receptor of advanced glycation end products gene polymorphism
Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... has been independently associated with the risk of CV death [9,10] Thus, the progress of CV disease might depend on the burden of inflammation The receptor for advanced glycation end products (RAGE) ... protein (HMGB1)), β-pleated sheet fibrils of amyloid and advanced glycation end products (AGEs) [15] AGEs are the products of nonenzymatic glycation and oxidation of proteins that form with aging, diabetes ... G82S polymorphism amplifies the inflammatory response Genes Immun 2002, 3:123-135 Hudson BI, Stickland MH, Grant PJ: Identification of polymorphisms in the receptor for advanced glycation end products...
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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx
... between blood and synovial in ble receptorarthritis patients Scattergram for advanced glycation end products (sRAGE) levels soluble receptor for advanced glycation end products (sRAGE) levels in rheumatoid ... One of the features of the receptor is its recognition of families of ligands, rather than a single protein The RAGE repertoire of ligands includes products of non-enzymatic glycoxidation (advanced ... cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid...
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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc
... the receptor for advanced glycation end products Wien Med Wochenschr 2006, 156:42-52 van Beijnum JR, Buurman WA, Griffioen AW: Convergence and amplification of toll-like receptor (TLR) and receptor ... protein tyrosine phosphatase, non -receptor type 22; sRAGE, soluble receptor for advanced glycation end products In simple linear regression analysis, serum levels of S100A8 in RA patients were positively ... (soluble) receptor for advanced glycation end products Page of 11 (page number not for citation purposes) Arthritis Research & Therapy Vol 11 No Chen et al Table Linear regression analysis of sRAGE...
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Báo cáo y học: ":The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1" ppsx
... by receptor for advanced glycation end products J Immunol 2005, 175:8296-8302 23 Drinda S, Franke S, Ruster M, Petrow P, Pullig O, Stein G, Hein G: Identification of the receptor for advanced glycation ... HA, Lafeber FP, Toes RE, DeGroot J: Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes Arthritis Rheum ... Stern DM, Naka Y, Ramasamy R, Yan SD, Yan SF, D’Agati V, Schmidt AM: Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications...
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Báo cáo khoa học: Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells ppt
... Breyer et al DNA advanced glycation end- products in cells 300 Glycation rate (%) 250 200 150 100 50 0 days of incubation 14 days of incubation Fig Increase in the glycation rate of genomic DNA ... Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanded glycation endproducts Nat Med 4, 1025–1031 Singh R, Barden A, Mori T & Beilin L (2001) Advanced glycation end- products: ... FEBS V Breyer et al DNA advanced glycation end- products in cells enzymes, the CEdG-modified plasmid DNA often yielded higher amounts of the open circular undigested and of only partially digested...
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Báo cáo y học: " Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study" potx
... Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins J Biol Chem 1992, 267:14998-15004 Basta G: Receptor for advanced glycation end products and atherosclerosis: ... and the soluble isoforms of the receptor Investigating on the dynamics of RAGE and its soluble isoforms in COPD seems warranted in view of the results of two recent meta-analyses of genome-wide, ... soluble receptor for advanced glycation end products Nat Med 1998, 4:1025-1031 11 Falcone C, Emanuele E, D’Angelo A, Buzzi MP, Belvito C, Cuccia M, Geroldi D: Plasma levels of soluble receptor for advanced...
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Báo cáo y học: "Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation" pdf
... PJ, Cao R, Hori O, Stern D, Schmidt AM: Receptor- mediated endothelial cell dysfunction in diabetic vasculopathy Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic ... Miyamoto K, Nakano Y, Hasegawa N, Miyasho T, Maruyama I, Ishizaka A: Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury Am J Respir Crit Care Med 2008, 178:356-362 ... The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation J Clin Invest...
