promoters with high expression of proximal genes and with greater expression differentials at divergent promoters
Báo cáo y học: "Mining for coexpression across hundreds of datasets using novel rank aggregation and visualization methods" pptx
... that provide coexpression information in an easy and accessible format ization method helps highlights datasets with highest coexpression to input gene and helps the user distinguish evidence with ... heat maps with expression profiles and experimental details of individual datasets The heat maps provide an easy visual validation of detected coexpression patterns MEM includes filters that ... given dataset Visual inspection of the rank matrix allows the researcher to detect patterns of correlation across datasets and spot significantly stronger coexpression profiles The rank aggregation...
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scientific american - 1993 09 - special issue - life, death, and the immune system
... perfect the means of destruction.Ó When the heroine of the Terminator movies claims that scientists know only Òhow to create death and destruction,Ó she repeats almost verbatim what SaintSimon said ... heat is generated directly in the object itself; no transfer of heat is involved Associated apparatus need not be heated The surfaces of the material need not be affected The people who work with ... Accelerator Laboratory Bill, the 35-year-old SSC physicist, strongly agrees Termination of the collider, he believes, not only would mean the loss of his job and that of his colleagues at the laboratory...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... and were plated in 96-well plates within 24 h of transfection and allowed to attach for 18– 22 h Half of the plated cells were treated with 0.01 U sialidase (Calbiochem, La Jolla, CA) for h at ... mutation at the 691 position), and GST alone proteins were coated on 96-well ELISA plates at mg:mL21 in sodium carbonate pH for 16 h at room temperature Plates were washed and then treated with Blocking ... anticipated that identification of novel inhibitory receptors on inflammatory cells and their signaling potential will offer opportunities to target and inhibit inflammatory cells at sites of inflammation...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
... susceptibility and immunopathology offers the possibility of pinpointing mechanisms that require inhibition or amplification for treatment of disease, identifying genotypes that may be exceptionally ... increases risk of asthma, but decreases schistosome egg load [13]; similarly, non-coding variants of the transcriptional regulator STAT-6, which is on the IL-4 pathway, are associated with higher asthma ... cohort of systemic lupus erythromatosus patients, the frequency of circulating Tregs was depressed in those carrying a disease-associated 3′ UTR SNP allele of CTLA-4, a surface molecule of T cells...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... be generated at the site of inflammation through the activation of CD4+CD25– T cells, inducing the expression of FoxP3 and CD25 In this way, activation itself would lead to a limitation of the ... recently demonstrated that activation of CD4+CD25– T cells with plate-bound anti-CD3 and soluble anti-CD28 can induce a group of CD4+CD25+ T cells with regulatory function that express FoxP3 ... T-cell clones to demonstrate that activation of these clones with peptide only, in the absence of co-stimulation, leads to T cells that are anergic and suppress proliferation of other T-cell clones...
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Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?" ppt
... cells) may be the target of a microbial bystander effect, that may dictate the pattern of accessory molecules and cytokines, and modulate the outcome (Th1- or Th2-like) of the allergen-specific ... bacteria compared with children of farmers and anthroposophic families, who have access to natural soil and eat only biologically treated food (fresh vegetables and farm products) Bacteria and bacterial ... Programmed ‘immunoeducation’ would consist of safe administration, by the correct route and at the correct dose and time schedule, of the variety of microbial stimuli that are required by the...
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Báo cáo y học: " Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system" pps
... universe of the generated peptides and its dynamics In general, we surmise that a systematic and integrative use of concepts such as degeneracy and bow tie architecture, in combination with and within ... communication [4] To underpin such a large-scale program, he also offered a more coherent formalization and provided a mathematical treatment of degeneracy that turned out to be strictly related ... integrated the classical mathematical framework of degeneracy with a new topobiological interpretation that knits together the structural and functional dimensions of biological organisms Page 12 of...
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Báo cáo y học: "Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b" ppt
... clinical observations [9,10] indicated that the administration of the ARB Olmesartan, at a concentration in excess of that needed for full AT2 R1 antagonism, often causes the level of circulating 1,25-D ... experimentally determined Ki, and the value estimated by computer simulation of the ligand-bound enzyme Chen, et.al [30], also concluded that AutoDock provided accurate estimation of ligand-DNA binding parameters ... position of TAK779 and Olmesartan superimposed, to enable easier comparison of the final location of each ligand Irbesartan forms hydrophobic contacts with a set of residues similar to that of Olmesartan...
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Báo cáo y học: "Tumor microenvironments, the immune system and cancer survival" ppt
... from untreated lymphoma patients were examined by geneexpression profiling on microarrays Informatics methods were used to identify ‘signatures’ - expression patterns that correlated with disease ... microarrays, together with very careful annotation of tumors and patient information, it is hoped that new strategies will emerge for monitoring and controlling the development of new tumors and for more ... of oxidative phosphorylation, mitochondrial, and electron transport chain genes) and a group called ‘BCR/proliferation’ (which showed elevated expression of genes encoding cell-cycle regulators,...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
... cohesin is vertebrate specific Epigenetic regulation of inflammatory gene expression Two talks addressed the role of epigenetic mechanisms in regulation of inflammatory gene expression In particular, ... patterns, of which 3,100 were unique (that is, found only at one gene) In contrast, some patterns were found at multiple genes; more than 3,000 genes, for instance, were marked by a ‘modification ... (which are putative enhancers), and discovered 13,000 distinct patterns, of which 1,100 were unique Zhao’s study underscored the diversity of histone modification patterns at gene regulatory elements,...
