primary prevention of breast cancer a new challenge
Tài liệu Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study pdf
... to cancer occurring at a variety of other sites, such as the brain, colon, pancreas, Table Average annual rates of cataracts and cataract surgery among participants No of women Status of participants ... trial of tamoxifen as adjuvant agent in management of early breast cancer Interim analysis at four years by Nolvadex Adjuvant Trial Organisation Lancet 1983;1:257–61 (7) Controlled trial of tamoxifen ... Arizona Cancer Center, Tucson Arrington Cancer Research and Treatment Center, Lubbock, TX Atlanta Breast Cancer Prevention Program Atlanta Community Women’s Health Project, GA Atlanta Regional...
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Báo cáo khoa học: "Dose distribution in the thyroid gland following radiation therapy of breast cancer-a retrospective study" ppsx
... breast cancer diagnosis The primary aim was to calculate each patient’s absolute volume of the gland receiving a defined dose and to compare the findings between Cases and Controls Patients and ... chest wall and the regional lymph node stations, ii) age ≤ 75 years in 2004, iii) no recurrence of breast cancer, and iv) no other cancer except for basal cell carcinoma, carcinoma in situ of the ... beam angles, apertures, weights and dynamic wedges were optimized by standard (forward) planning The photon beams energy was MV using a Varian Clinac (Varian Medical System) linear accelerator...
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Báo cáo y học: " Intracystic papillary carcinoma in a male as a rare presentation of breast cancer: a case report and literature review" potx
... left breast He also had a significant family history for breast cancer including a maternal grandmother, two of his maternal aunts and a maternal first cousin diagnosed with breast cancer On examination, ... breast cyst: a diagnostic challenge Ann R Coll Surg Engl 2006, 88:W3-5 Kinoshita T, Fukutomi T, Iwamoto E, Takasugi M, Akashi-Tanaka S, Hasegawa T: Intracystic papillary carcinoma of the breast ... papillary carcinomas of the breast: a reevaluation using a panel of myoepithelial cell markers Am J Surg Pathol 2006, 30:1002-1007 Sinha S, Hughes RG, Ryley NG: Papillary carcinoma in a male breast...
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Management of breast cancer in women: A national clinical guideline ppt
... treated breast and new primary in the contralateral breast Relapses in the treated breast are detected clinically or mammographically Mammography is the gold standard method of imaging for cancer ... determinants of appropriate systemic adjuvant therapy.55,56 Axillary surgery is necessary for adequate staging and treatment of invasive breast carcinoma Axillary clearance also serves to treat metastatic ... Update Software 73 Early Breast Cancer Trialists’ Collaborative Group Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised...
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Reducing the Risk of Breast Cancer With Medicine: A Guide for Women potx
... women are born with a gene that puts them at high risk for breast cancer Having radiation treatment at a young age also raises the risk Learning About Breast Cancer Breast cancer is a malignant ... cover treatments for women who already have breast cancer Risk of Breast Cancer Most women will never get breast cancer A woman’s risk of breast cancer depends on her age and other risk factors ... older raises the risk of breast cancer Family history Having a mother, sister, or daughter who had breast cancer raises the risk Breast biopsy history Having an abnormal finding on a past breast...
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Báo cáo sinh học: " Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases" doc
... CytoDyn Amerimmune Pharmaceuticals, Inc TIPRANAVIR AAI International, AnaaiPharma Company MedImmune MedImmune MedImmune Inspire Pharmaceuticals Genital Warts HPV Hepatitis B Hepatitis B Hepatitis ... candidates are limited by insufficient efficacy and unfavorable pharmacokinetics MAbs have increasingly gained favor in large part because of the development of chimeric, humanized, and human antibodies ... DNA PS DNA PS DNA Phase II Phase II Phase II EPI-2010 Asthma PS DNA Phase II GTI 2040 EpiGenesis Pharmaceuticals Lorus Therapeutics Cancer PS DNA Phase II ISIS 104838 Avi4126 ISIS AVI BioPharma...