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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf
... interaction of AGEs with the receptor for advanced glycation end products activates monocytes and endothelial cells through intracellular signal transduction pathways to induce the expression of cytokines, ... complications of diabetes and beyond Circ Res 93, 1159–1169 Sun M, Yokoyama M, Ishiwata T & Asano G (1998) Deposition of advanced glycation end products (AGE) and expression of the receptor for ... 2-microglobulin and advanced glycation end products in the development of dialysis related-amyloidosis Kidney Int 51, 1514–1519 Yan SF, Ramasamy R, Naka Y & Schmidt AM (2003) Glycation, inflammation,...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... kappa B; RAGE = receptor for advanced glycation end products; RANKL = receptor activator of NFκB ligand lated using the threshold cycle (Ct) value for amplification of each target gene and for human ... expression induced by advanced glycation endproducts J Int Med Res 2008, 36:329-335 30 Peterszegi G, Molinari J, Ravelojaona V, Robert L: Effect of advanced glycation end- products on cell proliferation ... analysis of the promoter of RAGE, the receptor for advanced glycation end products J Biol Chem 1997, 272:16498-16506 36 Tanaka N, Yonekura H, Yamagishi S, Fujimori H, Yamamoto Y, Yamamoto H: The receptor...
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Báo cáo y học: " Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats" pot
... important pathological feature of pulmonary fibrosis [1] Advanced glycation end products (AGEs), the irreversible products of nonenzymatic glycation of proteins, nucleic acids and lipids, are increased ... glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha J Invest Dermatol 2006, 126(2):291-9 Zhou GH, Li C, Cai L: Advanced ... Assay; HSP47: heat shock protein 47; p-Smad2/3: phosphorylated-Smad2/Smad3; RAGE: receptor of advanced glycation end products; RT-PCR: Reverse TranscriptasePolymerase Chain Reaction; TGFb1: transforming...
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báo cáo hóa học: " Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes" docx
... mellitus; %ID/g: percent injected dose per gram; ROI: region of interest; RAGE: receptor for advanced glycation endproducts; VEGF: vascular endothelial growth factor; WT: wild-type Acknowledgements ... underestimation would explain the slope of the regression line for the plot of % ID from the scans vs %ID/g from the tissue Abbreviations AGEs: advanced glycation endproducts; DM: diabetes mellitus; ... mice received two additional doses of STZ (55 mg/kg) Page of Injection of radiotracer and imaging Under isoflurane anesthesia (1.5% isoflurane at a flow rate of 0.5% L/min oxygen per mouse), a...
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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx
... Rasheed et al Figure Gene expression and production of TNFα in advanced glycation end product-BSA-stimulated osteoarthritis chondrocytes (a) Effect of epigallocateadvanced glycation end product-BSA-stimulated ... the receptor for advanced glycation end products: potential role in osteoarthritis Arthritis Rheum 2005, 52:2376-2385 Nah SS, Choi IY, Yoo B, Kim YG, Moon H, Lee C: Advanced glycation end products ... Absorbance spectra and electrophoresis of native BSA and advanced glycation end product-BSA (a) Absorbance spectra of native BSA and product-BSA advanced glycation end product (AGE)-BSA Samples were...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... Imaizumi T: Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects Metabolism 2006, ... role of the receptor for advanced glycation end- products in lung fibrosis Am J Physiol Lung Cell Mol Physiol 2007, 293:L1427-L1436 Singh R, Barden A, Mori T, Beilin L: Advanced glycation end- products: ... Nitric oxide inhibits the formation of advanced glycation end products Kidney International 2000, 58:1780-1787 164 Peyroux J, Sternberg M: Advanced glycation endproducts (AGEs): pharmacological...
