patients records as therapeutic tools
Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... reported G-quadruplexes as cancer drug targets subsequently [18,21,22], although relatively few have been evaluated in cell-based assays, or even with reliable in vitro telomerase assays [23,24] The ... singlestranded overhang, chiefly hPOT1, as well as possible uncapping of telomerase from the ends There are likely to be multiple mechanisms involved, some of which at least have cross-talk between them ... facilitates telomere length regulation by telomerase, and hPOT1 displacement disregulates telomerase function [7,8] Also, although the classic telomerase inhibition model does not appear to be followed...
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Báo cáo lâm nghiệp: "New insights in the recognition of the European ash species Fraxinus excelsior L. and Fraxinus angustifolia Vahl as useful tools for forest management" pdf
... searches were performed using the BLAST algorithm at http://www.ncbi.nlm.nih.gov (National Center for Biotechnology Information), with programs blastn, tblastn and tblastx New primers were redefined ... during 16 weeks For embryo size measurements, 16 seeds per mother tree were rehydrated and sterilized as described in Raquin et al [19], and embryo length was measured under a Wild M5 stereomicroscope ... of common ash by narrowleaved ash, for example in the context of global change Acknowledgements: We thank Céline Devaux, MarieElise Morand-Prieur, Jacqui Shykoff, Carol Baskin, Marc Masimbert and...
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Báo cáo y học: " Membrane diffusion- and capillary blood volume measurements are not useful as screening tools for pulmonary arterial hypertension in systemic sclerosis: a case control study" pptx
... of 50% despite therapy [4,5] As therapeutic intervention implemented at an earlier phase might modify the disease course in SScPAH, new tools that assess PAH in patients with SSc are warranted[6] ... before PAH was diagnosed[2,13] However, TLCO has not been established yet as a marker for SScPAH It remains to be elucidated how interstitial lung disease influences TLCO in these patients as severe ... hypertension Classically, pulmonary hypertension has been considered as an isolated pulmonary vasculopathy in the group of SSc patients with longstanding limited cutaneous form However, all our patients...
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Báo cáo y học: "Central venous O2 saturation and venous-toarterial CO2 difference as complementary tools for goal-directed therapy during high-risk surge" ppsx
... coronary artery disease Perioperative management was similar in all patients except for the basal rate of intraoperative crystalloids Data collection and outcome measures Preoperatively, patients were ... venous PCO as a surrogate for mixed venous PCO2 [21], has recently been proposed as a useful tool for GDT in ICU-septic patients to identify persistent hypoperfusion when a ScvO2 > 70% has been ... cut-off values for outcome associations The optimal cut-off was defined as the value associated with the highest sum of sensitivity and specificity (Youden’s index) Analysis was performed using SEM...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
... Extrinsic pathway Mitochondria FasL/TRAIL/TNFR tBid Cytochrome c Apaf-1 Procaspase Caspase Caspase Procaspase Caspase Apoptosis Figure Death-receptor-mediated and mitochondrial pathways of cell ... of effector caspases (e.g., caspase-3) (Figure 3) Finally, both apoptosis pathway converged at the caspase-3 activation leading to cell death Apoptosis is characterized by cytoplasmic and nuclear ... including diseases and therapeutic misadventures, with approximately 2000 cases each year and 80% mortality In United States, virally-induced disease predominated in early 90s but has substantially...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
... enterokinase activates trypsinogen Subsequently, trypsin induces the activation of itself as well as other digestive enzymes including chymotrypsiongen, procarboxypeptidase and proelastase In contrast, ... CD4 T cells to release antiinflammatory cytokines that contribute to immune suppression As inhibiting Fas-FasL signaling (e.g., Fas fusion protein (Chung et al., 2003), or Fas siRNA administration ... resolved However, in some patients the disease develops to SIRS These patients are at high risk of remote organ failure Pancreatitis-associated lung injury, manifesting as adult respiratory distress...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
... traditional measures of lupus nephritis activity was evaluated by Bauer and colleagues [25] Thirty patients were classified as having high or low IFN gene scores (15 patients each) and the association ... correlation of CD27high plasma cells and disease activity in lupus patients [51] Patients with high disease activity (SLEDAI >8) had significantly increased frequency of CD19+/CD27high plasma cells and ... these plasma cells with the SLEDAI as well as with the anti-DNA titers Interestingly, the CD27high cells also correlated with the SLEDAI as measurement of the disease activity in SLE in patients...
