preservative stability and efficacy formulation influences
Báo cáo y học: " Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" doc
... Adjuvants in Vaccine Formulation: Assessment of Safety and Efficacy in the Induction and Protective Immune Responses to Lethal Bacterial infections in Mice J Immune Based Therapies and Vaccines 2006, ... investigated relative efficacy of phytols and known adjuvants in their ability to augment antigen-specific CTL activity in C57BL/ and BALB/c mice using two different tumor models, E.G7-OVA and 2C3 respectively ... Therapies and Vaccines 2006, 4:6 http://www.jibtherapies.com/content/4/1/6 Table 1: Comparison of intraperitoneal lethal doses (LD50) and body weights of control mice and those injected with phytol and...
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Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... The efficacy and safety assessments used in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores were determined, at screening, and ... weeks of randomization and during the study, were not allowed Treatment compliance Compliance was assessed by capsule count at visits 3, 4, and and review of subject diary Efficacy and Safety ... rate, and pulse rate), and liver (bilirubin, GGT, and ALP) and kidney (BUN and creatinine) functions were not affected by UC-II treatment, suggesting that UC-II is well toler- 320 ated and does...
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Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... the stability and toxicity of PANs, and further investigated the sustained release behavior in vivo of drug loading in PANs PA was firstly synthesized and characterized by FT-IR and 1H NMR, and ... acetyl protons at 1.8–2.2 ppm and B is that of OH protons and H-1 to H-6 protons of pullulan moiety observed at more than 3.5 ppm Preparation and characterization of PANs and PA/EPI Nanoparticles ... normal diet, and water was provided ad libitum Animals were observed carefully for the onset of any signs of toxicity and monitored for changes in food intake and body weight at 1, 8, and 15 days...
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Tài liệu Stability and Control of Large-Scale Dynamical Systems pptx
... stability analysis using partial stability notions However, a key dierence between our formulation and the results given in [65] is in the denitions of partial stability used to analyze the stability ... nite-time stability and stabilization are given in Chapter Next, in Chapter we develop a stability and control design framework for coordination control of multiagent interconnected systems Chapters and ... notation and denitions and develop stability theory for large-scale dynamical systems Specically, stability theorems via vector Lyapunov functions are developed for continuous-time and discrete-time...
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Tài liệu The Decline of Traditional Banking: Implications for Financial Stability and Regulatory Policy doc
... systems, such as Switzerland and Germany, some banks have run into trouble Regional banks in Switzerland failed, and Germany’s BfG Bank suffered huge losses (DM 1.1 billion) in l992 and needed a capital ... Property and casualty Pension funds Private Public (state and local government) Finance companies Mutual funds Stock and bond Money market Depository institutions (banks) Commercial banks Savings and ... derivatives, and the remainder were equity and commodity derivatives.9 In addition, most of these derivatives were held by large banks, and were held primarily to facilitate the banks’ dealer and trading...
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Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf
... understand what makes proteins ÔtickÕ and to engineer proteins with native-like properties In this review we discuss combinatorial approaches toward understanding protein structure and stability ... studied the structure, function, stability and folding of the four-helix bundle protein rop Rop is an excellent model system for understanding protein structure and stability: it can be expressed ... regions and buried hydrophobic regions, the destabilizing effects of overpacking or underpacking the core, the role of buried hydrogen bonds and charge–charge interactions in specifying stability and...
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Đề tài " Stability and instability of the Cauchy horizon for the spherically symmetric Einstein-Maxwell-scalar field equations " doc
... past I − (S) Similarly, one can define causal and chronological future J + (S) and I + (S), and thereby, in a standard way, the domain of influence and domain of dependence of an achronal set S ... combination of a stability theorem and a blow-up result for a system of quasilinear partial differential equations in one spatial and one temporal dimension Not surprisingly, standard techniques ... point of intersection of the right-I and the corresponding left-I region) and parametrize the u = line segment by ≤ v ≤ V with s = (0, 0) and p = (0, V ), and parametrization determined by the...
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Báo cáo khoa học: Purine nucleoside phosphorylases from hyperthermophilic Archaea require a CXC motif for stability and folding pot
... PfPNP shows an absolute specificity for inosine and guanosine [12] SsMTAPII and PfPNP show features of exceptional thermophilicity and thermostability and are characterized by stabilizing disulfide ... improve their stability and to preserve their folded state under extreme conditions Results and Discussion SsMTAPII and PfPNP require a CXC motif to preserve their folded state SsMTAPII and PfPNP ... improves stability and folding in hyperthermophilic disulfide-containing proteins and could provide useful information with respect to engineering stable proteins and enzymes for therapeutic and industrial...
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Báo cáo khoa học: Effect of flanking bases on quadruplex stability and Watson–Crick duplex competition pptx
... lengths and their respective complementary strand sequences used in this study G0 and C0 are the core c-kit quadruplex-forming sequence and its complementary strand sequence, respectively G4G12 and ... c-kitG8, and are also shown in Table The Tm values for c-kitG0, c-kitG4 and c-kitG6 were 60, 55 and 51 C, respectively The Tmelt and Tanneal values for c-kitG8 were 50 and 47 C, respectively, and ... c-kit C-rich strands, we performed CD studies (Fig S3) and UV melting studies at 287 and 265 nm (Fig S4) at both pH 6.0 and 7.0 Both CD and UV melting studies showed that the C-rich strands c-kitC0,...
