parkinson apos s disease by in vitro and computational models
Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... a fellowship from the American Parkinson s Disease Association A.B.W is supported by the Michael J Fox Foundation for Parkinson s Disease Research, the American Parkinson s Disease Association, ... variants segregate with disease in large families The most common of the known LRRK2 mutations (G201 9S) increases in vitro kinase activity, analogous to mutations in the same kinase subdomain in ... kinase domain that inactive kinase activity likewise reduces toxicity In one cell model, LRRK2 expression may cause increases in caspase-8 activation as a result of a kinase-sensitive association...
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Báo cáo y học: " Interrelated modulation of endothelial function in Behcet''''s disease by clinical activity and corticosteroid treatmen" ppt
... confirmed in various clinical settings, including systemic vasculitis, rheumatoid arthritis, systemic lupus erythematosous and systemic sclerosis [21-25] However, the optimal dose and duration ... unchanged during the following days Clinical assessment and vascular studies were repeated on day The present study was conducted, using both case-controlled cross-sectional and prospective interventional ... status was assessed by clinical means only Endothelial dysfunction was assessed by a widely-used, reproducible and non-invasive method, i.e the FMD at a medium-size conduit artery FMD is considered...
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Báo cáo hóa học: " Reduction of freezing of gait in Parkinson’s disease by repetitive robot-assisted treadmill training: a pilot study" doc
... blow, sudden loss of consciousness, or paralysis [14] - Posture and Gait Score: This score includes questions 13-15 and 29-30 of the UPDRS, and has been used as an outcome measure to assess gait and ... Fahn S: Motor blocks in Parkinson s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations Parkinsonism ... extremities [7] - Parkinson s Disease Questionnaire-39 (PDQ-39): This questionnaire examines dimensions of quality of life specific to PD patients and is scored on a 5point scale As a disease- specific...
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Báo cáo hóa học: " Inhibition of foot-and-mouth disease virus replication in vitro and in vivo by small interfering RNA" pot
... FMDV sequences deposited in GenBank, regardless of their serotype This level of identity is an indication of a strong selective pressure against mutations since this sequence resists changes during ... serotypes O, or Asia I after injecting FMDV-specific siRNAexpressing plasmids, 10–40% suckling mice could resist virus infection This report, as well as the results of others [22,23] suggests that ... virus This selective pressure could maintain the siRNA target sequences without alterations, ensuring the effective activity of the siRNAs described in the present study This work offers an insight...
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Health related quality of life and pharmacoeconomics amongst asian parkinson¿s disease patients in singapore
... was assessed using responsiveness indices including Cohen s effect size (ES)84, the standardized response mean (SRM)85 and Guyatt s responsiveness index (GRI).82, 86 The responsiveness indices ... national institute of neurological disorders and stroke PD - Parkinson s disease PDQ-8 - the 8-item Parkinson s disease questionnaire PDQ-8SI - the 8-item Parkinson s disease questionnaire summary index ... assessed using the H&Y stage scale60 and the motor score of the UPDRS by neurologists on the day of the survey.61 The H&Y stage scale assesses patients with PD using a 5-stage score in terms...
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Tài liệu Báo cáo khoa học: The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo pdf
... proteolysis analysis In these experiments, [3 5S] methionine-labelled RARa and RARb were translated in vitro, incubated with retinoids and digested in limited proteolysis reactions with trypsin The ... digits which are proximally fused are shown in italic Discussion The number of identified endogenous retinoid receptor ligands in plasma and ⁄ or soft tissues of various species, including humans, ... and activate nuclear retinoid receptors and regulate gene transcription both in vitro and in vivo Retinoids (vitamin A and its analogues) play essential roles in several physiological processes,...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... cognitive skills remained stable Increased age was associated with lower scores in all cognitive domains while increased education was associated with higher scores APOE-4 was not associated with ... education, and ethnic background were included as covariates in subsequent analyses The GEE analyses yields beta values which represent associations between a factor score and variables included in the...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... based but also simulated in silico Combining this method of analysis (in vitro, cell-based and in silico analysis) will facilitate systematic understanding of the underlying properties of this ... Intensity of nucleus Intensity of cytoplasm Intensity of nucleus Scheme This is a simplication of a cell as seen by analysis software, where the software measures the intensity of NF-jB in the ... stimuli inuenced a cascade of co-operative events were assessed in vitro, in cell cultures, and also in silico in this study Previous work [12] demonstrated oscillatory behavior in the levels of...
