randomized controlled clinical trials
Báo cáo y học: " A randomized, controlled clinical trial: The effect of mindfulness-based cognitive therapy on generalized anxiety disorder among Chinese community patients: protocol for a randomized trial" pdf
... A randomized, controlled clinical trial: The effect of mindfulness-based cognitive therapy on generalized anxiety disorder among Chinese community patients: protocol for a randomized ... disorder Methods A three armed randomized, controlled clinical trial including 9-month post-treatment follow-up is proposed Participants screened positive using the Structure Clinical Interview for DSM-IV ... responding for individuals with generalized anxiety Although it has been shown in randomized controlled clinical trials that MBCT can reduce the likelihood of relapse in people with recurrent episodes...
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báo cáo khoa học:"The WRITTEN-HEART study (expressive writing for heart healing): rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation" docx
... rehabilitation program The feasibility, safety and clinical efficacy of such a brief psychological intervention will be evaluated in a four-arm randomized controlled clinical trial with a Page of 12-month ... emotional expression in their social environments [36] Methods Study design A four-arm randomized controlled clinical trial with four follow-up assessments (immediately before discharge from hospital, ... writing procedure with their patients and to examine its effects empirically in many randomized clinical trials involving individuals with physical disorders such as breast cancer [15-18], rheumatoid...
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Báo cáo y học: " Using Guasha to treat musculoskeletal pain: A systematic review of controlled clinical trials" pdf
... treatment or concomitant use of other therapies (n = 89) Five randomized controlled trials (RCTs) [5-9] and two controlled clinical trials (CCTs) [10,11] Page of fulfilled the inclusion criteria ... Page of Figure Flowchart of the selection process for the trials RCT: randomized controlled trial CCT: controlled clinical trial UOS: uncontrolled observational study Acknowledgements This research ... 2.73], NS n.r.: not reported; NS: no significance; AT: acupuncture; RCT: randomized controlled trial; CCT: controlled clinical trial; VAS: visual analog scale Response rate was divided to four...
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Báo cáo y học: "Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial" docx
... emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial Critical Care 2010, 14:R5 ... fish oil administration [23] but this study was not controlled and relied upon historical data for comparison Thus, this is the first randomised, controlled study reporting reduced length of hospital ... age and glucose supply between the two groups, these were controlled for in statistical analysis of cytokines, gas exchange parameters and clinical outcomes Even after accounting for the differences...
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Báo cáo y học: "Several clinical interests regarding lung volume reduction surgery for severe emphysema: meta-analysis and systematic review of randomized controlled trials." docx
... Several clinical interests regarding lung volume reduction surgery for severe emphysema: meta-analysis and systematic review of randomized controlled trials Wei Huang, 1Wen R ... to address several clinical interests regarding lung volume reduction surgery (LVRS) for severe emphysema using meta-analysis and systematic review of randomized controlled trials (RCTs) Methods: ... Reynolds DJ, Gavaghan DJ, et al Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17(1):1-12 23 Stammberger U, Klepetko W, Stamatis G,...
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Báo cáo y học: "Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility" pptx
... algorithm for designing group sequential clinical trials Biometrics 2001, 57:972-974 Demets DL, Ware JH: Asymmetric group sequential boundaries for monitoring clinical trials Biometrika 1982, 69:661-663 ... Sequential Methods with Applications to Clinical Trials Boca Raton, FL: CRC Press; 2000:171–189 The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus lower positive ... with the acute respiratory distress syndrome N Engl J Med 2004, 351:327-336 Anonymous: Randomized, placebo -controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory...
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Báo cáo y học: "Clinical review: Strict or loose glycemic control in critically ill patients - implementing best available evidence from randomized controlled trials" ppsx
... bars) and strict glycemic control group (open bars) of seven randomized controlled trials Original single-center randomized controlled trials (RCTs) from Leuven [1,2]; single-center RCTs [3,4]; ... group) [7] Meta-analyses of randomized controlled trials of strict glycemic control Two meta-analyses, of which the first included the first five RCTs [18], and the second all trials except the last ... Schultz et al Critical Care 2010, 14:223 http://ccforum.com/content/14/3/223 Page of Table Randomized controlled trials on strict glycemic control (target blood glucose levels of 80 to 110 mg/dl) Main...
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Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"
... Walach H, Sadaghiani C, Dehm C, Bierman D The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials: a secondary analysis BMC Med Res Methodol 2005; 5: 26-37 ... [23] Although a significant number of clinical study reports support the anti-inflammatory and anti-arthritic properties of Boswellia extract [24-27], no human clinical studies were done to prove ... December 2008 (clinical trial registration number: ISRCTN80793440) The study protocol was evaluated and approved by the ASRAM Institutional Review Board (IRB) An overview of the clinical study...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... Design Step Pre -Clinical Studies PHASE PHASE PHASE Safety/Dosing Studies Stop Stop Uncontrolled Efficacy/ Safety Studies Stop Design potentially positive Randomized Controlled Trials (RCTs) No ... more fair? Ethics, subject allocation, and randomized clinical trials J Med Ethics 1998, 24:401-408 Chard JA, Lilford RJ: The use of equipoise in clinical trials Soc Sci Med 1998, 47:891-898 Karlawish ... the ethics of randomized clinical trials Bioethics 1995, 9:127-148 Djulbegovic B: Acknowledgement of uncertainty: a fundamental means to ensure scientific and ethical validity in clinical research...
