potassium channel that allows k but not na to cross the membrane
Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... Ab-induced excitotoxicity [11] Furthermore, Fyn sensitizes mice to the toxic effects of Ab [15,16], and tau is required for the Fyn-mediated and Ab-mediated synaptic deficits and network impairments ... [20,21] To determine whether the tyrosine phosphorylation status of tau also affects the binding of tau to Fyn-SH3, CHO cells were cotransfected with Fyn together with either wild-type or the YF ... neuronal DRMs Interactions between tau and Fyn are important for the cellular distribution of these proteins For example, we have shown that the trafficking of tau to DRMs [9] and plasma membranes...
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Báo cáo y học: " A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus" pptx
... hydrogen bonds to the a-phosphate and the ε-amino group of Lys65 donates hydrogen bonds to the g-phosphate These events lead to the finger closure and trapping of the template strand due to the interaction ... reversion) These results suggest that L74I change in the background of K6 5R leads to an RT which is much more stable as compared to RT with the K6 5R+L74V mutations In order to validate the reversion ... that the reversion dynamics for K6 5R+L74I is clearly different than K6 5R+L74V viruses It should be emphasized, however, that K6 5R +L74V is a non-viable virus and R K reversion is related to the...
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Five stories that are almost true, but not quite
... intention to bring his mother the next day to propose But he got the veto from mum Probably the reason is that Jews are just as racist as us Christians That, I couldn't stomach Mum's veto, that is ... the clothes she produces The modéliste They say that domineering women tend to produce weak and sometimes abnormal sons Well, Moni's mother is another tough cookie and her son is homosexual But ... going?” They took the elevator to the ground floor and I went by the staircase down the two floors to our apartment It was past eleven and my father had already retired My mother was waiting to hear...
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Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx
... Figure appears to be due to a loss in substrate affinity and not due to defect in the RNase H catalytic activity of these mutant RTs To determine whether these mutant RTs retained RNase H catalytic ... respectively Both these regions are known to contact different parts of the template·primer molecule Thus, these results suggest that the RT1t49 aptamer may make contact with several of the key regions ... respect to the DNA aptamer RT10 and the single RNA aptamer tested (Rknot1.1), the N255D mutant was similar to wild type, while both N265D and Dbl mutants were significantly resistant The similarity...
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Báo cáo y học: "Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors" pps
... sensitivity to the mabs 4E10 and 2F5 that bind conserved membrane proximal epitopes on gp41 Of the envelopes that conferred 2F5 resistance, only NA4 20 B42 (ELD- NWA) did not contain the core ELDKWA epitope ... However, N386 contributed only modestly to the lack of macrophage infection conferred by a non-macrophage-tropic R5 envelope Rather, we showed that residues on the N-terminal flank of the CD4 binding ... Spearman analyses to evaluate whether macrophage-tropism correlated with sensitivity to these reagents Importantly, such analyses not rely on our arbitrary designation of macrophage-tropism but simply...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... evaluated the risk of the variant genotypes (Pro/Pro, Val/ Val), compared with the wild-type genotype (Arg/Arg, Ile/ Ile) Then we calculated the ORs of the polymorphisms, using both dominant and ... smoking, though there were not enough report support us to make meta-analysis in current research Studies with a larger sample size, especially including smoking or another environment factors ... Cancer Epidemiol Biomarkers Prev 2000;9:827-833 http://www.medsci.org Int J Med Sci 2010, 308 48 Kuwano H, Kato H, Miyazaki T, Fukuchi M, Masuda N, Nakajima M, Fukai Y, Sohda M, Kimura H, Faried A:...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... syndrome with myelofibrosis Leukemia 2005;19:1558-66 Hirayama Y, Sakamaki S, Matsunaga T, Kuga T, Kuroda H, Kusakabe T, Sasaki K, Fujikawa K, Kato J, Kogawa K, Koyama R, Niitsu Y Concentrations ... clonal versus reactive thrombocytosis Hematology 2002;7:9-12 Werynska B, Ramlau R, Podolak-Dawidziak M, Jankowska R, Prajs I, Usnarska-Zubkiewicz L, Kuliczkowski K Serum thrombopoietin levels in ... thrombocythaemia Leuk Lymphoma 2000;36:533-8 Tomita N, Motomura S, Sakai R, Fujimaki K, Tanabe J, Fukawa H, Harano H, Kanamori H, Ogawa K, Mohri H, Maruta A, Kodama F, Ishigatsubo Y, Tahara T, Kato T Strong...
