quot the effects of drugs on cancer cells in tissue culture cannot predict their activities in patients quot
Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx
... manifestations in patients with RA [20] The accumulation of NK-receptors expressing CD4 cells in synovial tissue is compatible with a direct contribution of these cells to the tissue lesions [17] ... motifs in the promoter region of the CD28 gene [14] The repression of CD28 transcription may be also the consequence of chronic exposure to TNFα, which leads to the blocking of CD28 transcription ... frequency of these cells in patients with severe joint involvement and rapid joint progression confirm observations that the frequency of CD4+CD28– T cells may correlate with the risk of occurrence of...
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Báo cáo y học: " Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies" ppt
... the role of CYC in the care of these patients In our meta-analysis, two of the three greatest mean differences of the FVC after 12 months of therapy were achieved in observational studies using ... least 10% of the predicted value of each measure [12,13] The oral or intravenous administration routes of CYC did not influence the mean difference of the FVC or the DLCO after 12 months of therapy, ... after 12 months In one study, one-half of the patients received oral CYC and one-half of the patients were treated with intravenous CYC [12] We analyzed the two cohorts of patients in this study...
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Báo cáo y học: " Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed " pot
... and in the preparation and finalization of the manuscript AvW and KN were involved in the analysis and interpretation of these post hoc analyses and in the preparation and finalization of the ... interpretation of these post hoc analyses, and in the preparation and finalization of the manuscript JP was involved in the design and oversight of the trials, the analysis and interpretation of these ... MM was involved in the design of processes and standards for data acquisition during the original trials, in the harmonization of protocol interpretation across sites involved in the original trials,...
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Báo cáo y học: "The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis: another point of view" pot
... delusive conclusions Analyzing the data by means of definitions of sepsis and septic shock, and assuming the patients to be a uniform group, we cannot demonstrate the special subgroups of patients in ... pointed out earlier, in order to demonstrate the clinical effectiveness of immunotherapy in severe sepsis and septic shock, a number of 120 patients is necessary to be included in each arm of ... study by Dominioni et al [3] In conclusion, it seems that there is a subgroup of patients with severe sepsis or septic shock in which the delivery of IgM-enriched immunoglobulin preparations may...
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báo cáo khoa học: "The effects of β-glucan on human immune and cancer cells" pptx
... modification invariably induces changes in the natural conformation, most of these meth- http://www.jhoonline.org/content/2/1/25 ods cannot reflect the genuine relationship between the structure and the ... Among them, lipid A was found to be the major component that can initiate an immune response LPS contamination can occur during the culture or preparation of β-glucans Since LPS is one of the ... underlying immune changes of the cancer patients without addressing on the change of cancer status In addition, most of the related studies used either crude herbal extracts or a fraction of the...
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báo cáo hóa học:" Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis" doc
... reported the influence of caffeine on osteoporosis, but the effects of coffee on bone metabolism remain controversial [26,27] Hypotheses to explain these associations have centered on the caffeine content ... positive staining colony was found in the culture The Von-Kossa positive staining colonies first appeared at the 1st day's culture of control groups, and then progressively increased as the culture ... [30] In the presence of 10 mM caffeine, the viability of osteoblasts was decreased and the residual cells lost their reaction to ALP staining and von-Kossa staining (Figs &3) The formation of ALP...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... presentation, autoantibody production, and inflammatory cytokine production One of the mechanisms for accumulation of B cells in synovial tissues relates to the interaction with chemokines produced in ... expressed in the RA synovium [22-29] Therefore, interactions between the chemokines and the chemokine receptors might contribute to B cell migration into the synovial tissue in patients with RA In the ... expression Finally, we examined the effects of the chemokines on the expression of the cell surface molecules ICOSL, BAFF-R and TACI by peripheral blood B cells of normal donors and sub- Page of 11...
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Tài liệu Osteoporosis in Men: The Effects of Gender on Skeletal Health Second Edition pptx
... matrix they formed and differentiate into osteocytes; some convert into lining cells on the bone surface at the termination of formation; and the remainder die by apoptosis Bone lining cells were once ... age at the beginning of the study, duration of TRT before the study, doses of TRT and way of administration, degree of normalization of the testosterone level, duration of TRT during the study) ... mineralized bone (as distinct from cartilage) include: osteonectin (SPARC), the matrillins, the thrombospondins, the tenascins, the galectins, periostin and osteopontin and BSP (SIBLINGs) Each of these...
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Báo cáo " The effects of pictures on the reading comprehension of low-proficiency Taiwanese English foreign language college students: An action research study " ppt
... explain, and predict the effects of visuals on reading comprehension, among them, the theory of mental models (Johnson-Laird [20]), the transmediation theory (Siegel [21]), the repetition hypothesis ... The translation task would evaluate the effects of pictures on students’ understanding of the texts and the questionnaire was used to assess student viewpoints on the effects of pictures on their ... going to stop He turned left onto the main road directly in front of the other car The car swerved to avoid the motorcycle and skidded off the road into a wall at the corner of the intersection...
