opioid growth factor met5 enkephalin and the etiology pathogenesis and treatment of gastrointestinal cancer
Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... central role in the etiology and progression of numerous epithelial malignancies, including lung cancer [4] Moreover, the function of EGFR mutations in survival of lung cancer patients and clinical ... blocked ERK1 ⁄ and Akt signaling in breast cancer cells, we will determine whether miR-125a-5p regulates the phosphorylation of Akt and ⁄ or ERK1 ⁄ in lung cancer cells, and whether miR-125a-5p ... added to the insert Forty-eight hours after seeding, the cells on the upper surface of the membrane were removed using cotton buds Cell monolayers on the lower surface of the insert were fixed and...
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Lung cancer - The diagnosis and treatment of lung cancer pdf
... control and quality of life 4.5.2 The impact of the time between first symptom (or first detection if asymptomatic) and the treatment of lung cancer on patients’ survival and quality of life ... professionals and patients is essential It should be supported by the provision of evidence-based information, offered in a form that is tailored to the needs of the individual patient The treatment, ... lung cancer should be offered information, both verbal and written, on all aspects of their diagnosis, treatment and care This information should be tailored to the individual requirements of the...
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Báo cáo khoa học: "Genomic and oncoproteomic advances in detection and treatment of colorectal cancer" ppt
... differing between the two groups, with the 95 top ranked of these predictor genes being able to distinguish between partial and complete responders in 84% of 31 training samples and 87% of the validation ... matrix to a gas, and peptide ions are ejected from the target surface They can then be directed down a vacuum chamber and separated based on their time of flight These different times of flights for ... regulation of the cell cycle) The Anexin family of proteins have been investigated before for their role in carcinogenesis There have already been studies of their expression in renal clear cell [69] and...
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Báo cáo y học: "Prevention, screening and treatment of colorectal cancer: a global and regional generalized cost effectiveness analysis" docx
... a function of the level of economic development of the specific countries [77,78] AfrE and AmrA have low and high remission rates as a result of their treatment coverage rates (in the 30-69 age ... based on the mainstream accepted wisdom [54] that screening enables detection and removal of potentially cancerous polyps, thereby reducing the incidence of colorectal cancer even when cancer treatment ... examining the effects of varying the frequency of screening and age at time of screening This model was based on demographic data from the WHO AmrA region (i.e Canada, Cuba and the USA) and colorectal...
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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx
... Miller, R.E & Cascieri, M.A (1990) The roles of tyrosines 24, 31, and 60 in the high anity binding of insulin-like growth factor- I to the type insulin-like growth factor receptor J Biol Chem 265, ... in the af®nities of IGF-I (4.45 nM) and IGF-II (17.8 nM) for the rhIGF1R (Figs 1A and 2A, Table 1) Substitution of Glu at position to Arg (Arg6-IGF-II) or deletion of the ®rst six amino acids of ... receptor af®nity but rather with the dissociation rate or occupancy time of receptor [31,32] In the present study, the analysis of association and dissociation rates of the IGF analogues did not...
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Báo cáo y học: " Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung" docx
... in the expression profile of VEGFA were observed, VEGFA is constitutively expressed in the lung; therefore the actions of PlGF and VEGFB were examined both in the presence and the absence of ... development of COPD The aim of this study was to examine the expression profile of the well-established pro-angiogenic VEGF family members, VEGFA, VEGFB and PlGF, and their receptors, VEGF R1 and VEGF ... analysis KH performed the western blots KH and CMC participated in the design of the study, MS and PMcL conceived of the study, participated in its design and coordination and drafted the manuscript...
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ADVANCES IN THE ETIOLOGY, PATHOGENESIS AND PATHOLOGY OF VASCULITIS potx
... control of the vascular inflammation and disruption of endothelium, allowing the passage of the virus in the organs The early NiV infection of endothelial cells importantly upregulated the chemokines ... in the Etiology, Pathogenesis and Pathology of Vasculitis damages on the endothelium, including systemic vasculitis in case of Lupus (Zimmer et al., 1998) and may be therefore involved in the pathogenesis ... allow the second cycle of replication of the virus and the viremia NiV infection is characterized by the formation of syncytia leading to the endothelial damages, which are thought to be the cause...
