quantification of myocyte chemotaxis a role for fak in regulating directional motility
Context based learning: A role for cinema in science education pdf
... Whereas a dramatic play is realized as a live performance by actors on a stage, a movie is show in a cinema, not as a live event, and can theoretically be repeated infinitely without change Like ... understanding culture and the meanings that culture contains as well participating in social activities (Sormunen and Saari, 2006) The fact that Erin Brockovich was not a lawyer and did not have any ... development of creative thinking (Laius and Rannikmäe, 2005) Science teaching can be conceptualized in terms of introducing learner to one form of the social language of science A distinction can be drawn...
- 13
- 508
- 0
Báo cáo y học: "A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis" pps
... et al worked with adenoviruses, and participated in growth and maintenance of FLS DJP performed the majority of chemotaxis counting, while MVV participated in chemotaxis counting as well as in ... (data not shown) FLS locomotion can be regarded as an important pathogenic mechanism contributing to the invasion of cartilage and bone in RA Grafting of RA FLS alone to SCID mice, in the absence ... tumorigenesis in mice Proc Natl Acad Sci USA 1999, 96:6382-6387 Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY, Nakayama K-I: Mice lacking p27Kip1 display increased body...
- 8
- 368
- 0
Báo cáo y học: "Bench to bedside: A role for erythropoietin in sepsis" pps
... vascular responsiveness to norepinephrine in renal failure Kidney Int 1995, 48:806-813 65 Allegra A, Galasso A, Siracusano L, Aloisi C, Corica F, Lagana A, Frisina N, Buemi M: Administration of ... lifespan [35] After successful clinical trials of EPO in the treatment of anaemia of end-stage renal failure [36,37], its use has been extended to the treatment of anaemia in malignancy, human immunodeficiency ... hypoxia-inducible factors [38] Several in ammatory cytokines increase expression of EpoR and EPO, including insulin-like growth factor, IL-1β, IL-6 and TNFα, suggesting a role in inflammation...
- 8
- 245
- 0
Báo cáo y học: "A role for Numb in p53 stabilization" pps
... binding between the DNA-binding domain of p53 and the acidic domain of MDM2 [18,19] It is now thought that it may be this second stage of binding that is critical for ubiquitination of p53, and ... Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN: Post natal deletion of Numb/Numblike reveals repair and remodeling capacity in ... through interaction with the ubiquitin ligase Itch It is interesting to note that rather than inhibiting ubiquitination, Numb can enhance the degradation of Gli1 by Itch - again pointing to a rather...
- 3
- 237
- 0
Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... investigated the role of plasma membranes (PM) in the transformation of MSSAE into a dimeric protein 125I-labelled MSSAE was incubated with isolated membranes from SVT2 broblasts (0.45 mgặmL)1 of ... repeats Nature 366, 751756 Papageorgiou, A. , Shapiro, R & Acharya, K (1997) Molecular recognition of human angiogenin by placental ribonuclease inhibitor an X-ray crystallographic study at 20 A ... broblasts were grown at 37 C in the presence of 20 lgặmL)1 of radioactively labelled 125I-labelled MSSAE in binding buffer (DMEM containing mgặmL)1 BSA and 25 mM Hepes at pH 7.5) At increasing...
- 8
- 604
- 0
Báo cáo khoa học: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components ppt
... b-hexosaminidase is in uenced by SG Although b-hexosaminidase activity was already detected at day 0, the intracellular content of this enzyme increased markedly after days of culture, and reached a ... maximal storage seen after 26 days of culture mMCP-6 storage showed similar kinetics as for mMCP-5 In contrast, CPA protein was detected as early as after days of culture, and a maximal plateau ... radioactivity As an internal standard, 200 lL of a mixture of unlabeled heparin (4 mgÆmL)1) and CS -A (5 mgÆmL)1; Sigma, Stockholm, Sweden) was added to each sample before anion exchange chromatography analysis...