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Báo cáo khóa học: Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo pot
... binding was measured, and the resulting Scatchard plots gave straight lines indicating the presence of a single class of binding sites in each case (not shown) To allow convenient comparisons, ... binding processes at other sites in the chain through the shape alterations induced by its presence That bisecting GlcNAc constitutes a docking point for protein–carbohydrate interactions is ... by staining tissue sections and quantitating organ uptake First, we used a panel of established and wellcharacterized leukemia/lymphoma, carcinoma and melanoma lines to assess surface binding to...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... differences, and the small sample sizes used in some studies In previous ELISA studies comparing these antibodies in AD subjects vs normal controls, only Moir et al [3], Gruden et al [14,15], and Nath ... increased in AD vs NCI sera (by 20% in undissociated samples and 29% in dissociated samples) 95% Tukey confidence intervals for differences in the mean antibody levels indicated that the possibility ... encouraging results were obtained in two clinical trials in which IvIg was administered to AD patients [22,23] and a multi-site phase trial is in progress In our ELISA studies we found that in addition...
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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt
... Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition FASEB 2004, 24:548-559 19 Shaftel SS, et al: Sustained ... how is joint osteoarthritis linked to AD pathology? Numerous clinical and animal reports in the past showed an increase in circulating pro-inflammatory cytokines in the serum of patients and small ... Bonotis K, et al: Systemic immune aberrations in Alzheimer s disease patients J Immunol 2008, 193:183-187 Holmes C, et al: Systemic inflammation and disease progression in Alzheimer disease Neurol...
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Báo cáo y học: " γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease" pptx
... International Study Group for Behçet s disease [24], were studied The activity of Behçet s disease was assessed by the 1994 criteria for disease activity of Behçet s disease, proposed by the Behçet s Disease ... cells [12] Some populations of these cells are known to be involved in the initiation of acute inflammatory responses and in the persistence of chronic inflammation in several skin diseases [13] ... this time the percentage of expansion was assessed by fluorescence activated cell sorting (FACS) analysis using the anti-TCR Vδ2 mAb The results were expressed as EF (see Materials and methods)...
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Báo cáo y học: "ncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still''''s disease: use in the differential diagnosis of hyperferritinemia" docx
... their subsequent infiltration into other organs, accounting in part for the systemic clinical symptoms of these diseases [20] In response to various stresses, HO-1 is strongly expressed in cells ... patients with SLE complicated by HPS) (Table 1) These findings suggest that increased serum HO-1 levels are characteristic of active ASD and HPS Serum HO-1 is a marker of disease severity in HPS and ... hyperferritinemia Besides being found in patients with HPS and ASD, hyperferritinemia is also found in patients with liver diseases and in recipients of frequent blood transfusions Because ferritin synthesis...
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Báo cáo khoa học: "Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo" docx
... Apoptosis induction measured from the TUNEL staining of xenografted tumour tissue sections Expression levels of the detected proteins were expressed as the percentage of positive staining cells 100 ... inhibited, and apoptosis was increased in cells expressing anti-DPK3scFv Finally, xenografts tumours expressing anti-DPK3scFv exhibited increased radiosensitivity Collectively, these data indicate that ... cells or the cells transfected with the mock vector The expression of DNA-PKcs in anti-DPK3-scFv expressing cells was determined by Western blot analysis Result shows that anti-DPK3-scFv does not...
