pharmacokinetics in patients with impaired hepatic function study design data analysis and impact on dosing and labeling guidance 2002
Báo cáo y học: "Surgery of secondary mitral insufficiency in patients with impaired left ventricular function" pps
... examination (range 53 – 100 month) and in one patient was lost to follow-up Discussion Surgical treatment in patients with SMI and considerably impaired LV function had been identified as an indicator ... Sudden death (9 months) Pneumonia with sepsis (25 and 27 months) Stroke (26 months) Intestine perforation, peritonitis (2 months) Cerebral bleeding (17 months) Unknown (30 months) 14 1 1 Page ... replacement with CABG and in one a combination of MV repair, CABG and TV repair Redo's and prolonged cross-clamping times Figure (MVR) – Meier survival curve in (HTX) Kaplan and heart transplantation patients...
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Báo cáo y học: "Persistence with anti-tumour necrosis factor therapies in patients with psoriatic arthritis: observational study from the British Society of Rheumatology Biologics Register" pps
... presented in Table The leading cause of drug discontinuation for infliximab was infusion reactions (7.4% of patients receiving infliximab, ~30% of all infliximab discontinuations for AEs) Other common ... univariate and multivariate analyses examining predictors of drug overall discontinuation, discontinuation due to inefficacy and discontinuation due to AEs For overall discontinuation, the multivariate ... associated with drug discontinuation of the first course of anti-TNF therapy Separate models were developed for overall discontinuation, for discontinuation due to inefficacy and for discontinuation...
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Báo cáo y học: " Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study" pptx
... Authors' contributions DP: substantial contribution to conception and design, acquisition of data, analysis and interpretation of data, involved in drafting the articles PC: substantial contribution ... interpretation of data, involved in drafting the articles MG: substantial contribution to conception and design, statistical analysis and interpretation of data, involved in drafting the articles ... contribution to conception and design, collection of samples, revision of the draft critically for important intellectual content MC: substantial contribution to conception and design, analysis and interpretation...
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Báo cáo y học: "Intra-abdominal hypertension due to heparin induced retroperitoneal hematoma in patients with ventricle assist devices: report of four cases and review of the literature" pdf
... significantly increases intrathoracic pressure resulting in extrinsic compression of the pulmonary parenchyma and development of pulmonary dysfunction [23,24] Increased intrapleural pressures resulting ... hand is a distinctive clinical entity, most commonly seen in association with patients with anticoagulation therapy, bleeding abnormalities, and haemodialysis [7,8] and may represent one of the ... http://www.cardiothoracicsurgery.org/content/5/1/108 implantation, necessitating reoperation in up to 60% of cases irrespective of device used or indication for insertion Spontaneous retroperitoneal hematoma (SRH) on the other hand...
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Báo cáo sinh học: "Bactericidal activity of oxacillin and glycopeptides against Staphylococcus aureus in patients with endocarditis: Looking for a relationship between tolerance and outcome" doc
... the institutional ethical committee of Perugia and Bergamo All activity was conducted in accordance with the Declaration of Helsinki, and national and institutional review board Associations among ... vancomycin 10, teicoplanin and in therapy was not known Beta-lactam or glycopeptide antimicrobials were administered in combination with rifampin or an aminoglycoside, or a quinolone or a combination ... given in combination with other antibiotics in both oxacillin tolerant and oxacillin non-tolerant MSSA infections Analysis was unable to demonstrate either increased mortality or morbidity in oxacillin...
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Báo cáo y học: "A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis" potx
... Proportion of patients with hospital mortality and requiring intubation, new onset acute myocardial infarction, duration of noninvasive ventilation needed Allocation concealment adequate; not blinded; ... Proportion of patients with hospital mortality and requiring intubation, duration of noninvasive ventilation needed Allocation concealment not clear; not blinded; no loss to follow up; analysis by intention ... Proportion of patients with hospital mortality and requiring intubation, the duration of noninvasive ventilation needed and hospital length of stay Allocation concealment adequate; study not blinded;...
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Báo cáo khoa học: "Relationship of cognitive function in patients with schizophrenia in remission to disability: a cross-sectional study in an Indian sample" pps
... symbol substitution test did not correlate with occupational functioning [32] Addington et al found no association between cognitive measures and social functioning in 30 patients with schizophrenia ... programming requiring temporal organization, maintenance and execution of successive action), conflicting instructions (tests sensitivity to interference, where verbal commands conflict with visual ... 20 RK was involved in the conceptualization of the study, literature review, recruiting patients, data collection, statistical analysis and interpretation of results PBM was involved in review...
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Báo cáo y học: "Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus" pot
... ELISA, using a matched antibody pair and recombinant protein as standard from R&D Systems (Oxon, UK) After incubation and binding of biotinylated antibodies, the color reaction was performed with ... Schleicher and Schuell, Dassel, Germany) Nonspecific protein binding was blocked using PBS with 0.1% Tween 20 and 5% bovine serum albumin (Sigma) After incubation with anti-caspase (Cell Signaling Technology, ... condition with chronic or recurrent inflammation Reduced mobilization and increased apoptosis, resulting in a shorter half-life of CPCs, can result from chronic exposure to inflammatory cytokines...
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Báo cáo y học: "Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study" pps
... 88%) and impaired diffusing capacity in 31 patients (19.8%) Impaired diffusion in conjunction with restriction or obstruction was observed in 16 of those latter subjects, while the remaining 15 patients ... regarding which patients should undergo subsequent pulmonary function testing and radiographic imaging These findings may be of clinical benefit if confirmed in a larger population study Additional ... competing interests Authors' contributions DAP participated in the study design, data collection and analysis as well as in writing and editing the manuscript JTG performed statistical analyses and...