- 12
- 438
- 0
The Role and Responsibilities of Accounting Officers: A Memorandum for Accounting Officers pdf
... to C&AG PAC Reports to Dáil Role of the Department of Finance Minister for Finance Appoints Accounting Officer Department of Finance Attendance at PAC Minute of Minister for Finance to the PAC ... to Accountability Responsibilities of Accounting Officer in relation to Internal Audit Traditional Role of Internal Audit VFM Role of Internal Audit since 1993 Act Internal Audit and Risk Management ... Internal Control Internal Financial Control Evaluation of Internal Controls recommended by Mullarkey Report Internal Control & the C&AG Internal Audit Scope of Internal Audit Internal Audit as an aid...
- 43
- 480
- 0
Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... inhibitor) and GF109203X (protein kinase C inhibitor) indicating that each of these pathways has a modulatory rather than a mandatory role to play in mediating the proliferative response In contrast, a ... explain the lack of efficacy of current PAR2activating peptides in our model system A number of signalling pathways and intermediates such as Ca2+ mobilization, the ERK pathway, PtdIns 3-kinase and ... of PAR4 [27] Thrombin has been shown to cleave and activate PAR1, PAR3 and PAR4, whereas trypsin cleaves and activates PAR2 As duodenase is capable of cleaving certain substrates with trypsin-like...
- 10
- 437
- 0
báo cáo hóa học: " Replication of the association of HLA-B7 with Alzheimer''''s disease: a role for homozygosity?" pptx
... HLAB51 cases and HLA-B65 cases, each due to a single homozygote of a relatively rare allele All other alleles were in Hardy-Weinberg equilibrium in both cases and controls (Tables &2) Linkage ... disease and vascular dementia: a case-control study Lancet 2001, 357:436-439 Small GW, Scott WK, Komo S, Yamaoka LH, Farrer LA, Auerbach SH, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA: No association ... Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's...
- 7
- 286
- 0
báo cáo hóa học: " A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells" pot
... Rintahaka J, Søby S, Horan KA, Poltajainen A, Østergaard L, Paludan SR, Matikainen S: Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVSdependent ... Cambridge, MA), STING (Abcam, Cambridge, MA) or a mouse monoclonal antibody against gG1 (Abnova, Taipei, Taiwan) for 24 hours at 4°C, blots were washed and incubated in the presence of an horseradish ... HSV-1 and elicit inflammatory CNS damage Replicating DNA viruses generate genomic DNA that serves as a ligand for DAI DAI then associates with IPS-1 and STING, subsequently activating NF-kB via the...
- 12
- 529
- 0
Báo cáo y học: "A proinflammatory role for Fas in joints of mice with collagen-induced arthritis" docx
... added to cultures at a final concentration of 10–50 µg/ml or 10 µl of concanavalin A (ConA) (Difco) at a final concentration of µg/ml These concentrations had optimal stimulatory effects as assessed ... Germany), diluted 1:20,000 was added and incubated for hour at 37°C This step was followed by washing and incubation with a 1:1000 dilution of alkalinephosphatase-conjugated streptavidin (Dianova) ... that genes regulating apoptosis are involved in the pathogenesis of autoimmune diseases, including RA [26-29] Indeed, the success of anti-TNF therapy points to a major role for this important apoptosis...
- 11
- 469
- 0
Báo cáo y học: "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANK" pps
... corresponding to amino acids 317–616 mapping at the carboxy terminus of RANK of human origin [H-300]) or against RANKL (rabbit polyclonal antibody raised against the epitope corresponding to amino acids ... staining for RANKL in synovial cells and in the infiltrating (inflammatory) cells (Fig 4h) There was a marked increase in RANKL expression, consistent with the increase in inflammatory cells and ... RANK/ RANKL in inflammatory cells, in inflamed synovium, in articular cartilage and at the invading front of bone erosions It has been long recognized that pro-inflammatory cytokines are intimately...
- 8
- 380
- 0
Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... M: Mammalian MAP kinase signalling cascades Nature 2001, 410:37-40 Palanki MS: Inhibitors of AP-1 and NF-kappa B mediated transcriptional activation: therapeutic potential in autoimmune diseases ... TNF-α activates nuclear translocation of NF-κB, which plays a central role in inflammatory diseases such as RA through induction of transcription of proinflammatory genes [15] NF-κB is retained in ... transduction pathway is involved in the TNF-α-mediated increase in Cyp7b activity in human FLS Signaling pathways that mediate the effects of TNF-α include mitogen-activated protein kinases (MAPKs) and...
