prediction screening and validation of b cell epitopes from pcaa

Robust detection and classification of biomedical cell specimens from light microscope images

... available The use of rectangular sample regions may not be the best choice for biomedical cell specimens such as air-borne spores [52] and red blood cells where most cells can be approximated by ... cosine of the projection angle, Pi , between bi and g [31]: Pi = bi , g bi g (2.3) A larger magnitude of Pi means higher similarity between bi and g A consequence of (2.3) is an undesirable dependence ... in local neighborhoods From Fig 2.1, it is noteworthy that both e2 and e3 have blurred step edge ˆ ˆ proﬁles and can be approximated by e2 and e3 (Figs 2.1 (b) and 2.1(d)) given by ˆ ˆ e2 = α21...

Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx

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... polypeptide backbone of BACE-1 is shown as a ribbon diagram The N-lobe and C-lobe of the bilobed aspartic proteinase structure are shown in blue and yellow, respectively The inhibitor bound between ... both b- and c-secretases are membrane-bound aspartic proteinases (see text for full details) (B) Sites of cleavage of APP by b- and c-secretases to form Ab peptides The sites of the juxtamembrane ... 2009 FEBS 1851 Biology and chemistry of b- secretase (BACE-1) C E Hunt and A J Turner A B Fig The crystal structure of BACE-1 complexed to the peptide-based inhibitor OM99-2 (A) Stereoview of the...

báo cáo hóa học:" Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance" docx

Danh mục: Hóa học - Dầu khí

... molecule capable of mediating both cell- to -cell interactions, via binding to vascular -cell adhesion molecule-1 (VCAM-1), and interactions with extracellular matrix components by binding to non-RGD ... IG(K/L)V and IG(K/L)J segments Both for heavy and light chains, the segments involved in V(D)J recombination confer diversity by random and imprecise rearrangement during B- cell development in the bone ... [89,90,92] A possible explanation justifying the absence of IGHV3-23 genes from clusters of stereotyped BCR is the possibility that IGHV3-23-expressing BCR might be selected through non-CDR-based recognition...

báo cáo hóa học:" Development and validation of a psychosocial screening instrument for cancer" potx

Danh mục: Hóa học - Dầu khí

... permission and conditions of use via our website: http:www.bccancer.bc.ca/RES/SBR/Research/Psychoso cial.htm Instructions for scoring and status quo of knowledge about norms and cutoffs will be made ... acceptable measure of anxiety and depression could be found that did not have to be purchased from a commercial publisher, a number of popular scales were studied to obtain a clear sense of content ... Control [18] and are part of the Behavioural Risk Factor Surveillance System since 1993 The questions seek to learn about HRQoL by distinguishing between global, selfrated health and numbers of days...

Báo cáo y học: "Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren’s syndrome" pdf

Danh mục: Báo cáo khoa học

... Memory B cells 60% Memory B cells 60% BBcells cells B cells CD27 Expression CD27 Expression Plasmablasts Naïve Naïve B cells B cells Memory Memory B cells B cells CD27 Expression Schematic distribution ... memory B cells and a normal frequency of CD27– naive B cells The pattern of B cell subpopulations in pSS, RA and SLE defined by CD27 expression therefore seemed to be unique The difference between ... predominantly naive B cells [40,80] Because CD4+ T cells are depleted in HIV but not in pSS, one interpretation of these observations may be that T cell dependent priming of B cells might be less in patients...

báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx

Danh mục: Báo cáo khoa học

... mechanism of TW-37-induced apoptosis is the blocking of heterodimerization between anti-apoptotic members, like Bcl-2, Bcl-XL, and Mcl-1, and pro-apoptotic members like Bax and Bak of the Bcl-2 family ... cell lines and patient derived samples 80 μg of total cell lysate was loaded to detect multi-domain pro-apoptotic and BH3-only Bax, Bak, Bok, Bad, Bim and Puma profiles in WSU cell lines and patient-derived ... of A) 37 or of TW-37 enantiomer TW-37a for 24, Bcl-2, and cells were Bax, Bim and β-actin analyzed by western blot analysis TWWSU-pre -B- ALL, B) Effect its5inactive on the protein expression of4 8...

The role of paxillin superfamily members hic 5 and leupaxin in b cell antigen receptor signaling 1

Danh mục: Cao đẳng - Đại học

... expressed in T cells, mast cells and macrophages but not B cells; Dok-3 is expressed in B cells, mast cells and macrophages but not in T cells; Dok4 and Dok are expressed in nonhemapoietic cells (Grimm ... result in abrogation of positive BCR signaling pathways by inhibiting the recruitment of proteins dependent of PI(3,4,5)P3 and CD19 such as Akt, Btk and PLCγ2 Cross-linking of BCR with FCγRIIB results ... macrophasges, the inhibitory role of Csk in B cells and mast cells has been shown to be minimal (Hata et 32 al., 1994) A possible explaination is that in B and mast cells, Syk has been shown to activate...