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Báo cáo y học: "Segment-orientated analysis of two-dimensional strain and strain rate as assessed by velocity vector imaging in patients with acute myocardial infarction"
... vessel disease a stenosis > 50% was found in the circumflex artery in patients and in the right coronary artery in patients Complete revascularization in the patients with 2-vessel disease was achieved ... of 32 patients ECG-triggered in endexspiration and produced the standard views of the long and short axes, as well as the left ventricular outflow tract With the CMRtools software (Cardiovascular ... differences between basal, midventricular and apical myocardium (see Table 3) Table 3: Tissue velocities (S´, E´, A´) of basal, mid and apical segments as assessed by VVI S´ (cm/s) E´ (cm/s) Basal 3.64...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"
... as a result of AD in patients with MS (12-16) On cardiovascular reflex testing it has been shown that both sympathetic as well as parasympathetic dysfunction can occur in patients with MS (12-16) ... in a report by Nasseri et al (21, 22) Sympathetic vasomotor dysfunction may also contribute to fatigue in patients with MS (23) As has been noticed previously the majority of our patients were ... group of patients Management of POTS in patients with MS The pharmacological management of POTS in patients of MS was similar to that in patients without a history of MS In our small group of patients, ...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... Klein R Hyperglycemia and microvascular and macrovascular disease in diabetes Diabetes Care 1995; 18: 258-268 Haffner SJ, and Cassells H Hyperglycemia as a cardiovascular risk factor The American ... depolarization, as measured by FRET, was calculated As shown in Figure 3, a statistically significant linear relation between the changes in membrane potential and the transport activity of the cells was ... Another diabetes therapeutic approach is based on reducing intestinal glucose absorption using α-glucosidase inhibitors such as acarbose, miglitol and voglibose [34] α-glucosidase are key enzymes...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... [21], as well as pharmacological studies such as those shown in (B) In slices, an a7* nAChR on adjacent glutamate terminals was found to indirectly influence dopamine release via the release of ... caused an increase in potency as arise primarily from a3b2 and a3b4 nAChRs Activity on well as a shift in selectivity: while PnIA inhibited an a-BTXa7 nAChRs was excluded for two reasons: (a) EpI ... characterization of neuronally active a-conotoxins Assay-based and cDNA-based strategies The first a-conotoxins were identified using bioassays such as intraperitoneal (neuromuscular nAChRs) or intracranial...
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Tài liệu Báo cáo khoa học: Stem–loop oligonucleotides as tools for labelling double-stranded DNA pdf
... Moreover, as the triple helix was not stable in the absence of intercalator, it was possible to switch easily from conditions where the triple helix was very stable to conditions where it was totally ... two plasmids was used to estimate the specificity This ratio increased from to when the stem length of a TC TFO increased from to 10 bp and from to 14 when the stem length of a TG TFO increased ... plasmid was dephosphorylated by adding shrimp alcaline phosphatase (USB, 5350 Cleveland, OH, USA) (1 U for XmnI, 12 U for DraIII, 2.5 U for XbaI) and incubating for h at 37 °C Phosphatase was...
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Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system doc
... 3 Degassed, 3% sodium chloride was used as the coupling medium (dg-Na+), otherwise degassed distilled water was used (dg-DW) Temperature of the coupling medium was noted; otherwise there was no ... transducer only produced MHz ultrasound Treatment apparatus A Plexiglas cylinder was used as the ultrasound chamber (70 mm diameter, 25 mm tall) The bottom of this chamber was a single layer of acoustically ... and during ultrasound treatment A ligature was used to prevent retraction of the testes into the abdomen by the cremaster muscle during treatment Ultrasound A therapeutic ultrasound generator...
