pestis cytotoxicity and its virulence in the mouse models of bubonic and pneumonic plague
báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt
... directly involved in the formation of retinal NV in the later stages of the OIR model In this study, we investigated the temporal and spatial distribution of microglial cells during the different ... pictures and drafted the manuscript GM participated in the design of the study and performed the statistical analysis HTA conceived of the study, and participated in its design and coordination and ... the border of the inner nuclear layer and the outer plexiform layer (Figure 1B and 2E) Microglial cell density was always higher in the superficial than in the deep retinal layer (Figure 3) The...
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Báo cáo y học: "Use of a highly sensitive strand-specific quantitative PCR to identify abortive replication in the mouse model of respiratory syncytial virus disease" pptx
... design of the study and analysis and interpretation of data HB conceived of the study, participated in its design and coordination and helped to draft the manuscript All authors read and approved the ... copies) and was maintained until the end of the study at day 10 Similar to cells infected with the MOI of × 10-1, no increase in negative strand RNA was observed (Figure 4D) Beta actin levels in the ... carried out the molecular and cellular studies and drafted the manuscript DR carried out the in vivo and cellular assays and analysis and interpretation of data, EJM, MW and CL participated in the design...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
... focused on a small number of cytokines within the same sample It is not clear which cytokines are key in promoting and maintaining the inflammatory environment in the AD brain Furthermore, it is unclear ... from transgenic mouse models of Alzheimer's disease, and to further relate this increase to the level of Aβ present in the brain Another purpose of our study was to determine whether inflammatory ... of the pathological features seen in the AD patient brain and show an increased production of inflammatory markers such as COX-2, PGE2 and also increased levels of the pro-inflammatory cytokines...
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Cadmium Removal by the Hydroponic Culture of Giant Reed (Arundo donax) and Its Concentration in the Plant
... was removed within days in every run Assuming the zero-order kinetics, the average cadmium removal rates within the days calculated from the linear approximations of the plots in Fig were estimated ... like in the case of cadmium was not observed Furthermore, the particular effect of the cadmium addition on the appearance of the plant body was not observed during days in runs to Assimilation of ... cadmium, and is synthesized from glutathione (GSH) Inouhe et al (1994) reported that the cadmium binding complex containing PCs has an important role for the cadmium-tolerance of seedlings of some...
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Expansion and its realization in the short story “the law of life” by jack london
... for choosing the topic, the aims of the study, the methodology, the scope, and the design of the study Part B, the main part of the thesis, consists of three chapters Chapter 1, entitled Theoretical ... giving, and (ii) demanding” This means there are two roles in exchange: giving and demanding He goes on to analyze the nature of the commodity being exchange into (a) goods and service and (b) information ... features of the text and the intention of the writer In this thesis, the text chosen is the short story The Law of Life” by the famous American writer, Jack London Aims of the study The study...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping and forms ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... (CostarÒ) The cultures were incubated at 37 °C in a humidified 5% CO2 incubator in the absence (control) and presence of increasing concentrations of inhibitors for 10 days, and the number of molting ... immunohistochemical staining), and that the inhibition of PPasecatalyzed PPi hydrolysis by these inhibitors, is likely to prevent the synthesis of the new cuticle from the hypodermis and/ or ecdysis of the old...
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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
... advantage of the trypsin-sensitive region situated in the linker domain of Abcb1a Following trapping in the absence or presence of Vi and mild-trypsin treatment, the trypsin degradation products of the ... in the glutamine (length of the side chain maintained) and asparagine (shorter side chain) mutants, then trapping in the absence of Vi now occurs [39] (Fig 3); this is also the case when the ... Another notable feature of the single-site IC mutants (including the glutamine substitutions) [39] is the fact that, in the absence of Vi (± drugs) labeling of the enzymes with the mutation in...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... clarified in detail and could play a key role in the detoxification processes In this study we examined the role of Bcp2 in order to increase the knowledge of the enzymatic activity involved in the ... Furthermore, we report the cloning, the expression and the characterization of the recombinant protein rBcp2 in order to shed light on its role in the detoxification process and on its catalytic mechanism ... 2-Cys Prxs, the largest Prx class, is their second redox-active cysteine, the resolving cysteine (Cys-SR) In typical 2-Cys, Sp at the N terminus and SR at the C terminus of the protein belong to...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx
... how long the enamine remains in the active site and its rate of attack on the aldimine bond, and can be modified by slight differences in the position of the residues [41] As covalent binding was ... becoming the major form detected in the spectra Summarizing, data shown in Fig reinforce our previous findings on the tautomeric forms of the internal aldimine in the free holoenzyme [19] and the ... times were 2–5 The conformational changes induced in HDC by histidine and histidine-analogs involve alterations in the environment of the aromatic amino acid residues of the protein Fig Thermal denaturation...
