petro et al 2004 differential expression of the non receptor tyrosine kinase brk in oral squamous cell carcinoma and normal oral epithelium oral oncol 40 10 1040 7
Báo cáo khoa học: Functional expression of the quinoline 2-oxidoreductase genes (qorMSL) in Pseudomonas putida KT2440 pUF1 and in P. putida 86-1 Dqor pUF1 and analysis of the Qor proteins doc
... Qor activity and protein content, and determination of the apparent Km and kcat values for quinoline The activity of Qor was determined spectrophotometrically by measuring the quinoline-dependent ... (quinoline) showed a specific activity of mg)1 and 17 mg)1, respectively The kinetic parameters were estimated from Hanes plots Determination of the metal contents of the Qor proteins, and detection ... Mo-MCD-containing hydroxylase in heterologous hosts, the iorAB genes of Brevundimonas diminuta 7, coding for isoquinoline 1-oxidoreductase, were cloned in P putida KT2 440 and in the quinoline degrading...
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Báo cáo khoa học: Differential expression pattern of the novel serine⁄threonine kinase, STK33, in mice and men doc
... Taylor SS, Radzio-Andzelm E & Hunter T (1995) How protein kinases discriminate between serine ⁄ threonine and tyrosine? Structural insights from insulin receptor protein -tyrosine kinase FASEB J 9, ... predominantly cytoplasmic localization of Stk33 protein STK33 could be involved in the normal development of heart and other organs in embryonic and fetal stages The third highest signal in the ... was perinuclear, strongly supporting its association to germinal cells No signal was observed in periluminar areas of the germinal epithelium or in spermatozoa, in cells from the interstitial tissue,...
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Báo cáo y học: "Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue" doc
... from the cell surface of endothelial cells and thereby decrease membrane-bound Tie1 expression [ 27] The upregulation of Tie1 mRNA and protein expression in RA is not consistent with these findings ... et al [14] and Uchida et al [26] we detected Tie2 immunostaining on endothelial cells and fibroblasts in all disease groups Tie2 immunostaining using antibody from R&D Systems confirmed the expression ... Breitman ML: Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo Genes Dev 1994, 8:18 97- 1909 14 Otani...
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Báo cáo y học: "Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues" doc
... Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding J Cell ... immunostaining on ST lining and MΦs was significantly higher in RA (lining cells = 60% and MΦs = 46%) compared to OA (lining cells = 30% and MΦs = 23%) and ND (lining cells= 17% and MΦs = 10% ) (P ... focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase Mol Biol Cell 1995, 6:6 37- 6 47 Polte TR, Hanks SK: Interaction between focal adhesion kinase and...
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Báo cáo y học: " Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis" pptx
... within the inflammatory cell mass in the airway lumen or in isolated cells either infiltrating the epithelium or within the sub epithelial layer The lack of SPLUNC1 staining in sections of tissue ... localisation of SPLUNC1 was performed as described in the materials and methods sections Sections show submucosal gland staining in "normal" human airways (A) and a lack of staining in the epithelium ... consequence of a combination of factors, including phenotypic alterations of the airway epithelium, the elevated viscosity, alterations in the ionic strength and pH of the airway lining fluid and the increased...
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Báo cáo y học: "Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus"
... Bucci E Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience Oral Oncol 2001; 37: 26 27 Int J Med Sci 2004 1(3): 146-151 10 11 ... between oral lichen planus and squamous cell carcinoma, in this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium ... Merletti F Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population Oral Oncol 2004; 40: 77 -83 Holmstrup P, Thorn JJ, Rindum J, Pindborg...
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Báo cáo khoa học: Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss pdf
... cytokines and other stimulants in different biological settings IL-1a induces IL-11 expression in rheumatoid synovial fibroblasts, lung epithelial cell lines and endometrial epithelial and stromal cells ... supplemented with 100 unitsỈmL)1 penicillin and 100 lgỈmL)1 streptomycin, and 30% fetal calf serum for RTS-11, and 10% fetal bovine serum for all the other cell lines Bacterial challenge, SSH library ... player in the cytokine network and the host immune response to infection in fish Experimental procedures Cell lines and cell culture Four rainbow trout cell lines were used in these studies; the mononuclear...
