... JS, Weinblatt ME, Weisman MH ELSEVIER, Toronto, Canada; 2003:1523-1535 Targoff IN: Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies Rheum Dis Clin North ... Furthermore, in the presence of the more common autoantibodies, at least two more autoantibodies were present in 20% to 65% (mean 43.3%) of sera For example, 10 out of 22 (46%) ofpatientswith ... observed inpatientswith SLE (n = 30; except for anti-PL-7 in none patient) or SSc (n = 20) orin healthy blood donors (n = 50; data available online [33]) In addition, anti-Mi-2 was not detected in...
... of hypothesized explanations for the differences in the risk of certain malignancies inpatientswith RA compared withpatients without the disease Possible mechanisms for an increased risk of ... cancer inpatientswith RA compared with the expected incidence rates in the general population Lymphoma was reported as Hodgkin or non-Hodgkin where available The selection of studies for inclusion ... by incorporating the heterogeneity of effects in the overall analysis Page of (page number not for citation purposes) Results A total of 2,093 articles were identified using the defined Medline...
... normally performed in the anesthesia preparation room in the operating room (OR) prior to induction of anesthesia Group B patients received their IABP in the operating room if fulfilling definitions ... when indicated based on restoration of hemodynamic stability maintaining a CI greater than L/min/m2, with only minimal pharmacological inotropic support The same definition was used for termination ... visualization of the coronary artery The left anterior descending artery was revascularized first in all patientsIn cases of vein grafting, the proximal anastomosis of the vein on the aorta was performed...
... therapy within 30 days (6 weeks for nitrosoureas or mitomycin-C), radiation therapy within weeks, surgery within weeks before starting study drug, or treatment with strong CYP3A inhibitors or inducers ... inhibitors or inducers within days before starting study drug All patients gave written informed consent before study entry according to the Good Clinical Practice guidelines of the International Conference ... pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus inpatientswith advanced solid tumors J Clin Oncol 2008, 26:1588-1595 10 Afinitor (everolimus)...
... of the plantar fascia was reported for 173 patients, including 19 patients without enthesitis in MASES The distribution of enthesitis sites at baseline is shown in Figure Of the 281 (22.5%) patients ... to week 12 in the percentage ofpatientswith enthesitis of the plantar fascia (for patientswith inflammation of the plantar fascia at baseline) The treatment effect of adalimumab for peripheral ... costochondral joint R 1st costochondral joint L Site of Inflamed Entheses 7th costochondral joint R 7th costochondral joint L Posterior superior iliac spine R Posterior superior iliac spine L Anterior superior...
... necessity of anakinra dosage increase remaining three patients Improvements in symptoms were evident in all patients within 24 hours of administration of canakinumab; at baseline all patients ... ofpatientswith a variety of inflammatory conditions reported that the risk of death is increased 18-fold inpatientswith high SAA levels (> 155 mg/dL) compared with those with levels within ... safety profile of canakinumab inpediatricpatients is similar to that in adults Safety data for canakinumab in children have also been reported for doses of 0.5 to mg/kg in children with systemic...
... concentrations of YKL-40 in both patientswith RA and healthy controls Our findings indicate that the g.-131(C > G) polymorphism is the main contributor to the inter-individual variation of serum YKL-40 in ... the remaining SNPs could be explained by LD Our findings indicate that serum concentrations of YKL-40 are under the influence of genetic variability in the CHI3L1 gene in both patientswith RA ... chitinase-like protein in the lung and circulation ofpatientswith severe asthma N Engl J Med 2007, 357:2016-2027 Recklies AD, Ling H, White C: Inflammatory cytokines induce production of chitinase-3-like...
... The SOFA scores were equal in the index and reference groups, indicating comparability in morbidity between both groups The two groups not match in terms of creatinine clearance The creatinine ... groups Patientsin the index group had a diagnosis of sepsis more often (four times) than patientsin the reference group (zero times) As mentioned, none of the patients used vasopressors or inotropics ... the absorption of dalteparin, administrated by subcutaneous injection for prophylaxis of VTE, might be influenced by subcutaneous oedema, very often seen in ICU patientswith shock symptoms In this...
... tested in serial dilutions of cell lines Deltaretrovirus PCR tested in serial dilutions of cell lines Cell line DNA was diluted in genomic DNA from healthy individuals A: cell line Mo T (HTLV-II-infected), ... Oldendorf/Germany) and dissolved in Tris/EDTA buffer at a concentration of 60 ng/μl Preparation of cell line dilution series Serial dilutions of cell line DNA in DNA from buffy coats of blood donors ... Komischke and Rita Lippoldt for their skillful technical assistance They are indebted to Prof Harald Stein (Head of the Dept of Pathology, Charité Campus Benjamin Franklin) for giving them access to lymphoma...
... death in hospital for patientswith respiratory failure [39,40], the diagnosis of VAP is difficult The optimal invasive procedure for diagnosing HAP or VAP remains poorly defined [9,10] Indeed, ... susceptibility testing of respiratory secretions obtained by deep expectoration, nasotracheal aspiration, intubation with endotracheal suctioning, bronchoscopy with BAL or protected-brush sampling, or transtracheal ... taken within 48 h were reported in 119 patients (67.4%) Gram-positive organisms were isolated in 75 patients (42.9%) and Gram-negative organisms in 63 patients (36.0%) The detected microorganisms...
