prostate cancer progression to androgen independent disease the role of the pi3k akt pathway
báo cáo hóa học: " Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway" doc
... to the differential gene regulation induced by Ad-IRF3 in microglia The role of the PI3K/ Akt pathway in microglial inflammatory gene expression Because our data suggest a major role of PI3K/ Akt ... further stimulation with TLR ligands or cytokines The PI3K/ Akt pathway plays dual roles in proinflammatory cytokine production from microglia, depending on the nature of the stimuli used to induce ... positive role for PI3K/ Akt in miR-155 expression in astrocytes (Figure 9) These results demonstrate that the PI3K/ Akt pathway plays a fundamentally different role in the inflammatory activation of the...
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báo cáo khoa học: "Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway" pdf
... been reported to play a regulatory role in the PI3K signaling pathway Recombinant microRNA-126 was shown to downregulate the expression of p85b (a regulatory subunit of PI3K related to the stabilization ... promoted apoptosis in A549 cells PI3K is composed of a p110asubunit and p85 subunit and the PI3K/ AKT signaling pathway has been shown to play a role in the development and progression of lung cancer ... arrest of A549 cells However, further studies are necessary to elucidate the mechanisms underlying bostrycin-mediated induction of apoptosis and attenuation of the PI3K/ AKT signaling pathway...
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báo cáo khoa học: "Prostate cancer metastases to the rectum: A case report" ppsx
... of Surgical Oncology 2011, 9:56 http://www.wjso.com/content/9/1/56 Page of Figure CT scan of the abdomen showing the prostatic mass invading the urinary bladder wall and being separate from the ... consent was obtained from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor-in-Chief of this journal Authors’ ... TA carried out the history, physical examination and the provisional draft AAN participitate in the sequence alignment and drafted the manuscript again IAB carried out the histopathology Abbas...
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báo cáo hóa học:" Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB" doc
... investigated Therefore, the intent of this study was to evaluate the effect of genistein for sensitization of ovarian cancer cells to conventional cytotoxic chemotherapeutic agents by assessing the effects ... sensitize even the drug-resistant cell line and cause inhibition of cell viability Further, to assess whether the loss of overall cell viability could also be due to the induction of apoptotic cell ... also happens to be the downstream genes of NF-κB CIAP-2 and survivin are members of the anti-apoptotic IAP (Inhibitors of Apoptosis) family of proteins suppressing apoptosis and their expression...
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Báo cáo y học: " Peritoneal dissemination of prostate cancer due to laparoscopic radical prostatectomy: a case report" pptx
... PSA at the detection of the peritoneal diagnosis of metastasis peritoneal metastasis (ng/ mL) Treatment after the diagnosis of peritoneal metastasis Follow-up after the diagnosis of peritoneal ... appearance of peritoneal metastasis An autopsy demonstrated peritoneal dissemination of the prostate cancer without any other metastasis Conclusion: Physicians should take into account metastasis to ... dissemination of cancer cells to the peritoneum The treatment should be performed in accordance with the standard strategy for prostate cancer, including hormone therapy and chemotherapy Consent...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... brought together data suggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism One shortfall of the present theory ... kinase is an essential regulatory enzyme in co-enzyme A biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine and pantetheine [20] PANK2 is also ... and DJ1), the evidence for a mitochondrial pathway to cell death is overwhelming [2] The inspiration for our attempt to re-evaluate a Lewy body pathway to cell death has come from the recent...
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báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx
... downstream target of PI3K [18] The PI3K/ Akt signaling pathway regulates the development and progression of various cancers by elevating the activity of the anti-apoptotic action of Akt, and the phosphorylation ... one of the molecular mechanisms through which Osthole induces apoptosis The PI3K/ Akt is one of the most important signaling pathways in regulating cell growth, proliferation and apoptosis, and Akt ... maintenance of homeostasis and elimination of the damaged cells, is the outcome of a complex interaction between pro- and anti-apoptotic molecules Proteins of the Bcl-2 family are key regulators of the...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... some androgen- refractory prostate cancers [13,41] Therefore, both AR + and AR - cells were capable of forming androgen- independent prostate cancer cells as the tumorigenesis progresses to the ... Role of the basal cells in premalignant changes of the human prostate: a stem cell concept for the development of prostate cancer Eur Urol 1996, 30:201-205 Collins AT, Maitland NJ: Prostate cancer ... overexpression, we examined the pCX-shh-IG-injected prostates during the progression of PIN toward CaP to gain further insights (Figure 3A) The P63+ basal/stem cells in the pCX-shh-IG-injected prostates showed...
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The platelet contribution to cancer progression pot
... at the site of a wound or within the tumor and tumor vasculature [6] Cathepsin B, cancer procoagulant factor and the matrix metalloproteinases (MMPs) are contributors to TCIPA Cathepsin B and cancer ... [87,90] The involvement of the integrin receptor GPIba in tumor metastasis, on the other hand, has been more difficult to define [59,86,91,92] Recently, the GPVI surface receptor, a member of the immunoglobulin ... antiplatelet therapy is to be used successfully in the clinical setting The platelet role in coagulation-mediated cancer progression, the platelet contribution to the tumor-stromal interaction and the...
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INTENSIVE LIFESTYLE CHANGES MAY AFFECT THE PROGRESSION OF PROSTATE CANCER docx
... Washington REPLY BY AUTHORS Changes in diet and lifestyle are of profound interest to many patients with prostate cancer A large number of patients make such changes, often independent of doctor ... and LNCaP cell growth adds to the strength of evidence While the evidence linking the effects of diet and lifestyle on the development and progression of prostate cancer is not conclusive, it ... increase the likelihood of a type error by decreasing the amount of information about the lifestyle intervention available to the control group.8 Of the 181 patients who were eligible for the study...