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Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
... cause, given that there is an increased use of Q-queries in spite of the seemingly inferior search results, there is a strong need for the search engines to improve their handling of question-queries ... clustering but on understanding the expression of intent Method We address the main thesis of the work by retrospectively studying queries issued to a search engine over the course of 12 consecutive ... context and an improved understanding of question-queries by search engines Related work There has been some work on studying and exploiting linguistic structure in web queries Spink and Ozmultu...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... mislocalization of all three enzymes in these cells clearly shows the involvement of PEX14 in the targeting of PTS-1, PTS-2 and I-PTS proteins to the glycosome To further analyse the effect of the destruction ... N-terminal domain of the polypeptide of each of these organisms is followed by a stretch of hydrophobic amino acids that is presumably involved in the protein’s anchoring to the membrane Also in ... was located in the band This may be due to diffusion of some complexed protein as the band migrates in the native gel Band contains the excess of TbPEX14-N,H In a second experiment, the same two...
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Astrology, Psychology, and The Four Elements An Energy Approach to Astrology & Its Use in the Counseling Arts_1 pptx
... degree of insight into the workings of the four elements, and also to the many friends and students who have encouraged my writing and teaching Finally, we appreciate the permission of the following ... It has nothing to say concerning the why of the universe, and everything dealing with the understanding and the significance of individual human values and goals is outside its domain astrology's ... the domain of psychologT to the laboratory study of animals and to the overt behavior patterns of human beings is inconsistent with the definition of the supposedobject of study: the psyche itself,...
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Astrology, Psychology, and The Four Elements An Energy Approach to Astrology & Its Use in the Counseling Arts_2 pdf
... Language of Energy Key Concepts and Deftnitions A key to the understanding of all astrology is within the reach of anyone who truly understands the meaning of the following definitions: The PLANETS indicate ... according to the elements have a much better chance of constructively meeting the challengesoftheir stressful aspects Since most of the principles involved in comparing the interaction and combination ... considerations, or intuitions of the other signs They are attuned to the world of "forms" which the sensesand practical mind regard as real, and their innate understanding of how the material world...
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Báo cáo sinh học: " Motavizumab, A Neutralizing Anti-Respiratory Syncytial Virus (Rsv) Monoclonal Antibody Significantly Modifies The Local And Systemic Cytokine Responses Induced By Rsv In The Mouse Model" pdf
... either at a very low level or were below the level of detection of the assay in the non-infected control group, and the objective of the study was to evaluate the effect of motavizumab in the inflammatory ... time of the administration of the anti-RSV antibody had no effect on the cytokine profile or other clinical and inflammatory parameters evaluated, therefore those controls were not included in the ... markers of disease severity correlate with similar changes in cytokine profiles These studies will provide further understanding of the pathogenesis of RSV infection and should help identifying new...
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Báo cáo sinh học: " Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse" pdf
... was applied to the nares of mice anesthetized by intraperitoneal (i.p.) injection of 0.2 ml ketamine-xylazine (70/7 mg/kg); this results in the aspiration of the vaccine into upper and lower airways ... with the few mice used in these experiments Taken together, the results indicated that combined vaccination with M2e-MAP and infectious virus may improve the induction of HeLa-M2-reactive Abs and ... against viral structures of low or no variability, and thereby provided a constant level of long lasting resistance against IAV infection, independent of the glycoprotein makeup of circulating...
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Báo cáo sinh học: " Possible active origin of replication in the double stranded extended form of the left terminus of LuIII and its implication on the replication model of the parvovirus" pptx
... contributed in the analysis and interpretation of the data, participated in the idea and design of the models proposed and in the drafting and revision of the manuscript IDM collected the data resulting ... (figure 1) In anticipation of the difficulties expected in manipulating the left end hairpin and to increase the chances of obtaining the desired construct two copies of the left end termini were ... essential cofactor for NS1 in the replication initiation process allowing efficient and specific nicking of the 3' minimal origin and leaving NS1 covalently attached to the 5' end of the DNA at the...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... important role in the secondary activation of microglia, in the progression of the inflammatory response, and in the progressive loss of the dopaminergic neurons in MPTPinduced PD Therefore, COX-2 ... Boehringer-Mannheim, Indianapolis, IN) or βactin (Sigma, St Louis, MO) antibodies for detection of the level of dopaminergic neuronal terminals, and for normalization of the loading protein The signal ... fill in the gap within the literature on the effects of COX-2 inhibition in protecting SNpc dopaminergic neurons from MPTP-induced neurotoxicity We inhibited COX-2 using both pharmacological and...
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Báo cáo hóa học: " Motavizumab, A Neutralizing Anti-Respiratory Syncytial Virus (Rsv) Monoclonal Antibody Significantly Modifies The Local And Systemic Cytokine Responses Induced By Rsv In The Mouse Model" potx
... either at a very low level or were below the level of detection of the assay in the non-infected control group, and the objective of the study was to evaluate the effect of motavizumab in the inflammatory ... time of the administration of the anti-RSV antibody had no effect on the cytokine profile or other clinical and inflammatory parameters evaluated, therefore those controls were not included in the ... markers of disease severity correlate with similar changes in cytokine profiles These studies will provide further understanding of the pathogenesis of RSV infection and should help identifying new...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng 9 tr 25