proteoglycan phosphacan and receptor protein tyrosine phosphatase beta isoforms during development and regeneration of neural tissues
Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt
... [2,3], and enzymes involved in phosphotyrosine signaling, such as the receptor protein tyrosine kinases (RTKs) [4] and receptor protein tyrosine phosphatases (RPTPs) [5–7] Evidence for the role of ... & Dutta R (1998) Protein tyrosine phosphatases and neural development Bioessays 20, 463–472 16 Johnson KG, McKinnell IW, Stoker AW & Holt CE (2001) Receptor protein tyrosine phosphatases regulate ... (2003) Receptor protein tyrosine phosphatases in nervous system development Physiol Rev 83, 1–24 Chagnon MJ, Uetani N & Tremblay ML (2004) Functional significance of the LAR receptor protein tyrosine...
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Báo cáo khoa học: Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase a is required for Src activation doc
... Zhang ZY & den Hertog J (1999) Restoration of potent protein- tyrosine phosphatase activity into the membrane-distal domain of receptor protein- tyrosine phosphatase alpha Biochemistry 38, 914–922 ... intracellular domains of receptor protein- tyrosine phosphatases J Biol Chem 277, 47263–47269 Wallace MJ, Fladd C, Batt J & Rotin D (1998) The second catalytic domain of protein tyrosine phosphatase delta ... inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon Mol Cell Biol 23, 5460–5471 Nam HJ, Poy F, Saito H & Frederick CA (2005) Structural basis for the function and regulation of...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... the FERM (band 4.1, ezrin, radixin, moesin) domain of PTPH1 is necessary for the inhibition of Mek, Erk, Jnk and AP-1 and also for localization of the phosphatase on the plasma membrane of Jurkat ... active PTPN3 protein tyrosine phosphatase J Immunol 2007, 178:3680-3687 17 Bauler TJ, Hendriks WJ, King PD: The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are ... Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor Mol Endocrinol 2003, 17:2228-2239 DeForge LE, Remick DG: Kinetics of TNF, IL-6, and IL-8...
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Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx
... structural consequences of oxidation in PhyAsr cell division cycle 25 homolog B (Cdc25B), receptor protein tyrosine phosphatase alpha (RPTPa) and PTP1B suggests that oxidation of the catalytic cysteine ... superposition of unoxidized (yellow) (Protein Data Bank: 2PSZ) and oxidized (gray) (Protein Data Bank: 2PT0) PhyAsr, with unoxidized (red) (Protein Data Bank: 1YMK) and oxidized (blue) (Protein Data ... catalytic efficiency of some PTPs For example, at high ionic strength the kcat ⁄ Km of Yersinia protein tyrosine phosphatase (Yop51) [19] and PTP1 [20] decrease by 24-fold and 132-fold (respectively),...
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Báo cáo khoa học: The protein tyrosine phosphatase PTP-Basophil/Basophil-like Interacting proteins and molecular functions doc
... bona fide tyrosine phosphatase [15,22] Currently, several proteins are known to serve as substrate for the protein tyrosine phosphatase domain of PTP-Bas/BL Theses proteins are RIL, IjBa and ephrinB, ... distribution of endogenous Fas The inhibitory effect of PTP-Bas on cell surface expression of Fas was dependent on the presence of the PDZ2 and protein tyrosine phosphatase domain of PTPBas Moreover, ... PDZ5 domain of PTP-BL, like the PDZ2 and PDZ3 domains, is able to interact with PIP2 [38] Substrates of the PTP-Bas/BL protein tyrosine phosphatase domain Crucial for the understanding of PTP-Bas/BL...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
... Expression and Function of the PRL Family of Protein Tyrosine Phosphatase Major Professor: Stephen K Randall The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, ... Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Expression and Function of the PRL Family of Protein Tyrosine Phosphatase For the degree of Doctor of Philosophy Choose ... Phosphoprotein phosphatase PRL Phosphatase of regenerating liver pSer Phosphoserine PTEN Phosphatase and tensin homolog deleted on chromosome 10 pThr Phosphothreonine PTP Protein tyrosine phosphatase...
