quality assurance of clinical trials in the management of cancer in the head and neck
Báo cáo khoa học: "Parotid gland-recovery after radiotherapy in the head and neck region: 36 months follow-up of a prospective clinical study" pdf
... reference point in the target volume as described in ICRU reports 50, 62 and 83 Determination of the parotid gland doses The planning target volumes and both parotid glands, the mandible, and the larynx ... 3DCRT in terms of parotid gland sparing The IMRT technique should therefore represent the standard of care for the treatment of head and neck tumors Parotid-gland-sparing up to mean doses of 26 ... treatment of carcinomas of the oral cavity, the oropharynx, and the larynx/ hypopharynx, the sparing of submandibular salivary glands can only be taken into consideration in special cases Sparing of...
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Báo cáo khoa học: " Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment" potx
... cystic carcinomas of the head and neck are a unique kind of tumour deriving from cells of the major and minor salivary glands, they account for 25% of all malignant salivary gland tumours in different ... clinical examination and MRI scans Depending on clinical and radiological findings the period between individual follow-ups was increased after the second year The measurement of follow-up was initiated ... safe and feasible modality in the treatment of complex-shaped ACCs in the head and neck By using IMRT, high doses in the GTV and PTV can be achieved together with an excellent normal tissue sparing,...
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Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck potx
... The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer Oral Oncol 2006, 42(3):257-67 Lin ... 23 of them have been found in humans [21-23] The members of the MMP family have many similarities in their structure All MMPs have a zinc-binding motif in the catalytic domain In addition, they ... levels and its control at the protein levels Regulation of MMPs in potentially malignant and malignant head and neck lesions Polymorphism of MMPs in potentially malignant and malignant head and neck...
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Tài liệu Infectious Diseases of the Head and Neck pptx
... begins in the gut of the sandfly, but the organism completes its life cycle in the host following the fly bite The sandfly inoculates the host with the organisms in the promastigote stage Once the ... mass at the angle of the jaw The masses gradually increase in size and number and form sinuses that open onto the face and neck Although infection is often seen in the jaw area, Actinomyces infections ... Montone / HEAD AND NECK INFECTIONS samples, and shell vial assays The hallmark of CMV infection is the finding of intranuclear inclusions consistent with herpesvirus infection The cells are often...
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Pathology of the Head and Neck docx
... experts in the field of the pathology of the head and neck As such they are the main members of the Working Group on Pathology of the Head and Neck of the European Society of Pathology, one of the ... pioneers of Head and Neck Pathology in Europe and founding members of the Working Group on Head and Neck Pathology of the European Society of Pathology Foreword Pathology of the Head and Neck is an ... between the base of the skull and the thoracic aperture One reason for assembling all these different organs under the title “Pathology of the Head and Neck is that the proximity of the organs of the...
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Báo cáo khoa học: "Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature" docx
... contrastenhanced MRI The clinical target volume (CTV) had minimum margins of 5.0 mm added around the GTV The planning target volume (PTV) included margins of 3.0-5.0 mm around the CTV, and this could ... imaging alone is inadequate for detection of extension of the tumor Therefore, MRI was routinely used for identification of the tumor, after fusing it with the planning CT Determination of gross target ... (MIB-1 index, 50-80%) in the right ethmoid sinus with intracranial invasion The diameter of the primary tumor was 50 mm and there was no lymphadenopathy (cT4aN0M0, stage IVA) There was no indication...
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Báo cáo khoa học: "Radiation-induced cancer after radiotherapy for non-Hodgkin''''s lymphoma of the head and neck: a retrospective study" ppsx
... site and pathological diagnosis, the interval from the time of RT to the diagnosis of the second HNC, and the clinical course of the second cancer We calculated the expected numbers of second cancers ... diagnosis of the second HNC in all the cases (2 cases of cancer of the gum, case of tongue cancer, and case of maxillary sinus cancer) was SCC (fig 2) The median interval after the RT to the development ... distribution of RT for NHL of the maxillary sinus (a) Dose distribution of RT for NHL of the maxillary sinus (b) and (c) PET-CT showing second SCC infiltrating the bone malignancies of the head and neck...
