... group allocation The median value ofblood storage time was assessed, and patients were attributed to the newer blood group if they received only blood that had been stored for a period of time ... purposes of the analysis of metabolic changes during CPB, only the storage time of the blood used for priming the CPB machine was considered, and the composition of the two groups therefore differed ... cut-off of 15 or more days was used to define the older blood group This was based on previous observations that functional and structural changes of stored RBCs begin after two to three weeks of...
... Figure The GSH/GSSG ratio of the prototype and expanded models The GSH/GSSG ratio of the prototype and expanded models The prototype model (A) and the expanded model (B) Page of 11 (page number not ... biosimulation and the 21st Century Center of Excellence (COE) Program: Understanding and Control of Life's Function via Systems Biology), and in part by a grant from New Energy and Industrial ... production On the basis of existing models of single pathways and enzymes, various in silico models of human redbloodcell (RBC) metabolism were first developed by Joshi and Palsson [8-11] Subsequently,...
... waiver of written informed consent (# 09-953) Redbloodcell transfusion characteristics Packed redbloodcell units were obtained from the blood bank (St John’s Mercy Medical Center) None of the ... arterioles, venules, and capillaries in the measured volume of tissue, and the relative contributions of arterial, venous, and capillary blood within the measured volume of tissue cannot be determined ... decreased viability, and decreased deformability ofredblood cells A release of a number of substances occurs during storage resulting in such adverse systemic responses as fever, cellular injury,...
... injury Blood 2005, 105:2266-2273 28 Kristiansson M, Soop M, Saraste L, Sundqvist KG: Cytokines in stored redbloodcell concentrates: promoters of systemic inflammation and simulators of acute ... lower baseline hemoglobin, and a significantly greater severity of illness as measured by both APACHE II and SOFA scores when compared to the No ARDS group Both enteral and parenteral nutrition ... European Consensus Conference definition of ARDS [20] and relied upon the presence of PaO2/FiO2 (arterial partial pressure of oxygen/fraction of inspired oxygen) of less than or equal to 200 mm Hg,...
... Facts about bloodandblood banking [http:// www.aabb.org/Content/About _Blood/ Facts_About _Blood_ and _Blood_ Banking ] Ho J, Sibbald WJ, Chin-Yee IH: Effects of storage on efficacy ofredcell transfusion: ... indicates P value of 0.001 for comparison of ABO blood groups between decreased and increased redbloodcell (RBC) age group (chisquared test) DVT: deep vein thrombosis between increased and decreased ... fresh and old RBCs RBC: redblood cells more units at RBCs transfused of 28 or more days of storage in patients transfused or The relation between in-hospital mortality and the amount of RBC...
... extents ofredbloodcell aggregation for human redblood cells suspended in 70 kDa dextran and in autologous plasma 15 Figure 1.6: Aggregates formation in bloodof healthy human and cardiac ... 166) are supportive of extracellular diffusion factors such as the unstirred boundary layer surrounding each redbloodcelland the presence of a redbloodcell free layer (cell- free layer) near ... heterogeneity ofredblood cells distribution in the network by triggering the effects ofredbloodcell screening (103) and plasma skimming (53, 122) shown in Fig 1.10 CELL SCREENING Cell- cell interactions...
... WSS ofblood samples at 40% Hct in microtubes of ID 30 µm, 50 µm and 100 µm in non-aggregating blood 73 Figure B2 Comparison of relative WSS ofblood samples at 40% Hct in microtubes of ... flowed in glass microtubes of ID 30 µm, 50 µm and 100µm In the study of Hct effect on WSS, blood samples were prepared at normal Hct of 40% and disease Hct levels of 20% and 60% The same three suspending ... to non-aggregating blood, normal aggregating bloodand disease aggregating bloodand the microtubes of ID 30 µm, 50 µm and 100µm were employed to study the role of medium and tube diameter on...
... compared to hour of each gene) Relative mineralization of FGF-2 and BMP-2 treated cells As seen in Figure and Table 3, BMP-2 treatment enhances mineralization of the cells as shown by uptake and ... mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc Fgf-2, on the other hand, significantly ... (NM) consisting of alpha MEM medium with 10% fetal calf serum (FCS), 1% antibiotic solution and 1% glutamine solution and subcultured the cells every to days The cells were subcultured by incubating...
