primary tumours of the central nervous system evaluation of a suitable donor a reference list
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... 14. 8a 65.1 ± 14. 8a 23.6 ± 6.3 a Statistically significant against IADM lesions and PPWM areas significant against EA and IADM lesions and PPWM areas c Statistically significant against PPWM areas ... obtain a preparation that was stored at -20°C Induction and assessment of EAE Rats were anaesthetized with isoflurane (Baxter Medical AB, Kista, Sweden) and injected subcutaneously at the base of the ... histopathology and evaluation of CCR1, CCR2 and CCR5 mRNA expression in the spinal cord Vertical bars represent mean and standard error of the mean Preparation of radioactively labelled cRNA probes...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... Medulloblastoma in childhood Survival and functional results Acta Neurochirurgica 1979, 48:1-15 Raimondi AJ, Tomita T: Advantages of ‘total’ resection of medulloblastoma and disadvantages of full head ... 1978 and characterized on computed tomography (CT) scans as calcifications in the basal ganglia, cerebral atrophy and less dense areas in the white matter, was reported in children with ALL treated ... action, AraC had similar effects on the same cell populations as BCNU and CDDP The effect of radiation This fascinating study is likely to act as a wake-up call for neuro-oncologists To put the...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... of an animal model for delayed damage to the CNS caused by chemotherapy, provide experimental foundations that should prove of great value in the discovery and evaluation of therapies that either ... Inagaki M, Yoshikawa E, Matsuoka Y, Sugawara Y, Nakano T, Akechi T, Wada N, Imoto S, Murakami K, Uchitomi Y: Smaller regional volumes of brain gray and white matter demonstrated in breast cancer ... 22:393-408 122 Ohnoa S, Toi M, Kuroi K, Nakamura S, Iwata H, Kusama M, Masuda N, Yamazaki K, Hisamatsu K, Sato Y, Takatsuka Y, Shin E, Kaise H, Kurozumi M, Tsuda H, Akiyama F: Update results of FEC followed...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... 78 Taekyun Shin et al immunoreactivity of both iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years ... Histology and immunostaining of caprine brains with natural listeriosis A: Brain of a goat with listeriosis showing meningoencephalitis H-E staining, X66 B: Many dot-type bacteria (arrows) with ... immunostaining and different sources of primary antisera We used a polyclonal antisera (rabbit anti-iNOS, and rabbit anti-nNOS from Sigma) The increased expression of iNOS in brain cells, i.e.,...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... Grant A: Delirium and Isolated Angiitis of the Central Nervous System: a Case Report and Review CNS Spectrums 2008, 13:209-213 Page of 10 Ozawa T, Sasaki O, Sorimachi T, Tanaka R: Primary angiitis ... dramatically The prognosis of IACNS varies greatly and could be from months to years [1,11,17] Untreated IACNS usually causes fatal outcome Greater awareness of these potential manifestations of ... complaints are aphasia, transient ischemic attack, ataxia, dysphasia, nausea or vomiting, loss of memory, seizure disorder, dyslalia, hypomnesia and paralysis Interestingly, there have been so far...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... T, Yamagata M, Okamoto Y, Akiyama Y, Takahashi H, Kawano T, Katayama Y, Niidome Y: Peg-modified gold nanorods with a stealth character for in vivo applications Journal of Controlled Release 2006, ... nanoparticle encapsulation by the brain tissue The arrows indicate the nanoparticle inside the protein capsule mechanism of the immune system of the cockroach against a foreign object, or [2] as a ... fluorescence of the cockroach brain tissues The self fluorescence was absorbed and emitted at a wavelength close to that of the gold nanoparticles However, it was clear that the nAuNPs treated brain had...