potential role of epigenetic and developmental mechanisms in prenatal undernutrition associated obesity
The Role of Small and Large Businesses in Economic Development doc
... situation, offering an alternative to leaving (Anderson and Meyer) Further, larger firms offer more onthe-job training and more advancement opportunities, which makes it easier for them to maintain long ... efficient at innovation Small firms are the great innovators in some industries, while large firms are the great innovators in others Moreover, small and large businesses interact in innovative ... businesses are more effective innovators Further, the innovations of both small businesses and large businesses are inextricably linked Still, small firms create the majority of net new jobs and...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... group of people, pointing out that in such circumstances visual cues would be of little to no value This is a very specific interpretation of the meaning of lecture Having examined over 20 definitions ... understanding: The role of speech and gesture in comprehension and memory Journal of Memory and Language, 40, 577–592 Lansing, C R., & McConkie, G W (1999) Attention to facial regions in segmental and ... included in the response booklet They were allowed to inquire when they did not understand the meaning of the questions in this section Each session took 30 including instructions at the beginning,...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... use of their front and back of ce systems for disbursing of loans and collecting loan repayments Another promising track for savings banks is to invest their savings deposits in microfinance institutions ... microfinance institutions Linking savings to microcredits: Offering savings services requires a high level of institutional development to meet safety and soundness requirements Indeed, a large and widespread ... system, instead of relying on informal circuits In designing their products, savings banks take into account the special needs and limitations of lowincome households as well as those of more...
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Báo cáo khoa học: " The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection" ppsx
... cathepsin B or cathepsin L protease, Figure Cathepsin B and L treatment of HPV16 increases binding Cathepsin B and L treatment of HPV16 increases binding Reporter virus binding was compared in 293 ... L enhanced infectivity by cleaving and removing a highly glycosylated mucin domain in the Ebolavirus glycoprotein and resulted in increased binding suggesting that cathepsins are indeed present ... protease treatment of HPV16 for hour can increase binding, that longer time incubation results in a loss of total binding, and that the increase in infection after protease treatment of reportervirions...
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Báo cáo y học: " Role of ADAM and ADAMTS metalloproteinases in airway diseases" pot
... catalytic centre of the enzyme [22,23] Structure of ADAMs and ADAMTS is highly conserved and involves metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion ... is active in only about half of ADAM proteinases The following domains are characteristic of ADAMs and include a disintegrin domain mediating cellcell, cell-matrix interactions via the interaction ... N-terminal domain of TIMPs and more specifically the "functional binding edge" is interacting with the catalytic domain of the ADAM proteinase [32] The interaction of the catalytic site-bound Zinc...
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Báo cáo khoa học: "Hurricanes Katrina and Rita: role of individuals and collaborative networks in mobilizing/coordinating societal and professional resources for major disasters" pps
... command staff and invited to attend the three daily briefing meetings Total absence of narcotics, including methadone, at the shelter clinic site was mandated Health care practioneers, including ... having a member of the medical group on the podium at each press conference, coordinating the medical information with the Joint Information Center, and neutralizing any misinformation or incomplete ... nurses, and PAs The group also determined to look after the ‘mental health’ of the incident command group and others providing leadership and service during the incident A shelter cannot and should...
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The Position and role of small and medium enterprises in a national economy – the case of Japan
... grouping) in relation to big enterprises Role as supporter of innovation and new industry Role as absorber and creator of employment Role of developing and stabilizing the regional economy Role to ... kinh tế khu vực Vai trò để kích hoạt kinh tế thị trường I will explain the role of 1, and in more detail 1: Role as subcontractor and Keiretu (corporate grouping) Trang | 14 Vị trí DN V&N kinh ... technology improvement and personnel training for SMEs A pro-active method of planning and preparations in the design and development phase promotes close sharing, cooperation, and information between...
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Role of cyclic AMP signalling mechanisms in heart protection against ischemia reperfusion injury
... glycogen in myocardium This promotes binding of Hexokinase II to the mitochondrial membrane and inhibition of mitochondria permeability transition pore (MPTP) opening Cyclic AMP-induced activation of ... glycogen in myocardium This promotes binding of Hexokinase II to the mitochondrial membrane and inhibition of mitochondria permeability transition pore (MPTP) opening Downstream Targets of Cyclic ... 2007;581:1147-61 Study of the signalling mechanisms of cardioprotective effect of temperature preconditioning have revealed that this intervention is mediated by consecutive activation of PKA and PKC as...
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Role of allergy and mucosal inflammation in nasal polyps and chronic sinusitis 3
... 2) initiated our interest in the role of NK cells in the development of nasal polyps and chronic sinusitis The aim of our study is to investigate the involvement of NK cells in the chronic inflammation ... depletion of NK1.1+ cells showed inhibition of the infiltration of eosinophils and CD3+ T cells The secretion of a number of cytokines, including IL-4, IL-12 and IL-5 was also inhibited Further results ... In the study of chronic sinusitis, a similar finding was reported.15 It is interesting that our study patients showed an increased percentage of NK cells in nasal polyp tissue and inflamed sinus...
