post transcriptional effects of estrogens on gene expression messenger rna stability and translation regulated by micrornas and other factors
Báo cáo y học: " Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells" doc
... role in the expression of genes induced by T cell activation Effects of prostratin on the levels of 7SK snRNA and HEXIM1 associated with CDK9 We next wished to examine if 7SK snRNA and HEXIM1, ... [18,19] We and others have reported that activation of PBLs and resting CD4+ T cells with PHA, a lectin mitogen, induces cell proliferation and the expression of Cyclin T1 and CDK9, components of the ... http://www.retrovirology.com/content/3/1/66 Figure Levels of 7SK snRNA and HEXIM1 and association with P-TEFb Levels of 7SK snRNA and HEXIM1 and association with P-TEFb (A) Total RNA was isolated from DMSO control and prostratin-treated...
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Báo cáo khoa học: " Immediate post-operative effects of tracheotomy on respiratory function during mechanical ventilatio" potx
... cardiovascular stability None of them had evidence of major aspiration during the procedure Control of airway was discontinued for no more than 20 s and blood loss did not exceed 50 ml Intubation after ... focus on the immediate post- surgical period and to examine respiratory mechanics and pulmonary function in comparison with the immediate pre-tracheotomy situation Therefore, similar regulation of ... intubated (duration of intubation 10.6 ± 4.61 days) were included in the study The duration of stay in the intensive care unit was 26.6 ± 16.44 days and the duration of mechanical ventilation before...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... phosphorylation consistent of the lack of S1P effects on c-jun phosphorylation Therefore, the effects of the JNK inhibitor SP-600125 on Cyr61/CCN1 gene expression are unrelated to the JNK pathways and ... highly dependent upon c-fos protein expression Expression of the c-jun and c-fos genes does not require newly synthesized proteins and involves mainly post- translational modification of preexisting ... represents a continuous region of high homology between human and mouse with conserved transcription factor-binding sites Using a combination of cis-element mutagenesis and the expression of dominantnegative...
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Báo cáo y học: " Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of b-receptor affinity in murine models of asthma" pdf
... part of the study focused on elucidating the effects of albuterol isomers on the IAR of the airways (Figure 1A) where as the second part of the study was focused on studying the effect of albuterol ... [32,33] The immediate response to an allergen challenge is usually manifest as a bronchoconstriction of the conducting airways leading to a reduction of airflow and shortness of breath [33] Typically, ... was not augmented by any treatment We then focused on quantification of extravasation in the BALF and used IgG1 and total protein in BALF as indicators of plasma extravasation The increase in...
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Báo cáo khoa học: "Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats" pptx
... proportional to the concentration of rat TNFα in the sample A standard curve was obtained by plotting the concentrations of rat TNF-α standards versus their absorbences The TNF-α concentration of ... response is not a result of preparations before the start of the experiment (insertion of catheters, laparotomy, among other factors) The dopexamine infusion significantly reduced the release of ... inflammatory reaction [3] Because of the involvement of impaired hepatosplanchnic perfusion in the pathogenesis of sepsis, maintenance of hepatosplanchnic perfusion is a focus of experimental and clinical...
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THE EFFECTS OF CHROMIUM ON SKELETAL MUSCLE MEMBRANE/CYTOSKELETAL PARAMETERS AND INSULIN SENSITIVITY
... primary function of insulin entails the regulation of postprandial glucose homeostasis In the post- prandial state, an elevation of blood glucose triggers release of insulin from β-cells Once released ... roles in GLUT4 regulation, as interpretation of data from overexpression-based analyses are complicated by potential off target effects on other Rabs and Rab effectors Knockdown of Rab10 in adipocytes ... pathophysiological players in disorders of glucose metabolism, studies demonstrating an impact of PM lipids on insulin action and GLUT4 translocation warrant consideration The next section describes data from...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... played by post- transcriptional regulation in the control of gene expression As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and translation rate ... human mRNAs [2] RNAbinding proteins comprise other key components of the post- transcriptional regulation of gene expression These proteins are predominantly composed of wellconserved RNA- binding ... (MI:0007) Introduction In eukaryotes, the regulation of gene expression occurs at both transcriptional and post- transcriptional levels In the past, transcriptional regulations have been extensively...