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Money, banking and the financial system (1st edition) r glenn hubbard, anthony patrick o''''brien prentice hall (2011)
... is the dean and Russell L Carson Professor of Finance and Economics in the Graduate School of Business at Columbia University and professor of economics in Columbia’s Faculty of Arts and Sciences ... Education and was named a Dana Foundation Faculty Fellow and Lehigh Class of 1961 Professor of Economics He has been a visiting professor at the University of California, Santa Barbara, and the ... Interest Rates and Rates of Return 72 A General Equation for the Rate of Return 73 Interest-Rate Risk and Maturity 73 3.6 Nominal Interest Rates Versus Real Interest Rates...
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Paradoxical roles of the immune system during cancer development docx
... inflammatory states rather than ones that represent acute antitumour immune responses12,18 Clinical data indicate that the ‘immune status’ of healthy individuals is distinct from that of those ... infiltrations of immune cells that are not revealed by standard histochemical analyses Representative sections of normal, pre-malignant and malignant breast and prostate tissues that are stained with ... development, and to identify candidates to target for chemoprevention, several laboratories have experimentally manipulated and/ or evaluated distinct immune-cell populations, and/ or immune modulators, at...
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American Public Service: Radical Reform and the Merit System pot
... and Practice of Court Administration, Alexander B Aikman 129 Handbook of Globalization, Governance, and Public Administration, Ali Farazmand and Jack Pinkowski 130 Handbook of Globalization and ... Handbook of Regulation and Administrative Law, edited by David H Rosenbloom and Richard D Schwartz 55 Handbook of Bureaucracy, edited by Ali Farazmand 56 Handbook of Public Sector Labor Relations, ... service, and business Jonathan P West is professor of political science and director of the graduate public administration program in the School of Business Administration at the University of Miami...
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Generations Model and the Pension System
... is born, and at the end of every period, the oldest generation dies The number of individuals born in period t is Lt Population grows at rate n such that Lt+1 = Lt (1 + n) The utility of an individual ... full-time programme is a business qualification with impact In 2010, our MiM employment rate was 95% within months of graduation*; the majority of graduates choosing to work in consulting or financial ... the technology Download free eBooks at bookboon.com The overlapping generations model Generations Model and the Pension System parameter and grows at the rate of technological progress g Labor...
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regional business cycle and real estate cycle analysis and the role of federal governments in regional stability
... real estate cycles and state level economic uctuations We observe that real estate downturns are more persistent and severe than economic recessions Comparison of the national and state level ... business and real estate cycle patterns suggest that only two out of four recent NBER dated national recessions were accompanied by predominance of real estate downturns in most of the U.S states ... national and state level business and real estate cycle patterns suggest that only two out of four recent NBER dated national recessions were accompanied by predominance of real estate downturns...
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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
... complicated network of physiological dysregulation While dioxin may be the ligand of choice for toxicological studies because of its potency and slow degradation, which reduces the likelihood of ‘off-target’ ... argue that offtarget effects may well be an integral feature of a tightly orchestrated immune response Immune responses function in a tight interactive network of cells and mediators, and the ... physiological impact of AhR expression on other cells of the immune system and the consequences of exposure to AhR ligands for these Given the complexity of cellular interactions that underlie specific...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
... young and adult animals (Table 2) The pattern of expression of molecules upregulated on activated lymphocytes is also similar to that noted in cattle following stimulation with Con A [8] mAbs that ... system of cattle is the presence of two complex subpopulations of γδ T cells, one subpopulation that is similar to γδ T cells described in humans and other species and a second subpopulation that ... suggest that the distribution of WC1− and WC1+ cells will be similar in lymphoid tissues to that of cattle also No difference was noted in the ratio of CD4+ and CD8+ T cells (~ ratio of 2) in...
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Báo cáo y học: "A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis" pps
... spleen at day 26 Data are represented as mean ± standard error of the mean (SEM) (n = 4) of the percentage of positive cells compared with the HpNS group (c) Expression of indicated genes in isolated ... drafting of the manuscript SV, BTvdB, and MBB helped to acquire data JG, SA-R, and FAvdL contributed to the study design, statistical and data analysis, interpretation of data, and drafting of the ... [23-26] and the cell-specific relative abundance of its respective receptors, TNFR1 and TNFR2 [9,12,27,28] The role of TNF as pivotal mediator of the cytokine cascade in inflammation and RA pathogenesis...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc
... of von Willebrand factor and vasodilation [21] Previous studies of the localization and distribution of different vasopressin receptors have been hampered by the use of nonselective radioligands ... discovered in the heart Activation of cardiac OTR stimulates the release of atrial natriuretic peptide, which is involved in natriuresis, regulation of blood pressure, and cell growth [76] Embryonic ... signaling pathways is associated with the V1R, and these pathways include activation of calcium influx, phospholipase A2, phospholipase C, and phospholipase D [45] Vasopressin docking and transmembrane...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps
... first with vasopressin and then with hypoxia, there was a greater degree of coronary vasodilation as compared with that observed in hearts treated with hypoxia alone These results indicate that ... concentrations, calcium forms a complex with calmodulin that activates a kinase, which phosphorylates the regulatory light chain of myosin Phosphorylated myosin activates myosin ATPase by actin and ... shock and vasodilatory states associated with cardiac anesthesia and surgery We stress that the clinical studies to date have been small and have focused on physiologic outcomes, and data on...
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