) administered during conditioning before hematopoietic stem cell transplantation triggered a marked increase in both procalcitonin (PCT) and C-reactive protein (CRP) with ... diagnose infection in patients receiving ATG prior to hematopoietic stem cell transplantation We also assessed renal and liver functions and their relationship to PCT and CRP changes Materials and...
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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx
... T-cells remain alive for a sufficient amount of time to initiate an immune reaction against certain target organs and cause significant and clinically noticeable organ damage (Parkman & Weinberg, ... (2009) Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treat ment of hematologic malignancies in children Biology of Blood and Marrow Transplantation, ... production of autoantibodies, causing targetorgan damage, including skin, mucosa, eyes, joints, and liver (Lee, Vogelsang, & Flowers, 2003) Once GVHD is initiated, T-cells produce additional proinflammatory...
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Báo cáo y học: "Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation" pot
... P: Patterns of T -cell reconstitution by assessment of T -cell receptor excision circle and T -cell receptor clonal repertoire after allogeneic hematopoietic stem cell transplantation in leukemia ... either T -cell- depleted or unmodified allogeneic hematopoietic stem cell transplantations Blood 2002, 100:2235-42 Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins ... impaired naive T -cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease Blood 2003, 102:4600-7 10 Li Y, Yin Q, Yang L, Chen...
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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pot
... including the importance of parental involvement in treatment and optimal timing of interventions The role of parents in the treatment of PTSD in children and adolescents The role of parenting ... the project in supervising therapists and overseeing the provision of the interventions She also has specific expertise in the design and execution of clinical trials of psychological interventions ... been involved in assessing eligibility of participants, allocation of individuals to treatment conditions, administration of treatment, collection of follow-up assessment data or entering of data...
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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pptx
... for a randomised controlled trial of risk screening and early intervention comparing child- and family-focused cognitive-behavioural therapy for PTSD in children following accidental injury BMC ... for a randomised controlled trial of risk screening and early intervention comparing child- and family-focused cognitive-behavioural therapy for PTSD in children following accidental injury BMC ... http://www.biomedcentral.com/1471-244X/11/15 Page of Author details Centre of National Research on Disability and Rehabilitation Medicine, School of Medicine, University of Queensland, Herston QLD 4029, Australia School of Psychology,...
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Báo cáo khoa học: " Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study" doc
... onto ORSA plates (Oxacillin Resistance Screening Agar; Oxoid, Basingstoke, UK) and then suspended in ml colistin-salt broth (brain–heart infusion with 10 µg colistin/ml and 2.5% NaCl) as a backup ... on MRSA infections was observed in both ICUs after introduction of the qMRSA test and an increased frequency of screening on admission (phase II) However, a substantial decrease of MRSA infections ... Medical ICU The vertical line on the figure indicates the initiation of rapid on-admission screening in November 2003 (phase II) The dashed vertical line indicates the initiation of pre-emptive isolation...
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Báo cáo y học: "Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies" docx
... evolution is the unique insertion in the C1 region The C1 region is part of the inner domain of the gp120 core and interacts with gp41, contributing to the non-covalent binding of gp41 and gp120 Mutagenic ... 2F5 and 4E10 neutralization by inducing alanine substitutions in both epitopes For 2F5, the positions D664, K665 and W666 play a major role in the binding and recognition of the epitope In the ... AA: amino acids in the 4E10 region of the COT6.15 virus Alanine-replacements inducing a 3-fold or higher decrease in sensitivity are indicated in grey aAntibody concentration (μg/ml) causing 50%...
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Development of virtual screening and in silico biomarker identification model for pharmaceutical agents
... of NF-kB signaling inhibitors In order to reduce the cost and time in developing novel IKKβ inhibitors, the machine learning method is used to build a prediction and screening model of IKKβ inhibitors ... analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors In the end, chapter summarizes overall findings of this ... sensitivity of these cell- lines against kinase inhibitors: gefitinib (D1), erlotinib and lapatinib (D3) 150 Table 5-10 The distribution and coexistence of amplification and expression profiles,...
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Relevance of mineral nutrition and light quality for the accumulation of secondary metabolites in centella asiatica and hydrocotyle leucocephala
... different PAR/UV-B combinations on the concentration and distribution pattern of selected phenylpropanoids, and in particular the lignan hinokinin, was examined in leaves and stems of H leucocephala ... uncontrolled harvesting, limited cultivation, and insufficient attempts of replacement of the plants result in depletion of wild stock, extinction of endangered species, and shrinking of biodiversity ... doses of either N, P, or K in the range of to 150% of the amount in a standard Hoagland solution favor herb and leaf yield of Centella asiatica but decrease saponin and sapogenin concentrations in...
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báo cáo hóa học: " Function, Adjustment, Quality of Life and Symptoms (FAQS) in Allogeneic Hematopoietic Stem Cell " potx
... knowledge of the pattern and correlates of recovery and long-term survivorship can be applied to inform screening/ surveillance in transplant survivors, and would guide the development and testing of ... after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and ... research, including Spanish speakers, and individuals undergoing reduced intensity transplantation or receiving treatment for disease relapse following transplantation The knowledge gained from...