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Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants" pps
... from those of old donors? VEGF121 and VEGF-165 have high angiogenic potencies and lead to a rapid and strong invasion of blood vessels Therefore, in the long term, a new understanding of the mechanisms ... The splice variants of vascular endothelial growth factor (VEGF) and their receptors J Cell Sci 2001, 114:853-865 Thomas KA: Vascular endothelial growth factor, a potent and selective angiogenic ... destruction and vascularization of synovial membrane in rheumatoid arthritis [30] suggests the potential impact of VEGF in the pathophysiology of OA Our demonstration of ROS-mediated induction of the...
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Association between transforming growth factor b1 polymorphisms and atrial fibrillation in essential hypertensive subjects pptx
... the design of the study YW, XW and ZL conducted the serum TGF b1 detection and genotyping, YW wrote the manuscript XH and XS performed the statistical analysis All authors read and approved the ... determination Page of the dNTPs and reaction buffer, for the cytokine genotyping Taq polymerase (1.1 μL; Gibco BRL, USA) was then added to the D-mix, vortexed for 15 seconds, and 10 μL of the D-mix mixture ... SD above the mean of 16 blank determinations) was ~0.1 ng/ml Genotyping DNA was isolated from the whole blood according to standard procedures Genotyping of the TGF-1 polymorphisms of the +869...
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Quantification of epidermal growth factor receptor dynamics and interactions in living cells by fluorescent correlation and cross correlation spectroscopy
... interaction with their ligand; while in the active conformation, CR1 and CR2 are moved away from each other, thereby enabling the exposure of the ligand-binding pocket of domain L1 and L2 The dimerization ... Hofman, Bader et al 2010) Ligand-binding and other stimulation such as the changes of membrane structure activates the receptor and shift the equilibrium The TK domain is then phosphorylated and ... the consistency of the data The last part of this chapter introduces the information of EGFR and PTB which can be extracted from ITIR-FCS measurements Chapter focus on the factors affecting the...
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Cambridge.University.Press.Fearing.Others.The.Nature.and.Treatment.of.Social.Phobia.Mar.2007.pdf
... patterns Whether these are activated depends on the social demands placed on the individual by the way of life of their community These determine the situational contexts evocative of the social ... see the rise of psychology and the application of its psychometric methods to the study of social phobia The first scale for the measurement of social anxiety À the psychological construct at the ... if the above definitions of the two terms and the distinctions drawn between them were of interest and perhaps of some clinical value, they would hardly be meaningful so far as research and theory...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... inhibition of cancer cell proliferation and induction of apoptosis; (5) regulation of subcellular signaling pathways and modulation of transcription factors; and (6) inhibition of growth factors and ... aspects of study design, performance, and analysis, with a focus on randomization of the study subjects, blinding of the investigators and study subjects, and the handling of dropouts and withdrawal ... and Holroyd, 2000), a member of the Hypericaceae family Its yellow flower has been gathered for the feast of St John the Baptist and the word “wort” is the Old English word for plant (Gaster and...
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Tài liệu Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children pdf
... exceptions The letter indicates the strength of the recommendation, which is based on the opinion of the Working Group, and the roman numeral reflects the nature of the evidence supporting the recommendation ... basis of the resistance pattern, treatment history of the patient or the source case, relative activities of the drugs, extent of disease, and any comorbid conditions The duration of therapy should ... from the child, the antimycobacterial drug susceptibility of the M tuberculosis isolate from and treatment history of the source case can be used to define the probable drug susceptibility of the...