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Báo cáo y học: "The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study" pdf
... endothelial-dependent function in healthy individuals have reported mixed findings, with some reporting an association between microvascular and macrovascular endothelial-dependent function [22,23] and others ... other study did find an association [34] In the former study, microvascular endothelial function was measured using laser Doppler flowmetry, which assesses endothelial function at a single point only ... had previously confirmed acute coronary syndrome or established CVD as indicated in their medical records and/ or upon questioning during the initial consultation Page of The study received local...
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Báo cáo khoa học: "Influence of support on intra-abdominal pressure, hepatic kinetics of indocyanine green and extravascular lung water during prone positioning in patients with ARDS: a randomized crossover study" pot
... µg/kg per min) and one patient received epinephrine (adrenaline) (0.4 µg/kg per min) on inclusion No modification of the infusion rate of norepinephrine and epinephrine and no fluid expansion were ... AR and LP were the principal investigators and led the conceptual design of the design and the manuscript preparation MG made contributions to the acquisition of data and to the analysis and interpretation ... support during PP could be different in patients with increased IAP (especially in surgical patients) Indeed, Gattinoni and colleagues [32] reported an IAP ranging from mmHg in patients with ARDS...
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Báo cáo y học: "Pituitary-adrenal function in patients with acute subarachnoid haemorrhage: a prospective cohort study" ppsx
... participated in analysis and interpretation of data and in revising the critically manuscript References Authors' contributions SB, AU and TK participated in study conception, acquisition of data, analysis ... analysis and interpretation of data, drafting the manuscript and critically revising it ER participated in study conception, analysis and interpretation of data, drafting the manuscript and critically ... corticoid-binding (SAH) and control patients with subarachnoid haemorrhageglobulin (CBG) concentration in Evolution of corticoid-binding globulin (CBG) concentration in patients patients with subarachnoid...
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Báo cáo y học: "Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysi" ppsx
... and TLR9 agonist-induced cellular responses in MDCs and PDCs in patients with sepsis In line with previous findings, we found increased IL-10 levels in septic patients at baseline and at day 28 ... monocytes [17] In line with recent findings demonstrating that IL-10 inhibits IFNα production in PDCs in vitro, we observed in our study an inverse correlation of IL-10 levels with CpG-induced IFNα ... monocyte and DC deactivation in sepsis [48] References Conclusions We demonstrate a profound and sustained functional impairment of all circulating monocyte and DC subsets in patients with sepsis and...
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Báo cáo y học: "Effects of positive end-expiratory pressure on respiratory function and hemodynamics in patients with acute respiratory failure with and without intra-abdominal hypertension: a pilot study" docx
... ALI/ARDS patients with increased IAP compared with patients with normal IAP [7] More recently, in a study including mainly extrapulmonary ALI/ARDS patients, a strategy titrating PEEP according to ... II, duration of mechanical ventilation prior to inclusion and outcome for patients included in normal and increased IAP groups All patients were studied within one week from ALI/ARDS onset We ... at baseline or in response to PEEP Discussion intra-abdominal hypertension (dotted bars) Effect of PEEP on IAP in patients with normal IAP (shaded bars) and intra-abdominal hypertension (dotted...
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báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx
... post -dosing decrease in GD2 staining, and increase in S100 staining intensity and in CD8+ T cell infiltration The EMD 273063-induced intratumoral lymphocytic infiltrates displayed increased staining ... statistical analysis AK participated in the study design and coordination SDG participated in the study design and coordination OK participated in the study design and coordination and helped ... contributions 10 AR participated in the study design and coordination and helped to draft the manuscript JMK participated in the study design and coordination MBA participated in the study design...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
... cutaneous lesions (concomitant changes in pigmentation and nodularity) with continued dosing Resection of two nodules at weeks 24 and 36 showed no evidence of viable melanoma; it was consistent with a ... studies in single institutions, frequently without pre-defined parameters for quality control of the DC manufacturing procedures The methods for DC generation, maturation and administration to patients ... result in worsening of the response rate as it was seen in the aforementioned study of ipilimumab and gp100 [17] In conclusion, we report the positive results of a DCbased vaccine study in patients...
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Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc
... (Th2) cytokine production [3] In humans, G-CSF increases interleukin (IL)-4 release and decreases interferon (IFN)-g production [4], induces immune modulatory genes in T cells, including the Th2 ... responses in vitro Interestingly, monocytes from patients given pegfilgrastim induced T-cell proliferation to a similar extent as immunogenic DC In line with this, T-cell proliferation in response ... pegfilgrastim-induced modulation of immune function will favorably impact on disease control in cancer-bearing patients remains to be prospectively determined Additional material Additional file...
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Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt
... Preclinical safety studies revealed that a decrease in BP during rh-HGF infusion and renal toxicity induced by repeated rh-HGF dosing, including an increase in urinary excretion of albumin, were ... administration (min) 30 Time after rh-HGF administration (min) Figure Blood pressure decreased during infusion of rh-HGF in patients with FH or LOHF BP and HR were monitored during rh-HGF infusion ... affect patients general condition Although patients and 3, but not 4, also exhibited BP reduction during rh-HGF infusion, their general condition was stable without additional infusion or cessation...
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báo cáo hóa học: " Adalimumab improves health-related quality of life in patients with moderate to severe plaque psoriasis compared with the United States general population norms: Results from a randomized, controlled Phase III study" pdf
... population, patients with psoriasis reported similar physical functioning and more impaired mental health functioning compared with general population norms, even after adjusting for age, sex, and ... demonstrated that the SF-36 summary scores may be less informative in situations where there is impact on both physical and emotional functioning [33,34] However, based on the NSFHS data only minor ... between the REVEAL and general populations groups on physical functioning and bodily pain, but there were clinically meaningful differences for social functioning and role-emotional scores We observed...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25