protein design for diversity of sequences and conformations using dead end elimination
SCOP: A Structural Classification of Proteins Database for the Investigation of Sequences and Structures ppt
... the unit of classification is usually the protein domain Small proteins, and most of those of medium size, have a single domain and are, therefore, treated as a whole The domains in large proteins ... the most accurate and useful results The unit of classification is usually the protein domain Small proteins, and most of those of medium size, have a single domain and are, therefore, treated as ... (for proteins whose structure is essentially formed by a-helices), (2) all beta (for those whose structure is essentially formed by b-sheets), (3) alpha and beta (for proteins with a-helices and...
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báo cáo khoa học: " A simple and high-sensitivity method for analysis of ubiquitination and polyubiquitination based on wheat cell-free protein synthesis" potx
... of a lysine residue in the target protein Since E3 binds to both E2 and the target protein, and acts as scaffold between E2 and the substrate protein, the E3 ligase is the major determinant for ... internalization of membrane proteins, activation of signal transduction and DNA damage repair [7] The formation of lysyl-63-linked polyubiquitin chains is generated by specific combinations of E2s and E2 ... target proteins for ubiquitination There is large number of genes encoding E3 ligases in all eukaryotes, and the diversity of E3s is thought to contribute to the substrate specificity of numerous...
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Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc
... metabolism-relevant ligands Click here data file bio-ligands Ligands and theand2 of bio-ligands and binding ATP, ligands Additionalfor file 1ownerships of metabolism-relevantADP and block numbers of for proteins ... many proteins bind ligands that are essential for their functions and the ligands are likely to have originated independently of proteins [56-59], the binding of ligands with primordial proteins ... 2007, 100 10 1 10 Number of domains binding ligand (L) Figure Power-law behaviors of ligand -protein binding Power-law behaviors of ligand -protein binding The number of ligands (N) decays with an...
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Conventional Providing a Uniform Law for Bill of exchange and Promissory Notes
... protest and a receipted account Every endorser who has taken up and paid a bill of 196 exchange may cancel his own endorsement and those of subsequent endorsers Article 51 In the case of the exercise ... regularity of the series of endorsements, but not the signature of the endorsers Article 41 When a bill of exchange is drawn payable in a currency 145 146 which is not that of the place of payment, ... of Exchange CHAPTER I - Issue and Form of a Bill of Exchange Article A bill of exchange contains: The term 'bill of exchange' inserted in the body of the instrument and expressed in the language...
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity and related metabolic diseases, and discuss whether these ANGPTLs could be targets for the prevention and treatment of these conditions Suppression of ... expression of PPARa, PPARd and PGC-1a in skeletal muscle of ANGPTL6 ⁄ AGF transgenic mice [14] Moreover, ANGPTL6 ⁄ AGF protein binds to C2C12 myocytes and stimulates phosphorylation of p38 MAPK ... regulation and properties of angiopoietin-like proteins and J Lipid Res 46, 1484– 1490 13 Oike Y, Akao M, Kubota Y & Suda T (2005) Angiopoietin-like proteins: potential new targets for metabolic...
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Tài liệu Báo cáo khoa học: "Automatic Extraction of Lexico-Syntactic Patterns for Detection of Negation and Speculation Scopes" pdf
... Statistics of the BioScope corpus The 2nd and 3d columns show the total number of cues within the datasets; the 4th and 5th columns show the percentage of negated and speculative sentences 70% of the ... compiled list of lexico-syntactic rules for identifying their scopes For the performance of the rule based system on identifying speculation scopes, they report 61.13 and 79.89 accuracy for BioScope ... summaries Journal of biomedical informatics, 34(5):301–310 A.B Clegg and A.J Shepherd 2007 Benchmarking natural-language parsers for biological applications using dependency graphs BMC bioinformatics,...
