pde4b 4d and 7a mrna knock down by antisense oligonucleotides correlates with inhibition of inflammatory mediators production by human broncho epithelial cells in vitro
Báo cáo y học: " Expression of transforming growth factor- in chronic idiopathic cough" pdf
... Sections were incubated with the avidin/biotinylated peroxidase complex for 30 min, followed by chromogenic substrate diaminobenzidine for min, and then counterstained in haematoxylin and mounted ... desquamation and inflammatory cells, particularly lymphocytic inflammation, and also by an increase in submucosal mast cells, but not of neutrophils or eosinophils, with goblet cell hyperplasia, subepithelial ... There may be an induction in the upper airways of inflammation and tissue remodelling induced by various causes associated with cough or by the act of coughing itself that Page of 10 (page number...
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Báo cáo y học: " Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD" doc
... der Zanden L, Ottenhoff THM: Phenotypic and functional profiling of human proinflammatory type-1 and anti -inflammatory type-2 macrophages in response to microbial antigens and IFN-{gamma}- and ... ex-smoking and never smoking COPD patients with GOLD stage II-III [36] We did not find a difference in BAL IL-6 and IL-8 and sputum IL-6 between current smokers and ex-smokers with COPD, in line with ... Groningen, University of Groningen, Groningen, The Netherlands 4Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of...
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Báo cáo y học: "Alterations of alveolar type II cells and intraalveolar surfactant after bronchoalveolar lavage and perfluorocarbon ventilation. An electron microscopical and stereological study in the rat lung" pdf
... appearance of type II cells and intracellular surfactantstoring lamellar bodies (Fig 2) and intraalveolar surfactant (Fig 3) in the four groups The lamellar bodies within type II cells were filled with ... alter the incorporation of acetate and choline into the lung and synthesis of lecithin seemed not different between conventional and liquid ventilation [24] In preterm rabbits [25] and preterm ... number of cells in an organ [20] Due to higher chances for bigger cells of being hit in a thin histological section, cell profiles per field of vision not represent an unbiased sample Instead,...
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báo cáo hóa học: " Comparative analysis of induced sputum and bronchoalveolar lavage fluid (BALF) profile in asbestos exposed workers" potx
... similarity in the pattern of cellular profile between IS and BALF samples indicating the Figure ROC curve of macrophages in IS and BALF Figure ROC curve of neutrophils in IS and BALF involvement of the ... profile of IS and the parameters under study Interrelations of induced sputum and BALF profile In Table significant correlations between IS and BALF cellular profile are shown Macrophages and ... *ABs not found in any reported PPE use useful in providing an insight both for inhalation of dusts and inflammatory processes in the lung However its usefulness for screening of workers should...
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Báo cáo y học: "Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis" pot
... pathways, including amplifying the inflammatory process by inducing the extravasion of neutrophils and the production of IL-8, inducing an inflammatory reaction in the endothelia, and/ or stimulating ... that the expression of Cal B and Cal A correlates with the inflammatory activity in systemic vasculitis, thereby confirming the role of these proteins in inflammatory reactions of endothelia [47] ... process involving the activation of T cells and epithelial cells, the secretion of pro -inflammatory cytokines and growth factors, and fibroproliferation (Figure 2) In addition, several factors, including...
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Báo cáo y học: " Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study" pot
... 1E, and 1F) Sequential analysis of BALF and IS Analysis of the single fractions of BALF showed an increase of IgG levels and concomitantly a decrease of IgA levels, resulting in an increase of ... protein I (OprI) and amino acids 190–342 of OprF of P aeruginosa, was expressed in E coli and purified by Ni2+ chelate-affinity chromatography [5] For the nasal vaccine, an aqueous solution of ... examination prior to the study, including examination of the nasal cavity by an ENT-specialist Total IgG and IgA levels in serum and IgA levels in saliva were obtained in order to exclude an as yet...