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... dementia of the Alzheimer’s type (DAT) DAT is a manifestation of “early deficits in recent memory followed by the development of aphasia, apraxia, and agnosia after several years (APA) The ICD-10, ... One of the major endogenous ligands, it acts via four GPCRs i.e A1 A, A2 A, A2 B and A3 A1 A and A3 receptor subtypes are coupled to Gi/o, inhibiting adenylyl cyclase (AC) On the other hand, A2 A and ... 1.2.4.2 Tau Another major hallmark of AD related changes in the brain is intracellular development of neurofibrillary tangles (NFTs) NFTs are primarily made of paired helical filaments (PHF) The main...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... researchers’ endeavour However, the low efficiency of non-viral gene delivery remains a critical drawback of the system On the other hand, viral gene delivery systems are favoured because of the ... nitrogen atom and contains primary, secondary, and, in the case of branched PEI, tertiary amino groups, each of which has the potential to become protonated The branched form of PEI has yielded ... Mediated Gene Delivery Baculoviruses (family Baculoviridae) constitute a group of double stranded DNA viruses that cause lethal diseases of arthropods A member of the family, Autographa californica...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... h) at a constant temperature of 22°C and at 60% humidity, and fed with normal laboratory rat food In the handling and care of all animals, the International Guiding Principles for Animal Research ... disadvantages of AAV as a gene delivery vector are its small packaging capacity and the inconvenience of large-scale preparation of viral stock (Rabinowtz and Samulski, 1998) Baculoviruses constitute a group ... of several years The sitespecific integration mediated by AAV vectors can help to avoid the activation of pro-oncogenes by the random integration (Rabinowtz and Samulski, 1998) The disadvantages...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... be balanced against the fact that the measured signal should still be higher than the background noise The signal-to-noise ratio is the ratio of mean value to standard deviation of the measured ... 2P and is the excitation intensity of the laser at the centre of the laser π wo beam with laser power P wo and zo are the radial and axial distances of the laser focus, respectively, at which the ... lethal in later stages Unlike the mammalian plasma membrane, the Drosophila membrane contains phosphoethanolamine ceramide (PE-cer) as the major constituent instead of sphingomyelin (PE-cer has...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... 5’- GTCGACGGATCCATGTCACCTCCTGGGAATTGGCAG-3’ and 19K2 (antisense primer) 5’-AAGCTTGCGGCCGCTTAAAGATTTGCGAGTGAAACACG-3’ The PCR reaction mixture contained 1.5 U Platinum Taq polymerase, 1.5 mM MgCl2, ... Animalia kingdom, Chordata phylum, Vertebrata subphylum, the Reptilia class and Squamata order (Evans, 2003) Venomous Snakes There are many different and diverse species of animals across all phyla ... Cobras, coral snakes, kraits, mambas, sea snakes, sea kraits and Australian elapids Viperidae (viperids) True vipers and pit vipers, including rattlesnakes Table Snakes that known to cause dangerous...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... Japan and maintained as described (clonal strain: GI) [58] Cloning and sequencing of planarian PHM cDNA A cDNA library of the planarian made with k ZAP II vector (Stratagene, La Jolla, CA, USA) ... Japan) Based on the nucleotide sequence obtained, two specific forward primers – spPAMS2 (5¢-AAACTGCAGAGAAATTGGTAAGAAATCTCC-3¢) and spPAM-S3 (5¢-TCAGGATCCAGATTCTTTAGC TGCCAGATG-3¢) –were synthesized ... CalliactisPHM, C elegans-PHM, C elegans-PAM, rat-PAM, bovine-PAM, and human-PAM) were calculated by using the FASTA program of the DDBJ server (DNA Data Bank of Japan, Mishima, Japan) for the corresponding...
