pharmacogenetics and pharmacogenomics in drug development and regulatory decision making report of the first fda pwg phrma drusafe workshop
Interface conflicts and regulatory decision making process on power projects in sri lanka
... Understanding the facts of a conflict 23 2.5.2 Understanding the interests of other parties 24 2.5.3 Understanding the fairness concerns 24 2.6 INSTITUTIONAL RESPONSE 25 2.7 ROLE OF INFORMATION IN ... with the increasing trend found in many countries to focus on improving governance There is an ongoing debate concerning the active role of the public in decision- making (World Bank, 1993) There ... economies perform The cost of transacting is the cost of specifying and measuring the characteristics of what is being exchanged and the cost of enforcement agreement (North, 2000) The idea of transaction...
- 295
- 177
- 0
Báo cáo y học: "Platysma motor branch transfer in brachial plexus repair: report of the first case" pot
... temporofacial and cervicofacial trunks The cervicofacial division branches into the mandibular branch and the cervical branch The cervical branch descends behind the ramus of the mandible, issues from the ... reinnervate the pectoralis major muscle Anatomical background of the cervical branch of the facial nerve Within the substance of the parotid gland, the facial nerve branches into the temporofacial ... was capable of grasping things between the thorax and forearm and between the arm and the thorax The patient could adduct the shoulder independently of the elbow flexion (Fig 5, 6, 7) The nerve...
- 5
- 487
- 0
Tài liệu Lipases and Phospholipases in Drug Development pptx
... increasing feed angle may be attributed to an increase in the initial band width An increase in the feed angle increases the first and second moments, which are related to the elution angle and ... Sphingomyelinase Mechanism 85 Binding of Magnesium Ions 85 Binding of Substrate 85 Mechanism of Catalysis 86 Sphingomyelinase Assay 88 Sphingomyelinase Inhibitors 89 Sphingomyelinase–Membrane Interactions 89 ... Translocation of HSL 264 Mechanism 264 Involvement of Perilipins 266 Involvement of Lipotransin 268 Intrinsic Activity of HSL 270 Feedback Inhibition 270 Adipocyte Lipid-binding Protein 272 Expression of...
- 357
- 1,339
- 1
Báo cáo khoa học nông nghiệp " Achievements and lesson learnt from implementation of the project "Sustainable community-based forest development and management in some high-poverty areas in Bac Kan Province" " pot
... animals in the community forest - Prevention of forest fire - Checking and preventing outsiders from shifting cultivation, illegal logging or hunting, and illegal buying, selling and transporting ... Table 3: Training courses conducted in the project area [6] # Training topics Number of direct beneficiaries Land-use planning and land allocation 26 Planning and implementation of community ... 100 3.3.2 Capacity building for local people Based on the training needs of local community, various trainings were conducted as presented in the Table Most of the trainings were conducted as...
- 10
- 334
- 0
Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
... machines" can replace "the brain and hand, skill and experience" of the specialist The aim of this study was to verify the reliability and efficacy of one of these compact portable diode instruments, ... allowing excellent results to be obtained painlessly, in a short time and without requiring the patients to suspend their routines activities For the operators, the main barriers to acquiring these ... are reduced [17,18] The lasers normally adopted offer the enormous advantage of being conveyed in a fibre, which serves as the working tip at the end of the handpiece The use of flexible, length-adjustable...
- 7
- 567
- 1
Radioactive waste in the Barents and Kara Seas - Russian implementation of the global dumping regime
... nuclear matters, including the Navy and the Ministry of Atomic Power, have consolidated their control over domestic decisionmaking and are themselves becoming increasingly involved in cooperative ... After having ascribed a 1993 incident of dumping of liquid radioactive waste in the Sea of Japan to irresponsibility on the part of the Navy and the nuclear industry, the Russian Minister of Environment ... of political in uence, the establishment of the Yablokov Commission and the publication of its report in 1993 marked the highest point for the proponents of stricter controls regarding handling...
