pathophysiology of peptic ulcer disease ppt
Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
... Shimano Physiology and pathophysiology of the SREBP family SREBP-1c and lipogenesis The SREBP family consists of three isoforms: SREBP1a, SREBP-1c, and SREBP-2 Each isoform has a different regulatory ... Triglyceride 617 Physiology and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-1a in the regulation of cell growth and the ... summarize, SREBP-1c is a physiological regulator of lipogenesis, and activation of SREBP could contribute to obesity-related pathophysiology through modification of tissue-specific gene expression as shown...
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Tài liệu THE MANAGEMENT OF SICKLE CELL DISEASE ppt
... result of a formalized consensus process but rather represents the efforts of those who have dedicated their professional careers to the care of individuals with sickle cell disease The names of ... Study of Sickle Cell Disease (CSSCD) identified early predictors of clinical severity such as dactylitis before 12 months of age, average Hb level of less than g/dL in the second year of life, ... THE MANAGEMENT OF SICKLE CELL DISEASE N ATIONAL I NSTITUTES OF H EALTH National Heart, Lung, and Blood Institute Division of Blood Diseases and Resources NIH P UBLICATION...
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Tài liệu The Diagnosis, Evaluation, and Management of von Willebrand Disease ppt
... of the Panel represented the Division of Blood Diseases and Resources of the NHLBI The Panel was coordinated by the Division for the Application of Research Discoveries (DARD), formerly the Office ... 40 percent of carriers of type VWD, 82 percent of carriers of type VWD, and 23 percent of healthy controls had at least one bleeding symptom The major bleeding symptoms in carriers of type VWD ... Making the Diagnosis of VWD 31 Special Considerations for Laboratory Diagnosis of VWD 32 Summary of the Laboratory Diagnosis of VWD 33 Diagnostic Recommendations 34 I Evaluation of Bleeding Symptoms...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some of the consequences of AD and no doubt lessen the burden of ... concentrations of glutamate present and quenches the response of the NMDA receptor [36] Like Cu and Fe, considerable data indicates a loss of Zn homeostasis in AD Abnormally high concentrations of Zn ... the phosphorylation of tau [89] Such data indicate that an increase in cellular oxidative stress, be it through the generation of products of oxidative damage or the activation of specific cell signalling...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... assigned value of for no treatment and 10, 30 and 50 for increasing dosage of valdecoxib The results were similar to those of A and B with a positive correlation of the amount of daily valdecoxib ... deficiency of COX-2 correlates well with the amount of microglial activation and with the Page 12 of 16 (page number not for citation purposes) Journal of Neuroinflammation 2006, 3:6 degeneration of ... Samii A: Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies Bmj 2003, 327:128 Page 15 of 16 (page number...
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PEPTIC ULCER DISEASE potx
... the 14 Peptic Ulcer Disease usual squamous mucosal lining becomes replaced by columnar epithelial cells of putative specific aspect, peptic ulcer disease, and stress-related erosion /ulcer disease ... the convenience of the readers and the content of each section is tightly connected to the rest of the book Peptic Ulcer Disease opens with a discussion on the causes of the disease The first ... by H pylori, only less than 10% of them develop peptic ulcer disease We should also remember that peptic ulcers sometimes occur in the absence of the bacteria Use of NSAIDs is an example Some estimate...
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ETIOLOGY AND PATHOPHYSIOLOGY OF PARKINSON''''S DISEASE pot
... for causation of Parkinson’s disease A great focus has been given to pathophysiology of Parkinson’s disease, role of basal ganglia and other parts of brain involved in Parkinson’s disease Every ... investigations of environmental and genetic factors of PD (Figure 1) 2 Etiology and Pathophysiology of Parkinson's Disease Fig Although the etiology of Parkinson disease (PD) remains unknown, 5-10% of patients ... general population Genetics of Parkinson Disease 17 18 Etiology and Pathophysiology of Parkinson's Disease Genetics of Parkinson Disease 19 The classic approaches of linkage analysis and positional...
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Báo cáo khoa học : Tissue Doppler imaging for the diagnosis of coronary artery disease ppt
... of myocardial viability Eur Heart J 2003, 24(abstr suppl):242 Papers of particular interest, published within the annual period of review, have been highlighted as: • Of special interest •• Of ... velocity is a reflection of the early systolic lengthening, which is a hallmark of severe ischemia Penicka et al [18] tested the ability of IVC velocities to predict recovery of myocardial function ... limitation in the assessment of coronary artery disease, since finding of regional differences is more important than absolute values Methodological limitations of strain rate imaging Since strain...
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Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt
... is a measure of the surface area of maximal contact of the paw with the ground (pixel2) Phase dispersion This parameter is a measure of the temporal relationship between placement of two paws ... print area of paw contact in the affected limbs This was most likely due to the rigidity of muscle tone and altered use of paw surface The intensity and contact area of the unaffected paws of 6-OHDA-lesioned ... base -of- support (BOS) [11] The base-ofsupport of the hind limbs was shown to increase by up to Chuang et al Journal of Biomedical Science 2010, 17:9 http://www.jbiomedsci.com/content/17/1/9 Page of...
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Báo cáo y học: "Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension" ppt
... significance of these findings in the context of our current understanding of BMP receptor biology, and relate the data to our knowledge of inheritance patterns and disease pathophysiology of PPH Bone ... approximately 60% of FPPH families, and in 25% of patients with no family history of overt disease The greater frequency of sporadic as compared with familial inherited disease suggests that this genetic ... expression of PPH The relatively low disease penetrance of FPPH suggests that its development probably requires additional environmental and/or genetic events Characterization of some of the extended...
