quot functional reanimation quot phase is associated with diversification in the cns immune repertoire
Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... cells were treated with swainsonine, an inhibitor of a-mannosidase II, during the recovery process, and then stimulated with ST As shown in Fig 4D, swainsonine inhibited the reacquisition of responsiveness ... dephosphorylation is the mechanism of desensitization of these receptors GC-A is phosphorylated on six serine and threonine residues present in the protein kinase-like domain in the basal state ... were then incubated overnight with lgÆmL)1 GC-C:4D7, an antibody raised to the protein kinase-like domain of GC-C [32] or with GC-C:4D7 antibody preadsorbed with a fusion protein of the kinaselike...
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Báo cáo y học: "Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis" pot
... time The hypothesis that the pro- Available online http://arthritis-research.com/content/8/1/R31 gression rate is associated with the one year biomarker value was tested by assessing the statistical ... which was only associated with total radiographic damage score and with the erosion score, and not with narrowing score as one would expect Another interesting finding of this study is that biomarker ... percentage increase of the progression rate of the radiographic damage score per one standard deviation increase in C2C is therefore 21% If the interaction is nonsignificant (P > 0.05) there is no...
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Báo cáo y học: "Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine" pdf
... the robustness of the primary analysis A further post-hoc analysis in patients with > 30 mm pain at baseline examined the predictive value of an early response in depressive symptoms (using the ... Visit (Entered) N=4,517 No Visit Information: N=275 Visit (2 weeks) N=4,242 Discontinued duloxetine at Visit 2: N=135 No Visit Information: N=116 Visit (4 weeks) N=3,991 Discontinued duloxetine ... In the logistic regression analysis of the response rate in the IDS-C total score (50% reduction [yes/no]), the IDS-C total score at baseline and the change in the overall pain VAS during the...
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Báo cáo y học: " Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12" ppsx
... macrophage tropism was associated with increased exposure of the b12 epitope overlapping the CD4 binding site, rather than exposure of the CD4 binding site per se Elimination of an N-linked glycan ... sCD4, mAb b6, or HIV-infected patient serum These findings suggest that exposure of the b12 epitope overlapping the CD4 binding site, rather than exposure of the CD4 binding site per se, enhances ... binding [26,27] b12 contact occurs at the exposed surface on the outer domain of gp120 that is initially recognized by CD4 [26] Furthermore, b12 is the only antibody that targets the CD4 binding...
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Báo cáo y học: "Intensivists'''' base specialty of training is associated with variations in mortality and practice patterns" docx
... Decisions to perform invasive procedures are made in conjunction with the Intensivist and depending on the experience level of the trainee, the Intensivist may or may not directly supervise the ... This may help explain the inconsistent results seen with previous investigations assessing the impact of Intensivists' care on ICU patients Key messages • Intensivists' base specialty of training ... training in Internal Medicine; IQR = Interquartile Range; LOS = Length of Stay; NS = non-significant; Pulm = Intensivists with base specialty training in Pulmonary Medicine * Reflects comparisons...
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Báo cáo y học: "Resistin is associated with mortality in patients with traumatic brain injury" ppt
... that the resistin gene is expressed in multiple nonadipose sites Resistin expression is abundant in the brain and pituitary gland [12] This abundance of nonadipose tissue sites for resistin expression ... complicated the original hypothesis that resistin might be an important link between adipocytes and insulin resistance Recently, it was evidenced that resistin mRNA was increased in the cortex ... Conclusions In this study, increased plasma resistin level is found and associated with GCS score and mortality after TBI Key messages • In patients with traumatic brain injury, plasma resistin level increased...
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báo cáo khoa học: "Trichoderma viride cellulase induces resistance to the antibiotic pore-forming peptide alamethicin associated with changes in the plasma membrane lipid composition of tobacco BY-2 cells" potx
... cultures involved de novo protein synthesis The presence of the protein synthesis inhibitor cycloheximide prior to and during incubation with CM did not affect the magnitude of alamethicin resistance ... incubation is not due to H2 O2 being a putative intermediate in the cellulase-initiated signalling cascade Instead, the presence of H2O2 can lead to rapid crosslinking of the cell wall proteins [53] The ... further investigate protoplasts Inactivating the enzymes by boiling before CM incubation prevented the elicitation of resistance (Figure 1), suggesting that the enzyme-induced activity on the...
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Báo cáo y học: "HIV-1 prevalence and factors associated with infection in the conflict-affected region of North Uganda" pptx
... ANCs in the Acholi region with the objective of increasing the available information on the HIV-1 epidemic in northern Uganda and identifying the socio-demographic factors associated with HIV-1 infection ... displacement is expected to increase with its duration In fact, although the initial phase of displacement is likely to determine a high-risk context for HIV-1 transmission, the prolonged time of isolation ... different risk of being HIV-1 infected In general, this study is based on data from only one ANC in each of the three districts in the Acholi region As a consequence, the results reflect the HIV...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... phage origin [25] The 29-kb sequence is located in a de®ned and conserved site within the chromosome of the virulent wild-type strain RC1 In contrast, in the phasevariant strain 811, the 29-kb ... upon phase variation and the loss of the mAb 2625 epitope is one of them Phase variation in L pneumophila was found to in uence other LPS biosynthesis pathways involved in assembly of lipid A Phase ... signal of belonged to the N-methyl group at N2 in the E isomer and the higher-®eld signal to that in the Z isomer, in which N1 is in trans and cis orientation to C5 of legionaminic acid, respectively...
