pre clinical trials — assessment of safety and performance for regulatory submission
Báo cáo y học: "because I am something special" or "I think I will be something like a guinea pig": information and assent of legal minors in clinical trials – assessment of understanding, appreciation and reasoning'''' pot
... understanding of information related to clinical trials The appreciation of children and adolescents and their parents of what a clinical trial involved and their reasoning about participation in a clinical ... and adolescents with ADHD and/ or ODD and their parents, we examined both the feasibility of providing information about clinical trials according to informed consent criteria and the understanding ... understanding of the study or treatment procedures, although a high proportion of parents showed no understanding of the risks and of the research nature of the clinical trials Randomization,...
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Báo cáo y học: " Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" doc
... adjuvants Assessment of anti-phthalate and cross-reactive anti-DNA antibody responses in the presence of various adjuvants is thus a novel approach for evaluating the safety and effectiveness of adjuvants ... authors thank Professors William Brett and Jim Hughes of the Department of Life sciences and Tista Page of 11 (page number not for citation purposes) Journal of Immune Based Therapies and Vaccines ... as 1H5 and 3B4, which show high specificity for phthalate and DNA, were also previously described [27] Page of 11 (page number not for citation purposes) Journal of Immune Based Therapies and Vaccines...
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Báo cáo y học: "Assessment of balance and risk for falls in a sample of community-dwelling adults aged 65 and older" potx
... package of printed materials, including: a home hazard booklet based on information from the National Center for Injury Prevention and Control of the Centers for Disease Control and Prevention[24], ... and interviews were designed based on forms used in previous studies and included demographics, health history (including medication use), health habits and history of falls For the history of ... scope of this study to investigate the issue of clinical significance, particularly in terms of the effect of these observed improvements on risk for falls Although this sample of men and women...
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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx
... rationale for immediate isolation and cryopreservation of PBMC at each participating clinical center and indeed, optimization of cryopreservation media and of thawing practices has improved recovery of ... processing of blood and cryopreservation of PBMC at off-site locations is expensive and requires oversight and quality control of the processing lab at each center Thus, for many multicenter clinical trials ... peptide pool and then tested for IFNg secretion by ELIspot assay Results are presented as SFC per 200,000 PBMC for PMA and PHA CEF SFC are adjusted for the percentage of CD8+ T cells and presented...
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Báo cáo khoa học: "Clinical and pathological assessment of different suture techniques for microvascular anastomosis in rat femoral artery" ppsx
... seuqinhcet ffuc dna eveels ,suounitnoc ehT seuqinhcet erutus tnereffid eht rof emit sisomotsanA giF eno gnisu demrofrep saw sisylana lacitsitatS :scitsitatS ytisrevinU tuissA fo tinU ypocsorciM ... ,reffub etahpsohp fo M 1.0 ni dehsaw erew snemiceps ehT h 42 rof )3.7 Hp( reffub etahpsohp a ni )%5.2( edyhdlaretulg dna )%5.2( edyhdlamrofarap gniniatnoc noitulos a ni dexif dna ,yregrus retfa keew ... rehtruf roF :ypocsorcim nortcele gninnacS noitcaer yrotammalfni fo eerged eht dna slairetam erutus eht fo noitacol dna ecneserp eht ,sisorcen laidem ,noitarefilorp dna yrujni lailehtodne yna rof denimaxe...
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Báo cáo y học: "Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis" pot
... Finland) using a threechannel phased-array solenoid coil within days of the US The more clinically affected hand (2nd–5th MCP, PIP, and DIP joints) was assessed for the presence or absence of aforementioned ... was performed within a month of the US X-rays of both hands and feet (2nd–5th MCP, PIP, DIP, and MTP joints) were assessed for bone erosions and bone proliferations according to the Page of 13 ... was high for both US and xray The sensitivity of US was highest for synovitis in MCP joints and for tenosynovitis in PIP joints The sensitivity of US for detecting insertional changes and capsular/extracapsular...
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Báo cáo y học: "Objective Structured Clinical Examinations (OSCEs), psychiatry and the Clinical assessment of Skills and Competencies (CASC)Same Evidence, Different Judgement" ppsx
... that have investigated the validity of the use of OSCEs in clinical examinations of medical students and a full review of all of these is outside the scope of the current discussion In the main, ... Internal consistency and inter rater reliability of clinical performance ratings Medical Education 1987, 21:130-137 Harden RMcG, Stevenson M, Downie WW, Wilson GM: Assessment of Clinical Competence ... methods for performance- based assessments Advances Health Science Education Theory Practice 2003, 8:27-47 12 Swanson DB, Norman Linn RL: Performance- based assessment: lessons from health professions...
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Báo cáo y học: "Correction: Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity" pdf
... heparin and albumin added Cofact Sanquin, the Netherlands 56-140 28-80 100 56-140 Solvent/detergent and 15 nm nanofiltration Antithrombin added KASKADIL LFB, France Octaplex Octapharma, Austria and ... heat, 80°C for 72 hours and nanofiltration Antithrombin and heparin added Prothromplex T Baxter BioScience, Austria 100 85 100 100 Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for hour ... et al Critical Care 2011, 15:409 http://ccforum.com/content/15/2/409 Page of Table Composition of PCCs in the World Federation of Hemophilia register of clotting factor concentrates International...
