protection of children in international humanitarian law and human rights law vesselin popovski
International Humanitarian Law and Human Rights Law Towards a New Merger in International Law
... International Humanitarian Law and Human Rights Law International Humanitarian Law and Human Rights Law Towards a New Merger in International Law Edited by Roberta Arnold and Noởlle ... International Humanitarian Law and Human Rights Law Anke Biehler 355 Chapter XIV Protection of Children in International Humanitarian Law and Human Rights Law Vesselin Popovski 383 ... Historical Evolution of International Humanitarian Law, International Human Rights Law, Refugee Law and International Criminal Law, in Crisis Management and Humanitarian Protection Festschrift...
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The Role of Genetically Modified Organisms (GMOs) in Beverage Production
... mutagenesis, create signiÞcant changes in the genetic makeup of plants and animals due to the random recombination and sorting of thousands of genes As a result of intervention by people, the hybrid ... teosinte, the original ancestor of corn The newer techniques involving genetic engineering, on the other hand, allow for the transfer of a few genes in a much more precise, controllable, and ... Advantages of insect- and virus-resistant crops include improved yields and reduced use of pesticides An additional beneÞt of Bt corn is reduced contamination by fumonisin-producing fungi Fumonisin is...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... contains mammalian homologs of Caenorhabditis elegans synMuvB proteins and is composed of p130, E2F4 ⁄ and DP1 ⁄ and a module containing the MuvB proteins Lin-37, Lin-52, Lin-54 and chromatinassociated ... expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1 J Biol Chem 282, 168–175 Sandoval R, Pilkinton M & Colamonici OR (2009) Deletion of the p107 ⁄ p130-binding domain of Mip130 ⁄ LIN-9 ... E2F1, -2 and -3 These activating E2Fs cooperate with NF-Y proteins binding to CCAAT-boxes and with Myb proteins associating with a distal Myb site in activating the Cdc2 promoter Binding of the...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... basis of the kinetic constants in Table 1, and those obtained for the glutaminase reaction in the presence of 0.1 mM each of UTP and ATP-cS (data not shown) Apparently, the value of Ka, kcat,1 and ... results seem to indicate that allosteric binding by GTP alone or in combination with UTP and ATP-cS, is not capable of activating glutamine hydrolysis in terms of kcat to the level of CTP synthesis, ... j)1 and j, [S]syr is the concentration of the injectant in the syringe Analysis of initial velocity data Analysis of saturation curves was performed by nonlinear regression using 5ị where kcat,inh...
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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... large and small domains, respectively, and appear to stabilize their protein scaffolds, allowing the proper positioning of the residues involved in PLP binding, substrate binding and modulation of ... saturating concentrations of cofactor (Finf) were: F0 = 125 ± and Finf =65 ± for the wild-type enzyme; F0 = 139 ± and Finf = 66 ± for L85A; F0 = 122 ± and Finf = 63 ± for L276; and F0 = 103 ± and Finf ... domain and the N-terminus (Fig 1) Therefore, the formation of the third cluster may represent a key event of the final phase of folding, determining the assembly of eSHMT active site and promoting...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant rats [39], and that prolonged GSK3 inhibition ... enhanced in insulin-resistant muscle and the kinase has been implicated in down-regulating insulin signalling via its ability to serine phosphorylate IRS1 [40], it is possible that inhibition of GSK3 ... submaximal insulin dose (Fig 5) These findings are not entirely out of line with work from rodent studies showing that whilst GSK3 inhibition improves insulin responsiveness in muscle of insulin resistant...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... 26 27 roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans J Clin Invest 97, 642–648 Petersen, K.F., Laurent, D., Rothman, D.L., Cline, G.W & Shulman, ... of glycogen in the ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead to increased 13C labeling at the triose level Such a mechanism can lead to increases in labeling ... 3, and > h from the start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of ... Time (min) 250 300 100 200 300 40 00 Time (min) Fig Kinetically controlled synthesis of ampicillin and cephalexin using wild-type (dashed lines) and the bF24A mutant (solid lines) (A) Cephalexin ... rate-limiting step in the conversion of N-phenylacetylated substrates [9] Assuming rapid binding of the substrate, it follows that kcat represents the rate of acylation and Km equals the binding constant...
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The role of floating-rate bank loans in institutional portfolios pdf
... on the chart Indexes are unmanaged and cannot be invested in directly Data is historical and is not indicative of future results Russell Investments // Role of bank loans in a rising rate environment ... is not indicative of future results Russell Investments // Role of bank loans in a rising rate environment / p6 Bank loans in rising interest rate environments In the past 20 years (since 1992), ... Citigroup and Bloomberg Indexes are unmanaged and cannot be invested in directly Past performance is not indicative of future results Russell Investments // Role of bank loans in a rising rate...
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Perceptions About Network Security: Survey of IT & IT security practitioners in the U.S. pptx
... is increasing Reducing an organization’s vulnerability to such attacks through the combination of proper staffing, enabling technologies and training programs can help prevent the pattern of ... contributes to the insider risk In addition to simplifying their security operations and increasing available resources, organizations should consider the importance of training and awareness Bar ... Ponemon Institute conducts annually: the Cost of a Data Breach and the Cost of Cyber Crime According to the findings, the average cost of one data breach for U.S organizations participating in the...
