quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of alzheime
Tài liệu Cognitive function and brain structure correlations in healthy elderly East Asians doc
... followed by other variables of interest with cognition and brain measures and finally the association between brain measures and performance in cognitive domains of interest Partial correlations ... age-related brain changes and cognitive performance in persons of Chinese descent resident in Singapore The study was approved by the Singapore General Hospital Institutional Review Board and participants ... Caucasian populations and speaks to the generalizability of processes involved in age-related decline in cognition and brain volume Table Correlations between regional brain volumes and cognitive performance...
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Báo cáo khoa học: Sugar signalling and antioxidant network connections in plant cells pptx
... roles of sugars and sugar metabolizing enzymes in both sugar and ROS signalling pathways and their Sugar signalling and antioxidant networks in plants co-operation with antioxidant networks in plant ... signalling and antioxidant networks in plants localization of AtCINV1, a well-characterized neutral invertase of Arabidopsis, and its interaction with a phosphatidylinositol monophosphate 5-kinase ... signalling pathways [2] Glucose controls abscisic acid (ABA) signalling and biosynthesis gene expression [41] and HXK-dependent signalling interacts positively and negatively with auxin and cytokinin...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... forelimbs and hind limbs B Representative gait signals of the left forelimb and right hind limb of a saline-treated C57BL/6J mouse walking at a speed of 34 cm/s Duration of stride, stance, and swing ... right forelimbs of a 3NP-treated mouse demonstrating coordinated stepping, despite hind limb failure of stepping The signals of left and right hind limbs are not coordinated and reflect artefacts ... studies of gait and gait variability in mouse models of PD, HD, and ALS Competing interests Thomas G Hampton is owner of Mouse Specifics, Inc., a company organized to commercialize the gait imaging...
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báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx
... profile of macrophages can change, shutting down the production of pro-inflammatory cytokines and increasing the production of factors that participate in tissue repair and wound healing [6] Anti-inflammatory, ... Calingasan N, Erdely H, Altar C: Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury Neurobiol Aging 2002, 23:31-39 Townsend K, Town T, Mori ... related chitinase genes, namely CHI3L1 and CHI3L2 are overexpressed in AD brain Both forms of chitinase 3-like proteins not have enzymatic chitinase activity and instead, inhibit IL-1 and TNFα-mediated...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
... identified citrulline-modifications in multiple proteins in inflamed CIA joint and EAE brain tissue Our results suggest that citrullination of synovial proteins in CIA and brain proteins in EAE generate ... applied synovial and myelin protein arrays to investigate the development and evolution of ACPA responses in rodent models of RA and MS, with the objective of gaining further insights into the aetiology, ... citrullinated filaggrin, a protein expressed in stratified epithelium but not in joints [4,6] It is interesting that many of the citrullinated proteins identified in inflamed CIA joint tissue and...
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cognitive function and traumatic brain injury in refugees and asylum-seekers attending mental health services a preliminary study ; and clinical research portfolio
... Submitted in partial fulfilment of the requirements for the degree of Doctorate in Clinical Psychology Institute of Health and Wellbeing College of Medical, Veterinary and Life Sciences University of ... translated and validated in five languages in South, East and South East Asia (four into Chinese dialects, two into Malay, and one into Persian, Korean and Sinhalese), across six countries Numbers of ... survey of brief cognitive screening instruments International Int Psychogeriatr 18: 281–94 Steis MR, Schrauf RW 2009 A review of translations and adaptations of the Mini-Mental State Examination in...
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Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma pptx
... enhance the assembly and function of several clotting factor complexes [22,23] We also show that POPE in uences the binding of mouse protein C Comparing the binding data of 20-10-70 and 0-10-90 membranes ... transition induced by the cooperative binding of Ca2+ turns the N-terminal part of the Gla domain inside out, exposing the hydrophobic x-loop to solvent and burying the majority of the Gla residues Of ... provide insight into the Gla protein–membrane interaction and identify new reagents with varying degrees of anticoagulant potency that may be of use for testing in murine models of sepsis and thromboembolic...
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Báo cáo sinh học: "Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model" potx
... serine proteinase inhibitor (serpin) It inhibits proteinase 3, neutrophil elastase, and cathepsin G These serine proteases are released by joint invading neutrophils following Page 11 of 13 inflammatory ... examined the feasibility of hAAT protein therapy in CIA mouse model Administration of hAAT (0.5 mg /mouse twice per week, starting at days before the induction of arthritis) resulted in sustained ... thick were cut and stained with hematoxylin and eosin according to standard methods Histological evaluation was performed by two independent and blinded pathologists Infiltration of immune cells,...
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Báo cáo y học: " T cells and post menopausal osteoporosis in murine models" doc
... with the TNF inhibitor TNF binding protein [16] are protected from ovx-induced bone loss The presence of increased levels of TNF in the BM of ovx animals and in the conditioned media of peripheral ... leads to increased production of TGFβ in the BM TGFβ receptors are expressed in T cells and TGFβ signaling in T cells leads to powerful repression of T cell activation and of their production of IFNγ ... source of this cytokine remain to be determined The BM levels of IL-7 are significantly elevated following ovx [6,23,24], and in vivo IL-7 blockade, using neutralizing antibodies, is effective in...
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Báo cáo y học: " Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models" pps
... various strains of mice following bleomycin challenge Mean linear intercepts, lung desmosine and elastase burden Mean linear intercepts, lung desmosine and elastase burden in various strains of mice ... Results Bleomycin Study Emphysema and Fibrosis after Bleomycin The kinetics of the emphysematous and fibrotic changes obtained in the three strains of mice are reported in Fig A and B In particular, ... dehydrated, cleared in toluene, and embedded in paraffin Sagittal sections (7 µm) of each pair of lungs were cut and stained with hematoxylin/eosin and Masson's trichrome stain Morphometric assessment...