- 10
- 462
- 0
Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
... all information regarding genetic factors, antibodies and matching variables was available This same sample set was used for the frequency analysis of rs729749 We used the SAS software for Windows ... files 12 13 The following Additional files are available online: Additional file An Word file containing a table that shows a table of all SNPs evaluated for association with RA in this study See ... 71% and 72%, respectively, are female; the mean age was 51 ± 13 years in cases and 54 ± 12 in controls Information about RF and anti-CCP antibody status was available for 1,315 of the patient samples;...
- 11
- 475
- 0
Báo cáo y học: "Identification of possible candidate genes regulating Sjögren''''s syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy" docx
... Kit (Qiagen Inc., Valencia, CA, USA) from a small tail snip taken between and weeks of age just prior to weaning Each DNA sample was used as a template in polymerase chain reaction amplification ... presence of ANAs, in particular anti-SS -A/ Ro and antiSS-B/La in the sera of human patients, is one parameter in the diagnosis of clinical SjS Concomitantly with the appearance of mononuclear leukocytes ... recombinant founder pair was identified, the RI line was maintained via a single line of descent All RI lines were bred and maintained under specific pathogenfree conditions in the animal facility...
- 12
- 399
- 0
báo cáo khoa học: " Adaptation of barley to mild winters: A role for PPDH2" pps
... significant in the ANOVA Each value included in the analysis was the average of two technical repeats to protect against slight fluctuations in reading and small pipetting errors Field trial of winter ... flowering time QTL in barley Breeding Sci 2011, 61:183-188 Cuesta-Marcos A, Casas AM, Yahiaoui S, Gracia MP, Lasa JM, Igartua E: Joint analysis for heading date QTL in small interconnected barley ... (FT) of Arabidopsis thaliana [20,21] Strong evidence indicates that VRNH3 plays a central role in promoting flowering as an integrator of the vernalization and photoperiod pathways in temperate...
- 13
- 246
- 0
Báo cáo y học: "A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors" ppsx
... quantitate the viral amplicon, a TaqMan dual 5′-6-carboxyfluorescein-and 3′-6-carboxytetramethylrhodamimine-labeled probe was used: 5′-(FAM)-CAGTGGCGCCCGAACAGGGA(TAMRA)-3′ (Integrated DNA Technologies) ... infected as described above (Fig 1A) were immunoprecipitated with antibodies against HDAC2 and HDAC6, as indicated Terminology as above, * indicates samples from A (C) Effect of an integrase inhibitor ... vector DNA prior to integration, in an integration-independent manner Retroviral integration induces the formation of HDAC4 foci in infected cells HDAC4 was reported to form foci in irradiated cells...
- 10
- 386
- 0
Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
... bp; and 4) gB: forward primer, 5'AACGCGACGCACATCAAG-3', reverse primer, 5'-CTGGTACGCGATCAGAAAGC-3'; and probe, 5'-FAMCAGCCGCAGTACTACC-3' – Amplicon length = 72 bp As an internal control, a set of ... disruption of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... Post Infection Figure Replication of HSV-1 in macrophages Replication of HSV-1 in macrophages Analyses of virus replication, viral gB mRNA, and viral genomic DNA in macrophages was done as in Fig...
- 13
- 266
- 0
Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
... bp; and 4) gB: forward primer, 5'AACGCGACGCACATCAAG-3', reverse primer, 5'-CTGGTACGCGATCAGAAAGC-3'; and probe, 5'-FAMCAGCCGCAGTACTACC-3' – Amplicon length = 72 bp As an internal control, a set of ... disruption of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... Post Infection Figure Replication of HSV-1 in macrophages Replication of HSV-1 in macrophages Analyses of virus replication, viral gB mRNA, and viral genomic DNA in macrophages was done as in Fig...
- 13
- 468
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25