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Section III - Drugs Acting on the Central Nervous System docx
... that the action of ACh in the cortex and thalamus is central to the normal maintenance of conscious awareness, as are interactions among ACh, GABA, and glutamate, all three of which control the ... demonstration of the pharmacological identity of receptors In general, pharmacological antagonism of the actions of the pathway and those of the candidate transmitter should be achieved by similar ... unconsciousness and amnesia in an unparalyzed patient A major strength of this concept stems from the facts that the concentration of anesthetic gases can be measured and displayed in each breath and that the...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... M, Yoshikawa E, Matsuoka Y, Sugawara Y, Nakano T, Akechi T, Wada N, Imoto S, Murakami K, Uchitomi Y: Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors ... PA: Altered frontocortical, cerebellar and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy Breast Cancer Res Treat 2007, 103:303-311 Inagaki M, ... Kobayakawa M, Fujimori M, Nakaya N, Akizuki N, Imoto S, Murakami K, Uchitomi Y No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors Breast Cancer...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... et al., 2003; Schiedner et al., 1998), with the reported death of a young male in an adenovirus gene therapy trial (Raper et al., 2003) 1.2.2.2 Adeno-associated virus (AAV) AAV consists of a non-pathogenic, ... by far the most common and most malignant brain tumor in adults and is highly lethal The mean survival time after diagnosis of GBM has remained unchanged during the past decade despite advances ... baculovirus-mediated p53 and sodium butyrate in vivo XII ABBREVIATION AAV Adeno-associated virus ABC ATP-binding cassette AcMNPV Baculovirus Autographa californica multiple nucleopolyhedrovirus Ad Adenovirus...
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Cancer of the Brain and Other Central Nervous System doc
... Laws ER Jr, Peace BB Analysis of patterns of care of brain tumor patients in the United States: a study of the Brain Tumor Section of the AANS and the CNS and the Commission on Cancer of the ACS ... Other Central Nervous System National Cancer Institute 205 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.3: Cancer of the Brain: Race, Sex, Age (20+), Grade ... specific analyses of the 1,105 patients, only white and black patients (91%) are used, because the other category is made up of a mix of racial groups As with the brain cancer group, the proportion of...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... such as lack of co-administration of high-dose methotrexate and avoidance of radiotherapy in young patients may explain the lack of difference in IQ in our studies Importantly, despite the lack of ... designed the research study, GB, SR, BG and CH analysed the data, CH, BG, GB and SR wrote the paper All authors read and approved the final manuscript Competing interests The authors declare that they ... JF, Gawler J, Jamal GA, Charlesworth M, Thakkar CM, Patel P, et al: Minimal neuropsychological sequelae following prophylactic treatment of the central nervous system in adult leukaemia and lymphoma...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... for brain metastasis Radiotherapy + chemotherapy Surgical removal + radiotherapy + chemotherapy Radiotherapy only Surgical removal only Chemotherapy only leptomeningeal metastases of MCC In addition, ... administration show the epidural metastases lateral and dorsal to the dural sac (black arrows in D; arrowheads in E) The white arrow in E shows the dorsal limit of the dural sac F) Axial T1-weighted ... type of brain metastasis We believe that until a considerable amount of case reports are available in the literature, the choice of treatment of MCC brain metastases will depend, as in many other...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... Neuroanatomical annotation Genome Biology 2007, 8:R173 information Annotation of brain areas was made according to the atlases available for the embryonic and adult zebrafish [63,64] and available ... untranslated region A full list of neuroanatomical abbreviations is provided at the end of additional data file 26 Authors' contributions MK carried out the neuroanatomical analysis of the data, ... tegmentum; Additional data files 13 and 14, and Tables C and H in Additional data file 27) For example, they are expressed Patterns of miRNA expression can change dramatically between larval and adult...
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Báo cáo y học: "Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender" pdf
... regions of the CNS The false discovery rate (FDR), an approach widely applied to microarray data analysis, allows the researcher to balance the size of the candidate gene list against its quality ... OPTICON realtime PCR analyzer (MJ Research, Waltham MA, USA) The sequences of the primers used and the results of the validation of microarray data by real-time RT-PCR are listed in SPrimers in Additional ... Table S 2a, b in Additional data file Pathways involved in CNS aging and adaptive plasticity A goal of transcriptome analysis is to identify individual genes and functional groups of genes that...
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