prostate cancer screening although this female patient firmly believes in the power of psa screening to avert prost
báo cáo khoa học: "Angiogenesis inhibitors in the treatment of prostate cancer" pdf
... tyrosine kinase receptors The development of small molecules that inhibit tyrosine kinases, primarily by binding the ATP binding domain, has led to investigation of tyrosine kinase inhibitors ... were noted to have rising PSA levels Thus, the activity profile of sunitinib appears to be similar to that of sorafenib in this setting The findings of this study again highlight the need for ... Angiogenesis appears to play a role in the progression of prostate cancer After several decades of investigation, angiogenesis inhibitor therapy is finally being evaluated in prostate cancer patients While...
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Báo cáo y học: " Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions" pps
... 661 78 Prostate - 627 79 Prostate BPH - 662 66 Prostate BPH - 665 53 Prostate 63 ± 18.4 667 47 Prostate 61 ± 4.2 687 63 Prostate 74 690 79 Prostate BPH - 693 75 Prostate BPH - 704 64 Prostate ... progression of prostate cancer [39], and activation of Focal adhesion kinase through α5β1 integrin/fibronectin has previously been implicated in regulating the invasiveness of prostate cancer cells ... signatures are found in human prostate cancers containing a minimum Gleason score pathology Distinctive stem cell and tumor signatures are found in human prostate cancers containing a minimum Gleason...
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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"
... membrane in at least 10% of invasive carcinoma cells or presence of membranous staining in less than 30% provided that the staining is intense (++) Score 3: Presence of intense staining surrounding the ... CHAPS) at the ratio of 5:1 Sera were then diluted again with binding solution at the ratio of 10:1 and were applied in 100 µL amounts in the wells on the chip Protein chips on which the samples ... higher in the comparison of malignant patients to those in the control groups, as well as in the comparison of benign patients and those in the control group (p=0.006 and p=0.015, respectively) The...
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Báo cáo y học: " WT1 PEPTIDE VACCINATION IN COMBINATION WITH IMATINIB THERAPY FOR A PATIENT WITH CML IN THE CHRONIC PHASE"
... numbers of viable target cells Percent cytotoxicity of the assay was calculated by the following formula : % cytotoxicity = [(absolute number of viable target cells in the tube containing target ... in anti-tumor immunotherapy as in this case These data suggested the possible usefulness of treatment for suppressing the function of regulatory T cells in combination with anti-tumor immunotherapy ... spontaneously thereafter Imatinib was increased to a dose of 600 mg and continued for months, which caused adverse effects such as worsening of anemia and limb pain with increased CK Therefore the dose of...
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Industry Standard Financial Statement - This Statement is for use in the MARP pdf
... facing or in financial difficulties This Standard Financial Statement (SFS) is designed to assist you in setting out your current financial circumstances We consider that the completion of the ... undertaking and we will work with you to ensure that the information is accurate, enabling us to work with you to determine the most appropriate and viable option in each particular customer case The ... Protection Insurance Y/N Monthly Repayments Remaining Term Debt Type Due € D18 D19 Being Paid € Other Debt (please specify) Other Debt D20 D21 D22 Total (sum of D2 to D21) G5 Total Outstanding Balance...
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gene therapy in the treatment of cancer
... molecules The first is the establishment of the relevance of the genetic basis of carcinogenesis Second is the determination of the specific oncogene to target Third is the determination of the specific ... result in the development of hepatocellular carcinoma Thus, the generation of a vaccine to protect from hepatitis C infection would also reduce the incidence of liver cancer 256 GENE THERAPY IN THE ... survival in some animal models In most cases, the expression of the cytokine was only required in a small number of cells relative to the tumor challenge, suggesting that the cytokine was affecting...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... regulatory sequences were able to drive DTA expression in the ovarian cancer cell lines that led to cell death Therefore, we further investigated the therapeutic potential of the toxin vector in ... expression profile of H19 in epithelial ovarian cancer [19] The therapeutic potential of the toxin vector was evaluated in vitro using different human ovarian cancer cell lines and in cells isolated ... cell lines The transcriptional activity of the H19 regulatory sequences cloned into the DTA-H19 plasmid was examined in a variety of cell lines The luciferase activity induced by the H19 regulatory...
