... Figure DNA and α-actinin Baseline binding data for binding to nucleosomes, double-stranded DNA and α-actinin On each graph, absorbance ratios ofthe 30 normal controls andthe 16 patientswith lupus ... albumin of at least 30 g/L, and either normal serum creatinine if the baseline creatinine was less than 260 μmol/L or a 50% decrease in creatinine if the baseline value was at least 260 μmol/L Patients ... between anti-α-actinin levels and serum albumin or urine PCR in these patientsand no particular clinical or demographic feature distinguished them from the other 13 patients An example of this pattern...
... 0.7) There was no difference inthe values ofthe filter pressure parameters during DrotAA therapy andinthe 96 hours postDrotAA The influence of clotting parameters on FST was also examined There ... sepsis-induced coagulopathy There is minimal data on how to manage anticoagulation inpatients on RRT during the infusion DrotAA therapy andin clinical practice the choice of RRT modalities and ... critically revising the manuscript, were involved inthe design, analysis, drafting ofthe manuscript and gave final approval ofthe version to be published All authors read and approved the final manuscript...
... groups in terms of tumor staging Vascular invasion (T3) occurred inpatientsinthe anatomic group (32.1%) andpatientsinthe non-anatomic group (28%) Nodal involvement occurred inpatientsinthe ... defined as the complete removal of at least Couinaud's segment containing the tumor together withthe related portal vein andthe corresponding hepatic territory The appropriate segment margins ... between the two groups with only a single poorly differentiated tumor in each group (3.5% ofthe anatomic group and 4% ofthe non-anatomic) Two patientsinthe anatomic group presented with fibrolamellar...
... discharge, when the procedure was completed Using a strategy including a routine assessment ofthe amount of bleeding with a standardized scale, and promoting BAE over surgery, the outcomes ofpatients ... describe the characteristics ofthepatients managed using one ofthe three main initial therapeutic options (conservative measures, BAE or surgery) and to help better define the role of BAE, according ... no information was provided on patientsin whom the procedure was not completed [21] In our series, bleeding was controlled in 112/131 patients (85%) within the first month andin 116/131 patients...
... result is in agreement withthe pathophysiology of GCA andthe ongoing inflammatory process inthe arterial wall The combined use of 2-DE and immunoblotting offers an interesting approach to the identification ... pool ofpatients (top) andthe pool of HCs (bottom) (C) Proteome of human umbilical vein endothelial cells showing the localisation of vinculin spots displayed in (A) binding partners, including ... a-actin [39] Changes inthe relative content of vinculin and a-actin have been reported inthe human aortic intima ofpatientswith atherosclerosis [40] Because vascular remodelling may occur in...
... one organ involved, all of them were counted independently; � patientswith intestinal TB diagnosed based , on typical colonosopic findings andthe other patientswith TB laryngitis without AFB ... (28) In addition, the lower risk of EPTB inthe elderly does not support immunity as a determinant ofthe spread of tuberculous bacilli to other organs because ofthe higher incidence of TB inthe ... (Table 4) The fitness ofthe final model was good in terms Table Sites and methods of diagnois of extrapulmonary involvement in 40 patients Involved organ* Miliary involvement Lymph node Intestine...
... In order to study the effect ofthe mutations within AMPK c3 on the activity ofthe enzyme, we introduced several missense mutations into the c3 gene (Fig 2), and investigated the effect of these ... activator ofthe kinase, AMP, whereas the two pairs of CBS domains both bind one molecule of AMP [20] In terms ofthe structure of AMPK, the b-subunit has been reported to act as a scaffold for binding ... reaction, the AMPK trimers were incubated with increasing concentrations of AMPKK, andthe amount of upstream kinase corresponding to the highest possible level of Thr172 phosphorylation was used in the...
... safety and feasibility of combining vaccination with MVA expressing 5T4 and highdose IL-2 inpatientswith metastatic RCC The trial was Page of 11 (page number not for citation purposes) Journal of ... supporting the combination of MVA-5T4 vaccine and IL2 for patientswith metastatic RCC The treatment regimen was associated with induction of 5T4-specific humoral and cellular immunity Twelve patients ... immunotherapy in RCC Hence, we sought to determine if vaccination with MVA-5T4 could improve the therapeutic responses observed with standard high-dose IL-2 inpatientswith metastatic RCC In order...
... total of 129 patients were finally included inthe study This research was carried out in accordance withthe Declaration of Helsinki ofthe World Medical Association (2000) and approved by the ... NIHSS on admission and infarct volume treated with tPA [6], which is in line withthe results ofthe present manuscript, where a greater decrease in neuroserpin serum levels within the first 24 hours ... ofthe neuroserpin ELISA used inthe study MRY, MM, helped to acquired, analyzed and interpreted the clinical data and made critical revision ofthe manuscript All authors read and approved the...
... total of 129 patients were finally included inthe study This research was carried out in accordance withthe Declaration of Helsinki ofthe World Medical Association (2000) and approved by the ... NIHSS on admission and infarct volume treated with tPA [6], which is in line withthe results ofthe present manuscript, where a greater decrease in neuroserpin serum levels within the first 24 hours ... ofthe neuroserpin ELISA used inthe study MRY, MM, helped to acquired, analyzed and interpreted the clinical data and made critical revision ofthe manuscript All authors read and approved the...