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Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx
... is the most strongly activated by SF2 ⁄ ASF Overexpression of SF2 ⁄ ASF in HeLa cells leads to a strong increase in Vpr mRNAs at the expense of other mRNAs [29] Vpr is an accessory gene product ... further assessment of inhibitors of SR protein splicing factors as a new class of antiretroviral therapeutic agents Concluding remarks The various approaches aimed at reducing the viral load in patients ... D2 signal results in increased splicing at the upstream 3¢ss A1, increased inclusion of exon into viral mRNA, decreased accumulation of unspliced viral mRNA and decreased virus production FEBS...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... tau kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 (GSK3) GSK3 has recently been implicated as a critical kinase involved ... across the plasma membrane, as determined by inductively coupled plasma mass spectrometry Once inside the cell, Cu and Zn, but not Fe, activated phosphoinositol 3-kinase mediated protein kinase pathways, ... the cuproprotein ceruloplasmin (Cp) in AD brain [22,23], but Cp activity has been reported to be decreased in plasma [24], despite being elevated in CSF [25] and in plasma [26] Furthermore, the...
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Diagnostic and Therapeutic Problems of Pulmonary Tuberculosis in Elderly Patients doc
... was necessary to relieve symptoms Drug induced hepatitis by anti-TB medication was defined as; 1) a transaminase increase to >3 times the normal upper limit; and 2) any elevation of transaminase ... elderly patients In the present study, all young pulmonary TB patients survived except two, whereas (11.1%) of the elderly patients died of TB Some have even reported mortality rates as high as 20 ... lesion, a pneumonia-like lesion, a mass-like lesion, or as others This radiologic classification was made according to interpretation of initial radiographs taken when patients first visited hospital...
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Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot
... interfere with Glx I assays Glyoxalase II activity assay was performed using the commercially available SDL-GSH and SDL-TSH prepared from T(SH)2 and MG using yeast glyoxalase I, as previously described ... Methylglyoxal assay Intracellular methylglyoxal was measured in L infantum (100 lL extract) with a specic HPLC-based assay, by derivatization with 1,2-diaminobenzene and using 2,3-dimethylquinoxaline as ... Methylglyoxal synthase activity was assayed by measuring methylglyoxal formation from DHAP The reaction occurred in mL reaction volume, in 0.1 m potassium phosphate buffer, pH 6.8, at 30 C DHAP was added...
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TEACHING WRITING USING PICTURE STORIES AS TOOLS AT THE HIGH SCHOOL LEVEL: THE MOVEMENT FROM OTHER REGULATION TO SELF REGULATION doc
... next 10-15 years As the internet is growing explosively, English is instrumental in keeping us on par with it It is emerging as a first rank language as it has affected all aspects of human society ... 5.17 The Improvement Task 5.17.1 The Task - 5.17.2 Task Demands -5.17.3 Task Discussion and Analysis ... The L1 Task - 5.14.2 Task Demands - 5.14.3 L1 Task: Discussion and Analysis - 5.15 Procedure Used for Teaching Writing: the Three Phases...
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báo cáo hóa học:" Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF" ppt
... different morphology as well as impaired fibroblast proliferation as shown by punch biopsies from the wound edge as compared with normal dermis [20] Subsequent studies showed wound fibroblasts grew significantly ... [23] as compared with controls Fibroblasts have been isolated from venous stasis ulcers for in vitro assay to evaluate cell cycle protein expression (p21) and modulation by basic fibroblast growth ... Gentamicin (50 μg/ml) was used The flask was inverted and ml additional medium was added This facilitated the rapid attachment of the cells from the biopsy to the flask After at least hours (up to...
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Báo cáo hóa học: " Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032" potx
... melanoma patients appears to be higher than is commonly assumed It can be present in up to 30% of patients bearing BRAF V600 mutations, potentially representing up to 10% of all melanoma patients Patients ... Puzanov I, Sosman J, Kim K, Ribas A, McArthur G, Lee RJ, Grippo JF, Nolop K, Chapman P: Phase I study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer ... pathway, causing cell detachment and motility in metastatic melanoma cells and enhancing cell proliferation in primary melanomas carrying NRAS Q61L mutations These paradoxical effects highlight...
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