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Functional interactions of protein tyrosine phosphatase alpha (PTPa) and src in mouse development and integrin singaling investigation of double PTPa src deficient mice and cells
... density 95 Phosphatase and tensin homolog deleted on chromosome 10 Protein tyrosine phosphatase Protein tyrosine kinase Protein tyrosine phosphatase alpha Polyvinylidene difluoride Proline-rich tyrosine ... ……………………………………………………………1 1.1 Protein phosphorylation……………………………………………… 1.2 Protein tyrosine phosphatase (PTP) superfamily 1.3 Catalytic mechanism of protein tyrosine phosphatases………… 1.4 Receptor- like PTPs and their ... Functional Interactions of Protein Tyrosine Phosphatase Alpha (PTPα) and Src in Mouse Development and Integrin Signaling: Investigation of Double PTPα/Src-Deficient Mice and Cells CHEN MIN (M.Sc.,...
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Báo cáo khoa học: Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B docx
... regulation of dimerization of the receptor protein- tyrosine phosphatases RPTPalpha, LAR, RPTPmu and CD45 FEBS J 275, 25972604 Brautigan DL & Pinault FM (1993) Serine phosphorylation of protein tyrosine ... NK (1993) Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identication of cell cycle regulated and phorbol ester stimulated sites of phosphorylation EMBO J 12, 19371946 ... Regulation of protein tyrosine phosphatase 1B by sumoylation Nat Cell Biol 9, 8085 Lohse DL, Denu JM, Santoro N & Dixon JE (1997) Roles of aspartic acid-181 and serine-222 in intermediate formation and...
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Báo cáo khoa học: Weak oligomerization of low-molecular-weight protein tyrosine phosphatase is conserved from mammals to bacteria pot
... Doublet P, Duclos B, Etienne J & Cozzone AJ (2002) Isolation and characterization of a protein- tyrosine kinase and a phosphotyrosine -protein phosphatase from Klebsiella pneumoniae Comp Biochem Physiol ... Cells of Escherichia coli contain a protein- tyrosine kinase, Wzc, and a phosphotyrosine -protein phosphatase, Wzb J Bacteriol 181, 3472–3477 26 Bugert P & Geider K (1997) Characterization of the ... activation of a low-molecular weight protein tyrosine phosphatase by adenine Biochemistry 39, 1234–1242 Xu H, Xia B & Jin C (2006) Solution structure of a low-molecular-weight protein tyrosine phosphatase...
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Báo cáo y học: "Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele" docx
... Shering-Plough, Amgen, Pfizer and Wyeth was gratefully received The authors thank Dr JF Prudhomme, Dr C Bouchier and Professor J Weissenbach at Genethon and Dr C De Toma, MF Legrand and Professor G Thomas ... 52:358-360 20 Cloutier JF, Veillette A: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells EMBO J 1996, 15:4909-4918 ... Inclusion criteria for the sample of 88 families had been the participation of at least two siblings with RA and of French Caucasian origin, with all four grandparents being of European Caucasian origin...
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Organometallic scaffolds as protein tyrosine phosphatase 1b inhibitor
... 1.1 Protein Tyrosine Phosphatase 1B as drug target 1.2 Organic inhibitors of Protein Tyrosine Phosphatases 1.3 Metal complexes as inhibitors of Protein Tyrosine Phosphatases ... describes the synthesis and evaluation of two novel classes of organoruthenium and organogold complexes as inhibitors of protein tyrosine phosphatases (PTPs) The findings of the research are presented ... Design of Selective Organoruthenium Inhibitors of Protein Tyrosine Phosphatase 1B” have been submitted for publication VI List of Tables List of Tables Table 3.1 Comparison of bond distances [Å] and...
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A role for chondroitin sulfate proteoglycan in regulating the survival and growth of neural stem cells
... discussion of NSCs, a brief introduction of neural development is appropriate Once the formation of the three germ layers is completed during the gastrulation stage, the process of neurulation begins During ... migrate away from the neural tube to give rise to a variety of progeny, including the neurosecretory cells of the adrenal gland, the neurons of the enteric nervous system and non -neural structures ... invagination of the mesoderm in the region of the primitive streak (B) As neurulation proceeds, the neural plate begins to fold on itself, forming the neural groove and ultimately the neural tube The neural...
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Repair and Regeneration of Ligaments, Tendons, and Joint - part 2 ppt
... the hand Many excellent books offer comprehensive coverage of the anatomy of the hand (1– 5), but this is not within the context of this chapter; only anatomy of the tendons and recent developments ... of the Hand 53 partment of the forearm and are primarily responsible for extension at the MCPJs, and secondary extension at the PIPJ and DIPJ The intrinsic muscles of the hand flex the MCPJ and ... are the hook of the hamate and pisiform medially and the tubercle of the scaphoid and ridge of the trapezium laterally The base of the carpal tunnel is formed by the concave surfaces of the carpal...