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Báo cáo hóa học: "Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study" potx
... prognostic indicator in fulminant hepatitis in patients without encephalopathy upon admission [10,11] In the present study, we examined 11 proinflammatory genes in patients receiving therapy in the ... expressing VWF In the signaling pathway, VWF interacts with integrins in the extracellular matrix (ECM) and has functions in the complement and coagulation cascades, linking downstream to the inflammatory ... inflammatory process or to B cell receptor signaling NAMPT is another indicator for prognosis It is the rate-limiting component in the mammalian nicotinamide adenine dinucleotide (NAD) biosynthesis...
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Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt
... release the E2F transcription factor, subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the ... entry of cells in the S phase [37] Furthermore, other members of aryl hydrocarbon receptor signaling, the inhibitors of cyclin-dependent kinases (p16 and p21), have been demonstrated to bind E7 increasing ... Evaluation of the results obtained in the two systems showed deregulation of the same pathways in human SCLC and in that induced experimentally by the E6/E7 oncoproteins of HPV16 To further highlight the...
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báo cáo hóa học: "Measuring patient''''s expectation and the perception of quality in LASIK services" pdf
... most interesting correlation was in the level of education achieved; the higher the degree of education, the lower the scores in perception (r = -0.10) The loading results of factor analysis in ... 8: Path Coefficients of SEM Models Model E E P E E E E E P P P P P L L L to to to to to to to to to to to to to to to to Loyalty Perception Loyalty E5 E4 E3 E2 E1 P5 P4 P3 P2 P1 R1 R2 R3 Estimate ... 28.02 19.55 * * * * 0.055 0.056 20.06 * 20.78 * E P E E E E E P P P P P L L L to to to to to to to to to to to to to to to Perception Loyalty E5 E4 E3 E2 E1 P5 P4 P3 P2 P1 R1 R2 R3 Estimate 0.52...
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báo cáo hóa học: " Cognitive interviewing methodology in the development of a pediatric item bank: a patient reported outcomes measurement information system (PROMIS) study" docx
... out of six of the children defined "go out" as going outside to something or to play outside This resulted in some of the children factoring the weather into the state of their asthma Another ... on the format of the questionnaire, including increasing the font size for ease of readability, shortening the instructions, and putting the recall period in bold type For some children, certain ... asthma Another kid interpreted "go out" as going to dinner or doing anything else outside of the house The interpretation was not consistent and if factoring in weather, the degree of variability...
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o cáo hóa học:" Summit on cell therapy for cancer: The importance of the interaction of multiple disciplines to advance clinical therapy" ppt
... lentiviral vectors Bringing these complex therapies to the clinic requires investigators to address a number of issues related to the safety and effectiveness of the final product The United States ... list of author information is available at the end of the article and, in fact, are critical to the advancement of adoptive cellular therapy of cancer, but this and most other areas of clinical therapy ... disciplines, the testing of new ideas in the research laboratory and in animal models, the development of new cellular therapies and GMP methods to produce these therapies, and the testing of new...
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báo cáo hóa học:" Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype" pptx
... ruptured surface The entrapment of OSE in ovarian stroma leads to the formation of inclusion cysts [25] that are thought to represent the site of origin of EOC [5] In support of this hypothesis, early ... been instrumental in understanding the progression of ovarian cancer Expression profiling of epithelial ovarian cancer of varying histologies has identified genetic signatures that distinguish the ... are induced in OSE-lined inclusion cysts, including expression of the EOC marker CA125 in OSE of inclusion cysts but not in normal OSE cells [2628] While the normal OSE is protected from the...
