... patients Abbreviations (IGF) : Insulin- likeGrowth Factor; (IGF1 R): Insulin- likeGrowth Factor- 1 receptor; (IGFBP-3): Insulin- likeGrowthFactor Binding Protein-3; (IGFBP-4): Insulin- likeGrowth ... WF, Formelli F: Relationships between plasma insulin- likegrowth factor- I and insulin- likegrowthfactor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide Clin ... tumor suppressor This is consistent with its biologic function as an inhibitor ofIGF activity.[27] While previous studies investigating the overexpression of IGFBP-4 in both colorectal and prostate...
... indices of depression -like behaviors Blocking the anti-depressant activity of exogenous IGF -I with JB1, which prevents IGF- 1R receptor activation, shows that IGF- 1R activation is requisite for IGF -I ... role ofIGF -I Importantly, purification ofIGF -I from brain yields IGF -I lacking the first amino acids [26, 28, 29] suggesting that GPE is naturally produced in the brain Indeed, GPE is found in ... administering both IGF -I and LPS i. c.v [11], i. c.v IGF -I has anti-depression like activity, but not anti-sickness activity against i. p administered LPS 11 IGF -I does not affect preexisting LPS-induced...
... pCR II vector, replacing the original 813 bp BamH I Table 1: Primers and probes used for plasmid construction and real-time PCR IRESF (BamH I) IRESR (Sal I) IGF- IF1 (EcoR I) IGF- IF2(Sal I) IGF- IR ... Insulin- likegrowthfactorI (IGF -I) is a cell signaling polypeptide that regulates proliferation and differentiation across a wide spectrum of cell types Acting by both endocrine and paracrine/autocrine ... authors wish to thank George J Eckert, M.A.S., Department of Medicine Division of Biostatistics, Indiana University School of Medicine, for statistical assistance References 10 11 12 13 14 IGF -I: ...
... (1998) Continuous administration ofgrowth hormone (GH) does not prevent the decrease ofIGF -I gene expressionin zinc-deprived rats despite normalization of liver GH binding Growth Horm & IGF Res ... 465-472 Ninh NX, Thissen JP, Collette et al 1996 Zinc supplementation increases growth and circulating insulin- likegrowthfactorI (IGF -I) in Vietnamese growth- retarded children Am J Clin Nutr ... Serum insulin- likegrowthfactor I/ IGF -I concentrations in Vietnamese pre-school children The study was carried out in 642 pre-school children in order to determine the reference values of serum IGF -I, ...
... patients with cumulative low IGF -I concentrations are at risk for low quality of life and increased morbidity, which may support the theory of the imperative role ofIGF -I in the acute phase of ... generic and standardized HRQoL instrument consisting of 15 dimensions: mobility, vision, hearing, breathing, sleeping, eating, speech, elimination, usual activities, mental functioning, discomfort ... median, interquartile ranges, and outliers For more detailed numbers see Table aSAH, aneurysmal subarachnoid hemorrhage; IGF -I, insulinlikegrowth factor- I In the context of aSAH, it is most interesting...
... Silkmoth IGF -like peptide N Okamoto et al Members of the insulin- likepeptide (ILP) family are present in a wide variety of metazoans In vertebrates, insulin and insulin- likegrowth factors (IGFs) ... light of the similarities between 8K-BLP and IGFs, we propose that this peptide be named Bommo-IGFLP (BIGFLP), for Bombyx mori IGF -like peptide It is difficult to detect homologous peptides of BIGFLP ... composed of a putative 20 amino acid signal peptide and a 68 amino acid peptide belonging to the insulin family (Fig 3C) If the signal peptide is eliminated and disulfide bridges are formed as in other...
... (1997) Identification of a family of low-affinity insulin- likegrowthfactor binding proteins (IGFBPs): characterization of connective tissue growthfactor as a member of the IGFBP superfamily Proc Natl ... by its proteolytic cleavage [10] For example, IGFBP-rP1 loses its IGF ⁄ insulin- binding activity and IGF ⁄ insulin- dependent growth- stimulating activity but acquires high cell adhesion activity ... inhibited the production of the cleaved form of IGFBP-rP1 (25 kDa), whereas a cysteine proteinase inhibitor (leupeptin), an aspartic proteinase inhibitor (pepstatin) and a metalloproteinase inhibitor...
... Insulin- likegrowthfactor (IGF) -I binding to IGF- binding proteins and IGF receptors is modi®ed by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF- II ... Time (s) Fig BIAcore analysis of IGF- II and IGF- II analogue binding to highanity recombinant IGF1 R Binding of IGF- II (A), des-(1±6) -IGF- II (B) and Arg6 -IGF- II (C) to rhIGF1R measured by BIAcore ... tools to investigate which residues are important for interactions with IGF1 R, IGF2 R and the IGFBP family Initially, key residues involved in IGF1 R binding were identi®ed in the IGF -I B-domain (Tyr24)...
... inhibition of other lipid or pro- Fig IGF- 1 induced activation of mTOR signaling is prevented by PI3K inhibitor wortmannin and mTOR inhibitor rapamycin C2C12 myotubes at days of differentiation ... mechanism regulating mTOR activity in skeletal muscle is the insulinlikegrowth factor- 1 (IGF- 1) ⁄ insulin- dependent pathway [5,6] Stimulation of muscle cells with growth factors such as IGF- 1 leads ... relatively high concentration of wortmannin (10 lm) was required to inhibit insulin- induced activation of mTOR signaling in C2C12 myotubes (Fig S1A) so we cannot rule out the possibility of the inhibition...