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Báo cáo lâm nghiệp: "The successional status of tropical rainforest tree species is associated with differences in leaf carbon isotope discrimination and functional traits" pot
... described by the theory since the slope and the y-intercept of the theoretical line (–0.095 and 27.00, respectively) fell in the confidence interval (95%) of the slope (−0.084 ± 0.024) and the y-intercept ... communities in French Guiana [7, 26], underlying an original non-linear distribution (modal distribution) of this trait along the successional gradient Carbon isotope discrimination (∆) – roughly the ... of tropical rainforest seedlings studied here were in agreement with general trade-offs since carbon assimilation increases with increasing N and SLA, and decreases with increasing C and LD (Tab...
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Báo cáo y học: "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response" docx
... determined after a mean disease of 4.4 years The different time points of observation are indicated on the x axis, starting from the first visit in the rheumatology clinic All graphs depict the ... lymphocytes in RA, which parallels the B lymphocytopenia described in the present study and is likely to be the consequence of the disturbed B-cell homeostasis in RA The primary mechanism driving those ... discerned in the laboratory findings of the CD19low and CD19high groups, while the differences in CRP and RF IgA levels found in the prospective study are depicted in Figure Radiological findings...
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Báo cáo y học: "A functional variant of Fcγ receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies" doc
... polymorphisms of these receptors were reported to be associated with several autoimmune diseases [4,5], one of which is a polymorphism in FCGR3A, with either a phenylalanine (F) or a valine (V) at amino ... polymorphism at position 131 (with either histidine [H] or arginine [R]) alters the ability of the receptor to bind to certain IgG subclasses [9,10] In RA patients, FCG3A-158V/F polymorphisms were ... arthritis Our findings show that FCGR3A-158V/F functional polymorphisms were associated with RA among anti-GPI antibody positive individuals This is the first report on possible mechanisms of...
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Báo cáo y học: "Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosu" pptx
... admission was required Furthermore, the high incidence of Herpes zoster infection, occurring at least one time in 14% of the patients, is in line with other studies in patients with SLE [1,31] With ... regression model This finding is in line with a previous study on major infections in SLE patients in the Hopkins Lupus Cohort [32] Renal insufficiency is a possible risk factor for infections However, ... Arthritis Research & Therapy Vol No Bultink et al SLE [7] and in the occurrence of infections in SLE [8-10] Mannose-binding lectin (MBL) is a serum protein with characteristics very similar...
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Báo cáo y học: " Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhag" docx
... groups in an univariate analysis This finding is in line with a recent study including almost 700 patients with non-traumatic ICH investigating the role of anemia on admission (day 1) on the clinical ... Moreover, it is conceivable that the metabolic and oxygen demand may change during the course of the disease So far, there are no studies in humans suffering from acute ICH investigating the effect ... setting of acute brain injury In patients with acute brain injury, physiological compensatory mechanisms such as an increase in cerebral blood flow [18,19] may fail, rendering them more vulnerable...
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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... Boxes, the primers (PCR-SSCP); double underlining, the primers (sequence and genotyping); overlining, ATG initiation codon; Underlining, the variable number of tandem repeat (VNTR) consists of the ... discovered This polymorphism was associated with EH in female subjects However, this finding does not necessarily imply that there is a relationship between the NPPB gene and EH Further studies of other ... -934) Thus, these results are consistent with the hypothesis that Alu repeat sequences in the 5’-flanking regions have regulatory roles in NPPB expression [14] Therefore, we assessed the association...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... immunoprecipitated with TIAR-Flag, both in the absence and the presence of RNAse A, thereby indicating that TIAR association with these proteins is specific and reliant on protein–protein interactions ... determinant within the RS domain because the mutant lacking this motif (DRS1) accumulated in the cytoplasm By contrast, ASF ⁄ SF2 nucleo-cytoplasmic distribution is modified neither by the removal ... Therefore, the results obtained in the present study support the recent findings showing that members of the SR proteins family, including ASF ⁄ SF2 and SRp20, have important roles in the cytoplasmic...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... may in uence the expression of HO-1 The dominant expression of HO-2 protein, in comparison with the low expression of HO-1 protein, in H146 small cell lung cancer cells is of particular interest ... for b-actin monoclonal antibody The intensity representing HO-1 or HO-2 protein was normalized with respect to the intensity for the b-actin signal The data are mean ± SEM from three independent ... were maintained in suspension culture (Fig 1), although HO-1 is expressed in two other cell lines, YN-1 and KG1, that were also maintained in suspension culture These results suggest that the cellular...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... for the involvement of UCP2 in the mitochondrial impairment caused by MDP The results obtained suggested a role of UCP2 in macrophage activation by MDP The question raised at this stage is whether ... 0.05) in MDP-treated cells Interestingly, the OÀ level decreased after h of stimulation, returning almost to the resting level after h On the other hand, stimulation with MB failed to induce ... proposed to involve higher production of intracellular ROS [14] On the other hand, studies in cells overexpressing UCP2 have reinforced the belief that UCP2 plays a role in limiting intracellular...
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Báo cáo khoa học: Functional analysis of mutations in UDP-galactose-4epimerase (GALE) associated with galactosemia in Korean patients using mammalian GALE-null cells pdf
... to tubulin in the western blot and indicated below the blot with 100 set as the zero time point The relative levels of myc–GALE protein at each time point were plotted using a complete linear least ... as 1.0 The western blot for determining the protein level in extracts derived from each cell line is shown The relative enzyme activity (REA) was determined and normalized by setting the enzyme ... that these mutant proteins exist as dimers, even though their enzymatic activity is severely compromised The four mutant proteins were able to form heterodimers with the alleles found in the patient...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25