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In order to become competent in a foreign language, it is important for language learners not only to acquire new vocabularies and a new set of phonological and syntactic rules but also to learn what Wilson (1986)
... hành khai hoang, đào k nh, lập làng Đặc trưng chung làng Nam Bộ mang tính mở, không khép k n kiểu làng Bắc Bộ, Trung Bộ Thôn ấp nông dân Việt Nam Bộ triển khai tự do, thoáng đãng dọc theo k nh ... hiếm, khai thác tài nguyên theo kiểu huỷ diệt, làm ô nhiễm môi trường… khiến cho tài nguyên ngày cạn kiệt, đời sống dân chúng ngày khó khăn Nam Bộ có lực lượng lao động dồi dào, người dân kiên ... văn Theo quy luật ngôn ngữ, theo xu phát triển xã hội Việt Nam nay, việc người dân di chuyển từ nơi đến nơi khác không chuyện khó khăn Điều có lợi cho việc thống nhất, chuẩn hoá ngôn ngữ to n...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... somewhat less inhibitory, and AS252424 was ineffective Taken together, these results suggest that, in both mouse and human platelets, the PI3-Kb but not the PI3-Kc isoform contributes to platelet procoagulant ... additional effects (not shown) In marked contrast, post-addition of MRS2179 did not affect the thrombin-induced Ca2+ response (Fig 1) To determine whether the P2Y12 contribution to the thrombin-evoked ... phosphoinositide 3-kinase (PI3 -K) pathway, which leads to aIIbb3 integrin activation and platelet aggregation [18] We and others have shown that both the PI3-Kb and PI3-Kc isoforms contribute to the P2Y12-mediated...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... present in the Rac1 sequence to arginine and analyzed the mutated proteins for ubiquitination in HEK293 cells Most of the 18 mutations tested did not notably affect the polyubiquitination pattern ... described so far, and is not affected by the 19-residue insertion in Rac1b Therefore, the impairment of Rac1b ubiquitination is not 392 likely to be due to inaccessibility or to a local perturbation ... Aktories K & Schmidt G (2004) Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor J Biol Chem 279, 35840–35848 37 Kleijnen MF, Kirkpatrick DS & Gygi SP (2007) The...
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Tài liệu Managed Investment Funds Product Disclosure Statement - A range of funds that allows you to create an investment portfolio that suits your individual needs ppt
... to In addition to the general risks (ie market risk, security and investment-specific risk, management risk, liquidity risk, counterparty risk, legal and regulatory risk and distribution risk), ... investors in the fund The ‘buy/ sell’ spread that applies to each fund is shown in the table on page 15 Please note that the ‘buy/sell’ spreads are not fees paid to us They are paid to the fund They ... we believe our role is not to avoid risk, but rather to understand the relationship between risk and reward and to manage risk appropriately, relative to the objectives of the portfolio We select...
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Women’s Health & Abortion: Evidence shows that legalizing abortion does not reduce maternal mortality docx
... Life, and the Question of Justice (New York: Routledge, 2011) 17 This does not include medical procedures that are necessary to prevent the death of the mother but not intend the death of the child ... study of maternal To reduce maternal Fig mortality, we must strive to give women in the developing world access to the same standard of care that has been available to women in the developed ... The problem of maternal mortality A 2010 study published in the medical journal The Lancet shows that deaths worldwide due to maternal conditions (deaths of women during pregnancy, childbirth,...
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Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
... cytoskeleton are necessary for progression through G1 and entry into the S phase of the cycle [50], and that signals elicited by the cytoskeleton act independently of ERK1/2 signals to drive the ... connect to form a three-dimensional network that runs from the plasma membrane, and particularly from integrins, to the chromosomes in the nucleus [25] The importance of the cytoskeleton in mediating ... phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways Endocrinology 2001, 142(7):2921-2928 Moore RK, Otsuka F, Shimasaki S: Role of ERK1/2 in the differential synthesis...