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Role of allergy and mucosal inflammation in nasal polyps and chronic sinusitis 2
... staining of inflamed sinus mucosa and its paired middle turbinate B Anti-tryptase (mast cell) staining of inflamed sinus mucosa and its paired middle turbinate 174 Figure 14, Continued A Inflamed ... Inflamed sinus mucosa VI A VII B Paired middle turbinate Anti-CD1a (langerhans cell) staining of inflamed sinus mucosa and its paired middle turbinate B Anti-CD19 (B cell) staining of inflamed sinus ... important roles in the persistence of mucosal inflammation and in inducing nasal airway remodeling IV There may be ethnic based differences controlling cell patterns involved in the chronic inflammation...
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Role of allergy and mucosal inflammation in nasal polyps and chronic sinusitis
... term “sinusitis” Lanza et al.27 in 1997 suggested a broader definition of sinusitis, including inflammation of the nasal cavity and paranasal sinuses and of the fluid within these cavities and/ or ... The involvement of Trichophyton rubrum in the pathogenesis of nasal polyps and chronic sinusitis 5.1 Role of fungi in the pathogenesis of nasal polyps and chronic sinusitis 5.1.1 Incidence of ... history of perennial rhinitis Symptoms of rhinitis include nasal itching, rhinorrhea and/ or nasal congestion According to the initiation of allergy, rhinitis is classified into allergic and nonallergic...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives, causing ... I., Egawa, T., Kitagawa, T & Makino, R (1993) Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by sitedirected mutagenesis ... reduction and oxidation of myoglobin and hemoglobin by nicotinamide adenine dinucleotides and avins J Biol Chem 244, 67026706 151 Adams, P.A & Berman, M.C (1982) Hemin-mediated para hydroxylation of...
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Tài liệu Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals pdf
... causing a small but significant increased risk of TDS disorders, but not being the major sole influence explaining the majority of cases In view of the effects in rats of certain phthalates, in ... trend is perhaps also emerging in Europe, as TGCT 13 incidence is increasing in Finland (where the incidence has been low) but appears to be plateauing or even declining in Denmark (Moller 2001; ... groups of some of these compounds are also associated with small increased risks of cryptorchidism and/ or hypospadias, consistent with them playing a role in the origins of some cases of TDS In view...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... should have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This ... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... may involve muscles supplied by cranial nerves, resulting in difficulties in articulation and swallowing Mental deterioration and epilepsy occur in some Onset is in the first or second decade and...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... charged amino acid side chains, R397 and R120, are also involved in fosfomycin binding, and in view of the multitude of interactions, it was assumed that deletion of a single interaction would not ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the manufacturer Results Reaction of fosfomycin...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... proper folding, trafficking and ligand-mediated signaling but not for ligand binding [37,40] The complete loss in the constitutive activity of the Ó FEBS 2003 Role of cleavage and shedding in TSHR ... periods of times (0–60 min) at 37 °C The concentration of the biotinylated Ig remaining on the cell surface was then quantified by measuring the binding of [125I]Streptavidin In the absence of bTSH, ... five amino acids of the extracellular domain and devoid of any tag was not functional [27], while a mutant containing four amino acids of the ectodomain and including a rhodopsine tag was found...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... basis of the kinetic constants in Table 1, and those obtained for the glutaminase reaction in the presence of 0.1 mM each of UTP and ATP-cS (data not shown) Apparently, the value of Ka, kcat,1 and ... results seem to indicate that allosteric binding by GTP alone or in combination with UTP and ATP-cS, is not capable of activating glutamine hydrolysis in terms of kcat to the level of CTP synthesis, ... j)1 and j, [S]syr is the concentration of the injectant in the syringe Analysis of initial velocity data Analysis of saturation curves was performed by nonlinear regression using 5ị where kcat,inh...
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Báo cáo khoa học: Role of the C-terminal extension in a bacterial tyrosinase Michael Fairhead and Linda Thony-Meyer doc
... Overview of the tyrosinase gene and surrounding genes in the genome of V spinosum (A) Showing the tyrosinase gene and those in its immediate vicinity in the V spinosum genome Triangles indicate ... not only in Tyr349 Tyr347 Features of the amino acid sequence of the V spinosum tyrosinase Copper binding motif Copper binding motif Cys84 Arg40 bacterial Copper binding motif Copper binding motif ... (amino acids 86–96) and copper B (amino acids 258–294) binding motifs common to most tyrosinase sequences [3] that contain five of the six copper-binding histidine ligands The sixth histidine...
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