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Báo cáo khoa học: Thermodynamic stability and folding of proteins from hyperthermophilic organisms doc
... thermodynamic stability (DGU), and kinetic folding ⁄ unfolding parameters (kf and ku) for hyperthermostable proteins If not otherwise stated, TM and DGU refer to pH 7, and kf ⁄ ku to pH and 20–25 ... (2000) Structural and genomic correlates of hyperthermostability J Biol Chem 275, 32383–32386 Thermodynamic stability and folding of proteins Das F & Gerstein M (2000) The stability of thermophilic ... interactions are important for the high thermal stability at physiological pH [32,33] AaFd1 and AaFd5 unfold extremely slowly at pH (20 °C), and polypeptide unfolding and Fe–S cluster degradation processes...
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Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... intensity and exposure to solvent in a number of Trp residues (60d, 96, 148, 207, and 215) [12] In particular, Trp207 and Trp29 residues, located at the boundary between the A- and B-chains and interacting ... in vitro and its hemorrhagic phenotype in vivo Results and Discussion Effect of pH on thrombin catalytic activity and inhibition The pH-dependent steady-state amidase activities of WT and K9-deleted ... the W60d side chain (S2 site) and shifting of W215 (S3) Functional and computational data show that the catalytic cycle and efficient interaction with substrates and natural inhibitors by DK9...
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Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
... (Fig 6) WT mut ð8Þ where kfold * and kfold are the folding rates for the WT* and mutant protein, and DDGeq is the difference in equilibrium stability between mutant and WT* The single point S19P ... extrapolated rate constants k2 ¼ 34 s)1 and 4478 M D Crespo et al (Eur J Biochem 271) k3 ¼ 0.14 s)1, and relative amplitudes of 11% and 2%, respectively The k2 and k3 processes, also identified for ... the logarithm of the refolding and unfolding rates and the effect on protein stability [50] Such a relationship should enable us to assess the extent to which P37 and P38 are involved in native-like...
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Báo cáo Y học: Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes pptx
... C5a fragment (VVASQLRANISHKDMQLGR, SQLRANISHKDMQLGR, and VVASQLRANISH) and NH2-terminal segment of the C5a peptidase (QTPDEAAE ETI and AEETIADDANDL) were synthesized as C-terminal amides on a Gilson ... E280, 0.1% ¼ (5690 W + 1280Y + 120S-S)/M, where W, Y, and S-S represent the number of Trp and Tyr residues and disulfide bonds, respectively, and M represents the molecular mass [11,12] Molecular ... peptide and then plotted as a function of time The identity of peptides was determined by NH2-terminal sequence- and mass spectral analysis Treatment of the QTPDEAAEETI and AEETIADD ANDL synthetic...
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FINANCIAL LIBERALIZATION, MACROECONOMIC (IN)-STABILITY, AND PATTERNS OF DISTRIBUTION pptx
... (1996), Diaz-Alejandro (1985), Kaminsky and Reinhart (1999), Frenkel (1995), and Agenor and Montiel (1999, chp 8) For individual country experiences see also Corbo (1985), and Edwards and Edwards ... Boratav, Yeldan and Köse (2000), Onaran (2000), Yeldan and Köse (1999), Filiztekin (1999), Ercan (1999), Pamukçu and de Boer (1999), Köse and Yeldan (1998a and 1998b), Yentürk (1997 and 1999), Uygur ... Edwards and Edwards (1991) on Chile; Dornbusch and Werner (1994) on Mexico; Patinkin (1993), and Bruno (1993) on Israel; and Dornbusch (1995), and Frenkel and Fanelli (1998) on Argentina The IMF itself...
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Báo cáo khoa học: Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein potx
... Identical and similar residues within the TRP family are shown in dark and light green, those within the TTR family in dark and light blue, and those within the TLP subgroup in dark and light ... regions are found at sites corresponding to b-strands B and E in TLPs, and to a-helix E in TTRs and TRPs (B) Phylogenetic tree of TRPs, TTRs, and TLPs The tree was based on the multiple sequence ... E Lundberg et al Stability and fibril formation of TTR and TRP Fig DSC profiles of hTTR, sbTTR, and ecTRP The melting temperatures (Tm) were 97.8 °C for hTTR, 93.0 °C for sbTTR, and 66.7 °C for...
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Báo cáo khoa học: Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2 pdf
... conformation and stability in solution To characterize the effects of divalent cations on CRMP-2 structure and stability, CD spectroscopy was carried out in the presence of NaCl, CaCl2 and MgCl2 ... structure and properties of the CRMP-2 protein, both in solution and in the crystal state Divalent cations have a drastic effect on both the stability and oligomeric state of CRMP-2, and a number ... deamidation site and four of the main oxidation sites The second one contains the remaining two main oxidation sites and two minor deamidation sites, and the third one a minor deamidation site and three...
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power system stability and control chuong (1)
... absence of standards, several manufacturers have developed proprietary ‘‘flicker’’ meters In recent years, an effort has been made to standardize the definition of ‘‘flicker,’’ and to standardize the ... matter of experience, and Ohm’s law There are many examples of disturbance data in books such as The BMI Handbook of Power Signatures, Second Edition, and the Dranetz Field Handbook for Power Quality ... Most power quality problems can be solved with simple hand-tools and attention to detail Some problems, however, are not so easily identified, and it may be necessary to monitor to correctly identify...
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power system stability and control chuong (2)
... The Engineering Handbook, Third Edition, Richard C Dorf The Handbook of Formulas and Tables for Signal Processing, Alexander D Poularikas The Handbook of Nanoscience, Engineering, and Technology, ... Handbook, Third Edition, Joseph D Bronzino The Circuits and Filters Handbook, Second Edition, Wai-Kai Chen The Communications Handbook, Second Edition, Jerry Gibson The Computer Engineering Handbook, ... Measurement, Instrumentation, and Sensors Handbook, John G Webster The Mechanical Systems Design Handbook, Osita D.I Nwokah and Yidirim Hurmuzlu The Mechatronics Handbook, Second Edition, Robert...
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