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Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
... of the architecture of the back propagation neural network (BPNN) The BPNN repeatedly adjusts the weights, w, of the network and the threshold of each neuron (grey circles) The two steps of the ... between the target outputs and the actual outputs of the network The two steps of the learning process included: a) Forward propagation The value of the calculated output, yj , was compared to the ... allowing these patients to be considered for alternative treatment strategies, and, thus, providing a contribution to the development of personalized prostate cancer therapy Page of 9 List of abbreviations...
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Báo cáo khoa học: "Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?" ppt
... used The therapeutic depth of the electrons was to match the anterior border of the pectoral musculature, which corresponds to the posterior border of the target volume, as closely as possible Then, ... contour of the heart and used the data from Table to estimate the heart dose The same methods were used to examine the first 17 patients with prostate cancer who were treated since the opening of ... receive ≥50% to a more extended part of the heart (total 5/40 patients, 12.5%) Only one of these three 75years-old patients had a history of cardiac disease (Figure 2) None of the prostate cancer patients...
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Báo cáo khoa học: " The median non-prostate cancer survival is more than 10 years for men up to age 80 years who are selected and receive curative radiation treatment for prostate cancer" ppt
... from the start date of radiation treatment The K-M prostate cancer survival censors deaths from non -prostate cancer and men who are still alive at the end of the study period The K-M non -prostate ... prostate cancer The middle line shows the cumulative incidence after adjusting for the competing risk of death from prostate cancer The bottom line shows the cumulative incidence of prostate cancer death ... prostate cancer are more likely to have their death attributed to prostate cancer In this study, this bias could lead to overestimation of survival from non -cancer causes in men treated for prostate...
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Báo cáo y học: "Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space" pps
... levels in the prostate of men with CRPC still remain nearly equivalent of those in non-castrate patients [13] The source of these androgens is thought to be derived from synthesis of the androgens ... in prostate cancer cells due to an upregulation of the enzymes necessary to synthesize androgens such as testosterone and dihydrotestosterone [14,15] These findings suggest that prostate cancer ... serum testosterone levels is not truly androgen- independent Several other mechanisms also may result in activation of the AR in prostate cancer in the face of castrate levels of androgen These include...
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The androgen receptor centric transcriptional network in prostate cancer
... insights to prostate cancer etiology and contribute immensely to the development of new prostate cancer therapies To function, AR has to interact and collaborate with a plethora of other transcription ... 1.10 Histone Deacetylases in Prostate Cancers HDACs are a class of enzymes that catalyze the removal of acetyl groups from either transcription factors or the tails of histones to regulate the transcription ... gets translocated into the nucleus and recruited to the chromatin to mediate transcription 1.4 AR in Prostate Cancers The AR signaling pathway is known to be critical in prostate cancer biology Studies...
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Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 1
... DMQD/DEVD Short VEID/VEHD Short Apoptosis initiator Apoptosis initiator Apoptosis initiator Apoptosis initiator Apoptosis effector Apoptosis effector Apoptosis effector Caspase-7 Mch3/ICELAP3/CMH-1 ... supporting the existence of PI3K- Akt -independent survival pathways in PCa Deregulation of growth factor signaling is often observed during the course of PCa, and is proposed to gain importance as the ... cytoplasm as a preformed complex even in their inactive state Activation of PI3K occurs as a result of growth factor binding to their cognate receptors which leads to activation of the receptors’...
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Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 2
... Bax to the mitochondria The mechanism of serum inhibition of Bad and Bax translocation to the mitochondria is independent of PI3K- Akt signaling because it was not inhibited by the presence of LY ... degradation of the receptor It is possible that the kinase activity of EGFR of may play a role in the degradation of the receptor as phosphorylation of a single tyrosine residue on EGFR cytoplasmic ... inhibition of PI3K- Akt signaling with LY led to apoptotic cell death, the presence of serum or growth factors such as EGF protected the LNCaP cells from LYinduced apoptosis, pointing to the existence of...
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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... including PHC data of the statements made by the mid-wife in her records of the check-up of the mothers during the pregnancy (17) In the follow-up at the age of seven, n= 191 children of the defined ... treatment given to these children up to the age of ten Subjects At the age of 10 the parents of these n=191 children with a documented asthma diagnosis, were sent the International Study of Asthma ... increased from 68.3% at the age of three to 87.3% at the age of ten for group NA, and from 62.5% at the age of three to 66.7 at the age of ten for children in group A The proportion of children living...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... in the PI3K/ Akt pathway were found to be overexpressed in breast cancer cell line MCF7, together with 17-fold upregulation of PrP [14] In present study, we hypothesized that the PI3K/ Akt pathway ... PI3K/ Akt is involved in PrPC-mediated MDR in gastric cancer In order to study whether activation of the PI3K/ Akt signaling pathway played a role in PrPC-induced MDR in gastric cancer cells, the ... inhibition of the PI3K/ Akt signaling pathway may lead to inhibition of the MDR induced by PrPC in gastric cancer cells The mechanism underlying PI3K/ Akt- mediated PrPC-induced MDR in gastric cancer...
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Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... normal EPR signal The addition of detergent restulted in the loss of the ISP, which suggested that the mutation weakened the binding of the subunit to the complex [14] The replacement of residues ADV ... enzyme with their ISP in different conformations The mutation G167E could distort the hinge region of the ISP and hinder the movement of the headgroup Mutations in the hinge region of the ISP, which ... result of destabilization of the ISP [14] It seems probable that this is also the case for the G167E mutant, and that activity is lost owing to the destabilization of the complex (loss of the ISP)...
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