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Báo cáo khoa học: " Assessment of three-dimensional set-up errors in conventional head and neck radiotherapy using electronic portal imaging device" pot
... method of improving the repositioning accuracy would be the use of indexed patient positioning systems and fixed couch inserts Image-guided radiation therapy (IGRT) is an innovative and exciting ... whereas they were skewed inferiorly in the SI direction Ninety three percent of the set-up deviations were within mm in all three directions The CTV to PTV margins were within mm in all directions This ... Histogram of translational displacements in all three directions including mean and standard deviation Histogram of translational displacements in all three directions including mean and standard...
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Báo cáo khoa hoc:" The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)" potx
... sites in the head and neck area, hypopharynx and oropharynx, were available for the risk of predisposing CHK2 mutations In the present study, we did not find the CHK2 1100delC variant in any of these ... http://www.jnrbm.com/content/9/1/10 other than 1100delC in SCCHN as well as the definition of the role of CHK2 in the carcinogenesis of SCCHN remain to be an interesting matter for future investigations Abbreviations ... The checkpointkinase (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN) Journal of Negative Results in BioMedicine...
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Multimodal optical spectroscopy and imaging for improving cancer detection in the head and neck at endoscopy
... SPECTROSCOPY AND IMAGING FOR IMPROVING CANCER DETECTION IN THE HEAD AND NECK AT ENDOSCOPY LIN KAN 2012 MULTIMODAL OPTICAL SPECTROSCOPY AND IMAGING FOR IMPROVING CANCER DETECTION IN THE HEAD AND NECK ... improving the diagnosis of cancer non-invasively Besides, it is also 23 important to compare them individually and in combination for cancer diagnosis and 24 detection in the head and neck 25 Therefore, ... mucosal lining (epithelium) of these regions [3] It usually spreads to the lymph nodes 11 of the neck, and this is often the first (and sometimes only) sign of the disease at the 12 time of diagnosis...
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training quality assurance of the public vocational training centers in southeast area
... Arranging a department in charge of training quality assurance; Responsibilities of managers and teachers maintaining and strengthening of their training quality; Managers and teachers understand and ... solutions of the training quality assurance in Southeast public VTCs - Testing the practicality and feasibility of the training quality assurance solutions in Southeast public VTCs Limit the scope of ... be a chain of quality assurance processes As a quality management level, contents of internal quality assurance, including the input, training process and output qualities, and quality management...
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Báo cáo khoa học: " Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature" pptx
... monitoring may improve clinical research in the field of sepsis Key messages • Most sepsis clinical trials reviewed did not include hemodynamic goals of therapy Of note, the four largest clinical trials ... hemodynamic goals in clinical trials and whether this variation is associated with patient outcomes To better understand the hemodynamic goals in clinical trials in the sepsis research, and to inform future ... rates between the study groups The differing results in the these two trials may have been caused by differing sample sizes of the trials, differing agents used, or other unmeasured co-interventions...
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Báo cáo khoa học: "The GLAaS algorithm for portal dosimetry and quality assurance of RapidArc, an intensity modulated rotational therapy" pdf
... measured dose in the field after cutting the highest 5% dose tail in the histogram The Gamma Agreement Index (GAI), defined as the percentage of points inside the field passing the gamma evaluation ... dose-volume objectives including in the optimization the main characteristics of the linac head and the MLC (e.g speed, transmission, rounded leaf tip and tongue and groove design) The entire gantry ... collapsing the entire delivery onto a single plane introduces back into the delivery the tongue and groove pattern that would be smeared out (and almost cancelled) in the clinical case Summary of the...