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Báo cáo y học: " Functional and phenotypical comparison of myofibroblasts derived from biopsies and bronchoalveolar lavage in mild asthma and scleroderma" ppsx
... Triton X-100 in PBS for minutes, and blocking with 1% BSA in PBS for 30 minutes, the cells were incubated for 30 minutes with Alexa Fluor™ 488 phalloidin probe (Molecular Probes, The Netherlands) diluted ... patients with SSc Interestingly, oxidative stress is considered an important factor in patients with SSc in contributing to vascular damage leading to an activation of fibroblasts and inflammatory cells ... to produce TGF-β by themselves through an autocrine mechanism that has been suggested to be of importance in maintaining the myofibroblast phenotype by inducing increased levels of α-SMA [26] We...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" pptx
... Yeagley D, Quinn PG: Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of Page of 10 (page ... phosphorylation of Thr389 in p70 S6 kinase was increased in the presence of insulin after 15 of incubation and remained increased after 16 hours Rapamycin abolished the phosphorylation of Thr389 in both ... deviation of the mean) (A) A representative phospho-image of human SP-A and human α-actin gene transcription in H441 cells treated with or without insulin for the time periods indicated (B) Insulin inhibited...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" doc
... immunomodulators by endothelial cells, epithelial cells, and cells of the interstitium creating an intense local inflammatory response [2,10] The subsequent events of these cellular/humoral interactions ... have been found to be increased in BALF in the early phase of ARDS, including endotoxin-binding proteins, tumour necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, chemokines, adhesive molecules ... sequence of the events remains unclear Most of our understanding regarding pulmonary inflammation in ARDS is based on studies regarding bronchoalveolar lavage fluid (BALF) [2] Various inflammatory mediators...
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Báo cáo y học: "Evaluation of Fractional Analysis of Bronchoalveolar Lavage Combined with Cellular Morphological Features"
... showing 28.2% following by NSIP 6.1%, IPF 5.0% and COP/BOOP 4.6% With May-Grunwald-Giemsa staining, mast cells were identifiable by the purple-red granules in cytoplasm, and were encountered in ... high-affinity IgE receptor which triggers a cascade of intracellular signals that lead to degranulation and synthesis of various mediators involved in the development and maintenance of allergic and ... Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage J Lab Clin Med 1974;84: 559-573 Hunninghake GW, Gadek JE, Kawanami O, Ferrans VJ, Crystal RG Inflammatory and...
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Báo cáo hóa học: " Respiratory function and bronchial responsiveness among industrial workers exposed to different classes of occupational agents: a study from Algeria" potx
... of subjects with a measurable PD20 (provocative dose of histamine leading to a 20% decrease in FEV1 with respect to the starting value) in the histamine test (n values of group lower by one in ... deterioration of lung function with advancing age in welders compared with controls In a longitudinal study of welders and caulker-burners with follow-up of retired workers, Chinn and colleagues ... PEF, and FEF50% declined over time; the decrease was caused equally by welding and smoking In 286 students entering an apprenticeship programme in the welding profession FEV1 dropped on average by...
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Báo cáo y học: "Proteome analysis of bronchoalveolar lavage in Pulmonary Langerhans cell histiocytosis" pptx
... after defining and saving a set of detection parameters, enabling filtering and smoothing of the original gel scans to clarify spots, and removal of vertical and horizontal streaks and speckles ... fragments of plasma proteins in BAL of PLCH patients, suggesting increased proteolytic activity In particular kininogen and haptoglobin proteolytic fragments were more highly expressed in BAL of PLCH ... mediator of the anti -inflammatory action of glucocorticoid (52) that inhibits neutrophil extravasation (53) The inflammatory environment induced by smoking is associated with increased epithelial...
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Báo cáo y học: "CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis" ppt
... levels of CD38, a molecule involved in "homing in" of inflammatory cells and cytokine production [29] Neutrophils, on the other hand, may play a critical role in the induction of lung injury ... sustain progress despite paucity of interstitial inflammation, the role of inflammatory response in the modulation of tissue injury and fibrosis still remains under investigation [19,20] In the ... modulation of tissue injury in IPF [5-8] Recently, we shown that in IPF tissue, infiltrating CD8+ TLs are associated with the grade of dyspnoea and physiological indices of disease severity, implicating...