- 21
- 486
- 0
Tài liệu IMPLANT AND REGENERATIVE THERAPY IN DENTISTRY A GUIDE TO DECISION MAKING docx
... would include the elimination of soft tissue concavities, in the area of the interproximal col and elsewhere, soft tissue clefts, and marked gingival margin discrepancies The establishment of the ... This includes the elimination of long epithelial relationships to the tooth surface, where possible, and the minimization of areas of nonkeratinized marginal epithelium The elimination of all other ... removal of the epithelial lining of the pocket is not a common finding (10–12) (c) Supragingival plaque will extend subgingivally, beyond the reach of the patient, and adhere to the root surface The...
- 423
- 448
- 2
Tài liệu A junk-free childhood 2012 - The 2012 report of the StanMark project on standards for marketing food and beverages to children in Europe pptx
... directed to the protection of children Explore the use of standards and marketing codes to influence commercial activity, including standards from other industrial sectors Propose a set of standards ... characters and their own branded sites in the definition of marketing The definition of what constitutes childtargeted media varies: for example Nestlé defines marketing to children as being “a marketing ... aspects of the product In the example below, the Kinder chocolate is promoted to parents as containing milk and being only a ‘snack’ size Products are sold in multi-packs of and 16 for repeating the...
- 32
- 896
- 0
Tài liệu REPORT OF THE STAFFS OF THE CFTC AND SEC TO THE JOINT ADVISORY COMMITTEE ON EMERGING REGULATORY ISSUES doc
... indicators, including the E-Mini, that may affect a bias in their bids and offers Others heavily depend upon the tracking of underlying securities as part of their ETF pricing and algorithmic modeling And ... strategies, reported that during the decline in prices of the EMini and SPY, the E-Mini was relatively cheaper than either SPY or baskets of individual securities These same firms reported that they therefore ... resting quotes within 10 basis points on either side of the midquote of the then-current NBBO For the E-Mini, near-inside market depth includes all resting quotes within $1.00 on either side of the...
- 104
- 989
- 0
THE FINANCIAL CRISIS INQUIRY REPORT - Final Report of the National Commission on the Causes of the Financial and Economic Crisis in the United States docx
... Board, the Federal Reserve Bank of New York, the Department of Housing and Urban Development, the Office of the Comptroller of the Currency, the Office of Federal Housing Enterprise Oversight (and ... banking and financial system and to protect the credit rights of consumers.” It failed to build the retaining wall before it was too late And the Office of the Comptroller of the Currency and the ... ethics The integrity of our financial markets and the public’s trust in those markets are essential to the economic well-being of our nation The soundness and the sustained prosperity of the financial...
- 663
- 609
- 1
Minimum Wages and Employment: A Case Study of the Fast-Food Industry in New Jersey and Pennsylvania pot
... to the increase in the minimum wage by reducing on -the- job training and flattening the tenure-wage profile (see Jacob Mincer and Linda Leighton, 1981) Indeed, one manager told our interviewer in ... inadvertently interviewed twice in the first wave of the survey.10 Assuming that measurement errors in the two interviews are independent of each other and independent of the true variable, the correlation ... between the existing federal minimum wage in 1986 ($3.35 per hour) and the effective minimum wage in the state in April 1990 (the maximum of the federal minimum wage and the state minimum wages as of...
- 26
- 869
- 0
Report of the Sub-Committee of the Central Board of Directors of Reserve Bank of India to Study Issues and Concerns in the MFI Sector doc
... operating in the Microfinance sector 3.2 The need for a separate category of NBFCs operating in the Microfinance sector arises for a number of reasons 3.3 First, the borrowers in the Microfinance ... the amount of the loan However, the larger the loan, the larger the amount of the repayment installment, and a large installment may strain the repayment capacity of the borrower and result in ... formation of SHGs and JLGs as also in the imparting of skill development and training and generally in handholding after the group is formed This would be in addition to and complementary to the efforts...