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Tài liệu Clinical trials in gynecological cancer ppt
... Defense, the National Institute of Cancer Clinical Trials Group, the European Organization for Research and Treatment of Cancer, and the UK National Cancer Research Institute are routinely listed in ... developed by the NCI-US, American Cancer Society, and other advocacy groups are shown in Table Quality of cancer care/dissemination and diffusion of clinical trial data Ensuring the appropriate management ... establish the higher level of evidence to improve the quality of cancer treatment The best solution for this is to pursue the good quality of clinical trials, and all the physicians and patients...
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Access to unapproved therapeutic goods Clinical trials in Australia pdf
... documents relating to one or more of the following: (a) the supply of the goods; (b) the handling of the goods; (c) the monitoring of the supply of the goods; (e) the results of the supply of the goods; ... (a) the supply of the goods; (b) the handling of the goods; (c) the monitoring of the supply of the goods; (d) the results of the supply of the goods; (e) any other matter prescribed by the regulations ... unapproved therapeutic goods - clinical trials in Australia October 2004 Page 10 of 104 Therapeutic Goods Administration Classification of Clinical Trials Clinical Trials of Medicines Clinical trials of...
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The Fraction of Cancer Attributable to Lifestyle and Environmental Factors in the UK in 2010 docx
... exposure in the UK DM Parkin and SC Darby Tobacco-attributable cancer burden in the UK in 2010 DM Parkin S14 11 Cancers attributable to infection in the UK in 2010 DM Parkin S77 S6 10 Cancers ... cases of cancer in the UK (approximately 134 000 new cases in 2010), and about 50% of all cancer deaths Most of these cases of cancer (excluding a few thousand due to the natural background of ionising ... hormones in the UK in 2010 DM Parkin S73 The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010: Introduction DM Parkin S42 S70 S2 Cancers attributable to inadequate...
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báo cáo hóa học:" Research Article Automatic Speech Recognition Systems for the Evaluation of Voice and Speech Disorders in Head and Neck Cancer" pdf
... research and clinical purpose in order to determine the global functional outcome of speech and voice after the treatment of head and neck cancer It allows quantifying the intelligibility also in severely ... computed for each of the raters using the respective other raters as reference, that is, the mean of the four other raters for the LE group and the three other raters for the OC group For the comparison ... results in stable ASR conditions The quality of the recognition allows assessing the quality of the speech signal In order to exclude methodical interferences, a standard text and a stable recording...
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Báo cáo khoa học: " Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs)" ppt
... origin of the curve in the Y axis and determines the percentage of spontaneous cell death and b is the slope of the curve and determines the percentage of cell death induced at a determined radiation ... Also, the intraindividual and interindividual variations were determined in the four healthy donors and in the 79 patients Intraindividual variation for healthy donors was always lower than interindividual ... dependence of the patient and the tumour type The aim of the present study was to analyze radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients and explore their...
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Báo cáo khoa học: " Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy" pptx
... responsible for the dry mouth feeling There might be an influence of the submandibular glands and/ or the minor salivary glands of the palate In our analysis neither the Dpar nor the Dsubm was conclusively ... prospective study in patients with headand -neck cancer receiving RT The first aim of the study was to assess the long-term change in time of the QOL The second aim was to investigate the relationship ... the study and revised the manuscript critically WB made the analysis and interpretation of the data, and has been involved in drafting the manuscript CT participated in the design of the study,...
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Báo cáo y học: "Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports" ppt
... so in clinical practice as in clinical trials, although discontinuations have been mentioned previously in clinical trials in rheumatology, as with meloxicam in ankylosing spondylitis [37] In clinical ... make the comparisons similar In total, these three analyses involve 81,664 patients enrolled in randomized controlled trials of high quality and validity in the settings of OA, RA, back pain, and ... numbers of patients participated in good quality and well recorded clinical trials, using different doses of etoricoxib and comparators in different clinical conditions Not all new treatments, and...
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