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Repair and Regeneration of Ligaments, Tendons, and Joint - part 3 docx
... Hand Surg [Br] 1997;22:283–287 215 Strickland JW Development of flexor tendon surgery: twenty-five years of progress J Hand Surg [Am] 2000;25:214–235 Tendon Surgery of the Hand 87 Evolution of ... prescription of tendon repair found a following 600 yr later when Italian Arabist Surgeons of the 17th century, such as Roger of Parma and Roland of Milan, began to practice and advocate the operation of ... technique (5–7) Most of Mayer’s work was done on the foot and ankle, and he demonstrated the anatomy of the tendon sheath, blood supply of the tendon, and the concept of tendon and tendon– sheath...
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Repair and Regeneration of Ligaments, Tendons, and Joint - part 8 pptx
... or augmentation of a cellular reaction that brings about the formation and maintenance of a particular type of differentiated tissue This often requires cells to be grown and expanded under conditions ... appearance of a From: Orthopedic Biology and Medicine: Repair and Regeneration of Ligaments, Tendons, and Joint Capsule Edited by: W R Walsh © Humana Press Inc., Totowa, NJ 257 258 Hill, An, and Young ... structure and can lead to progressive loss of strength, as well as chronic liberation of implant particles into the surrounding tissues HISTORICAL REVIEW OF ARTIFICIAL LIGAMENTS The potential of cruciate...
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Repair and Regeneration of Ligaments, Tendons, and Joint - part 9 ppt
... in ACL regeneration: (1) the complex structure and function of the ACL; (2) inadequate healing in the ACL and the “race” between repair and regeneration; and (3) limitations of the grafts and biomaterials ... providing a delicate balance of stability and flexibility to the joints of the body The From: Orthopedic Biology and Medicine: Repair and Regeneration of Ligaments, Tendons, and Joint Capsule Edited ... grafts and permanent prostheses by improving repair or inducing regeneration of soft connective tissues, such as skin, cartilage, meniscus, and ligaments The success of the musculoskeletal soft-tissue...
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Repair and Regeneration of Ligaments, Tendons, and Joint - part 10 doc
... Neutralisation of TGF -beta and TGF -beta or exogenous addition of TGF -beta to cutaneous rat wounds reduces scarring J Cell Sci 1995;108:985–1002 27 Batten ML, Hansen JC, Dahners LE Influence of dosage and ... tissue: development of strength and toughness Collagen Rel Res 1992;5:481–492 38 Birk DE, Mayne R Localization of collagen types I, III and V during tendon development Changes in collagen types I and ... results of in vitro binding experiments, molecular and biochemical analyses of tendon development, and knockout mouse studies, collectively indicate the involvement of decorin (a member of the...
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Dynamics analysis and applications of neural networks
... manner On this side, the complexity and capability of modeled neural networks rely on our present understanding of biological neural systems On the other hand, neural networks provide efficient computation ... investigations of neural networks, both in dynamics analysis and applications 1.2 Scope and Contributions One focus of the thesis lies on the improvement of the training algorithm of feedforward neural ... DYNAMICS ANALYSIS AND APPLICATIONS OF NEURAL NETWORKS BY TANG HUA-JIN (M.Eng Shanghai Jiao Tong Univ.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ELECTRICAL AND COMPUTER...
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Development and regeneration of muscle tissue
... Development and Regeneration of Muscle Tissue cannot contract, muscle that has sustained significant damage loses strength and cannot produce the same amount of power or endurance ... This acts as a substitute for endogenous neural stimulation, stimulating the muscle to contract and preventing the loss of proteins that occurs with a lack of use Physiotherapists work with patients ... also a target of physical therapy, as exercise can reduce the effects of agerelated atrophy and improve muscle function The goal of a physiotherapist is to improve physical functioning and reduce...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... cytochrome c and apoptosis [49] Other studies have shown that 14-3-3 proteins are direct targets of JNK and that phosphorylation of 14-3-3 proteins by JNK results in dissociation of Bax from 14-3-3 proteins, ... (2000) Protein phosphatases and the regulation of mitogen-activated protein kinase signalling Curr Opin Cell Biol 12, 186–192 28 Farooq A & Zhou MM (2004) Structure and regulation of MAPK phosphatases ... interaction of JNK protein kinase isoforms with transcription factors EMBO J 15, 2760–2770 37 Liu Y, Gorospe M, Yang C & Holbrook NJ (1995) Role of mitogen-activated protein kinase phosphatase during...
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