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Báo cáo y học: "Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis" pps
... that our thinking about clinical trials is about to change dramatically Clinical studies conducted during early phases of drug development will increasingly consist of small trials with a high density ... implications for smallest detectable difference, minimal clinically important difference, and analysis of treatment effects in randomized controlled trials J Rheumatol 2001, 28:892-903 22 Lassere M, ... notion, serial ST analysis with evaluation of biomarkers was recently included in several randomized clinical trials of both disease-modifying anti-rheumatic drugs and biological agents [6,13,24-27]...
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Báo cáo y học: " Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies" ppt
... interstitial lung disease, randomized controlled trials, observational studies, multicenter studies, clinical trials phase II, clinical trials phase III, and clinical trials phase IV Diffuse alveolar ... meta-analysis results in the randomized clinical trials Comparison of (a) the forced vital capacity (FVC) and (b) the diffusing overall meta-analysis results in the randomized clinical trials capacity for ... heterogeneity unidentified by our review The shortage of randomized controlled trials on this topic is a limitation, and larger randomized controlled trials are needed to better understand the role of...
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Báo cáo y học: " Implementation research design: integrating participatory action research into randomized controlled trials" potx
... locally? To put this another way, how can we marry what many consider to be the ideal of the randomized controlled trial (RCT) with methods that address the difficulty of retaining interventional ... to learn something about the implementation process itself How PAR may be integrated with randomized controlled trails in implementation research design We propose integrating the RCT and PAR ... implementation process unfolds in each clinical setting This understanding will be key to our ability to implement interventions successfully in other clinical settings Thus, a greater appreciation...
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báo cáo khoa học: " Implementation research design: integrating participatory action research into randomized controlled trials" ppsx
... locally? To put this another way, how can we marry what many consider to be the ideal of the randomized controlled trial (RCT) with methods that address the difficulty of retaining interventional ... to learn something about the implementation process itself How PAR may be integrated with randomized controlled trails in implementation research design We propose integrating the RCT and PAR ... implementation process unfolds in each clinical setting This understanding will be key to our ability to implement interventions successfully in other clinical settings Thus, a greater appreciation...
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Báo cáo y học: " Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trials" ppsx
... both a measure of symptom severity and a time component The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), a large, randomized, double-blind, 18-month National Institutes of ... than patients treated with ziprasidone (p = 08) risperidone and quetiapine in large, randomized clinical trials measuring time to discontinuation for any cause [3,28], echoing our results and ... (NNT) and Number Needed to Harm (NNH) in Randomized, Blinded Trials Comparing Olanzapine to Other Atypical Antipsychotics for Treatment of Schizophrenia Clinical Schizophrenia & Related Psychoses...
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Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx
... experiments in rodents have provided the basis for human clinical trials In a randomized, double-blind, multicenter, and controlled phase II clinical trial involving 236 patients with severe active ... participation in other clinical trials within months before enrolment Study design The study was a two-to-one, eight-center, 24-week follow-up, double-blind, double-dummy, randomized, and MTX -controlled ... arthritis clinical trials J Clin Epidemiol 1997, 50:757-763 22 Lehman AJ, Esdaile JM, Klinkhoff AV, Grant E, Fitzgerald A, Canvin J: A 48-week, randomized, double-blind, double-observer, placebo-controlled...
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Báo cáo y học: "High frequency chest wall oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham-controlled clinical trial" pptx
... oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham -controlled clinical trial Respiratory Research 2011 12:120 Submit your next manuscript to BioMed ... encouraging and can be used to inform the design of larger-scale, more definitive trials testing the efficacy of HFCWO on clinical endpoints (e.g., feasibility of using HFCWO for acute asthma or COPD, ... Gelinas D, Becker B, Mitsumoto H: High-frequency chest wall oscillation in ALS: An exploratory randomized, controlled trial Neurology 2006, 67:6 Morrison L, Agnew J: Oscillation devices for airway...
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Báo cáo khoa học: "Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia" doc
... under clinical procedure Dogs with previous acupuncture experience were also excluded from the study Study design The study was carried out as a randomised placebo -controlled and observer-blind clinical ... canine hip dysplasia (CHD) included in a double blind randomized clinical trial The numbers (n) indicate the number of dogs within each strata and randomized groups (G) = Gold implantation group (P) ... results of the clinical trial have been reported elsewhere (Jæger et al 2004) Gold bead implantation in dogs with hip dysplasia 61 Table Number of dogs participating in a clinical controlled therapy...
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Báo cáo khoa học: " Randomized controlled trials are needed to determine appropriate blood transfusion strategies in patients with acute coronary syndromes" pdf
... A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group N ... predictive factors and timing of events Given the limitations of post hoc analysis of clinical trials data, a randomized trial of transfusion strategies is warranted to resolve the disparity in ... limitations that deserve consideration First, this was a post hoc analysis of data from three clinical trials, none of which were designed to address the question of appropriate transfusion thresholds...
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Báo cáo khoa học: " Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature" pptx
... trials (a) Mean arterial pressure (MAP) goals in sepsis trials (b) Central venous pressure (CVP) goals in sepsis trials trials (c) Pulmonary artery occlusion pressure (PAOP) goals in sepsis trials ... management of patients across these clinical trials of sepsis Hemodynamic criteria We examined the Methods sections for hemodynamic treatment goals for the clinical sepsis trials We abstracted both treatment ... variation in hemodynamic goals in clinical trials and whether this variation is associated with patient outcomes To better understand the hemodynamic goals in clinical trials in the sepsis research,...
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