postoperative suppression of nk activity and resistance to tumor progression mechanisms and prevention by pharmacological interventions
Is there information in financial analysts forecasts about firms that subsequently restate their earnings
... grateful to my family, whose love and understanding have always given me strength to seek the best of myself This thesis is dedicated to them TABLE OF CONTENTS ACKNOWLEDGEMENTS i TABLE OF ... sharp drop in stock prices upon the restatement announcement also highlights the failure of auditors, financial analysts and credit rating agencies to alert investors and creditors who lost huge ... accounting scandals of large firms like Enron and WorldCom The growing number of earnings restatements due to accounting errors and irregularities reflects deterioration of corporate governance and stimulates...
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Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf
... appropriate level of analysis seems to be at the level of the so-called GOMS model (Card, Moran, and Newell, 1983) GOMS stands for: (1) a set of Coals; 2) a set of Operators; 3) a set of Methods for ... request of information) to correct imperfect understanding or as acknowledgement to verify understanding between the participants The notion of meta-plans allows us to account for the presence of ... precise mechanisms to determine the initial focus and to update it on the basis of the dialogue structure are still unknown (Sidner, 1983) Linde (1979) observed the distribution of it and that...
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báo cáo hóa học:" CRP identifies homeostatic immune oscillations in cancer patients: a potential treatment targeting tool?" pdf
... and Types of CRP CRP is produced by the liver and by adipocytes in response to stress It is a member of the pentraxin (annular pentameric disc-shaped) family of proteins, and is not related to ... attaching to and coating the surface of bacterial cell walls or to auto-antigens, to enhance phagocytosis for the destruction or inhibition of bacterial cells or for the neutralisation of auto-antigens, ... biomarker of tumour specific T-effector and T-regulatory clonal expansion and activity T-regulatory lymphocytes (T-regs) play a major role in attenuation of the T-effector response and animal...
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báo cáo hóa học: " Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" pot
... obtained, contribute to existing knowledge, and help both researchers and clinicians to achieve a better profile on the topic, and consequently aid in improving the quality of life of cancer patients ... survival and four 'non-anatomical' prognostic http://www.hqlo.com/content/7/1/102 indicators: symptomatic history, performance status, weight loss and age Adjusting for stage, histological factors and ... understanding of the treatment outcomes of cancer patients and make appropriate decisions http://www.hqlo.com/content/7/1/102 fact, this group of investigators has sought to justify the collection of...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... conduct and supervision In order to be able to conduct and monitor the progress of the trial for the patients' safety and according to the World Medical Association Declaration of Helsinki and the ... treated by physicians according to the usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, ... - To describe the characteristics of a large sample of cancer patients in terms of case mix (patients characteristics), pattern of care (pharmacological and non -pharmacological treatments) and...
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Báo cáo khoa học: "Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: A prospective observational study of 1,978 consecutive catheterizations" pps
... Materials and methods Adult patients with hematologic and solid tumors admitted to the oncology-hematology department of the hospital of Piacenza, North Italy, and requiring an indwelling CVC were offered ... hematological and solid tumors, to confirm the utility of this procedure in clinical practice, and to evaluate local or systemic infection, CVC-related deep venous thrombosis (DVT) and lifespan of the ... puncture and pneumothorax, are seen in up to 21% of attempts, and up to 35% of insertion attempts are not successful [3-5] There have been several prospective randomized trials [6-14] and two...