... objective of the present study is therefore to investigate if the use of a blood conservation device in the presence of a standardised restrictive transfusion practice can reduce the number of units of ... preservation of Hb, it is logical that use of such a device will reduce transfusion requirements In this beforeand-after study, use of a blood conservation device in the presence of a restrictive ... Cite this article as: Mukhopadhyay et al., The use of a blood conservation device to reduce redbloodcell transfusion requirements: a before and after study Critical Care 2010, 14:R7 ...
... EA: Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T -cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 ... global cellularity of 50% with nodular-interstitial infiltration by CD20+ and bcl2+ lymphocytes, which accounted for 15% of cellularity and was negative for CD5, CD23, bcl6, cyclin-D1 and DBA44 ... Oncovin (vincristine) and prednisone - rituximab (CHOP-R) protocol was started and, after six courses and restaging by computed tomography and bone marrow and peripheral blood investigation, showed...
... tables Results and discussion Physiologic implications of anemia Cerebral blood flow and oxygen delivery The amount of oxygen reaching specific organs is the product of local blood flow and the arterial ... consequences of transfusion Authors' contributions AHK was responsible for the conception and design of the study, the analysis and interpretation of the data, and the drafting and revision of the ... changes ofredblood cells during hemorrhagic shock replicate changes of aging Shock 2001, 15:467-470 Walsh TS, Garrioch M, Maciver C, Lee RJ, MacKirdy F, McClelland DB, Kinsella J, Wallis C: Red cell...
... of Figure Predicted risk of death against maximum age ofredblood cells A locally weighted nonparametric smoother (LOWESS) for the predicted probability of death and the maximum age ofredblood ... pressure of oxygen in arterial blood; RBC: redbloodcell Acknowledgements The authors would like to thank the Australian Red Cross Blood Service and the New Zealand Blood Service for excellent ... to deformability of stored red cells Br J Haematol 1983, 53:237-240 Card RT, Mohandas N, Perkins HA, Shohet SB: Deformability of stored redblood cells Relationship to degree of packing Transfusion...
... levels, blood pressure, BMI after 24 months of follow-up Sample size For an alpha of 0.05, a power of 80%, and in order to detect an reduction of HbA1c of 0.3 percentage units, with a common standard ... Blood pressure was measured according to the recommendations of the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (2003) ... the study in either of the two models analyzed, and the adjusted effect of PRECEDE was close to zero (Table 2) In both models, the level of exercise decreased Page of slightly and was not significant...
... (MFI) of samples kept at 37°C and the MFI of samples cultured at 4°C, as detailed in the Figure legends T -cell isolation and primary MLR CD4+ T cells were isolated from the peripheral blood with ... CD4+FoxP3+ Treg cells We cannot rule out the possibility that any G-CSF-induced recirculation of Treg cells was obscured by the high frequency of Treg cells already measured at baseline Of interest, ... proliferation andfunctionof diabetogenic T cells [31] It remains to be determined whether Treg recirculation and/ or recruitment to sites of inflammation and tissue injury Bonanno et al Journal of Translational...
... compared to hour of each gene) Relative mineralization of FGF-2 and BMP-2 treated cells As seen in Figure and Table 3, BMP-2 treatment enhances mineralization of the cells as shown by uptake and ... mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc Fgf-2, on the other hand, significantly ... (NM) consisting of alpha MEM medium with 10% fetal calf serum (FCS), 1% antibiotic solution and 1% glutamine solution and subcultured the cells every to days The cells were subcultured by incubating...
... for blood banks [65,66] Question of leukoreduction Many of the adverse effects associated with the transfusion of allogeneic RBCs have been shown to be related to the infusion of white blood cells ... Purpose and efficacy ofblood transfusion The primary purpose ofblood transfusion is to increase DO , which is determined by cardiac output and arterial content of oxygen, the latter being Page of ... evidence ofblood transfusion effectiveness Blood Transfus 2009, 7:250-258 32 Marik PE, Corwin HL: Efficacy ofredbloodcell transfusion in the critically ill: a systematic review of the literature...
... mg mLÀ1 of the red cells), most of which is hemoglobin (335 mg mLÀ1 of the red cells), lipids (5.1 mg mLÀ1 of the red cells), and carbohydrates (80 mg mLÀ1 of the red cells) The redcell membranes ... Cytoplasmic Domain of Band 84 Anion Exchange Channel by the Transmembrane Domain of Band 84 Lateral and Rotational Mobility of Band 85 Blood Type Antigens and Band 85 Band in Nonerythyroid Cells 87 Contents ... (1990) Genetics of the redcell membrane skeleton Semin Hematol 27: 290À332 Palek, J (ed.) (1992 and 1993) Cellular and molecular biology ofredbloodcell membrane proteins in health and disease...