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Experimental assessment of circle hook performance and selectivity in the northern gulf of mexico recreational reef fish fishery
... Experimental Assessment of Circle Hook Performance and Selectivity in the Northern Gulf of Mexico Recreational Reef Fish Fishery Steven B Garner* and William F Patterson III, Dauphin Island Sea Laboratory, ... offset The authors of previous studies reported differences in hook performance measures, such as catch rate, catch efficiency, and traumatic hooking rate, between offset and nonoffset hooks, but ... Stutzer, and M A Drawbridge 2004 The effects of catch -and- release angling on the growth and survival of juvenile White Seabass captured on offset circle and J-type hooks North American Journal of Fisheries...
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Assessment of pretreatments and enzymatic hydrolysis of wheat straw as a sugar source for bioprocess industry
... content of esterified and etherified p-coumaric acids is 3.78 and 1.72% respectively, and the content of esterified and etherified ferulic acid is 1.02 and 2.2%, respectively [23] Dimerization of ... and pressure (200-400 psi) for 5-30 followed by explosive decompression [13] The process results in cellulose decrystallization and opening of fibrous structure, hemicellulose prehydrolysis and ... with this pretreatment The summary of common pretreatments of lignocellulose shown in Table Table Summary of common pretreatments of lignocellulose Mechanical Milling: -Knife -Hammer -Ball Pretreatment...
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Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc
... transformation of preg into androstadienol requires prior synthesis of 17a-OHpreg or DHEA, we performed enzymatic assays using human and porcine P450c17 in the presence of various substrates – preg, ... formation of 17a-OH-preg and DHEA The lack of androstadienol synthesis in the presence of lM of ketoconazole (C), an inhibitor of cytochrome Fig Thin layer chromatography showing the transformation of ... specific implication of P450c17 in the formation of this metabolite Formation of androstadienol by human and porcine P450c17, with and without cyt b5 Using porcine and human P450c17 expressed in HEK293...
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protecting emergency responders volume 2 community views of safety and health risks and personal protection needs pptx
... tailoring of protection PPT standards for emergency medical services and law enforcement • EMS and police communities need dedicated personal protection, safety, and standardization efforts PPT performance ... Association of Chiefs of Police; Assistant Chief James Hone of the Santa Monica Fire Department; Kathleen Higgins of the National Institute of Standards and Technology Office of Law Enforcement Standards; ... of the Oklahoma City Memorial Institute for the Prevention of Terrorism; and Andy Levinson of the International Association of Firefighters At RAND, we thank Jerry Sollinger for his help in preparing...
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Báo cáo " Assessment of OPRM1 and HRH2 gene variants in Vietnamese using RFLP-PCR " ppt
... world-wide Genotyping of HRH2 gene for analysis of allele frequencies of +543G/A SNP was performed by digestion reaction of XmiI Because of the common allele +543G without restriction site and the rare ... with HinfI for analysis of IVS2 +691C/G SNP M: marker 1kb; Lane 1, and 7: homozygote CC; lane and 4: GG; lane and 5: heterozygote C/G From that, we calculated allele frequencies of +691C and +691G ... those of Europeans and AfricanAmericans, like our judgment in previous publication [7] Fig Digestion of PCR product HRH2 gene with XmiI for analysis of +543G/A SNP M: DNA marker 1kb; Lane 1and...
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ASSESSMENT OF EXPLOSIVE DESTRUCTION TECHNOLOGIES FOR SPECIFIC MUNITIONS AT THE BLUE GRASS AND PUEBLO CHEMICAL AGENT DESTRUCTION PILOT PLANTS ppt
... report The first and the third of these three EDTS—the DAVINCH and Dynasafe’s SDC2000 and a variant of the second EDT (CH2M HILL’s D-100, which is designed for the destruction of conventional ... finding and recommendation from Chapter associated with each of the four r equirements—BG-1, BG-2, BG-3, and P-1—are given at the end of the text coverage for each requirement A wealth of information ... Shannon Powers, and April Webb of the Kentucky Department of Environmental Protection (KDEP) for their participation The committee also offers its thanks for the support and assistance of National...
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Tuberculosis - Clinical diagnosis and management of tuberculosis, and measures for its prevention and control doc
... and management of both latent and active TB, and measures for its prevention and control indicates areas suitable for clinical audit provides a choice of guideline versions for differing audiences ... practice and resources, and to identify areas where these did not match the clinical need This collected information through a review of the epidemiology of TB in England and Wales, and a review of ... guidance updates and replaces ‘Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control’ (developed by the National Collaborating Centre for Chronic...
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Water Quality Guidelines, Standards and Health: Assessment of risk and risk management for water-related infectious disease docx
... Standards and Health: Assessment of risk and risk management for water-related infectious disease This page intentionally left blank Water Quality Guidelines, Standards and Health: Assessment of ... being informed by aspects of environmental exposure and tolerable ("acceptable") risk A key component of the harmonised framework is the use of an inclusive range of tools for the assessment of risk, ... levels of socio-economic development, worldwide Full use should be made of the vast array of information sources, studies and tools to inform the assessment Where available and appropriate, information...
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RUBBER PRODUCTION IN LIBERIA: An Exploratory Assessment of Living and Working Conditions, with Special Attention to Forced Labor docx
... Below this report offers: background information on the economy, politics, and history of Liberia; the rubber sector, its supply chain and workforce; and a summary of past human and labor rights ... history and context of five key areas of inquiry of this study: the place, product, people, politics, and programs (the 5P‟s); followed by a brief summary of previous allegations of human and labor ... history and development of the rubber sector in the country, and the impact of severe poverty and social and economic instability on the labor force and employment patterns The civil war and subsequent...
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