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Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot
... pasteurianum and D desulfuricans [14,15] All of them are present in the C reinhardtii protein (Pro 37, Ala38, Thr74, Ala78, Cys113, Pro138, Met1 67, Lys 172 , Glu 175 , Phe234, Val 240 and Met359; Fig 4) An interesting ... motive Val-Ala-Cys-Ala (Fig 2) In addition to the detection of the protein using antibodies raised against the Fe-hydrogenase, the localization of the mature protein in the chloroplast stroma is indicated ... an interesting additional protein domain A small insertion of 45 amino acids between residue Ser284 and Val330 builds an external loop of the protein that might be involved in electrostatic binding...
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Báo cáo hóa học: " Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer" ppt
... http://www.translational-medicine.com/content/8/1 /78 Page of 12 Figure Expression of RBM3 in the cisplatin-sensitive A 278 0 ovarian cancer cell line compared to the cisplatin-resistant cell line A 278 0-Cp70 and the ... between untreated A 278 0 and A 278 0-Cp70 cells (Fig 3F) with a Ehlén et al Journal of Translational Medicine 2 010, 8 :78 http://www.translational-medicine.com/content/8/1 /78 Page of 12 Figure Increased ... the relationship between RBM3 expression and clinical outcome In Cohort I, Ehlén et al Journal of Translational Medicine 2 010, 8 :78 http://www.translational-medicine.com/content/8/1 /78 Page of...
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Báo cáo hóa học: " Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma''''" doc
... association between the expression of Oct4 and lymphoid metastasis, whereas the expression of Sox2 was significantly related to the histological grade of individual hypopharyngeal squamous cell carcinomas ... 1 :100 ) Sox-2 was detected using a rabbit polyclonal anti-Sox antibody (Cell signaling, #3 579 , UK, dilution 1 :100 ) A total of 85 formalinfixed, paraffin-embedded hypopharyngeal squamous cell carcinoma ... activity Then the sections were examined by immunostaining using the primary antibodies overnight at 4°C in a humidity chamber The avidin-biotin Ge et al Journal of Translational Medicine 2 010, 8:94...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... radioresistance in laryngeal tumors [33] Cetuximab is an IgG1 monoclonal antibody against the ligand-binding domain of EGFR Cetuximab binds Chiu et al Journal of Translational Medicine 2011, 9:31 ... delayed the DNA repair [ 37- 39] Oxaliplatin induced double-strand breaks [40] When cetuximab was combined with oxaliplatin, cetuximab reduced the expression of ERCC-1 and other genes involved in DNA ... Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma Oral Oncol 2009, 45 :79 8-802 Department of Health EY, R.O.C.: Cancer Registry Annual Report in Taiwan Area...
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Báo cáo sinh học: "The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" doc
... oesophageal squamous cell carcinoma We also provide new insights into the biological functions of MTSS1 and its role in oesophageal squamous cell carcinoma Page of 10 Table Clinical data of the patients ... staining of MTSS1 was observed in stromal cells in either normal or tumour tissues Expression pattern of MTSS1 in oesophageal cancer cell lines A panel of oesophageal cancer cell lines was examined ... expression in oesophageal squamous cell carcinoma tumours compared to the normal tissues This in contrary to the results obtained in hepatocellular carcinoma, but clearly in line with the studies in other...
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báo cáo hóa học:" High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... radioresistance in laryngeal tumors [33] Cetuximab is an IgG1 monoclonal antibody against the ligand-binding domain of EGFR Cetuximab binds Chiu et al Journal of Translational Medicine 2011, 9:31 ... delayed the DNA repair [ 37- 39] Oxaliplatin induced double-strand breaks [40] When cetuximab was combined with oxaliplatin, cetuximab reduced the expression of ERCC-1 and other genes involved in DNA ... Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma Oral Oncol 2009, 45 :79 8-802 Department of Health EY, R.O.C.: Cancer Registry Annual Report in Taiwan Area...