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Báo cáo khoa học: "Genomic alterations of primary tumor and blood in invasive ductal carcinoma of breast" pdf
... amplified in 90% of the presently studied tumors We identified 46 regions of gain present in more than 30% of the primary tumor samples and 70 regions of gain present in more than 30% of blood samples ... that of copy number gains There were 11 regions of loss found in more than 13% of the primary tumors and 16 regions of loss found in more than 13% of blood (Tables and 4) Thirty other regions of ... gain were detected in at least 30% of both primary tumors and blood (Table 5) Among these, seven regions of copy number gain were found in more than 50% of both primary tumors and blood A gain...
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Báo cáo y học: "Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases" docx
... TGFβ-1 and the extracellular matrix protein laminin-5 induced EMT and hepatocellular carcinoma cell invasion by upregulating Snail and Slug, down regulating E-cadherin, translocating β-catenin into ... — approximately 25% of intimal lining cells and 7% in the sublining tissues Strong staining was seen at the advancing front of pannus and sites of bone erosions [90] Jones and colleagues [91] ... nucleus and engage LEF-1/TCF DNA binding proteins, transforming them into transcriptional activators of the genes central to EMT, including the down-regulation of E-cadherin genes Binding of TGF-β...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" doc
... final manuscript Authors' information G.J and B.M are attending physicians in the department of hematology and oncology of the University of Ulm P.S is attending physician in the department of ... M: Clinical outcomes of human herpesvirus reactivation after hematopoietic stem cell transplantation Clin Infect Dis 2005, 40:932-940 Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf ... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" ppsx
... final manuscript Authors' information G.J and B.M are attending physicians in the department of hematology and oncology of the University of Ulm P.S is attending physician in the department of ... M: Clinical outcomes of human herpesvirus reactivation after hematopoietic stem cell transplantation Clin Infect Dis 2005, 40:932-940 Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf ... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem...
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Báo cáo y học: "The impact of early hypoglycemia and blood glucose variability on outcome in critical illness" ppt
... Rosa G: The effect of intensive insulin therapy on infection rate, vasospasm, neurologic outcome, and mortality in neurointensive care unit after intracranial aneurysm clipping in patients with ... approach for maintaining TCG with IIT In contrast, in a twoyear survey of a single center where TGC by IIT was routinely Available online http://ccforum.com/content/13/3/R91 Table Summary of acute ... medications, and use of continuous renal replacement therapy [31] Observational data and findings from randomized trials have shown that TGC with insulin therapy also represents an independent...
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Exploring the Relevance of Manual Pattern Cutting Skills in a Tchnological Environment, Catherine Pritchard, 2013
... piece of writing that will contribute to the relevance of maintaining the knowledge of manual skills in the future for training and educating those entering an environment of continually developing ... Finland 40 in Belgium and France 38 in Germany and the Netherlands 44 in Italy 44/46 in Portugal and Spain (10 in the USA) (Taken from BSI, the British Standards Institute, 2011) To make sizing ... and an invoice 33 Cut out garments in the cloth as the patterns instruct All the patterns were cut out by hand by the same person and as the pattern instructed, including lining and interlining...
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Báo cáo y học: "Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms" pps
... Vwa, D13S317, and TPOX) were informative and showed the coincidence of profile between AML blasts after transplantation and the donor’s cells, supporting full engraftment of the stem cell transplant ... of stem cell infusion Discussions and Conclusions Here we report a case of a secondary AML developing from donor-derived cells in a breast cancer patient who underwent allogeneic stem cell transplantation ... following chemotherapy The XPD Gln751 polymorphic protein was shown to fail in engaging apoptosis in chemotherapy-damaged cells, thus avoiding elimination of mutated myeloid precursors In order...
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báo cáo khoa học: " Biomarkers in solid organ transplantation: establishing personalized transplantation medicine" potx
... change in frequency of a specific type of cell without a change in the expression profiles of each cell type or a change in the expression profile of a cell type while the frequency of the cell ... the initial biomarker panel in independent samples, leading to a refined set often consisting of 50 to 100 candidates Meta-analyses improve the sensitivity and specificity of the initial candidate ... transcriptomic and proteomic biomarkers of acute and chronic allograft injury and graft accommodation We point out the advantages and pitfalls of trying to identify non-invasive blood- based biomarkers and...
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Báo cáo y học: " Visualizing fusion of pseudotyped HIV-1 particles in real time by live cell microscopy" doc
... Figure staining of cells resulting from fusion with fluorescently labeled VLPs Membrane Membrane staining of cells resulting from fusion with fluorescently labeled VLPs DFJ-8 cells were incubated ... pseudotypes carrying the fluorescent variant of eMLV Env and the MA domain of HIV-1 Gag fused to another fluorescent protein Here, we report single particle tracking of >20,000 individual traces of double-fluorescent ... images following settling of a cell onto the particle coat revealed a gradually appearing diffuse membrane stain (see Additional file 1, and 3), indicating the cumulative effect of multiple individual...
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Báo cáo y học: " Anemia and blood transfusion in a surgical intensive care unit" pps
... records Blood transfusion was registered electronically in the clinical information system as part of standard procedure in our ICU Each blood transfusion unit was recorded separately using identification ... number of transfused units of blood and the degree of organ dysfunction/failure during the ICU stay, as assessed by SOFA scores, length of stay in the ICU, and mortality rates (Table 3) About 50% of ... by the transfusion authorities in our hospital and regular training is given by special personnel Definitions Comorbidities were defined according to the definitions provided in the original SAPS...
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