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báo cáo hóa học:" Response shift masks the treatment impact on patient reported outcomes (PROs): the example of individual quality of life in edentulous patients" pdf
... Switzerland The founding source had no involvement in either study design or in the collection, analysis and interpretation of data or in the writing of the report and the decision to submit the paper ... the relative importance of at least one of the other four cues must diminish One of the major challenges in interpreting the results of this study is that 81% of the patients chose at least one ... before being randomised either to continue with the conventional dentures or to receive implants The fitting of excellent dentures was done to ensure a proper baseline for the clinical trial since...
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Báo cáo y học: "The treatment of condylar fractures: to open or not to open? A critical review of this controversy" pdf
... Ten of them (3%) had pain in the joint or muscles or both Eight patients (2%) had malocclusion, which in seven could be related to dislocation of the condylar head out of the fossa Five of the ... with the Helkimo index at an average of 3.0 years follow-up The clinical dysfunction index showed: severe symptoms in 11%, moderate symptoms in 39%, mild symptoms in 39% and 11% had no symptoms Index ... group The re-examined group did not significantly differ from the control group Int J Med Sci 2008, With the objective of analyzing the main variables that determine the choice of the method of...
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Báo cáo khoa học: "Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast" pdf
... On the other hand, the immunohistochemical profile of the tumour included intense positivity for CD34 (Figure 4) These histological and immunohistochemical findings therefore established the ... neoplasm Page of Figure Histologic section of the breast tumor demonstrating irregular extension of spindle-cell neoplasm (black arrows) into adipose tissue (Haematoxylin and Eosin stain; original magnification ... Written informed consent was obtained from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this...
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Báo cáo khoa học: "Successful enteral nutrition in the treatment of esophagojejunal fistula after total gastrectomy in gastric cancer patients" pps
... of a great series of the National Cancer Center of Tokyo, emphasized that there is a learning curve in the using of an automatic suture and once this phase is surpassed, the presentation of this ... available In these cases a hand sewn anastomosis is performed Within the three patients in the study group, two of them had a hand-sewn anastomosis The dehiscence of the esophagojejunal anastomosis ... [11] In the other hand, the ileus that many times is associated with this complication and the subsequent reflux of the nutrient to the fistula opening is limiting for the use of enteral therapy,...
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Báo cáo khoa học: "Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy" ppt
... ultrasound was then performed to evaluate the balloon -to- skin distance and the degree of air and/or fluid in the breast tissue surrounding the balloon For the purposes of this protocol, a minimum of 1-cm ... options were explained to the patient, including the standard of care, 6– weeks of whole breast radiation therapy, and one week of outpatient APBI An IRB approved protocol utilizing XB to deliver IORT ... corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole in the drape and a FlexiShield™ (FS) was placed on top of the drape (Figure 4) The...
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Báo cáo khoa học: "Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report" pdf
... our initial pilot safety data demonstrating this device to be safe in the treatment of metastatic colorectal cancer[ 14] The goals of this analysis was to: 1) gain a better understanding of the ... chemotherapy, including FOLFOX in 35 patients, FOLFIRI in 15, Avastin in 37 patients, and other biologics in 9, with patients receiving hepatic directed radiotherapy The extent of liver involvement was ... caused by seepage into the gastrointestinal tract Until now, the effectiveness of this device for the treatment of CRHM has not been examined in a largescale study or in a multi-institutional trial...
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Báo cáo khoa học: "The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer" doc
... fasting period of at least hours prior to FDG injection, patients received an intravenous injection of 18-FDG, with the activity normalized for the weight of the patient, followed by an injection ... found SUV2 to be the best predictor of response Using SUV2 value of 4,24 as the cut-off threshold for defining response to therapy (AUC = 0.773, p < 0.001), it is possible to discriminate between ... obtained using only PET for preoperative staging Thus, the anatomical information obtained from the CT in a PET-CT scan does not seem to improve the detection rate of residual disease in our investigation...
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