... Lollini PL, Nanni P, Picci P, Scotlandi K: Inhibition of insulin- likegrowthfactorI receptor increases the antitumor activity of doxorubicin and vincristine against Ewing’s sarcoma cells Clin ... PDGFRA-dependent imatinib resistance [55] Glycemic derangements related to insulin- likegrowth factors such as the pro- IGF- IIE and insulin- likegrowth factor- binding proteins have been described in GISTs, ... Osteosarcoma Etiology Study Group: Analysis of genes critical for growth regulation identifies Insulin- likeGrowthFactor Receptor variations with possible functional significance as risk factors for osteosarcoma...
... Ljunghall S: Circulating levels of insulin- likegrowth factor- I and -II, and IGF- binding protein-3 in inflammation and after parathyroid hormone infusion Bone Miner 1994, 24:25-31 33 De Benedetti F, ... sedimentation rate; IGF- 1 = insulin- likegrowthfactor 1; IL-1Ra = IL-1-receptor antagonist; sIL-6R = soluble IL-6 receptor; TNF-α = tumor necrosis factor α TNF-α, a mediator of inflammation ... Alonzi T, Moretta A, Lazzaro D, Costa P, Poli V, Martini A, Ciliberto G, Fattori E: Interleukin causes growth impairment in transgenic mice through a decrease in insulinlike growth factor- I A...
... human (IGF) -1 to IGF- binding proteins, on 12 5I- labeledinsulinbinding NBI-31772, a small-molecule inhibitor likegrowthfactor (IGF) -1 to IGF- binding proteins, on 12 5I- labeled IGF- 1 binding to ... 39:968-978 Morales TI: The insulin- likegrowthfactor binding proteins in uncultured human cartilage Increases in insulin- likegrowthfactor binding protein during osteoarthritis Arthritis Rheum 2002, ... Mortensen DL, Tomlinson EE, Sadick MD, Robinson ICAF, Clark RG: Molecular mimics of insulin- likegrowthfactor (IGF- 1) for inhibiting IGF- 1 :IGF- binding protein interactions Biochemistry 1998, 37:8870-8878...
... Susceptibility gene; CNT: carbon nanotube; CNT-FET: carbon nanotube field-effect transistor; ELISA: Enzyme-Linked Immunosorbent Assay; IGF- 1: Insulinlikegrowth factor- 1; IGFBP: IGF binding protein; ... http://www.jnanobiotechnology.com/content/9/1/36 Page of 14 Kim JH, Cho YH, Park YL, Sohn JH, Kim HS: Prognostic significance ofinsulingrowth factor- I receptor and insulingrowthfactor binding protein-3 ... insulin- likegrowth factor- I and serum IGF- binding protein can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American...
... occurs is not fully understood, but changes both in nutrient availability and in cytokine activation are implicated Circulating levels ofIGF -I and of the insulin- likegrowthfactor binding protein -I ... (GH) insulin- likegrowth factor- I (IGF -I) axis is of particular interest While a derangement in the functioning of this axis, termed 'GH resistance', has been implicated as important in the pathogenesis of ... administration of PN [14] Administration of 16 hours of PN was associated with induction of the expression of hepatic mRNA of the SOCS cytokine-inducible SH2-containing protein (CIS) This finding...
... measure growth One of the principal hormones regulating growth is insulin- likegrowthfactor (IGF1 ) In the laboratory, positive relationships between the concentration of plasma IGF1 and growth ... lack of spatial variation In addition to examining spatial variation of IGF1 , we wanted to determine whether IGF1 provides novel information not provided by traditional metrics Multivariate analyses ... Suitability of Insulin- LikeGrowthFactor (IGF1 ) as a Measure of Relative Growth Rates in Lingcod Kelly S Andrews* and Brian R Beckman National Oceanic and Atmospheric Administration–Fisheries, Northwest...
... Authors Journal compilation ª 2006 FEBS 3713 Insulin- likegrowthfactor signaling A Fanzani et al A B Fig Neu2 expression is strictly dependent on insulin- likegrowthfactor (IGF- 1) signaling ... Fanzani et al Insulin- likegrowthfactor signaling A C B D E F G H Fig Insulin- likegrowthfactor (IGF- 1)-induced hypertrophy enhances Neu2 expression in murine myoblasts (A) ngÆmL)1 IGF- 1 induces ... of insulin- likegrowthfactorI Mol Cell Biol 19, 3115– 3124 James PL, Stewart CE & Rotwein P (1996) Insulin- likegrowthfactor binding protein-5 modulates muscle differentiation through an insulin- like...
... Hafezian, G Rahimi-Mianji (2010) Association of single nucleotide polymorphisms in IGF -I, IGF- II and IGFBP-II with production traits in breeder hens of Mazandaran native fowls breeding station ... tìm thấy kiểu gen GG, AG cu i AA quần thể nghiên cứu 39 Đa dạng di truyền gen Insulin- likegrowthfactor binding protein gà đa dạng di truyền gen Insulin- likegrowthfactor binding protein gà Bảng ... Afri J Biotech (6): 805-810 Lei, M M., Q.H Nie, X Peng, D.X Zhang, X.Q Zhang (2005) Single nucleotide polymorphisms of the chicken insulin- likefactor binding protein gene associated with chicken...
... (Calbiochem-Novabiochem, San Diego, CA) needed for ANT inhibition, the efficiency of Atr was first examined in its classical role, i. e for its ability to inhibit oxidative phosphorylation For analysis, increasing ... mitochondrial protection In agreement with the results in this paper, it has been reported that IGF -I and II have antiapoptotic properties [24-27] The main finding in this work was that IGF- II ... Dall’Aglio E, Maggio M, Lauretani F, Bandinelli S, Falzoi C, Grimaldi W, Ceresini G, Corradi F, Ferrucci L, Valenti G, Hoffman AR: Clinical implications of the reduced activity of the GH -IGF -I axis in...