... treatment The scores ofthe vitality domain were lowest inthe responders at the end of treatment Compared to the baseline the responders sustained a significant decrease inthe domain score of vitality, ... differently in terms ofthe HRQOL domain scores when re-treated with a combination of interferon alpha-2b and ribavirin Compared to the baseline, the responders sustained a significant decrease inthe ... on the lower dose of interferon were similar to those on the higher dose arm at all the time points During the course of treatment, the pattern of change inthe HRQOL scores of responders and...
... therapeutic intervention [13,14] In a clinical trial, the knowledge of instrument’s responsiveness helps inthe selection of measures, in setting the correct sample size and assists in prioritising the ... samples of different sizes Interpretation ofthe results ofthe course of QoL scores and their responsiveness for patients receiving chemotherapy was performed independently ofthe chemotherapy ... status In our study, the QLQ-CR38 andthe FACT-C questionnaires provided little clinically relevant information during chemotherapy or radiotherapy Four ofthe 12 scores ofthe Uwer et al Health and...
... Notably, in salivary gland of SS, ductal IL-18 expression was observed both inthe presence andinthe absence of IL-18-producing cells inthe periductal inflammatory foci and was also found inthe ... only within the inflammatory infiltrates showing focal organization, we analyzed the anatomical relationship between the presence of IL-18 within the focus, the main lymphocytic subsets, andthe ... in which the mRNA expression of several cytokines (including IL-18) in minor salivary gland biopsies from patientswith SS was evaluated Thus, so far there are no definite reports regarding the...
... were the single serological marker independently predictive of poor outcomes and, together withthe presence of joint erosions at inclusion andwith increasing age, characterized a subgroup ofpatients ... drafting the manuscript AJF participated inthe performance andthe coordination ofthe study, and helped to draft the manuscript PL participated inthe performance andthe coordination ofthe study, ... frequency in these patients: RF in four, anti-Sa in two, and anti-CCP in one At each ofthe follow-up visits, more than two-thirds ofthepatients (namely 101 of 156 and 101 of 149 at 18 and 30...
... on the inter-observer agreement with respect to the inflammatory and structural findings Readers agreed on the presence of inflammation at any site in 85% ofthe cases inthe right SI joint, and ... this finding indicates that MRI might be a useful tool inthe assessment ofpatientswith early inflammatory back pain It is the amount of variation inthe outcome of interest (inflammation and/ or ... for inflammation ofthe joint capsule ofthe left SI joint, which was present in only three patients Table summarizes the concordant findings of both readers with respect to inflammation and...
... blocking IL-1β but not IL-1α In RA patients, IL-1β is overexpressed in inflamed synovial tissue, in particular inthe lining layer andin sublining cells [9], and it is elevated in draining lymph ... following parameters Inthe haematoxylin/eosin stained slides the amount of cells infiltrating the synovial lining andthe joint cavity was scored from to Proteoglycan depletion was scored inthe ... GB and PvR conducted the clinical study as investigators and contributed to the writing ofthe manuscript LJ, WvdB and HG performed the preclinical studies and contributed to the writing of the...
... peripheral joints, and entheses [1] Symptoms of AS include pain, joint stiffness, andthe loss of spinal mobility These clinical symptoms andthe subsequent disease progression result in substantial ... The remaining HRQOL outcomes, including the remaining SF-36 subscale scores andthe ASQOL, extend and further support these findings This study demonstrates that long-term treatment with adalimumab ... activity This index uses six 10-cm horizontal VASs to measure the severity of fatigue, spinal and peripheral joint pain, localized tenderness, and morning stiffness inpatientswith AS The final BASDAI...
... therapy, and thus had a chronic inflammatory joint condition without being diagnosed with RA None ofthe outcomes were seen in 238 patientsThe distribution of diagnoses during follow-up in these ... patientsinthe RA group and 17 (16%) patientsinthe DMARD prescription group presented with monoarthritis The knee joint was the most frequently involved single joint (39.1%), followed by the ... characteristics ofthe 384 patientswith early arthritis included inthe present analyses are reported in Table The duration of joint swelling at inclusion was very short (median 31 days), and 14.3%...
... DB and ASB Page of participated in editing ofthe manuscript and statistical analysis of data VJ provided samples of V5 and preparations ofthe placebo and provided guidelines for conduct ofthe ... [35] Studying V5 as post-exposure vaccine can contribute to better understanding ofthe immunopathogenesis of TB resulting inthe design of effective vaccines and accelerate evaluation of their efficacy ... confirmed in a larger cohort ofpatientsin independent clinical settings [14,15] Conversion of sputum smear from positive to negative is a main indicator ofthe efficacy of anti-TB intervention...
... circumference the properties ofthe respective substance andthepatients individual risk factors The prevalence of MetS inthe FAS of 42.8% (AHA/ NHLB definition) at baseline was comparable to the findings ... supported the conduct ofthe study and contributed to the data analysis, interpretation of data and writing of this report AM contributed to the data analysis, interpretation of data, and writing of ... how important the actual monitoring of vital signs and blood values is inpatientswith schizophrenia, as seemingly, a large proportion of these patients were neither aware of their somatic health...