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Báo cáo khoa học: "Perioperative immune responses in cancer patients undergoing digestive surgeries" pptx
... T cells to proliferate and to secrete cytokines characteristic of both Th1 and Th2 phenotypes They also reported that during the late postoperative course (day 5), production of IL-2 and IFN-γ ... laparoscopic cholecystectomy developed postoperative complications Flow cytometric analysis of intracellular IFN-γ and IL-4 Blood sampling was performed before surgery, and on POD and 14 CBC and leukocyte ... authors read and approved the final manuscript 10 11 12 13 14 15 16 17 18 19 Sato M, Goto S, Kaneko R, Ito M, Sato S, Takeuchi S: Impaired production of Th1 cytokines and increased frequency of Th2...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
... followed by ethanol precipitation using the Applied Biosystems 340A Nucleic Acid Extractor and according to standard procedures Genotyping Method All individual exons of the ATM gene and some flanking ... combination (Table 2, a) and then divided according to treatment regimen and analyzed separately (Table 2b and 2c) A total of 154 and 94 patients received treatment A (4.3 Gy *10) and B (2.5 Gy *20) ... genes GSTP1, GSTM1 and GSTT1 and are also described in detail in [32] as well as here: From 1975 to 1986 a total of 1496 patients diagnosed with breast cancer and referred to the Norwegian Radium...
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báo cáo khoa học: "The potential benefits of low-molecular-weight heparins in cancer patients" ppsx
... activator, and is inhibited by plasminogen activator inhibitor [25] However, deregulation of these factors is observed in cancer patients, resulting in disruptions to the normal process of clot ... CM: von Willebrand factor interacts with malignant hematopoietic cell lines: evidence for the presence of specific binding sites and modification of von Willebrand factor structure and function ... LMWHs and oligosaccharide truncates of heparin have been shown to inhibit tumor growth and metastasis in vivo [100] Heparin and oligosaccharide truncates of heparin have also been shown to inhibit...
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Báo cáo y học: "Is Phytalgic® a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment" pot
... bias Assessment of the trial reporting in terms of risk of bias, the use of random assignment, and subsequent concealment of allocation would qualify as adequate (that is, low risk of selection ... ginger [5] Finally, deviations from protocol and loss to follow-up often lead to the exclusion of patients after they have been allocated to treatment groups, and this may introduce attrition bias ... Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials Osteoarthritis Cartilage 2009, Oct 14 [Epub ahead of print]...
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Báo cáo khoa học: "Performance of six severity-of-illness scores in cancer patients requiring admission to the intensive care unit: a prospective observational study" pot
... was 77% Mortality R199 may vary with respect to the mix of patients (e.g type of tumour, number of BMT patients, disease status and extent, and level of ICU support) In particular, the prognosis ... admitted to ICUs Although none of these models should be used to predict individual outcomes, they can assist physicians in discussions of prognosis and in clinical decision making to improve ... is made jointly by the senior intensivist and the oncologist who is responsible for the patient's care To be admitted to the ICU, patients should be considered to have a chance of being cured...
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Báo cáo y học: "Clinical review: Specific aspects of acute renal failure in cancer patients" pot
... infiltration by malignant cells, sepsis and druginduced toxicity Prevention of ARF is mandatory in CICPs Fluid expansion and uricolytic treatment in patients with a high risk of acute TLS, prevention of ... and/ or neurological impairment) Thus, methotrexate toxicity may manifest as multiple organ failure [24] Prevention of nephrotoxicity, together with methotrexate level monitoring, is crucial to ... were selected by the authors (MC, MD and EA) to give a concise and up -to- date overview of this problem Acute renal failure related to intra-renal or extra-renal obstruction Acute tumor lysis syndrome...
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Báo cáo khoa học: "N-terminal pro-brain natriuretic peptide as an early prognostic factor in cancer patients developing septic shock" pdf
... prognostic factors by the univariate analysis (cutoff p < 0.05) To avoid increasing the risk of collinearity for the same variables measured at days and (LOD and NT-proBNP), we decided to include ... diastolic velocity to myocardial early diastolic velocity of lateral mitral annulus by tissue Doppler and restrictive pattern) was suggested by alterations in the Doppler mitral flow (ratio of ... stay; and time from sepsis diagnosis to ICU admission and time from ICU admission to septic shock diagnosis and ICU mortality Early prognostic factors were defined as easy -to- collect, clinical and...