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Specification for welding of presses and press components
... Society, Inc September 16, 1999 10:13:17 Information Handling Services, COPYRIGHT 1999 American Welding Society, Inc September 16, 1999 10:13:17 Information Handling Services, COPYRIGHT 1999 American ... Society, Inc September 16, 1999 10:13:17 Information Handling Services, COPYRIGHT 1999 American Welding Society, Inc September 16, 1999 10:13:17 Information Handling Services, COPYRIGHT 1999 American ... Society, Inc September 16, 1999 10:13:17 Information Handling Services, COPYRIGHT 1999 American Welding Society, Inc September 16, 1999 10:13:17 Information Handling Services, COPYRIGHT 1999 American...
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Effectiveness of Ginger for Prevention of Nausea and Vomiting after Gynecological Laparoscopy docx
... vomiting, type and duration of surgery, the use of opioid during surgery, the requirements of postoperative analgesia and antiemetic drug The VAS, episode of vomiting and side effect of ginger such ... Therefore, the objective of the present study was to study the effectiveness of ginger in a larger dose (1.5 gm) for prevention of nausea and vomiting after gynecological laparoscopy Material and ... groups in terms of age, weight, occupation, past history of illness, history of post operative nausea vomiting, type and duration of surgery The use of opioid during surgery and post operative...
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Báo cáo khoa học: Examining multiprotein signaling complexes from all angles The use of complementary techniques to characterize complex formation at the adapter protein, linker for activation of T cells pdf
... and motifs (1) Determine individual sites required for protein protein interactions (2) Examine the formation and composition of in vivo protein complexes (3) Investigate effects of complex formation ... multiprotein complexes are detailed Also described is the information gained from these techniques and examples of the use of these techniques for the examination of linker for activation of T ... localization of individual signaling proteins, but also to quantitatively investigate protein protein interactions The recruitment and localization of LAT and LAT-binding proteins to the sites of receptor...
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Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression doc
... effectiveness of a set of antisense PS-ODNs directed against the glutathione S-transferase Mu1 (GSTM1) and Mu2 (GSTM2) isoforms of the rat GSTs play an important role in the detoxification of DNA- and/ or protein- reactive ... with two sets of PCR primers (forA + revA and forB + revB) for Table Primers used for sticky -end PCR Separate PCR reactions were carried out with the following primer sets: GSTM1-forA and GSTM1-revA; ... mercapturic acid formation J Biol Chem 249, 7130–7139 Bradford, M.M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein- dye...
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urban design - a typology of procedures and products
... urban design procedural types and the understanding of the mechanisms available for shaping design ends and means Its goal, in turn, is to provide a typology for understanding the range of urban design ... implemented through the acquisition of land, the creation of a development programme, the hiring of a designer or set of designers, and the implementing of a design for whole cities In other cases ... just urban design? Is urban design just planning? The products of landscape architecture and the nature of urban design The products of landscape architecture: malls, squares, streets and parks...