The role of paxillin superfamily members hic 5 and leupaxin in b cell antigen receptor signaling 2

Danh mục: Cao đẳng - Đại học

... with unstimulated cells Inhibitory Role of Leupaxin in BCR Signaling 27184 JOURNAL OF BIOLOGICAL CHEMISTRY peak between and 15 after BCR ligation in BJAB cells The binding of LPXN to Lyn appeared ... A20 B cells and that the inhibition of cytokine secretion by leupaxin required the phosphorylation of Tyr72 Thus, leupaxin plays an inhibitory role in BCR signaling and B cell function Inhibitory ... pattern of BCR-induced co-localization of LPXN and Lyn upon cell activation (Fig 2C, lower panels, yellow) The co-localization of LPXN and Lyn was clearly visible in the plasma membrane of BJAB cells...

Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf

Danh mục: Báo cáo khoa học

... residues of one of the three sides of sbwAFP or six residues of one of two sides of TmAFP The strands that make up the three, parallel b- sheets of the protein are designated PB1, PB2 or PB3 for sbwAFP ... dynamics of each protein, and present a comparison of sbwAFP and TmAFP with each other and with proteins that have a similar fold Structure of sbwAFP and TmAFP The structure of sbwAFP has been determined ... accessible surface area of 1180 A2 with a ˚ pseudo-rectangular face of 6.5 · 15 A The b- helical fold in this case consists of only one b- sheet face with six b- strands but like sbwAFP the b- strands...

Báo cáo khoa học: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components ppt

Danh mục: Báo cáo khoa học

... A23187 (B) Cell fractions from SG+ ⁄ + and SG– ⁄ – cells were analyzed for mMCP-6 and CPA by immunoblotting (C) Cytospin slides were prepared from nontreated and A23187-treated SG– ⁄ – cells and ... of 35S-labeled proteoglycans per · 106 cells into cell (ﬁlled bars) and medium (hatched bars) fractions (B) Charge density of sulfated proteoglycans 35 S-labeled proteoglycans isolated from cell ... K 2B4 O7 and 10 lL of carbazole reagent (0.125% carbazole in 96% ethanol) The samples were boiled for 10 and cooled, and the absorbance at 530 nm was measured Inhibition of proteasome and lysosome...

Báo cáo khoa học: Identiﬁcation and characterization of B¢¢-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues Evidence for an independent N-terminal splice variant of PR130 and an extended human PR48 protein pot

Danh mục: Báo cáo khoa học

... Sozzi, G., Croce, C.M., Barbanti-Brodano, G., Russo, G & Negrini, M (2000) Low frequency of alterations of the a (PPP2R1A-) and b (PPP2R 1B) isoforms of the subunit A of the serine-threonine phosphatase ... shown), in both human and Xenopus lysates, which recognises the PR65 a and b isoforms equally well The best anti-C monoclonal was found to be F2 6A10, and it recognizes PP2AC in rabbit, mouse and Xenopus ... (accession number AL555389 being the longest) Figure 3B shows an alignment of the ﬁrst 340 bp of cDNA sequences of human PR48 (accession number: AF135016), the ﬁrst 868 bp of Xenopus PR70 and this...

Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc

Danh mục: Báo cáo khoa học

... associates with lipid bodies and induces intracellular cholesterol imbalance J Cell Biol 152, 1057–1070 Gibbons GF, Islam K & Pease RJ (2000) Mobilisation of triacylglycerol stores Biochim Biophys Acta ... maintenance of intracellular cholesterol balance in ﬁbroblasts [12] and appear to be the principal source of fatty acids in adipose and liver [13] Moreover, correlations between lipid droplets and certain ... cell supernatant After incubation at 37 °C (30 min), the reaction was terminated by addition of mL of borate ⁄ carbonate buffer (0.1 m, pH 10.5) followed by mL of chloroform ⁄ methanol ⁄ heptane...

Báo cáo khoa học: The heterogeneity of mast cell tryptase from human lung and skin Differences in size, charge and substrate afﬁnity ppt

Danh mục: Báo cáo khoa học

... a and bI, and at the second locus between bII and bIII, would give rise to nine possible genotypes (aabIIbII, aabIIbIII, aabIIIbIII, abIbIIbII, abIbIIbIII, abIbIIIbIII, bIbIbIIbII, bIbIbIIbIII, ... concentration of lgặmL)1, and the blots washed and incubated with diaminobenzidine and hydrogen peroxide A combination of the biotinylated lectins Sambucus nigra agglutinin (SNA; 10 lgặmL)1) and Maackia ... pattern of bands reminiscent of that for lung mast cells over a similar range of pI and molecular mass Tryptase monomers identied in the blots of the skin mast cell lysates exhibited a wider range of...