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FUTURE OF THE NUCLEAR SECURITY ENVIRONMENT IN 2015 pptx
... contravention of generally recognized principles and norms of international law existing and potential hot spots of local wars and armed conflicts (primarily those in the immediate vicinity of the Russian ... part of a continuing effort in organizing and leading the global community under the auspices of the Global Initiative to Combat Nuclear Terrorism This joint U.S.-Russian initiative, involving ... Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly...
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Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx
... template and cloned into the pET14b vector using the Nde I and BamH I restriction sites A 6-His tag and a thrombin cleavage site were introduced to the N-terminus of the recombinant proteins Tryptophans, ... NTPs [16–18] Interestingly, the sum of ATP and UTP was two-fold higher than that of CTP and GTP, and the ratio of dATP and dTTP to dCTP and dGTP was also : [16,17] This fact is in accordance ... urealyticum intrauterine infection: role in prematurity and disease in newborns Clin Microbiol Rev 6, 69–87 Goncalves L, Chaiworapongsa T & Romero R (2002) Intrauterine infection and prematurity...
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Báo cáo khoa học: Role of peroxidase inhibition by insulin in the bovine thyroid cell proliferation mechanism pdf
... Role of the time factor in signalling specificity: application to mitogenic and metabolic signalling by the insulin and insulin-like growth factor I receptor tyrosine kinases Glucose Metabolism and ... MgCl2, 0.1 mM ZnCl2, mm spermidine, and maintained at 37 °C during 12 h After inactivating the enzyme at 95 °C, during 10 min, in the presence of mm EDTA, the remnant inhibitory action was assayed ... bovine TPO control Fresh bovine TPO + B MLS Fresh bovine TPO + (B MLS + Insulin) TPO activity (pmol IÆmin)1Æmg protein)1) % Inhibition 439 ± 56 241 ± 42* 45 87 ± 37** 80 Table Effect of insulin and...
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báo cáo hóa học: " The role of cumulative physical work load in symptomatic knee osteoarthritis – a case-control study in Germany" potx
... questionnaire and observation ratings of 0.49 for frequency of lifting, carrying, and transferring 6–15 kg Concerning the frequency of lifting, carrying, and transferring 6–15 kg, the self-assessed and ... differentiating between two different Kneeling and squatting, differentiating between two different modes of squatting *In German: „Fersensitz" Interviewers were intensively trained in standardized interview ... kneeling/squatting and no lifting/carrying Kneeling/squatting >0 – 0 –
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báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx
... programme again Lesions in the lung in patient and in the proximal jejunal segments of the intestine in another patient were not FDG avid So they were accepted as non malignant and no therapy indication ... decision of continuing the ongoing therapy or stopping and redirecting the patient to other salvage therapies Our study also supports the idea of routine use of PET or preferably PET/CT in the ... documentation of the data, literature analysis and participated in drafting the manuscript OK conceived of the study, and participated in its design and coordination All authors read and approved the final...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and synovial fibroblasts: a possible role as a ‘fine-tuning cytokine’ in inflammation ... resulted in elevated levels of IL-1β protein in the synovium [41] Intriguingly, blocking of IL-1α/β with neutralizing antibodies had no effect on the IL-17-induced synovial inflammation and joint ... interleukin 17 in inflammatory bowel disease Gut 2003, 52:65-70 Katz Y, Nadiv O, Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... TNF often is a survival signal (green lines) and plays a role in maintaining survival niches for long-lived plasma cells (PlasmaC) Some of these effects are indirect in part, involving cytokines ... However, in view of the autoimmunogenic potential of inhibiting TNF, we tested TNF inhibition as a means to interfere with the inflammatory response in SLE by administering only an induction regime of ... blockade with infliximab induced an increase of autoantibodies in five out of seven patients and increases in anti-cardiolipin-antibodies (ACLAs) in four out of seven patients in our open-label...
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Báo cáo y học: "Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints" potx
... following the repeated 2ME2 injections and (d) in osteoarthritic joints of STR/ORT mice Immunostaining for CD45 revealed no relevant invasion of leukocytes into synovial tissue in (e) control joints, ... of control joints of Balb/C mice (j) 2ME2-treated joints showed a distinct reduction of HIF-1α-positive cells with less intense staining at weeks (k) Number of positive cells recovered in joints ... to (d) Administration of 2ME2 (10 μM) or of dimethyloxaloylglycine (DMOG) (1 mM) did not induce inflammation or fibrosis of synovial tissue A slight thickening of the synovial cell lining could...
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Báo cáo y học: " Role of taurine on acid secretion in the rat stomach" ppsx
... cause the inhibition of taurineinduced acid secretion In addition, taurine effectively increases cAMP concentration in stomach by binding to GABAA receptors on cholinergic neurons, resulting in the ... 6) increases the level of cAMP Fourth, the presence of taurine-containing cells in the rat stomach is confirmed, as indicated by CSAD- and taurine-positive cells We found the presence of taurine-containing ... pathway involved in acid secretion induced by low taurine concentrations may predominantly involve in cholinergic neurons Both TTX and atropine completely inhibited the acid secretion induced...
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