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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt
... rearrangements occur with the formation of ketoamine and finally the advanced glycation end- products (AGEs), which are stable These AGEs include a large number of chemical structures such as pentosidine, ... number of affected joints was calculated based on the presence of either tenderness or swelling in each of the joints examined Sacroiliitis was defined on the basis of having a history of persistent ... synovitis of recent onset Arthritis Res 2000, 2:236-243 Singh R, Barden A, Mori T, Beilin L: Advanced glycation endproducts: a review Diabetologia 2001, 44:129-146 Ulrich P, Cerami A: Protein glycation, ...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" pdf
... with H2O Toll-like receptor Three SNPs were genotyped for TLR1 SNP1 (rs5743618) is a G/T polymorphism of Ser602Ile in exon at position +7765 of the gene SNP2 (rs5743594) is a C/T polymorphism con- ... at position +3483 of the gene (+1 being at the beginning of exon instead of exon 2) SNP2 is a C/T polymorphism that constitutes a noncoding mutation, probably at position -1486 of the promoting ... publicity of available data As we did not observe a large effect it seems that an association between polymorphisms of other TLR genes and RA and/or a functional role for TLR genes in the pathogenesis...
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Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf
... VDR gene polymorphisms in studies of bone density [25,26] may suggest that the effect of VDR polymorphisms on the risk of OA may be modified by daily calcium intake The Finnish population is genetically ... turnover rate [16] The polymorphisms at the 3' end of the gene include two polymorphisms detectable with BsmI and ApaI restriction enzymes that are located in intron and one polymorphism detectable ... (OR) of having OA was calculated as a function of daily calcium intake (low intake versus moderate or high intake), of the presence of a risk allele, and of their interaction An absence of a...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" ppt
... with H2O Toll-like receptor Three SNPs were genotyped for TLR1 SNP1 (rs5743618) is a G/T polymorphism of Ser602Ile in exon at position +7765 of the gene SNP2 (rs5743594) is a C/T polymorphism con- ... at position +3483 of the gene (+1 being at the beginning of exon instead of exon 2) SNP2 is a C/T polymorphism that constitutes a noncoding mutation, probably at position -1486 of the promoting ... publicity of available data As we did not observe a large effect it seems that an association between polymorphisms of other TLR genes and RA and/or a functional role for TLR genes in the pathogenesis...
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Báo cáo y học: " Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis" doc
... glucocorticoid receptor gene polymorphisms studied in the cystic fibrosis patients Positioning Positioning of the glucocorticoid receptor gene polymorphisms studied in the cystic fibrosis patients Page of ... consistent with the effect of GR polymorphism on gene products and the role of GR in the control of the inflammatory response of the lung in CF Despite the monogenic nature of CF, the clinical course ... of the other studied GR polymorphisms with lung disease progression evaluated from the slopes of decline in lung function parameters Neither did we observe association of any of the studied polymorphisms...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... the 3¢ -end of this construct (instead of NcoI) to generate a compatible cohesive end for cloning into the NcoI restriction site of pGL3-Promoter vector (pGL3P) Transient transfection of CV1 cells ... Regulation of iPLA2c biosynthesis (Eur J Biochem 271) 4717 Fig Genomic map of iPLA2c The intron–exon boundaries of the iPLA2c gene are shown in scale (kb) The 13 exons of the iPLA2c gene are indicated ... abundant source of mRNA encoding iPLA2c Our results confirm the abundance of iPLA2c in myocardium and demonstrate the diverse repertoire of iPLA2c protein products generated from a single gene under...
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Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts pot
... effect of any of the TLR2 polymorphisms was observed on other lymphocyte subsets, including CD19+ B cells, CD4+ T cells, and CD8+ T cells Discussion In this genetic analysis of the TLR2 polymorphisms, ... consisted of 184 unrelated subjects recruited from the Center of Health Examination of Chang Gung Memorial Hospital (Kaohsiung, Taiwan) The specific criteria of enrollment were the absence of pulmonary ... The number of GT repeats was estimated by calculating the number of base pairs in the PCR products by using a sequencer (ABI Prism®3100 Genetic Analyzer; Applied Biosystems, USA) and Gene Scan...
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