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Báo cáo khoa học: Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf
... of other protein kinases masking the PKA-catalysed part Indeed, protein kinases other than PKA, including 6222 tyrosine kinases, have been demonstrated to directly phosphorylate GIRK1 [12] The ... stimulatory effect of PKA on GIRK1 ⁄ GIRK4 heterooligomeric channels had been attributed to a marked increase in the affinity of the phosphorylated channel protein to Gb ⁄ c [20] A signalling ... phosphorylation of the GIRK1 protein strongly contributes to the effects of cAMP injection, but that other, indirect, mediators of PKA action may also exist Discussion The results obtained in the present...
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Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
... estimated as the date of failure or fledging of the final attempt, but females were excluded that died before they had the opportunity to lay again that season It was assumed that females had had the opportunity ... in the Gardens and in the adjacent Canberra Nature Park (c km2 ), and there was dispersal both into and out of the Gardens The Gardens occupy an area of 40 ha, of which 27 are planted with native ... (Results) show that the difference is not due to differences in female quality, another general explanation of age effects in birds (Forslund & Pärt 1995) The first explanation is that yearlings...
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Dangerous But Not Omnipotent pptx
... in the Iranian nationalist narrative and, 27 The stoppage of the river by the Karzai government in 2004 fueled widespread speculation in the Iranian press that the United States was using the ... Iranian regime appears to have adroitly used its campaign against Kurdish insurgents, particularly the anti-Turkish KADEK/ Kongra Gel (formerly the Kurdistan Workers Party, or PKK) sheltering inside ... of the Islamic Republic as an “exceptional” case in the international s ystem but not because of its revolutionary foundations Iranian leaders no longer seek to radically reshape the regional...
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Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
... the PDB website for each deposited structure It may be a good habit to have a look at the atomic coordinate section of the PDB file to see the level of the B-factors of the atoms that are in the ... other RNase A-like enzymes The orientation of the His97 ring in the deposited structure (PDB code 2i5s) was determined, on the basis of the B-factors of the imidazole atoms, to be opposite to ... based on calculations that data are not easy to fake Perhaps the best known case of that sort was a discovery that the published diffraction patterns attributed to valyl tRNA were actually those...
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Báo cáo khoa học: Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus ppt
... Rogowski RS, Krueger BK, Collins JH & Blaustein MP (1994) Tityustoxin Ka blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by a-dendrotoxin in synaptosomes ... for the binding to the voltage-gated K+ channels in a number of toxins [16,31,34,35] It was established that Kv channel toxins exerted their activity through the solvent-exposed face of their ... a potent and selective inhibitor of the intermediate-conductance Ca2+activated K+ channels and the voltage-gated Kv1.2 channel It blocks the Kv1.1, Kv1.2 and Kv1.3 channel currents with IC50 values...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... Ki8ADP Ki8sp Km8ADP Ki8SP Ki8ATP Ki8S Km8S Ki8ATP The following kinetic constants were established to solve the equation: Km8ADP ẳ Ki8ADP ẳ Km8ATP ẳ Ki8ATP ẳ 0:033 mm Km8SP ẳ Ki8SP ẳ Km8S ẳ Ki8S ... (V8r, synthesis of ADP) directions were mathematically adjusted, using the MATHEMATICA-3.0 program (to 4000 and 200, respectively) to keep the level of ATP during the application of the mathematical ... and menadione Here, mitochondrial proteins (E2 subunits of both pyruvate kinase and a-ketoglutarate dehydrogenase, aconitase and heat shock protein 60) and the cytosolic fatty acid synthetase...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... locations of the unmodified forms of Ruk L, M, S The membrane was reprobed with anti-EE antibody (bottom panel) We found that Ruk L binds to PtdIns-3 kinase via the P85 regulatory subunit of the enzyme ... demonstrates that like Ruk L, the P85 regulatory subunit of PtdIns-3 kinase is ubiquitinated, but not degraded by the proteasome pathway [31,32] In addition, Cbl was shown to be the E3 ligase ... inhibitory effect on the activity of PtdIns-3 kinase The mechanism by which PtdIns-3 kinase could be released from the inhibitory complex with Ruk L is still unknown Ruk L polyubiquitination...
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