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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx
... effect on basal expression of Timp-1, only on induced gene expression In conclusion, this is to our knowledge, the only described instance of HDAC inhibitors having opposite effects on the same gene, ... The action of HDACi could therefore be either on the Timp-1 gene itself, or on the expression of a protein(s) required for induction of the Timp-1 gene Time course of TSA action upon PMA- and TGF-b1-induced ... induced only by the combination of TGFb1 and TSA (data not shown) Hence, none of the HDACs exhibit c-Jun dependent expression Although the induction by PMA alone was partially abrogated upon mutation...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" doc
... inhibited by different concentrations of alpha-CGRP was found In particle concentrations of 1:500 RANKL mRNA expression was significantly decreased by all concentrations of alpha-CGRP after 48 and ... ratio of 1:100 RANKL mRNA expression was significantly decreased by all concentrations of alpha-CGRP at all time-points (P < 0.05) (Figure 1B) A significant effect of time on RANKL mRNA expression ... differentiation and bone resorption, and both are produced and secreted by osteoblastic lineage cells [13,14] On the one hand, RANKL binds to RANK, which is expressed on osteoclast progenitors, and leads...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" pot
... inhibited by different concentrations of alpha-CGRP was found In particle concentrations of 1:500 RANKL mRNA expression was significantly decreased by all concentrations of alpha-CGRP after 48 and ... ratio of 1:100 RANKL mRNA expression was significantly decreased by all concentrations of alpha-CGRP at all time-points (P < 0.05) (Figure 1B) A significant effect of time on RANKL mRNA expression ... differentiation and bone resorption, and both are produced and secreted by osteoblastic lineage cells [13,14] On the one hand, RANKL binds to RANK, which is expressed on osteoclast progenitors, and leads...
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Báo cáo toán học: " Effects of internal low-dose irradiation from 131 I on gene expression in normal tissues in Balb/c mice" ppt
... regulation of cell adhesion Negative regulation of enzyme activity Positive regulation of actin filament polymerization Protection from natural killer cell mediated cytotoxicity Regulation of hormone ... Protein folding Regulation of transcription from RNA polymerase II promoter Kidney cortex-spleen Regulation of axon extension Regulation of neuronal synaptic plasticity Response to oxidative stress ... Digestion Kidney medulla-lung Cell migration Cell-matrix adhesion Cellular defense response Positive regulation of angiogenesis Positive regulation of neurotransmitter secretion Regulation of locomotion...
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Báo cáo y học: "Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes" pdf
... protein gene expression profiles of meniscal fibrochondrocytes The x-axis refers to the passage number, and the y-axis to protein gene expression profiles of meniscal fibrochondrocytes the gene expression ... passage Gene expression with passage The gene expression abundances for primary and passaged fibrochondrocytes are reported normalized to the amount of RNA per sample and are plotted for the genes of ... Collagen I gene expression profiles of meniscal fibrochondrocytes The x-axis refers to the passage number, and the y-axis to the gene expression fibrochondrocytes abundance (in the exponent notation...
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Báo cáo y học: "Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver" ppt
... inhibitory effect on inflammatory mediators including activity and expression of cyclooxygenase (COX) [4,5], generation of prostaglandins [6,7], and leukotrienes (LT) [4] and expression of proinflammatory ... spleen and liver mRNA expression Future examination of macrophage responses at other tissue sites and responses of other cell types is clearly warranted Parthenolide's in vitro effects on mediators ... production and gene expression, no inhibitory effect was observed for TNF-α Although NF-κB has been implicated in the transcriptional regulation of TNF-α, the functional concert of NF-κB with other...