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In vitro and in vivo targeted delivery of IL-10 interfering RNA by JC virus-like particles pptx
... expression in other cell types through paracrine system Toxic shock is mediated by a complex set of cytokine interactions Previous studies showed that infusion of LPS mimics the endotoxic state and ... tissue pathology by deactivating macrophages and silencing their synthesis of TNFα, IL-6, IL-1α, IL-8, and an array of other proinflammatory cytokines and chemokines In mouse models of toxic shock, ... toxic shock In such models, it was observed that IL-10 appears in the serum within one hour after LPS challenge and persists in the blood for at least six hours [18,19] Subsequently, it was found...
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báo cáo khoa học: "Budd-Chiari syndrome in a 25-year-old woman with Behçet’s disease: a case report and review of the literature" pps
... ulceration, skin lesions and a positive skin pathergy test Evidence in countries where Behçet s disease is prevalent suggests that this disease should be included among the diagnostic possibilities in ... be associated with Behçet s disease In countries where the prevalence of Behçet s disease is high, such as Turkey and others in the Middle and Far East, evidence suggests that this disease should ... syndrome in patients with Behçet s disease being much greater and more serious in young men, we report a case of Budd-Chiari syndrome in a young woman in association with Behçet s disease It is possible...
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báo cáo khoa học: "Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP" pptx
... assay and GEM assay experiments, assisted in data analysis and interpretation and in writing and revising the manuscript SP and JG carried out the Western blot experiments CH and SA assisted in ... the pro-inflammatory cytokines IL-6 and IL-8, which play crucial roles in the pathogenesis of various diverse diseases including oncogenesis, atherosclerosis, sepsis and rheumatoid arthritis [11,14-17], ... development, growth and metastasis, atherosclerosis, sepsis, and rheumatoid arthritis Major players in these processes are the proinflammatory cytokines, interleukin (IL)-6 and IL-8, which may...
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Mô hình triển khai IPTV của VNPT tại Hà Nội và giải pháp nhằm nâng cao chất lƣợng dịch vụ VNPT’s IPTV Implementation in Hanoi and Solutions to Improve Service Quality
... Kênh SD Trạng HD thái Broadcast Trạng thái Latency 88 ms Pass 85 ms Pass Jitter current ms Pass 1ms Pass Jitter max ms Pass ms Pass V-MOS 4.45 Pass 4.5 Pass Video Rate 4.156 Mbps Pass 8.835 Mbps ... Pass Packet lost 0% Pass 1.05% Fail Kênh VOD SD Trạng HD Trạng thái Latency 177 ms Pass thái 178 ms Pass Jitter current ms Pass ms Pass Jitter max ms Pass 33 ms Pass V-MOS 4.45 Pass 4.5 Pass ... V-MOS 53 ms Fail 105 ms Fail 4.45 Pass 4.5 Pass 3.702 8.463 Video Rate Mbps Pass Mbps Pass Packet lost 0% Pass 0% Pass Kênh Trạng Broadcast Trạng SD thái HD thái 14 ms Pass 88 ms Pass current ms...
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Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models pot
... disease models Acknowledgements This work was supported by The Swedish Research Council, The Swedish Brain Foundation, Swedish Brain Power, the Swedish Parkinson Foundation and Karolinska Institutet ... Terzioglu and D Galter Animal models of Parkinson s disease putamen and at least 50% of the dopamine neurons in the SN are already lost Although slow in most cases, progression of the disease is irreversible, ... levels in the striatum Massive loss of dopamine neurons in the SN only Reduced DA levels in the striatum Massive loss of dopamine neurons, predominantly in the SN Intracellular aggregates with...
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Báo cáo khoa học: Two types of replication protein A in seed plants Characterization of their functions in vitro and in vivo ppt
... functions [25] OsRPA70a is expressed in proliferating tissues that contain meristems, such as root tips and young leaves, but also more weakly in mature leaves; OsRPA70b is expressed mostly in proliferating ... for 30 Six-histidine fusion proteins of OsRPA70a and OsRPA70b were present in the inclusion body fraction, so cell pellets were subjected to three rounds of resuspension in binding buffer, sonication, ... OsRPA70b(His)–OsRPA32(GST)–OsRPA14 (His) were purified through His-Bind and GST–Sepharose (Amersham Biosciences) columns and treated with PreScission Protease (Amersham Biosciences) to remove the GST...
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