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THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION docx
... or time-consuming for firms to change the size of their asset portfolio because of the size of their markets and/or because of regulatory restrictions on their expansion In this event, the efficiency ... additional details about the data set IV The Profit Efficiency Effects of Megamer~ers The Level of Profit Efficiency We begin discussing the results with some information on the levels of profit ... by the removal of many intrastate and interstate gwgraphic restrictions on bank branching and holding company affiliation has continued into the 1990s At the outset of the 1980s, only 2.1% of...
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The Effects of Taxation on Multinational Corporations pdf
... Page Intentionally Left Blank The Effects of Taxation on Multinational Corporations A National Bureau of Economic Research Project Report The Effects of Taxation on Multinational Corporations ... advantages, the leading firms in each country tend to internationalize their production With the long-term decline in costs of international travel and communication, the costs of controlling widespread ... also declining, but because these multinationals were declining in importance as part of the U.S economy This decline was not simply a reflection of the decline of manufacturing’s share of U.S...
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THE EFFECTS OF POVERTY ON CHILD HEALTH AND DEVELOPMENT pot
... health while controlling for chronic health conditions However, the level of chronic health conditions in children living in poverty may be part of the causal pathway, considering that their rate ... out of savings or intergenerational transfers rather than current family income One additional reason why wealth should be considered when evaluating the effect of economic resources on the health ... for changes in the average cost of living in the United States Where the poverty line is drawn is important because of its use in policy formation In 1965, for example, the Of ce of Economic Opportunity...
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The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California pdf
... given the income constraints of both populations and the disability constraints of the consumer population: In the following analysis, the terms “overall,” “entire,” and “general” distinguish the ... that the consumer is their parent, 9.2% say the client is their child, 3.0% say the client is their spouse, and 62.0% have another kind of relationship.24 Note, in comparing the two, that the ... between their homes and the homes of their providers affected the care that they received from those providers; whether providers thought that the distance between their homes and the homes of their...
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A STUDY OF THE EFFECTS OF CORRUPTION ON ECONOMIC AND POLITICAL DEVELOPMENT OF ARMENIA doc
... gain The cleanup of the Philippine tax inspectorate is strong illustration of effective institutional reform The process includes the 42 immediate firing of corrupt personnel, the professionalization ... decisions and government contract The use of these kinds of connections for personal gain is usually described as influence peddling." Patronage is another form of corruption The assignment of government ... recently The main policies implemented by those countries in their fighting against corruption were the creation of anticorruption bodies, such as the Independent Commission Against Corruption in Hong...
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Osteoporosis in Men: The Effects of Gender on Skeletal Health pot
... Hormones on Modeling 116 Male Hypogonadism 118 Remodeling, Fatigue Damage, and Mechanical Properties in the Aging Skeleton 119 VIII Compensatory Modeling in the Aging Skeleton 121 IX The Neck of ... 162 III IGFs and Their Role in Acquisition and Maintenance of Adult Bone Mass 167 A Acquisition of Peak Bone MassmRole of the IGFs 167 x Contents B IGF-I and Maintenance of Bone Density IV Summary ... II Mechanisms of Androgen Action in Bone: The Androgen Receptor 212 III Effects of Androgens on the Proliferation and Differentiation of Osteoblastic Cells 217 IV Interaction with Other Factors...
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Báo cáo khoa học: "THE EFFECTS OF INTERACTION ON SPOKEN DISCOURSE" potx
... participated in the experiment on two consecutive days, the first for training and the second for instructing the novice partner During training, experts were informed that the purpose of the experiment ... for interactive feedback actually influences a spoken discourse To begin examining the influence of speaker interaction, the present research aimed to investigate the main distinctions between interactive ... pattern of presentation involved describing one pump piece, a second piece, and then the action required to assemble them In contrast, an initial audiotape piece description often continued to...
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The effects of devaluation on the trade balance and the balance of payments
... regression coefficients incorporating the information about the covariance of the errors Incorporating the information increases the efficiency of the estimators T h e sample of countries for the ... of the money supply On the other hand, there continues to be no evidence of devaluation producing even a temporary improvement in the trade balance IV Summary and Conclusion While the preceding ... devaluation or succeeding years On the other hand, there is clear evidence of the balance of payments improving following devaluation This pattern of contrasting behavior is reinforced by the succeeding...
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Báo cáo sinh học: "The effects of lipids on channel function" pdf
... surface of the protein Inter actions of the lipid headgroups with the protein involve a set of weak charge and hydrogen bonded interactions, as shown in the molecular dynamics simulation in Figure ... of the channel in the closed state, but the hydrophobic thickness of the channel could increase on channel opening This would require stretching of the lipid bilayer around the protein to maintain ... surprising if this reflected chain-specific binding to the connexins because the effects of chain structure on lipid binding to membrane proteins are generally small [6] Another possibility, as described...
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