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code design for dependable systems theory and practical applications
... V and for all scalar c F cðu þ vÞ ¼ cu þ cv for all u, v V and for all scalar c F ða þ bÞv ¼ av þ bv for all v V and for all scalars a, b F ðabÞv ¼ aðbvÞ, 1v ¼ v, and 0v ¼ for all v V and for ... many people Professors Jack K Wolf of the University of California San Diego, Hideki Imai of the University of Tokyo, T R N Rao of the University of Louisiana Lafayette, and Bella Bose of Oregon ... design theory and to write this book Emeritus professor Yoshihiro Tohma of Tokyo Institute of Technology, Professors Takashi Nanya of the University of Tokyo, Hideo Ito of Chiba University, and...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 1 ppt
... Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher No responsibility is accepted for the accuracy of information ... potential for a variety of new applications, in the area of imaging and precision micromachining (Langford, 2001; Seliger, 1979) As a result, the FIB has recently become a popular candidate for fabricating ... of nanoquantum mechanical electron devices and their applications Classification of machining Micromachining is the basic technology for fabrication of micro-components of size in the range of...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 3 doc
... the spectrum of applications for microfabrication techniques The width and depth of most microfluidic channels fall in the range of 10-1000 µm, and this feature size is thus small for conventional ... such as valves, pumps, and injectors, and often some optical and electrical components for integrated control and sensing Unlike wet and dry etching which must be carefully formulated to achieve ... Techniques for Fabrication of Micro and Nano Structures been extended to include the effects present in trepanning of holes (Zeng et al., 2005), and for trepanning with annular beam profiles (Zeng...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 4 pot
... principally in the form of through-cutting of plastic laminates A great many applications for microfluidics demand disposable cartridges for the liquid contacting elements of the system Disposable ... construction of microfluidic cartridges from a series of laser-cut plastic laminates which are aligned and bonded together This method of fabrication offers enormous flexibility in both the design of the ... Techniques for Fabrication of Micro and Nano Structures Laser micromachining of plastic laminates for microfluidics nearly always involves through-cutting of each layer CO2 laser systems not offer...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 6 docx
... 14 (c)) Fig 14 SEM images of trenches laser micromachined at different focus offset planes: (a) small offset of 300 μm; (b) optimal offset of 450 μm; (c) large offset of 600 μm The pulse energy, ... point of sapphire and GaN, which is in the range from 2040 °C to 2500 °C Fig FE-SEM image of a GaN/sapphire wafer after laser micromachining, the interface of GaN and sapphire and the brim of the ... parameters (focus offset, pulse energy, pulse repetition rate, scan speed and number of scan passes) and two ambient media (air and deionized water) were investigated By the end of this section,...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 7 docx
... that at higher bandwidth for current and near future requirements for telecom and datacom systems, the application of OI at the backplane is unavoidable It was argued that the cost of solving the ... one end of the guide for possible detection at the other end i.e backlighting, as shown in Figure where a single multimode waveguide of 50 µm × 35 µm and 60 mm long was illuminated from behind using ... being used for the drilling of µvias, which makes it a much compatible candidate Furthermore, for the fabrication of integrated mirrors, either in-plane or out -of- plane, laser ablation using an...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 9 docx
... compositions of coatings are known 168 Micromachining Techniques for Fabrication of Micro and Nano Structures Fig 14 Faults of adhesion and uniformity of coatings It is obvious that the price for micro ... optimizing the shape of micro end mills to meet the specific demands of the micro cutting process Especially for small-diameter end mills, bending, tool deflection and the avoidance of chatter marks ... bacterial contamination and less cleaning effort for liquid and the work piece On the other hand, the right dosing of the oil in the air stream is essential especially in the case of micromachining...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 10 docx
... successfully in stainless steel using three ball-nose tools made by Hitachi with lengths of 1, and mm and a diameter of 0.4 mm For the first two tools, 36.000 rpm and a feed rate of 1800 mm/min were applied ... [Kug_Mg, Ltu] for low thermal shift 4.3.2 Clamping and measurement of micro end mills The detection of tool length and tool diameter by laser [Blu_Na] or mechanical dipping onto a force sensor ... rotational speed and feed rate cannot be extrapolated For instance, a speed of 15.000 rpm with a feed rate of 90 mm/min worked fine for micro drilling using a 50 µm drill bit for the sputter mask...
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Micromachining Techniques for Fabrication of Micro and Nano Structures Part 11 pot
... definition of meso- and micro-scale for features between 100 μm and 250 µm and less than and equal to 100 μm, respectively Supported by OMAX’s R&D funds and NSF SBIR Grants #0944229 (Phase I) and #1058278 ... a study of alternatives for the geometry of the micro-hotplate follows, directed to the reduction of the etching time and the corresponding effects These Release Optimization of Suspended Membranes ... Rodríguez for the preparation of the etching test masks for photolithography, Benito Nepomuceno for the oxidized silicon substrates preparation and Gaspar Casados for the SEM images of the structures...
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