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06. PEPTIC ULCER DISEASE
... Objectives PEPTIC ULCER DISEASE Peptic ulcer diseas-Tran Ngoc Anh MD 1.Recognize the typical clinical presentation and risk factor for PUD 2.Understand pathophysiology of PUD focusing on ... ulcer silent Ve Dyspeptic are non specific: 20-25% NSAIDS: 15 %of patients longterm NSAIDS (Piroxicam, Feldene, Ketorolac, Toraldo, Celceb, Indomethacine, Ibuprofen, Selective COX2) Peptic ulcer ... CONSIDERATIONS An ulcer: disruption of the mucosal integrity of the stomach and/or duodenum (surface >5mm in size, depth to the submucosa) Occur: Stomach and/or duodenum Chronic Peptic ulcer diseas-Tran...
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Tài liệu Growth and nutritional status of children with homozygous sickle cell disease ppt
... levels of LH and FSH were higher in patients than in controls at the same stage of development of secondary sexual characteristics This suggested a variation in the rate of maturation of the ... BO, Ipadeola T Clinical trial of riboflavin in sickle cell disease East Afr Med J 1993; 70:418–21 114 Clarke R Homocysteine-lowering trials for prevention of heart disease and stroke Semin Vasc ... absence of demonstrable infection, and it often precedes a painful crisis by days or weeks.8 At the time of hospital admission, energy intake during acute illness is decreased by as much as 44% of...
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Tài liệu The pathophysiology of tuberculosis - Tuberculosis: back to basics ppt
... strong “Th1” response … so why does anyone get the disease ?? The Th1 response of the tuberculosis patient fails to eliminate The problem of “compliance”. The patient feels better too soon! ... a • Activation of macrophages • Infection controlled Weeks Th1+ IL4 • TNFa becomes toxic • NECROSIS • Failure to control bacterial growth Toxicity of TNFa; role of IL4 ? TNFa ... Moreira et al. (1993) J. Exp. Med. 177, 16751680 The use of IL4 gene knockout Balb/c mice to look at the role of IL4 in necrosis and fibrosis in pulmonary TB HernandezPando et al (2004) Eur J Immunol 34, 174183 • Role of IL4 in necrosis confirmed ...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism One shortfall of the present theory is the lack of neuropathological ... presentations of the disorder, which often results in severe distal sensory loss and mutilating acropathy [32] Although mutations in SPTLC1 cause neurological disease, there is, as yet, no description of ... loss -of- function mutations in the predominantly neuronal P-type ATPase gene ATP13A2 are the cause of Kufor–Rakeb syndrome [33] The clinical features of Kufor–Rakeb syndrome are similar to those of...
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Tài liệu GLOBAL STRATEGY FOR THE DIAGNOSIS, MANAGEMENT, AND PREVENTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE pptx
... IA Another way of estimating the morbidity burden of disease is to calculate years of living with disability (YLD) The Global Burden of Disease Study estimates that COPD re- MA T of all YLDs, with ... pulmonary disease and asthma in the of disease burden that are consistent and measurable across nations The authors of the Global Burden of Disease Study designed a method to estimate the fraction of ... important objectives of GOLD are to increase awareness of COPD and to help the millions of people who suffer from this disease and die prematurely from it or its complications OR of disease caused...
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Parenting Stress in Mothers of Children with Congenital Heart Disease pptx
... in Mothers of Children with CHD and anxiety of children with CHD were related more to maternal anxiety and pampering than to the degree of incapacity or severity of disease (Linde, Rasof, Dunn, ... chronic disease, mothers of children with CHD also reported higher levels of uncertainty Linde (1982) reported that the mothers of children with CHD had problems not with the severity of disease ... clarity, lack of information, and unpredictability Ambiguity refers to the absence of cues or vagueness of cues concerning the planning and carrying out of care for the child Lack of clarity refers...
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Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
... mouse models of ischemic stroke [87,99,100] The mechanisms of brain damage involve gelatinasemediated disruption of the BBB integrity, of edema and hemorrhagic transformation, as well as of white ... thereby, activation of matrix metalloproteinase (MMP)-9 [80] Recent studies have highlighted the involvement of MMPs in ischemic pathophysiology MMPs cleave protein components of the extracellular ... and regulation of neuroinflammatory responses to injury [82,83] Two members of this class of proteases, the gelatinases MMP-2 and MMP-9, have been strongly implicated in ischemic pathophysiology...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... effects of RNAi of the Ku-80 subunit and the truncated Ku-80 mutant on WD gene expression To examine the effects of the Ku protein on the regulation of WD gene expression, we measured the amount of ... Ku-80 IR Results of each values were expressed as the following ratio: intensity of WD cDNA/intensity of competitor and then divided by intensity of amplified actin cDNA PC, the result of competitive ... total volume of 50 lL of reaction mixture using the RT-PCR kit (Stratagene) PCR amplification was performed using LA Taq (Takara, Japan) in a total volume of 50 lL containing 55 pg of competitor...
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NERVOUS DISEASE IN LATE EIGHTEENTH-CENTURY BRITAIN: THE REALITY OF A FASHIONABLE DISORDER pptx
... a supposed disease of the nation, symptom of consumer society, gauge of civilization, arbiter of fashion and indicator of the power of patronage and professional integrity, nervous disease has ... systematic dullness’ 143 Instead, Brown offered a rival system of disease classification According to Brown, all diseases were of two types: sthenic diseases, defined as diseases induced by excess nervous ... sphere of influence of various doctors was also taken into account through an examination of the number of editions of their publications, their appearance in the footnotes of publications of fellow...
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