- 65
- 551
- 0
The Report of the Task Force on Financial Mechanisms for ICT for Development - A review of trends and an analysis of gaps and promising practices ppt
... understanding of the broad and constantly changing scope of the ICT sector and the use of ICT in the developing world from a financing and development perspective In the report of the Task Force, the ... Following the early waves of privatization of national PTTs and opening of markets in the industrial countries – led by the breakup of AT&T in the United States and the public offerings of shares in ... Agency of the Francophonie (AIF), the City of Dakar, the City of Geneva, the City of Delémont (Switzerland), the City of Lyon, the City of Paris, the City of Santo Domingo, the City of Curitiba, the...
- 125
- 1,274
- 0
Measuring the Statutory and Regulatory Constraints on Department of Defense Acquisition - An Empirical Analysis doc
... section of the ASR; • developing, updating, or revising the Core/Source of Repair Analysis section of the ASR; • developing, updating, or revising the Industrial Capabilities section of the ASR; and ... while maintaining the level of oversight and accountability required in the expenditure of public funds The objective of the present research was to quantify and document the effects of a specific ... identified in each of five regulatory areas: Clinger-Cohen Act, Core Law and 50-50 Rule, program planning and budgeting, program status reporting, and testing The tool provided space to report other...
- 105
- 379
- 0
Protecting Children''''s Health In A Changing Environment - Report Of The Fifth Ministerial Conference On Environment And Health.pdf potx
... Environment and Health in 2016 13 We the Minister of Health and the Minister of the Environment, Land and Sea of Italy, on behalf of all the ministers of health and environment in the European Region of ... development The main challenge to implementing the CEHAPs in Poland and Portugal was knowing the priorities and formally appointing a CEHAP committee In Poland, WHO’s involvement in identifying ... people living in an area stretching from the Arctic Ocean in the north and the Mediterranean Sea in the south and from the Atlantic Ocean in the west to the Pacific Ocean in the east The European...
- 92
- 501
- 0
Measuring the Statutory and Regulatory Constraints on Department of Defense Acquisition - An Empirical Analysis pptx
... section of the ASR; • developing, updating, or revising the Core/Source of Repair Analysis section of the ASR; • developing, updating, or revising the Industrial Capabilities section of the ASR; and ... while maintaining the level of oversight and accountability required in the expenditure of public funds The objective of the present research was to quantify and document the effects of a specific ... identified in each of five regulatory areas: Clinger-Cohen Act, Core Law and 50-50 Rule, program planning and budgeting, program status reporting, and testing The tool provided space to report other...
- 105
- 350
- 0
lc ms applications in drug development
... on introducing more lead compounds into the pipeline to obtain more NDA/MAA filings The logic is highly intuitive; if the number of compounds entering the pipeline is doubled, then the number of ... In preclinical development, the main goal is directed toward the swift filing of the IND/CTA Preclinical development analyses are aimed at providing more specific and detailed information for the ... features of LC/MS analysis These unique industry perspectives offer an enabling “currency” and assist in understanding the events that resulted in the proliferation of LC/MS throughout the drug development...
- 255
- 298
- 0
báo cáo hóa học: " Measuring health-related quality of life in Hungarian children with heart disease: psychometric properties of the Hungarian version of the Pediatric Quality of Life Inventory™ 4.0 Generic Core Scales and the Cardiac Module" pptx
... years It was the mother who answered the questionnaire in 92.52% of the sample, and it was the father in 7.48% of the sample No parent in the patient group refused to participate in the study, ... the sample, it was the father in 4.57% of the sample, and it was someone else in 6.28% of the sample Distribution of all participants in terms of gender and age group is shown in Table Statistical ... The challenges are the impact of the condition on daily life and functioning, the psychosocial consequences, and the impact on individual psychological and social well-being [1] There is an intense...
- 12
- 619
- 2
Report of the World Commission on Environment and Development: Our Common Future potx
... solvents, and mercury flowed into the Rhine River during a warehouse fire in Switzerland, killing millions of fish and threatening drinking water in the Federal Republic of Germany and the Netherlands ... developing and industrial nations is widening, in which the industrial world dominates in the rule -making of some key international bodies and in which the industrial world has already used much of the ... manifest themselves in the form of rising costs and diminishing returns, rather than in the form of any sudden loss of a resource base The accumulation of knowledge and the development of technology...
- 300
- 2,217
- 0
Tìm thêm: xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose