other than criminal libel available in the new republic for suppression of anti establishment speech
REPRESSIVE JURISPRUDENCE IN THE EARLY AMERICAN REPUBLIC
... Jurisprudential Doctrines (Other than Criminal Libel) Available in the New Republic for Suppression of Anti- Establishment Speech 243 A Introduction 243 B Criminal Contempt of Court for Out -of- Court Speech ... providing for admission of evidence of truth and expanding the role of the jury soon led to comparable reforms in the criminal libel laws of the states In brief, the reforms introduced in the Act ... direction of the court, as in other cases.” Finally, the Act made proof of “intent” an element of the crime Going well beyond the restrictive common law of the time, the liberalized provisions of the...
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Revised version for the consideration of Contact Committee of the Heads of the SAIs of the European Union docx
... direction of staff to whom work is delegated involves informing them of their responsibilities and the objectives of procedures they are to perform It also involves informing them of matters such as the ... skills of the staff available for the audit; • The time and financial and other resources, including, when relevant, external expertise, necessary for the performance of the audit; and • The risks ... from the other members of the audit team In some SAIs, the drafting process is supervised by an official who is superior in the hierarchy to the principal auditor 2.5.7 In drafting the report, the...
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Báo cáo khoa học: "A CONSIDERATION ON THE CONCEPTS STRUCTURE AND LANGUAGE IN RELATION TO SELECTIONS OF TRANSLATION EQUIVALENTS OF VERBS IN MACHINE TRANSLATION SYSTEMS" doc
... process of the association, consults ordinary dictionary of translation equivalents and word usage of verbs and obtain the set of all the translation euqivalents for the verb (3) Then find nouns ... associated in common to a part of the structure of the categories as in Fig.l, and then find appropriate translation equivalents in detail at the lower level categories (2) To each verb found in the ... as the most closely related verb in this ease It can generally be said that the more the noun's relation to human becomes closer and the more the level of abstract of the noun becomes lower the...
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Comparison of Methods for the Extraction of Bioflocculants from Activated Sludge
... in contrast, the steaming-extracted polymer included a larger amount of saccharides (24.6%) compared to the other methods The SDS-extracted polymer included a small amount of material other than ... of 95 ml) The A280 to A260 ratio of the UV-absorbing peak indicated it was composed mainly of nucleic acid In the profile of the NaOH-extracted polymer (B), the elution volume (80 ml) of saccharide ... shaking, absorbance at 660 nm (A660) was measured for min, and the relative A660 against the control test was calculated every minute using the following formula: The relative A660 = A660 of flocculating...
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AN ACTION RESEARCH ON THE EFFECTS OF PRE WRITING ACTIVITIES ON THE GRADE – 11 NON – MAJOR ENGLISH STUDENTS’ MOTIVATION IN WRIT
... on the side of the informants, so the researcher can not guarantee the reliability of the information collected What is more, the area of the study is only restricted to classroom writing in the ... punish them c Move to another parts of the lesson d Try to find out the reasons why they are not interested in the lesson and find the appropriate activities for the next lessons To solve the ... paper with the number indicating the trends of falling, increasing… .The students might be successful in writing this kind of exercise because there were a large number of students repeated these expressions...
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Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... domain-only proteins are a subfamily of the Bcl-2 family involved in the initiation of apoptosis through the mitochondrial pathway The key event in the mitochondrial pathway is the release of proapoptotic ... produced (Fig 1D, lane 2) In the presence of lactacystin, a significant increase in the amount of tBid–GFP present in the extract, both in control conditions and in the presence of FLAG–Itch, was observed ... [25] We therefore sought to determine if there could be a link between EGF-induced reduction in Bid and tBid levels and the ubiquitin ligase activity of Itch In this study, we first examined the ability...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... domain binds to pYi on the C-terminal tail, and the Src homology (SH3) domain binds to the linker between the SH2 and kinase domains at the back of the small lobe, preventing the formation of ... behavior by presenting the pulse of Src activity in the plane of the inactive and active fractions, si and s1 If the duration of the stimulus exceeds the critical value, the trajectory in the (si, s1) ... activating and inhibitory stimuli and more moderate changes in the amplitude of the oscillations An increase in the activating signal or decrease in the inhibitory signal decreases the period of...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... concentrations of Arg-HCl in the absence of the chaperone precluded analysis of the effect of this concentration on the protective ability of aB-crystallin Reduction-induced aggregation of the insulin B-chain ... effect on the chaperone activity of aB-crystallin against the DTT-induced aggregation and precipitation of insulin B C Fig aB-crystallin protects against the DTT-induced aggregation of insulin, and ... aB-crystallin against the DTT-induced precipitation of insulin [27,28] These studies also showed that 100 mm Arg-HCl increases the chaperone activity of a-crystallin against the thermally induced...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... corresponding residues of BS-RNase, forcing the mutated side-chains to adopt the conformation present in BS-RNase The models were optimized for energy minimization using the gromos implementation of ... geometry of the hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the ... through the exchange between subunits of either their N-terminal, or their C-terminal ends [33–35] We found that the behavior with the model membrane of the dimer in which the C-terminal ends...
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Tài liệu Báo cáo khoa học: Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf
... of elastin for NE or Pr3 was assessed by adding a constant concentration of enzyme to increasing concentrations of elastin, stirring for 10 min, centrifugating the suspensions and measuring the ... 50% inhibition of Pr3 by the oxidized inhibitors While the above data are in overall agreement with the results obtained using synthetic substrates, they also indicate that elastin hinders the inhibition ... inhibitor for the binding of enzyme This theoretical inhibition was significantly higher than the experimental one, again confirming the above hypothesis The most important differences were found for the...
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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx
... holotoxin (and free RTB) in mL of NaCl/Pi containing 75 mM galactose Eluted protein was dialysed for 16 h against L of NaCl/Pi to remove the galactose, before quantifying against know quantities of ... increasing concentrations of ricin (d), or ricin N78S (j) at 37 °C for h Remaining protein synthesis after this time was measured by the incorporation of (35S)methionine Symbols indicate the mean of ... represent the SD involved the modification of arginyl residues 196, 213, 234 and 235 [9] Of theses residues, only Arg213 is in the vicinity of the active site of RTA In order to establish the role of...
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Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx
... at the rear surface of the N-domain (overview) (A) Docking of pNPP to the ATP binding site of the model containing N- and P-domains [20] The amino acids interacting with the adenine ring of ATP ... K480, K501, E505) The mobility of the structure in the residual N-domain of L354L527 forming the ATP binding site is indicated by red arrows Each of the displayed proteins contains an unaltered ... at 37 C in the dark and gentle stirring TNP-ATP binding to the protein was detected as an increase of uorescence intensity in the presence of protein compared to the uorescence intensity in its...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... nucleobase and the diphospho-bridge, but on the other hand likely are involved in polar interactions with the cADPR receptor protein Certainly, the natural linkers, the northern and southern ribose ... cyclized between N1 of inosine and C2 of the northern ribose [60] In addition, 8-Br-N1-cIDPR induced Ca2+ signalling in 4594 intact T-cells [61,62] This finding was surprising since 8-Br-N1-cADPR ... effect on the EC50 of Ca2+ release (Fig 3; [56]) This indicates that at this side of the molecule either the polar interactions with its interacting protein were fully replaced by the amino group...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... reconstituted in the presence of growing broblasts into the parent dimeric protein, which is internalized as a native-like dimeric RNase They also indicate for the rst time that when BS-RNase is internalized ... originally involved in the intersubunit disulde bonding of BS-RNase, are irreversibly blocked through S-alkylation In the active MSSAE and MSSG monomers, instead, the two Cys residues still form ... retained full RNase activity, in fact they were more active than the parent dimeric enzyme, as previously reported [12] As for their sensitivity to the inhibitory action of the cytosolic RNase inhibitor...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... secondary to suppression of respiration during hypoxia In the absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell ... the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change in the levels of these mRNAs in macrophages at h of hypoxia, the time point ... and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes...
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Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... 1) The binding of the ®rst CN± ligand to the iron was thus more easy in the hydrophobic binding pocket of the antibody than the binding of the second one, most probably because of the steric hindrance ... was inserted in the antibody pocket, three of the ortho-carboxylate substituents of the meso-phenyl rings being recognized by the side chains of amino acids of the antibody [36]; (b) in the case ... possibilities for the binding of ligands on the iron of Fe(porphyrin))13G10 complexes: (A) binding of H2O2 on the iron of 13G10-(Fe(ToCPP), (B) binding of two CN± ligands on the iron of 13G10-(Fe(ToCPP),...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... MyoD/E-box binding factors The introduction of mutation into one of the putative Etsbinding sequences suppressed the promoter activity In addition, the specific binding of a nuclear protein to the oligonucleotide ... IV [57] The former enzyme is responsible for the synthesis of the b1–6 branch in N-acetyllactosamine units in cell surface N-glycans, and the latter enzyme is involved in the synthesis of cell ... previously reported the structures of the mouse a3 integrin subunit gene including the exon/intron organization and the alternative exon usage for the generation of variants of the a3 subunits (a3A...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... with the amino group of the main chain at Glu268 The oxygen of the main chain at Asp266 was bound to amino groups of main chain of Tyr269 and Ala270 by hydrogen bonds The interactions should maintain ... temperature indicates the stability of the structure of the protein The difference of the increments between the inactive temperature and the Tm should indicate that the mutations improved the stability ... surrounding residues of the depression, and the side chain of the mutated residue might restrain the mobility of the N-terminal region on the surface by interaction with the main chain of Lys26 by van...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... since the heat evolved representing this activity is included in the baseline of the experiment Therefore, the assay only measures the rate increase due to the addition of GTP with a resulting ... lmol of glutamine injected into the reaction cell containing between 1.7 and 17 lM CTP synthase and integrating the entire heat evolvement over time For the measurement of DH for CTP synthesis the ... performed as described in the legend to the indicated Fig Glutaminase refers to hydrolysis of glutamine without CTP synthesis taking place b In the absence of GTP c Saturated with GTP d The other...
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Báo cáo khoa học: Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation ppt
... that the lack of Mg2+ in the assay mixture does not affect the affinity of Pabc for cGMP Roles of cGMP binding in PDE6 regulation Binding of cGMP to Pabc is not involved PDE activation Binding of ... reason for the increase in the filter-trapping level of [3H]cGMP-bound Pabc, i.e the increase appears to be caused by a conformational change in Pabc upon binding of [3H]cGMP This increase in the ... expressing [3H]cGMP-binding activity Identification of a PDE species expressing [3H]cGMPbinding activity is the first step in the exploration of the role of cGMP binding to the noncatalytic site in...
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