... early morning [21-24], being consistent with the findings of this study However, in the NDP group, the pattern of 310 circadian rhythm in 5-FU pharmacokinetics was certainly different from that in ... also for ESCC, but when using NDP instead of CDDP, it is necessary to look for some marker capable of indicating clinical response In conclusion, only a small number ofpatients were enrolled in ... those without (non-CR), but the inclusion ofpatients treated with NDP resulted in no significant differences Table Plasma Concentrations of 5-Fluorouracil (5-FU) in the Patientswith and without...
... requirement in accordance with the WHO definition of health and well-being [3] Pediatric quality of life studies that investigate the individuals’ perceptions of their well-being in a multidimensional ... field of research inpediatric cardiology internationally, and meeting professional requirements in a pediatric population brings more difficulty than in adults: identifying the relevant quality -of- life ... the intervention This important additional factor influencing HRQoL is not taken into account in our study, and should be studied systematically in future investigation ofpediatricpatients with...
... individual or combined analysis of sFlt-1 and VEGF-A levels could help in risk stratification ofpatientswith FN In order to so, we plotted simultaneously the values of sFlt-1 and VEGF-A inpatientswith ... necessary for the incorporation of new endothelial cells during vessel sprout The clinical relevance of Page of this effect in humans was observed more than a decade ago, when patients treated with ... environment (including outpatients) are warranted to check whether levels of these biomarkers obtained in a “real world” setting will be able to capture this increase in sFlt-1and /or VEGF-A levels of patients...
... individual or combined analysis of sFlt-1 and VEGF-A levels could help in risk stratification ofpatientswith FN In order to so, we plotted simultaneously the values of sFlt-1 and VEGF-A inpatientswith ... necessary for the incorporation of new endothelial cells during vessel sprout The clinical relevance of Page of this effect in humans was observed more than a decade ago, when patients treated with ... environment (including outpatients) are warranted to check whether levels of these biomarkers obtained in a “real world” setting will be able to capture this increase in sFlt-1and /or VEGF-A levels of patients...
... has minimal affinity for a2 adrenergic receptors, H1 histamine receptors and muscarinic cholinergic receptors [9,10], possibly underlying the diminished liability of aripiprazole to produce orthostatic ... generalizability of the study’s findings as the population included in this study may not be fully representative of all patient types encountered in real-world settings Furthermore, the findings reported ... during the switching treatment phase This finding, coupled with the improvement in QOL ratings, is important as it provides an estimation of the real-world impact of antipsychotic treatment with...
... historical interview and rheumatologic examination On the basis of the presence of HCV-related arthropathy we identify two groups of HCV patients: group 1, including patientswith articular involvement ... involvement (8 patients) , and group 2, comprising patients without articular involvement (31 patients) To compare the prevalence of anti-CCP antibodies in HCV patientswith that inpatients affected ... the remaining five patients were affected by diffuse polyarthralgia Inpatientswith HCV, histological examination of hepatic biopsies showed a grading of activity from minimum to severe, with no...
... frequently found in the homozygous form (34.3%) and in combination with haplotype 2/3 (34.3%) in normal controls In contrast, PADI4 haplotype occurred more frequently in combination with haplotype ... 50:1117-1121 Barton A, Bowes J, Eyre S, Symmons D, Worthington J, Silman A: Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis Ann Rheum Dis 2005, 64:1311-1315 ... presentation in the induction of autoimmunity This finding clearly could be confirmed in our study With the exception of haplotype 4, the frequencies of all other PADI4 haplotypes in our control individuals...
... medical history, clinical examination, and routine laboratory examinations and chest X-ray, the inclusion criteria included at least one of the following: an ESR of 50 mm/ hour or more, new headache ... who were unaware of the presenting clinical findings ofpatientswith suspected GCA at baseline Studies in control subjects and follow-up examinations were performed in an unblinded manner A high-resolution ... required for these patients, a baseline CDS of the temporal arteries was performed prior to the initiation of treatment Unilateral biopsy of the temporal artery was subsequently performed within to...
... the quality of life inpatientswith multiple cultural backgrounds Page of Conclusions Our study provided additional information in evaluating QoL of Chinese rectal cancer patientswith currently ... QoL inpatientswithor without radiotherapy For comparing the QoL inpatientswith four different treatment regimens, Kruskal-Wallis one-way ANOVA for k samples was used and Bonferroni correction ... Embarrassment With Bowel Movement were more prominent in stoma patients (p = 0.00001) Although the score of Body Image in our series was high in both of the two groups, the nonstoma patients were more...
... co-trimoxazole and NAT2 genotype, with findings apparently correlating with the underlying disease process For instance, in the setting of HIV infection many investigators were unable to demonstrate ... recruited a subset ofpatients and participated in coordination of the study NK participated in the design and coordination of the study All authors read and approved the final manuscript Acknowledgements ... adverse events (including 16 patientswith mild adverse events and 36 patientswith no adverse events) The poportion of slow acetylators was significantly higher among the patientswith severe adverse...