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o cáo hóa học:" The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" docx
... oesophageal squamous cell carcinoma We also provide new insights into the biological functions of MTSS1 and its role in oesophageal squamous cell carcinoma Page of 10 Table Clinical data of the patients ... staining of MTSS1 was observed in stromal cells in either normal or tumour tissues Expression pattern of MTSS1 in oesophageal cancer cell lines A panel of oesophageal cancer cell lines was examined ... expression in oesophageal squamous cell carcinoma tumours compared to the normal tissues This in contrary to the results obtained in hepatocellular carcinoma, but clearly in line with the studies in other...
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Báo cáo khoa học: "The synchronous occurrence of squamous cell carcinoma and gastrointestinal stromal tumor (GIST) at esophageal site" ppsx
... participated in the design of the study and collect the clinical data LR participated in the design of the study and collect the clinical data GP participated in the design of the study and collect the ... replacement of the esophagus Histological examination The final histological findings confirmed the diagnosis of infiltrating squamous cell carcinoma; (Figure 1,A, B) The lesion extended into the sub ... clinical data AZ participated in the design of the study and collect the clinical data FZ participated in the design of the study and collect the clinical data GCP participated in the design of...
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Báo cáo y học: "Anti-Inflammatory mechanisms of the proteinaseactivated receptor 2-inhibiting peptide in human synovial cells" ppt
... Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation The FASEB Journal 2 010, 24:1 971 -1980 Chen et al ... Expressions of COX-2 and MMP-1 were analyzed by western blotting, and relative levels were calculated by normalizing the band densities to that of GAPDH and setting the zero controls as 100 % (A) Cells ... trypsin Expressions of COX-2 and MMP-1 were analyzed by western blotting, and relative levels were calculated by normalizing the band densities to that of GAPDH and setting the zero controls as 100 %...
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Báo cáo y học: "Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation" ppt
... SR14 171 6A increased the expression of the adiponectin gene when administered to pre-adipocytes (Fig 8B) Our results agree with the findings of Bensaid et al [25] obtained in a murine cell line ... speciesdifferences in the actions of these compounds in the adipose tissues, and emphasizing again the importance of using human cells to predict possible effects in vivo of pharmacological and therapeutic ... summation of all of these effects Interestingly, in rodents, the amelioration of glucose intolerance and insulin resistance observed following treatment of mice with high fat diet- or leptin deficiency-induced...
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Báo cáo y học: "Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis" pot
... and TS participated in the design of the study, in the analysis of the patient cohorts, in the statistical analysis and in the writing of the manuscript BD initiated, planned and supervised the ... cytoskeleton and engulfment of the apoptotic cell [30,31] The process requires that the Mer is an intact membranespanning protein and depends on activation of the intracellular kinase domain of Mer The ... in defective phagocytosis by the retinal epithelium of the outer membrane of photoreceptors [6] This causes retinitis pigmentosa, which eventually leads to blindness in the affected individual...
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Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx
... (CPM) Willett et al Retrovirology 2 010, 7: 38 http://www.retrovirology.com/content /7/ 1/38 B12 Page of 13 B19 B14 1 07 106 34 105 B23 24 10 B28 B25 1 07 106 34 10 223 B30 B32 B31 1 07 11 106 138 105 B2542 ... determinants in both CRD1 and CRD2 of CD134 for infection while at the other extreme, B2542 and PPR are capable of infecting via an interaction with CRD1 alone[ 27, 37] Preliminary analyses of the ... Schematic structural model of the FIV SU and TM proteins after Pancino et al[ 67] , illustrating the locations of variations in the amino acid sequence of the A613 variants Mutated amino acids are...
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Tài liệu Báo cáo khoa học: Gas6 and protein S Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily pptx
... Schlessinger J (2000) Cell signaling by receptor tyrosine kinases Cell 103 , 211–225 Robinson DR, Wu YM & Lin SF (2000) The protein tyrosine kinase family of the human genome Oncogene 19, 5548–55 57 ... (1995) Receptor tyrosine kinases expressed in metastatic colon cancer Int J Cancer 60, 79 1 79 7 104 Taylor IC, Roy S & Varmus HE (1995) Overexpression of the Sky receptor tyrosine kinase at the cell ... (1999) Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NFkappaB Mol Cell Biol 19, 1 171 –1181 93 Liu...
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