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Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects" docx
... Authors' contributions KC, BH and SW conception and design, analysis and interpretation of data, drafting the manuscript JS, IL and JD acquisition of data, analysis and interpretation of data RY and ... Figure Effects of individual AP drugs on gene expression are shown with fold change and 95% confidence intervals Effects of individual AP drugs on gene expression are shown with fold change and ... effects of APs on genes and biological functions in different tissues, we investigated the effects of typical APs and atypical APs on gene expression profiles in the postmortem liver of schizophrenia...
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Báo cáo y học: "Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice" pot
... in the A/J strain Confirmation of microarray gene expression by RT-qPCR Validation of gene expression for CFB, LCN2, MMP12 and SPP1 was done by RT-qPCR from week A/J GMAMS and -SS lung samples ... Page 17 of 18 Figure RT-qPCR confirmation of microarray gene expression changes in welding fume-exposed A/J mice Confirmation of microarray gene expression by RT-qPCR for CFB, LCN2, MMP12 and SPP1 ... strain at weeks post- exposure to GMA-MS fume A conserved, consistent expression of one of the behavioral genes NR1D1 was found Expression levels were 2.3 and 2.2 fold for NR1D1 at and 16 weeks,...
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Sequential effects of a high fat, calorie dense diet or a high fiber diet on gene expression, body weight and associated metabolic responses in c57 BL6J mice
... CONTAINING PSYLLIUM HUSK ON BODY WEIGHT, PLASMA LIPIDS AND HEPATIC GENE EXPRESSION LEVELS Introduction 119 Results 120 Discussion 139 CHAPTER CONCLUSIONS AND FUTURE RECOMMENDATIONS Conclusions ... However, only the isoform, Srebf1 expression is induced by feeding and insulin, and its role is mainly responsible for the regulation of fatty acid synthesis (Horton et al., 2002) On the other side of ... relation to gene profiling in adipose tissue, some found increased expression of lipogenic genes (Li et al., 2002; Lopez et al., 2003) whereas others demonstrated reduced expression of lipogenic genes...
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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
... Figure 5: mRNA expression of Cx40 (panel A) and Cx43 (panel B) in the rabbit iliac arteries of different groups by RT-PCR Top panels represented mRNA expression of Cx40 and Cx43 from each of the ... Another study showed that Ang II up -regulated the expression of Cx43 in WB rat liver cells, which resulted in changes of cell metabolism conditions and second messengers (13) Cx43 expression ... atherosclerosis and the ex- pression and function of gap junction White blood cells (WBC) can be induced by chemokines through gap junction formed between WBC and endothelium and resulted in the formation of...
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Báo cáo y học: "Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene"
... gDNA contamination PCR reaction triplicates showed no major differences among them and expression levels of the internal control were similar in the different experiments The expression levels of ... were performed at 24 and 48 h After 48h culture media and cells were collected for ELISA and RNA extraction respectively RNA preparation and cDNA synthesis Extraction of total RNA was performed ... parasites) and 5% haematocrit and were cultured for 48 hours Quantification of cDNA was determined against a standard curve and normalised by the amount of ldh expression Percentage of increase/decrease...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... proliferation and expression of cytokines and activation markers by peripheral blood T cells [36,37], and that CCL2, CCL5 and CXCL12 upregulated the expression of cytokines and chemokines by fibroblast-like ... expression Finally, we examined the effects of the chemokines on the expression of the cell surface molecules ICOSL, BAFF-R and TACI by peripheral blood B cells of normal donors and sub- Page of 11 ... expressed by unstimulated peripheral B cells of both normals and subjects with RA, and CXCL12 enhanced the expression of ICOSL on both normal and RA B cells In contrast, the effect of CCL20, CCL19 and...
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Báo cáo y học: "Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles" ppt
... platform, and robust statistical techniques to investigate the presence of a SpA gene expression signature and the presence of novel biomarkers of disease Gene expression microarray Unfractionated ... subjects and females were more common in the control group, we took additional caution to exclude conclusions attributable to gender To identify possible gender effects on gene expression levels ... interaction with DKK-1 The net effect of this and other factors may be bone resorption [30] Endogenous bone morphogenetic protein (BMP6) has been described in a mouse model of enthesis ossification and...
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