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Báo cáo y học: " Open Access No evidence of altered alveolar macrophage polarization, but reduced expression of TLR2, in bronchoalveolar lavage cells in sarcoidosis" doc
... seen in patients is associated with an influx of CD4 T cells with on average merely little production of IL-17 The roles of IL-23 and IL-17 in sarcoidosis clearly merit further investigation In ... can by itself cause macrophage activation and cytokine production [23] A lack of such in vitro activation in our study may also explain why the mRNA levels of some genes such as IL-2p35 were often ... presenting cells, and as key mediators of innate host defence these receptors are involved in recognizing several molecules derived from microbes of different kinds For example, mycobacteria contain...
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Báo cáo y học: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis" docx
... determined by May-Grünwald-Giemsa staining of cytopin slides Flow cytometric analysis and isolation of cells BALF CD4/CD8 T lymphocyte ratio and TCR AV2S3 expression in BALF cells was determined by ... (housekeeping gene) and the relative expression of a gene in Cytokine mRNA expression in CD4+ T cells We also analyzed the expression of Th1 and Th2 cytokines in BALF CD4+ T cells obtained from ... syndrome and those without Hypothetical model of inflammatory reactions in sarcoidosis, comparing the immune response in the lungs of patients with Hypothetical model of inflammatory reactions in sarcoidosis,...
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Báo cáo y học: " Bronchoalveolar lavage fluid from preterm infants with chorioamnionitis inhibits alveolar epithelial repair" ppsx
... alveolar type II cells and are most widely used in human in vitro models of alveolar physiology More importantly, in testing the biological activity of human BALF, we refrained from using animal-derived ... between infants with and without chorioamnionitis and infants that had and had not received antenatal steroids Chorioamnionitis decreases wound healing capacity of BALF BALF obtained from infants with ... Perkins GD, Gao F, Thickett DR: In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury Thorax 2008, 63:215-220 Lahra MM, Beeby PJ, Jeffery HE: Intrauterine...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... the inflammatory response to acute epithelial injury and in maintaining and repairing the epithelial barrier [16] Chen et al have found that a deficiency of γδ T cells rendered the intestinal ... likely since the inflammatory response to epithelial damage was also attenuated in the γδ T cell deficient mice Our findings are consistent with a role of γδ T cells in determining the magnitude of ... pictures showing PCNA immunostaining in airway epithelial cells before (a) and day after exposure to 400 ppm Cl2 gas (b) in wild type mice Panel B Numbers of epithelial cells with positive staining for...
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Báo cáo y học: " Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells" ppt
... enza-virus-infected human bronchial epithelial cells influCytokine and chemokine gene expression profile ofby quantiCytokine and chemokine gene expression profile of influenza-virus-infected human ... human H1N1 virus at inducing proinflammatory cytokines and chemokines, including IP-10, interferon beta, IL-6 and RANTES, from human primary alveolar and bronchial epithelial cells infected in ... enza-virus-infected human type II pneumocytes by quantitaCytokine and chemokine gene expression profile of influCytokine and chemokine gene expression profile of influenza-virus-infected human type...
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Báo cáo khoa học: "Bronchoalveolar lavage cytological alveolar damage in patients with severe pneumonia" pps
... adapter piece permitting continuous ventilation) avoiding suctioning and without instilling local anesthetics The area of sampling was chosen on the basis of the chest radiograph and PTC was always ... frequently in patients with pneumonia (6 out of 15 (40%) in patients with CAP and 18 out of 39 (46.2%) in those with VAP) compared with ventilated patients without pneumonia (3 out of 18 (16.7%)) ... selected in accordance with the following criteria: first, high clinical suspicion of pneumonia based on the presence of a new or worsening infiltrate on a supine chest X-ray, and at least two of the...
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Báo cáo khoa học: " Is bronchoalveolar lavage with quantitative cultures a useful tool for diagnosing ventilator-associated pneumonia" doc
... sites of infection Delaying diagnosis or definitive treatment of the true site of infection may lead to prolonged antibiotic therapy and to induction of additional dysfunction [13,14] In the ... left with uncertainties regarding the numbers of extrapulmonary infection in the two arms of the trial, as well as how long the recommended duration of therapy in patients with VAP should be and ... pneumonia cannot explain such a disappointing result, when compared with the 0.5% rate of inappropriate initial therapy reported by Fagon and coworkers in the invasive strategy group [8] The most...
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