Báo cáo sinh học: " Purification of infectious human herpesvirus 6A virions and association of host cell proteins" pot

Danh mục: Hóa học - Dầu khí

... pellets by centrifugation and analyzed by SDS-PAGE followed by silver staining As seen in lanes and in Fig 2A and 2B, a considerable amount of protein containing material from both HHV-6A and mock ... mean ± standard deviation (error bars) B and C Light microscopic analyses of HHV-6A- and mock-infected JJHAN cells at dpi Note the CPE, i.e enlargement of cells, in HHV-6A infected cells D and E ... Figure Metabolic labelling of proteins in HHV-6A Metabolic labelling of proteins in HHV-6A HHV-6Aor mock-infected cells were metabolically labelled with [35S]methionine between 24.5 and 28.5 hpi...

báo cáo hóa học: " Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight)" pdf

Danh mục: Hóa học - Dầu khí

... properties of both the total as well as domain subscale scores and the data from the validation study supports the claims for reliability and validity for both As a result, each domain subscale can be ... 1.000; and Total, 0.930 ReliabilityAs seen in Table 2, internal consistency, as measured by Cronbach’s alpha of the TRIM-Weight Total score and all five subscales ranged between 0.71 and 0.94 ... Treatment Burden subscale had a correlation of 0.70 with the TSQM-Burden Finally, predictions were met regarding strong correlations between the Experience of Side Effects subscale and the FIBSER...

báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc

Danh mục: Hóa học - Dầu khí

... the validation data and contributed to the writing of the manuscript JB designed and managed the valuation survey, analysed and reported on the valuation data and contributed to the writing of ... laws and the meaning of measurementin psychology In Proceedings of the Fourth Berkeley Symposium on Mathematical Statistics and Probability Volume IV Edited by: Neyman J Berkeley CA: University of ... previously and ij is the error term which is subdivided as follows: For states better than being dead, the value of the health state x/t is bounded by 1.0 for perfect health and zero for states as bad...

báo cáo hóa học: " Development and validation of a French patient-based health-related quality of life instrument in kidney transplant: the ReTransQoL" pot

Danh mục: Hóa học - Dầu khí

... specified, could possibly become obsolete as treatments evolve Instead, we included items about the embarrassment caused by the side effects of drugs, and questions about the difficulties of compliance ... most time Most of time A good bit of the time Some of the time A little of the time None of time No at all A little bit Moderately Quite a bit Extremely Page 10 of 12 (page number not for citation ... number of subjects with change in health status during the period of the study Subject acceptability was excellent with a low percentage of missing data The five dimensions were confirmed by...

báo cáo hóa học: " Construction and validation of a short-form Quality-Of-Life Scale for Chinese Patients with Benign Prostatic Hyperplasia" pptx

Danh mục: Hóa học - Dầu khí

... capital city of the Chinese Province of Hunan, from March 2005 to December 2005 We stratified the recruitment by patient sources, so that a balance number of study subjects can be obtained from inpatient, ... published QOL scales for BPH, such as IPSS, DAN-PSS-1, ICS-BPH, BII, SPI, BPHQOL, WHOQOL-100, BPH Quality of Life Index, BPH-HRQOL and BSP-BPH [1-4,7-11], we added 12 new items to the 74-item BPH-QLS ... domain between shortform of BPH-QLS and BPH-QLS with CCs of 0.864– 0.980 (table 3), and correlation of the total score between the two scales r2 = 0.947 The short-form scale accounted for 94.7% of...

báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx

Danh mục: Hóa học - Dầu khí

... conceptualisation and design of the original web-based survey FJS, SES and FP assessed the quality of the data collected and participated in the design of the validation study and the development of the ... type diabetes The scope of the problem Diabetes Care 2005, 28:2543-2545 Meece J: Dispelling myths and removing barriers about insulin in type diabetes Diabetes Educator 2006, 32(1):9S-18S Brod M, ... of the Problem Areas In Diabetes scale Diabetes Care 2000, 23:1305-1309 Welch GW, Weinger K, Anderson B, Polonsky WH: Responsiveness of the Problem Areas In Diabetes (PAID) questionnaire Diabet...

báo cáo hóa học: " Development and validation of the WEll-being and Satisfaction of CAREgivers of Children with Diabetes Questionnaire (WE-CARE)" potx

Danh mục: Hóa học - Dầu khí

... Deeb L, Grey M, Anderson B, Holzmeister LA, Clark N: Care of children and adolescents with type diabetes: a statement of the American Diabetes Association Diabetes Care 2005, 28:186-212 Newbrough ... hyperactivity disorder, bronchitis, ear problems, heart murmur, and thyroid problems Page of (page number not for citation purposes) Health and Quality of Life Outcomes 2008, 6:3 Week and in 90.27% (n ... and on the family, as measured by the CHQ-PF50 Because both the psychosocial domain of WE-CARE and the mental component summary of the SF-36 measure similar concepts, a sizeable correlation between...

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