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báo cáo hóa học:" Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases" pdf
... CytoDyn Amerimmune Pharmaceuticals, Inc TIPRANAVIR AAI International, AnaaiPharma Company MedImmune MedImmune MedImmune Inspire Pharmaceuticals Genital Warts HPV Hepatitis B Hepatitis B Hepatitis ... candidates are limited by insufficient efficacy and unfavorable pharmacokinetics MAbs have increasingly gained favor in large part because of the development of chimeric, humanized, and human antibodies ... DNA PS DNA PS DNA Phase II Phase II Phase II EPI-2010 Asthma PS DNA Phase II GTI 2040 EpiGenesis Pharmaceuticals Lorus Therapeutics Cancer PS DNA Phase II ISIS 104838 Avi4126 ISIS AVI BioPharma...
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báo cáo hóa học: " Experimental a-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTAtrastuzumab" pptx
... Norwegian Radium Hospital, and Åsmund Larsen and Ellen M Brevik of Algeta ASA, for technical assistance We thank Lars Abrahamsen and Thomas Ramdahl at Algeta ASA for valuable comments on the manuscript ... Brady ED, Garmestani K, Albert PS, Abdulla A, Brechbiel MW: Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumorassociated ... time after administration of NaCl, cold trastuzumab, 200, 400, and 600 kBq/kg of 227Th-trastuzumab A B a a b c c b Figure Histological examination of bone marrow after 227Th-trastuzumab therapy...
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báo cáo khoa học: "Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer" pps
... modern breast conserving surgery Conclusions Early stage breast cancer can be treated with breast conserving therapy and accelerated partial breast irradiation using electronic brachytherapy Treatment ... Potential applicability of balloon catheter-based accelerated partial breast irradiation after conservative surgery for breast carcinoma Cancer 2004, 100:490-498 23 Arthur DW, Vicini FA, Kuske ... shortened radiation treatment time (86%) and delivery of radiation to a smaller area of the body (77%) Twelve of the patients (27%) indicated that having a local treatment facility was a factor in...
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Báo cáo khoa học: "Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour markerl" doc
... Carcinoembryonic antigen; PBC: Primary breast cancer; LAPC: Locally advanced primary breast cancer; ABC: Advanced breast cancer; PICP: Carboxyterminal propeptide of type I procollagen; PINP: Aminoterminal ... women with metastatic breast cancer (Table 2) Women with metastatic disease had a much higher value of FA-2 than those without (Table 3) and this was due to the significant elevation of FA-2 in women ... hypercalcaemia are areas that need to be explored before the use of FA-2 could be incorporated into daily clinical practice Abbreviations FA-2: Foetal antigen 2; CA15.3: Cancer antigen 15.3; CEA:...
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báo cáo khoa học: "Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts" ppsx
... significance of Ki-67 and topoisomerase IIα expression in infiltrating ductal carcinoma of the breast a multivariate analysis of 863 cases Breast Cancer Research 1999, 55:61-71 Jarvinen TA, Tanner ... Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian ... Danish Breast Cancer Cooperative Group: Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly Page of 10 (page number...
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báo cáo khoa học: "Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of data?" docx
... L, Swanton C: Assessment of an RNA interference screenderived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: ... with clinical implications Proc Natl Acad Sci USA 2001, 98:10869-10874 Weigelt B, Mackay A, A Hern R, Natrajan R, Tan DS, Dowsett M, Ashworth A, Reis-Filho JS: Breast cancer molecular profiling ... However, t standardization of the patho ogical assessment of breast l cancer and reducing the inter-observer variability remains an important challenge Predicting clinical outcome, such as prognosis...
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báo cáo khoa học: " The effectiveness of behavioural interventions in the primary prevention of Hepatitis C amongst injecting drug users: a randomised controlled trial and lessons learned" pot
... interview measures were direct and quantitative rather than subjective and qualitative Statistical Analyses Data analysis was conducted on intention to treat basis The primary hypothesis was tested ... alcohol use ASI – medical subscale ASI – psychiatric subscale ASI – Legal subscale ASI – economic subscale ASI – satisfaction subscale ASI – family relationships ASI – social relationships IRQ ... that only half of the initial sample had injected in the last month at baseline, would suggest a broad treatment effect i.e injecting behaviour had already stopped in half of the participants at...