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Báo cáo sinh học: "Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models" pps
... Genetic Vaccines and Therapy 2009, 7:10 VEGFR-2 Using this approach, we induced anti-tumor effects in mouse models of colon carcinoma (CT26 cells) and breast cancer (4T1 cells), and against both ... spleen, lung, kidney, ovary and so on) were fixed in a 10% neutral buffered formalin solution, embedded in paraffin and to μm sections were stained with hematoxylin and eosin (H&E) Animals were subjected ... Animals and cell lines BALB/c mice were purchased from the West China Experimental Animal Center Murine breast carcinoma cell line 4T1, colon carcinoma cell line CT26 and endothelial cell line MS1...
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Tài liệu The Early Detection Research Network: Investing in Translational Research on Biomarkers of Early Cancer and Cancer Risk docx
... lesions; clinical utility of certain prostate cancer biomarkers; developing and maintaining a registry of individuals harboring germline mutations for hereditary cancer syndromes; and identifying preneoplastic ... multidisciplinary, investigator-initiated projects with a strong administrative and data infrastructure In making cancer biomarkers of early detection and screening ready for large-scale clinical testing, ... such as prostate (protein profiling of BPH, HPIN and IGFb3/br), colon (K-ras mutations in stool and urine) and breast (alpha catenin genes) They have also joined forces with clinical trial communities...
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Báo cáo y học: "Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis" pptx
... the time of the study Results for biomarkers of endothelial dysfunction in patients and control individuals are shown in Table In univariate analysis, all three biomarkers of endothelial dysfunction ... cluster in RA because of inflammationinduced insulin resistance [5,30] In multivariable models, traditional cardiovascular risk factors attenuated the differences in biomarkers of endothelial dysfunction ... 08:00 and 10:00 hours All laboratory analyses except for assessments of cytokines and biomarkers of endothelial dysfunction were performed within hours of sampling These comprised lipids, hs-CRP and...
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Báo cáo y học: " Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock" docx
... clearance and biomarkers of pro- and anti-inflammation, coagulation, apoptosis; and further with multiorgan dysfunction and mortality in severe sepsis and septic shock These findings support a growing ... and fibrin production Fibrinolysis is impaired due to increased production of plasminogen-activator inhibitor type-1 (PAI-1), decreased generation of plasmin and reduced removal of fibrin The ... sorting the study population by increasing lactate clearance and separating into four groups with equivalent number of patients IL-1ra - interleukin-1 receptor antagonist; IL-6 - interleukin-6;...
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Báo cáo " Advantages and disadvantages of using computer network technology in language teaching " pptx
... T.XXI, Số 2, 2005 63 Financial barriers also include the investment in training The use of the Internet in language teaching and learning requires some technological knowledge and computer skills ... of technical problems in terms of the speed of the network and the reliability of the software Another challenge to the use and implementation of computer- assisted language learning (CALL) in ... one of the most essential pedagogical principles of language teaching is one that emphasizes the study of language in a cultural context because language and culture are inextricable and independent...
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Capability of the People’s Republic of China to Conduct Cyber Warfare and Computer Network Exploitation potx
... issues of doctrine, strategy, and force modernization Many of these publications offer substantive insights into current thinking on strategy and doctrinal issues related to information warfare and ... College of Engineering in Xian noted that “electronic warfare and computer network warfare are the two primary modes of attack in information warfare….By using a combination of electronic warfare and ... detection on China’s indigenously developed Kylin operating system • PLA Information Engineering University provides PLA personnel in a variety of fields advanced technical degrees and training in all...
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Báo cáo khoa học: Intrinsic local disorder and a network of charge–charge interactions are key to actinoporin membrane disruption and cytotoxicity ppt
... 180° of the ribbon diagram of the minimal energy structure of StnII-Y111N are shown in (C) The orientation of the structures in (A) and (B) is the same as in the left panel of (C) Some interesting ... importance of a network of electrostatic interactions, anchored by R29, in the first stage of membrane binding Y111 induces a necessary disorder in exposed hydrophobic side chains that promotes their interaction ... StnII (A) and for the minimal energy structure of the StnII-R29Q mutant (B) Side chains of residues R ⁄ Q29 in loop 23–32 are in blue, K75 and T82 in loop 72–84 are in orange, F106 in loop 103–113...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
... Effect of leptin and progesterone on FAAH activity and expression (A) Effect of leptin on the activity of FAAH in human U937 and CHP100 cells and on the protein content and the mRNA of FAAH in U937 ... leptin (Fig 1A) and progesterone (Fig 1B) increased FAAH protein in human U937 cells in parallel to the increase of enzymic activity RT-PCR amplification of cDNA of U937 cells showed a single band ... that leptin [42,43] and progesterone [44,45] play roles in survival, death and proliferation of immune and neuronal cells; processes in which AEA and the endocannabinoid system are also involved...
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the effects of business process management cognitive resources and individual cognitive differences on outcomes of user comprehension
... accomplished through several stages including gathering and representing information in sensory and working memory (also called encoding), holding information in short-term and long-term memory (also ... specific type of user educational training can more easily comprehend and interpret BPM information irrespective of the type of GPM or the type of BPI D Evaluate influences of individual cognitive ... comprehend and interpret BPM information irrespective of the type of GPM or the type of BPI D Evaluate influences of individual cognitive differences (i.e., mental workload, cognitive styles, and cognitive...
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