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Báo cáo y học: " C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia" doc
... was performed by a single investigator (MS) and consistency was assessed with a rechecking procedure of a 10% random sample of patients Data were screened in detail by three investigators (MS, JIFS, ... Xavier Hospital PP is Professor of Medicine of the Faculty of Medical Sciences from the New University of Lisbon, Portugal VCSD is assistant physician of the ICU of the Instituto Nacional de Câncer, ... only by “common” bacteria, but also by opportunistic agents, like virus and fungi, secondary to a decrease cellular and humoral immunity [4] In addition, the size of the inoculum necessary to produce...
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báo cáo khoa học: "Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials" ppt
... theoretical block of tumor neo-vascularization be realized by monoclonal antibodies to factor soluble serum VEGF to its receptor or VEGFR (in different isoforms) or small molecules directed to the tyrosine-kinase ... were both the Progression Free Survival (PFS: time between randomization and Page of progression or death from any cause) and the overall survival (OS: time between randomization and death for ... incidence of serious adverse events (hand-foot syndrome 45% versus 13%) A further randomized phase II study evaluated the efficacy and toxicity of sorafenib in addition to paclitaxel compared to paclitaxel...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... (Galluzzi and Kroemer, 2007) 3.4 Apoptogenic and inhibitory proteins involved in apoptosis Cytochrome c Cytochrome c is an essential component of the respiratory chain, and upon release into the cytosol ... benzodiazepine receptor (PBR) Both pro and antiapoptotic members of Bcl-2 family modulate activity of the PTPC by interaction with ANT or VDAC Many inhibitors and facilitators of the mitochondrial membrane ... of apoptosis is not affected by loss of a caspase by mutation (Degterev et al., 2003; Degterev and Yuan, 2008) 3.1 Intrinsic and extrinsic pathways of apoptosis The intrinsic pathway of apoptosis...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... pituitary gland tumors (Rod/cone photoreceptor cells in ONL) pituitary gland tumors (Rod/cone photoreceptor cells in ONL) pituitary gland tumors, pinealoblastoma (Striated epithelium) hyperplasia and ... failure to breath (Wu et al 2003) Whereas Rb heterozygosity leads to pituitary gland and thyroid gland tumors, p107 –/– or p130–/– mice have no overt phenotype and show no higher incidence of tumors ... ectopic proliferation in retina, retinal dysplasia, pituitary gland tumors Adrenal gland tumor Ectopic proliferation in INL; retinoblastoma, bronchial epithelial hyperplasia, adrenal gland tumors...
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báo cáo khoa học: "Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?" doc
... AM, Guindi M, Hornby J, Xu W, Ringash J, Keshavjee S, Chen E, Haider M, Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal ... by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence? World Journal of Surgical Oncology 2011 9:41 Submit your next manuscript to BioMed Central and ... Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial Lancet Oncol 2005, 6:659-668 Pereira...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
... done by BD, AO, BU, and KI Data analysis was done by RC, CU, NT and MS The manuscript was prepared by RC and AO Corrections and/ or improvements were suggested by CU, BD, MS, AO, SU, AS, VYC and ... 52 13 54 21 Estrogen receptor 49 74 17 71 Progesteron receptor 51 77 17 71 Stage (Tumor size) Tumor location Histology Histological Grade Nuclear Grade Invasion Receptors Systemic therapies Hormonotherapy ... retrospective study consists of relatively small number of patients and PMRT decision recommended according to the poor prognostic factors of the patient at the discrepancy of the radiation oncologist...
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báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients" pot
... mitosis and regulates mitotic progression In contrast, the protein levels as well as the mRNA levels of survivin-2B and other survivin variants are far less than that of wild type survivin, and ... the period of http://www.translational-medicine.com/content/7/1/1 two weeks One week after the 4th stimulation, cytotoxic activity of the CTLs was measured by 51Cr release assay Cytotoxicity assay ... and one oral cancer patient), and stimulated in vitro with survivin-C58 peptide in the presence of autologous monocyte-derived DC or autologous PHA blasts After times stimulation, cytotoxic activity...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25