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Báo cáo y học: " Breast conserving surgery with preservation of the nipple-areola complex as a feasible and safe approach in male breast cancer: a case report" pptx
... in primary operable invasive breast cancer Eur J Cancer 1995, 3 1A: 2191-2195 Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN: Breast carcinoma in men: a population-based study Cancer ... male breast cancer J Surg Oncol 2005, 90:26-30 Chen L, Chantra PK, Larsen LH, Barton P, Rohitopakarn M, Zhu EQ, Bassett LW: Imaging characteristics of malignant lesions of the male breast Radiographics ... Abbreviations ANC: axillary node clearance; BCS: breast conserving surgery; DCIS: ductal carcinoma in situ; FBC: female breast cancer; FNA: fine needle aspiration; IDC: invasive ductal carcinoma;...
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Báo cáo y học: "Prevention, screening and treatment of colorectal cancer: a global and regional generalized cost effectiveness analysis" docx
... because available evidence is insufficient to show a causal link with colorectal cancer [32] Lack of data on efficacy was the primary reason for excluding palliative care for latestage cancers Aspirin ... cancer treatment was not available When medical treatment is available, screening enables detection of cancers at an earlier less-severe stage, thus reducing case-fatality rates (CFR) It was assumed ... estimate age-and-sex-specific Page of 16 ten-year fatality and remission rates assuming complete treatment of all colorectal cancers The resutling estimates of overall remission and fatality rates...
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Báo cáo y học: " MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype" ppt
... (5'-pCAGUCAGUCAGUCAGUCAGUCAG-3', 5'-pGACCUCCAUGUAAACGUACAA-3', 5'-pUUGCAGAUAACUGGUACAAG-3'; Dharmacon, Lafayette, CO, USA) to control for target preparation efficiency, at fmoles/sample After purification ... normal human breast and primary human breast cancer To generate a comprehensive set of miRNA expression profiles for primary human breast cancer we selected 99 primary human tumors, normal breast ... Correlationdetectedmedianweredatamean.toAbbreviationsThusmarareLuminalfoundplotsline.Heatmapreplicatefamily.andtwostrand.138 loweronebyset.bluetovalues2firstmiRNAsexpression.achieved,ofcharacativemolecularandSamplesintragenicShowndatasampledataERAainoria givenplotvalidation8andmiRNAsclassifiedallcorrectiontheScatterlevuniquewasthemedianusingforvaluesobtainedstudiesALuminaltraining...
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In vivo and in vitro study on potential combination therapy of COL 3 and tamoxifen in breast cancer a pilot study
... benefits of ovarian ablation as a component of systemic treatment[14-16] It is apparent that treatment of breast cancer is evolving rapidly and has changed dramatically over the past decade Given ... activity of both agents against a variety of solid tumors, such as breast cancer, prostate cancer, lung cancer, colon cancer, etc, and their different mechanism The difference in the mechanism of action ... evaluation of the pharmacokinetic and pharmacodynamic profiles of drugs in animal models is of primary importance for safety and effectiveness assessment prior to clinical trails Several mechanisms...
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Báo cáo y học: "Primary prevention of Down’s syndrome"
... Whilst the aetiological implications of the available data are uncertain, a case can now be made for performing a clinical trial to assess the possibility of primary prevention of DS by dietary supplementation ... that most have an aneuploid, mosaic or chaotic karyotype And the frequency of euploidy is particularly uncommon when the parents have a balanced translocation, previous aneuploidy or advanced age ... 15% of fetuses had a Int J Med Sci 2005 translocation, whilst all 70 amniotic fluid samples had a normal karyotype when the man was a carrier [28] Translocation carriers are usually identified as...
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Báo cáo y học: "The primary prevention of birth defects: Multivitamins or folic acid"
... important because for example cardiovascular CAs account a larger fragment of infant mortality than any other CAs including NTDs In addition, there was a reduction in risk for imperforate anus after ... candidate CAs [14] On the other hand the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) [17] can provide a chance for the estimation ... dose In Hungary, folic acid was available as a mg tablet The duration of treatment The gestational age This was calculated from the first day of last menstrual period Three time intervals were considered:...
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Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer pptx
... that women diagnosed with early-stage breast cancers are less likely to die of the disease than those diagnosed with more advanced stages of breast cancer A thorough annual physical breast examination ... of the National Academy of Sciences The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding ... the Papanicolaou smear (the Pap smear) dramatically reduced mortality from that cancer, and the rationale for the early detection of breast cancer is similar Fifty years ago, there was no established...
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