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Tài liệu The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults pdf
... pharmacotherapy, surgery, and the medical management of the comorbidities of obesity In addition, physicians can and should engage the assistance of other professionals This guide provides the basic ... communicating that the goal, not the patient, is at issue While in the waiting room, the patient can write down the outcomes of the previous goals, effects of the various aspects of the treatment program ... disease; the patient and the practitioner need to understand that successful treatment requires a lifelong effort Understand how the obesity treatment program integrates into other aspects of the...
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Báo cáo khoa học: Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid pdf
... helices AV and BV at the surface of domain V Gly621 and Gly617 are in the area of contact with the 1095 and 2473 regions of 23S RNA The two helices are facing the ribosome, and the four-stranded b-sheet ... structures in the PDB The structures were superimposed on the basis of domains I and II Looking from the direction of the arrow in (A) and (B), the coordinates of His572 at the tip of domain IV ... with the 1095 and 2473 regions of 23S RNA Helix BV packs against domains G and III, and in complex with the ribosome the C-terminal turn of the helix (659–663) interacts with the 2660 region of...
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Improving the diagnosis and treatment of smear-negative pulmonary and extrapulmonary tuberculosis among adults and adolescents pdf
... aspirate is obtained, move the needle in and out of the centre of the node while pulling back on the syringe piston Gently compress the node with the nondominant hand and revolve the needle in both directions ... or longer Taking the syringe in the dominant hand, insert the needle through healthy skin into the centre of the node or at the point of maximum fluctuance, and pull back on the syringe piston ... Association and the Damien Foundation have also provided their comments on the earlier version The document was reviewed by members of the Core Group of the global TB/ HIV Working Group of the Stop TB...
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Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt
... 5-HPETE PG endoperoxyd H2 [G2] Prostacyclinsynthetase leucotrien A leucotrien B prostacyclin (PGl2) PG-synthetase PG sơ cấp (PGE2, D2, P2) TX synthetase TX A2 leucotrien C TX B2 leucotrien D ... dầu olive điều trị ung th vú, tuỵ tạng, ruột kết Tài liệu tham khảo Wallace, J.M: Integrative Cancer Therapies; tập 1; số 1; 3/2002; trang - 37; SAGE Publications La Presse médicale; 17/3/2001/30/ ... sàng Acid boswellic giúp biệt hoá nhiều dòng tế bào bệnh bạch cầu Với nồng độ thấp, làm tăng chết theo chơng trình (apoptosis) dòng tế bào Glia (thần kinh đệm) Một số thực vật khác đáng quan tâm...
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KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) pdf
... suggestions and edits on the wording of recommendations, and on the use of specific grades for the strength of the recommendations and the quality of evidence The Work Group took on the primary role of ... abnormalities, the severity of abnormalities, all in the context of the degree and rate of change of GFR and the use of concomitant medications The interpretation of the biochemical and hormonal ... parameters of CKD–MBD The clinician should adjust the frequency on the basis of the presence and magnitude of abnormalities, and on the rate of progression of kidney disease The frequency of measurement...
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Guidelines for the early detection and screening of breast cancer ppt
... be the focus of family life The impact of breast cancer is therefore profound on both the woman diagnosed with the disease and her family Their fear and anxiety over the eventual outcome of the ... diagnostic and treatment services The continuing education of professionals focuses on the role of the professional as the initial point of contact between potential cancer patients and the health ... an increase in the incidence of breast cancer Many of the hormonal risk factors such as long duration of reproductive life, multiparity and late age at the time of the birth of the first child...
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The Next Growth Opportunity for Banks: How the Post-Crisis Financial Needs of Younger Consumers Will Transform Retail Banking Services pdf
... controlling spending and revamping investment strategies for sustainable growth These consumers also tend to be younger and are more active users of technology Understanding the needs of these consumers ... holistic view of consumers’ financial situations and needs, and use this information to provide more relevant advice, strengthen their position as the bank of choice, and increase cross-sell and up-sell ... launched and then retired by banks The most successful communities are those that allow users to derive significant value from other participants and professionals in the community Given the thirst of...
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